D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming by Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luis Ribeiro, Mirit I. Aladjem, Chunzhang Yang

“…IDH mutated malignancies are signatured with “BRCAness”, highlighted with the sensitivity to DNA repair inhibitors and genotoxic agents, although the underlying molecular mechanism remains elusive. …”
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Comparison of chemical constituents in Lysimachia species and their antimicrobial activity for extending the shelf life of foods by Li-Li Chen, Shuang Long Yang, Ji-Cun Bao, Wei-You Xie, Zhao-Chan Wang, Nian Shi, Zhao-Jie Wang

“…Developing novel antimicrobial agents and preservatives is urgently needed for anti-foodborne diseases and improving food storage. …”
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Iron(III) photoinduced degradation: Catalytic method for 4,4′-diaminostilbene-2,2′-disulfonic acid removal from water by Pascal Wong-Wah-Chung, Gilles Mailhot, Michèle Bolte

“…The Fe(III)-photoinduced degradation of 4,4′-diaminostilbene-2,2′-disulfonic acid (DSD), used as a model compound of fluorescent whitening agents, was investigated in aqueous solution. The mixing of DSD and iron(III) solutions immediately led to DSD degradation into two oxidation products 5-amino-2- formyl-benzene sulfonic acid (1) and DSD epoxide (2) together with the formation of Fe(II). …”
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Interference of a phytoconstituent from Nymphaea lotus-derived ligand N-acetyl glucosamine with signaling receptors in diabetes mellitus development: A targeted computational analy... by Sunday Amos Onikanni, Tran Nhat-Phong Dao, Adewale Oluwaseun Fadaka, Halliru Zailani, Oluwafemi Shittu Bakare, Omolola Esther Amos, Ashwil Klein, Valens Munyembaraga, Morenike Grace Ajayi, Adebola Iyabode Akinjokun, Babatunji Emmanuel Oyinloye, Leandro Miranda-Alves

“…It provides innovative methods that can speed up drug discovery and lower costs thereby results to increase enthusiasm at developing instinctive antidiabetic agents as alternatives for managing diabetes. Nymphaea lotus, a plant with medicinal properties known for its anti-diabetic effects, contains bioactive components like N-acetyl glucosamine. …”
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A comprehensive review on multifunctional bioactive properties of elm oyster mushroom Hypsizygus ulmarius (Bull.) Redhead (Agaricomycetes): Current research, challenges and future... by Aditya, Neeraj, J.N. Bhatia, Ajar Nath Yadav

“…This review focuses on the nutrition and bioactive molecules present in this mushroom species and their further implications in medicine, agriculture, biotechnology for the development of new anti-bacterial agents and their potential industrial uses for human health. …”
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Breast Cancer Profile among Patients with a History of Chemoprevention by Freya R. Schnabel, Sarah Pivo, Jennifer Chun, Shira Schwartz, Ana Paula Refinetti, Deborah Axelrod, Amber Guth

“…This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease. …”
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Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis by Xiangyang Xia, Quanwei Tao, Qunchao Ma, Huiqiang Chen, Jian’an Wang, Hong Yu

“…GHRH and its agonists are proangiogenic in responsive tissues including tumors, and GHRH antagonists have been tested as antitumor agents through their ability to suppress angiogenesis and cell growth. …”
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Digital twin of a large-aspect-ratio Rayleigh–Bénard experiment: role of thermal boundary conditions, measurement errors and uncertainties by Philipp P. Vieweg, Theo Käufer, Christian Cierpka, Jörg Schumacher

“…Albeit laboratory experiments and numerical simulations have proven themselves successful in enhancing our understanding of long-living large-scale flow structures in horizontally extended Rayleigh–Bénard convection, some discrepancies with respect to their size and induced heat transfer remain. …”
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Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats by Artur Dembiński, Zygmunt Warzecha, Piotr Ceranowicz, Marcin Dembiński, Jakub Cieszkowski, Tomasz Gosiewski, Małgorzata Bulanda, Beata Kuśnierz-Cabala, Krystyna Gałązka, Peter Christopher Konturek

“…Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of acetic acid-induced colitis. …”
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Diagnostics and treatment of biliary dyskinesia: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, Yu. O. Shulpekova, Ye. K. Baranskaya, A. V. Okhlobystin, A. S. Trukhmanov, T. L. Lapina, A. A. Sheptulin

