Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease by Alfredo Smiriglia, Nicla Lorito, Marina Bacci, Angela Subbiani, Francesca Bonechi, Giuseppina Comito, Marta Anna Kowalik, Andrea Perra, Andrea Morandi

“…In this study, we utilized preclinical in vitro models—immortalized cell lines and hepatocyte-like cells derived from human embryonic stem cells—exposed to clinically relevant steatotic-inducing agents. These exposures led to lipid droplet (LD) accumulation, increased reactive oxygen species (ROS) levels, and mitochondrial dysfunction, along with decreased expression of markers associated with hepatocyte functionality and differentiation. …”
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cGAS-STING targeting offers therapy choice in lung diseases by Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang

“…Insights into the biology of the cGAS-STING pathway have enabled the discovery of small-molecule agents which have the potential to inhibit the cGAS-STING axis in lung diseases. …”
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Free Triiodothyronine and Cholesterol Levels in Euthyroid Elderly T2DM Patients by F. Strollo, I. Carucci, M. Morè, G. Marico, G. Strollo, M. A. Masini, S. Gentile

“…When divided according to treatment by oral hypoglycaemic agents (OHA) and insulin (IT), they reacted differently with respect to investigated associations: in the OHA’s TC and LDL-C correlated negatively with FT4 and showed no association with FT3, whereas, in the IT’s TC and LDL-C correlated positively with FT3 and negatively with FT4. …”
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Enabling Semantic Technology Empowered Smart Spaces by Jussi Kiljander, Arto Ylisaukko-oja, Janne Takalo-Mattila, Matti Eteläperä, Juha-Pekka Soininen

“…In particular the paper describes (1) methods for utilizing semantic technologies with resource restricted-devices, (2) a solution for identifying real world objects in semantic technology empowered smart spaces, (3) a method for users to modify the behavior of context-aware smart space applications, and (4) an approach for content sharing between autonomous smart space agents. The proposed solutions include ontologies, system models, and guidelines for building smart spaces with the M3 semantic information sharing platform. …”
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MINIMUM INHIBITORY CONCENTRATION OF PURPLE LEAF EXTRACT (GRAPTOPHYLLUM PICTUM L. GRIFF) AGAINST LACTOBACILLUS ACIDOPHILUS ATCC 4356 by Shafira Indriyani Chusnadia, Atik Kurniawati, Sari Setyaningsih, Erawati Wulandari, Pudji Astuti

“…Control of bacteria in the form of antibacterial agents is needed to suppress the growth of L. acidophilus. …”
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Prevention and management of cytomegalovirus infection and disease in kidney transplant: A consensus statement of the Transplantation Society of Taiwan by Mu-Chi Chung, Cheng-Hsu Chen, Shen-Shin Chang, Chih-Yuan Lee, Ya-Chung Tian, Mei-Yi Wu, Hsu-Han Wang, Chia-Cheng Yu, Teng-Wei Chen, Chien-Chang Kao, Chih-Yang Hsu, Yang-Jen Chiang, Ming-Ju Wu, Yen-Ta Chen, Mai-Szu Wu

“…Letermovir and marabavir are emerging CMV agents used for prophylaxis and refractory CMV disease. …”
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Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors by Alshimaa A. Y. Ahmed, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif

“…IntroductionThis work outlines the design, synthesis, and biological evaluation of a new series of benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit the EGFR pathway.MethodsThe research assesses the antiproliferative efficacy of compounds 6a-i and 10a-i against various cancer cell lines.Results and DiscussionThe research emphasizing hybrids 6i and 10e for their remarkable activity, with GI50 values of 29 nM and 25 nM, respectively. …”
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From polymer matrix to cell structure: STG/TEMs/PU energy-absorbing foamed composites with strain rate-dependent and bimodal cellular structure by Xiaoke Liu, Kejing Yu, Pengwan Chen

“…In this study, based on polyurethane (PU) foam material, intelligent macromolecular material “shear thickening gel (STG)” with strain rate-dependent characteristic was chosen as the reinforcing material to strengthen the PU matrix, and water together with thermal expansion microspheres (TEMs) were used as double foaming agents to prepare STG/TEMs/PU foamed composites with bimodal cell structure and excellent mechanical properties. …”
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Induction of tyrosine aminotransferase in mice is inhibited by activated metabolites of ortho- aminoazotoluene by V. I. Kaledin, S. I. Ilnitskaya, N. A. Popova, O. A. Koval, I. A. Pyshnaya, L. F. Gulyaeva

“…In contrast, nonspecific genotoxic agents such as cyclophosphamide and cisplatin exert no effect on TAT induction by glucocorticoids. …”
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Case report: Dysphonia associated with high-dose cytarabine therapy by Ling Ma, Niya Huang, Haixi Zhang, Jia Liu, Zhiqing Zhang