“…Therapeutic approach should include correction of diet and lifestyle modification, administration of antispasmodic medications and agents modulating the state of nervous system, in selected cases the option of papillosphincterotomy should be considered.…”
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Characterization of the Hypercitrullination Reaction in Human Neutrophils and Other Leukocytes by Yebin Zhou, Tiziana Di Pucchio, Gary P. Sims, Nanette Mittereder, Tomas Mustelin

“…Using two independent western blotting methods, we report that agents that trigger a sufficiently large influx of extracellular calcium ions induced a marked citrullination of multiple proteins in human neutrophils, monocytes, and, to a lesser extent, T lymphocytes and natural killer cells, but not B lymphocytes or dendritic cells. …”
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Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer by Xiaoxia Jin, Yingze Wei, Yushan Liu, Xiaoyun Lu, Fei Ding, Jiatai Wang, Shuyun Yang

“…Doxorubicin (DOX) is one of the most commonly used chemotherapeutic agents against breast cancer, but acquired resistance to DOX can seriously impede the efficacy of chemotherapy, leading to poor prognosis and recurrences of cancer. …”
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Diversidade sexual no Tribunal de Justiça do Estado do Rio Grande do Sul: homofobia clássica e moderna em 50 anos de decisões criminais (1970-2019) by Gabriel Bigarella Zugno, Roger Raupp Rios, Leonardo Mello Garcia dos Santos, Adolfo Pizzinato, Angelo Brandelli Costa

“…Empregando o método da Análise Temática e por buscas realizadas por ferramenta informatizada no banco de dados de decisões judiciais do Tribunal de Justiça do Estado do Rio Grande do Sul (TJRS) e pesquisa física junto ao Arquivo Judicial Central de Porto Alegre, foram selecionados 112 processos, totalizando 100 decisões. …”
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Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments by Krzysztof Dobrzeniecki, Anna Zygmunt, Karolina Karoń, Łukasz Karoń, Patrycja Karnas-Bogacka

“…Review methods: The literature review utilized databases covering sources from PubMed, Google Scholar, Scopus, and Web of Science using the search terms encompassing the following keywords: ‘acne vulgaris’ and ‘topical retinoid therapy’, ‘benzoyl peroxide’, ‘azelaic acid’, ‘topical antibiotics’, ‘oral antibiotics’, ‘contraceptive agents’, ‘antiandrogen therapy’, ‘isotretinoin’. …”
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Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids by Wanli Zhao, Jihua Liu, Yu Chen

“…Examples include analgesics such as morphine, tetrahydropalmatine, antimicrobials such as berberine, and antineoplastic agents including cepharanthine. Most BIAs are derived and isolated from medicinal plants; however, these plants are predominantly wild resources that are scarce. …”
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Acesso à justiça e violência doméstica e familiar contra as mulheres: as percepções dos operadores jurídicos e os limites para a aplicação da Lei Maria da Penha by Wânia Pasinato

“…Empiricamente, a pesquisa se realizou como estudos de caso em Porto Alegre, Recife, Salvador, Rio de Janeiro e São Paulo. …”
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Optimizing Acidic Reductive Leaching for Lithium Recovery: Enhancing Sustainable Lithium Supply for Energy Markets by Agnieszka Sobianowska-Turek, Amelia Zielińska, Weronika Urbańska, Anna Mielniczek, Agnieszka Fornalczyk, Szymon Pawlak, Tomasz Małysa, Janusz Cebulski

“…., acid concentration, reducing agents, temperature, and time) that could maximize lithium recovery while minimizing environmental and economic costs. …”
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Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications by Ali A. Alshahrani, Evangelos Kontopantelis, Catharine Morgan, Rathi Ravindrarajah, Glen P. Martin, Mamas A. Mamas, Rongman Jia

“…Many chemotherapeutic agents used to treat cancer are associated with cardiovascular complications (such as heart failure, myocardial infarction, and thrombosis). …”
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B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies by Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Ziliang Ao, Mark Meloche, C. Bruce Verchere, Lieping Chen, Dawei Ou, Alice Mui, Garth L. Warnock

“…More importantly, B7-H4 plays an indispensable role in alloimmunity in the absence of the classic CD28/CTLA-4 : B7 pathway, suggesting a synergistic/additive effect with other agents such as CTLA-4 on inhibition of unwanted immune responses.…”
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Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) by Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa

“…Finally, the review underscores the immense potential of marine natural products as a valuable reservoir of novel anticancer agents and advocates for continued exploration and exploitation of the marine environment to address the unmet medical needs in cancer therapy Graphical Abstract…”
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