Subjects: “…acute myeloid leukemia…”
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Mesenchymal Stem Cell-Based Therapy of Inflammatory Lung Diseases: Current Understanding and Future Perspectives by C. Randall Harrell, Ruxana Sadikot, Jose Pascual, Crissy Fellabaum, Marina Gazdic Jankovic, Nemanja Jovicic, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic

“…During acute or chronic lung injury, inappropriate immune response and/or aberrant repair process causes irreversible damage in lung tissue and most usually results in the development of fibrosis followed by decline in lung function. …”
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A Novel Complex Event Processing Engine for Intelligent Data Analysis in Integrated Information Systems by Dong Wang, Mingquan Zhou, Sajid Ali, Pengbo Zhou, Yusong Liu, Xuesong Wang

“…These operators and rules have been utilized for constructing new CEP system architecture which combines expressiveness and efficiency in analysis. It adopts the agents and filter conception explicitly to provide the event transmission mechanism efficiently. …”
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Motivos de prática do triatlo: um estudo com atletas de Santa Catarina by Patrik Felipe Nazario, Bruno Boppré Besen, Glauber Carvalho Nobre, Marucs Vinicius Mizoguchi

“…Conclui-se que o conhecimento dos fatores que envolvem a motivação é de grande importância para técnicos e treinadores, pois proporciona subsídios necessários para a estimulação de programas e treinos específicos voltados ao interesse do praticante, a fim de tornar sua prática mais alegre e duradoura. …”
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A comprehensive review on nutritional composition, health benefits, and industrial applications of Jackfruit Seeds by Simran Dhani, Hamid, Nomali Ziphorah Ngobese, Sunny Sharma, Amit K. Jaiswal

“…Furthermore, starch extracted from discarded jackfruit seeds can be utilized as thickeners, gelling agents and fillers meanwhile its potential applications in the pharmaceutical industry. …”
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Glycosylation Patterns in <i>Meccus (Triatoma) pallidipennis</i> Gut: Implications for the Development of Vector Control Strategies by Elia Torres-Gutiérrez, Frida Noelly Candelas-Otero, Olivia Alicia Reynoso-Ducoing, Berenice González-Rete, Mauro Omar Vences-Blanco, Margarita Cabrera-Bravo, Martha Irene Bucio-Torres, Paz María Silvia Salazar-Schettino

“…Furthermore, the potential use of lectins as insecticidal agents highlights the broader implications of glycoprotein research in the future development of strategies on vector control to disrupt <i>T. cruzi</i> transmission.…”
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Análise de um empreendimento de economia solidária sob a ótica da sociologia das ausências e das emergências by Marília Veríssimo Veronese

“…This paper is a result of a doctorate research in psychology, a case study done in an urban cooperative society in Porto Alegre (RS). Its goal is to discuss the work in the solidary economy, analyzing the experiences of workers in an enterprise, as well as the subjectivity questions linked to laboral processes. …”
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Mold Alkaloid Cytochalasin D Modifies the Morphology and Secretion of fMLP-, LPS-, or PMA-Stimulated Neutrophils upon Adhesion to Fibronectin by Svetlana I. Galkina, Natalia V. Fedorova, Marina V. Serebryakova, Evgenii A. Arifulin, Vladimir I. Stadnichuk, Ludmila A. Baratova, Galina F. Sud’ina

“…Cytochalasin D impaired the MMP-9 secretion but initiated the release of cathepsin G and other granular bactericides, proinflammatory agents. The release of bactericides apparently occurs through the formation, shedding, and lysis of cytonemes. …”
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High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches by Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang

“…Thus, this system is promising for the treatment of CKD and bHDL has good potential for delivering agents to damaged renal tubular epithelial cells.…”
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Synthetic peptides as valuable and versatile tools for research: our 20 year journey in Chile by Constanza Cárdenas, Paula Santana, Claudio Álvarez, Luis Mercado, Sergio Marshall, Fernando Albericio, Fanny Guzmán

“…They are ubiquitous across the evolutionary scale, fulfilling a wide variety of functions, from immune system effectors in simple organisms to signaling or neuromodulating agents in high vertebrates. Following nature’s example, peptides have emerged as alternatives in various fields. …”
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Enhancing antimicrobial resistance strategies: Leveraging artificial intelligence for improved outcomes by Aeshah M. Mohammed, Mohammed Mohammed, Jawad K. Oleiwi, Azlin F. Osman, Tijjani Adam, Bashir O. Betar, Subash C.B. Gopinath, Falah H. Ihmedee

“…This review not only highlights AI's potential to enhance AMR management but also calls for a concerted effort to harness its capabilities, thereby safeguarding the efficacy of antimicrobial agents and ensuring a sustainable healthcare future.…”
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