An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase by Lois Kwane Kyei, Edward Ntim Gasu, Gilbert Boadu Ampomah, Jehoshaphat Oppong Mensah, Lawrence Sheringham Borquaye

“…The Plasmodium falciparum dihydrofolate reductase (PfDHFR) and dihydroorotate dehydrogenase (PfDHODH) are essential for Plasmodium falciparum growth and development, and have been validated as targets for the development of new antimalarial agents. Several alkaloids isolated from Cryptolepis sanguinolenta have been reported to have antiplasmodial activity, but their protein targets are unknown. …”
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Effect of antacid gastric syrups on surface properties of dental restorative materials: an in vitro analysis of roughness and microhardness by Fikri Öcal, Burak Dayi

“…SEM and AFM results were in agreement with the mechanical profilometer findings. Conclusion Agents such as calcium carbonate, sodium bicarbonate and magnesium carbonate in antacid gastric syrups can affect the surface properties of restorative dental materials. …”
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Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment by Julia Günter, Petra Wolint, Annina Bopp, Julia Steiger, Elena Cambria, Simon P. Hoerstrup, Maximilian Y. Emmert

“…Of great interest is the use of so-called microtissues or spheroids, which have evolved from their traditional role as in vitro models to their novel role as therapeutic agents. This review will provide an overview of the therapeutic potential of microtissues by addressing primarily cardiovascular regeneration. …”
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Análisis Marginal: Un Procedimiento Económico para Seleccionar Tecnologías o Prácticas Alternativas by Edward A. Evans

“… Hoy en día, muchos agentes de extensión e investigadores agrícolas incorporan cierto nivel de análisis económico a las decisiones relacionadas con la selección de tecnologas o prácticas que recomiendan a los productores agrícolas para mejorar sus ingresos. …”
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Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes by Ewa M. Sokolewicz, Kamil Dzwilewski, Natalia Omieczyńska, Marta Zawadzka, Maria Mazurkiewicz-Bełdzińska

“…In conclusion, glucose is one of the key metabolic agents for the proper brain function and any imbalances in its blood level may impair the neuronal computation. …”
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A Clinically-Reasoned Approach to Manual Therapy in Sports Physical Therapy by Steven Short, Matthew Tuttle, Dillon Youngman

“…Given the risks associated with pharmacological pain management, the cost of passive modalities like biophysical agents (electrical stimulation, photobiomodulation, ultrasound, etc), and the indications from the evidence-base when combined with active therapies, manual therapy can be a safe and effective treatment strategy to keep athletes active…”
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FOOD PRODUCT CONTAMINATION RISKS AT DIFFERENT STAGES OF PRODUCTION by O. I. Lavrukhina, V. G. Amelin, L. B. Prokhvatilova, O. I. Ruchnova

“…Feed can be a potential source of contamination of raw materials and animal food products as a result of bioaccumulation and transfer of toxic agents and their metabolites to meat, offal, milk and eggs. …”
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Efficacy of Abiraterone and Enzalutamide in Pre- and Postdocetaxel Castration-Resistant Prostate Cancer: A Trial-Level Meta-Analysis by Mike Fang, Mary Nakazawa, Emmanuel S. Antonarakis, Chun Li

“…In the postdocetaxel setting, the advantage of enzalutamide use was nominally significant for median PFS (1.2 months p=0.02 without adjustment and 2.2 months and p=0.0007 after adjustment); there was no significant difference in median OS between the two agents. The results from this comprehensive meta-analysis suggest a survival advantage with the use of first-line enzalutamide over abiraterone in CRPC and highlight the need for prospective clinical trials.…”
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DESIGNING AND EFFICIENCY EFFECT OF AUTOMATIC BALL-CLEANING SYSTEM FOR CONDENSER 180-KTsS-1 OF TURBINE Т-180/210-130-1 LMZ. Part 1 by Yu. A. Zenovich-Leshkevich-Ol’pinskiy, A. Yu. Naumov, A. Yu. Zenovich-Leshkevich-Ol’pinskaya

“…Depending on the sedimentation character and composition, and the quality of cooling water at the power plant, they apply various methods of the condenser tubes clearing: heat drying, vacuum dehydration, acid-washing, pipes-shooting with water and water-air pistols, ablution with high-pressure water jet etc. All the applied cleaning methods are the periodical means to fight the sedimentations and require the turbine halting or unloading, predetermine the equipment operating between clearings with constantly smearing cooling surfaces of the condensers, i.e. with reduced efficiency of equipment operation.The installation of the ball-cleaning system practically excludes defects of the chemical and mechanical cleaning methods, which leads to the condenser pipes life-in-service increase, the full-flow condensate quality improvement, reliability and efficient performance enhancement of the steam turbines equipment. …”
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Activins and Follistatin in Chronic Hepatitis C and Its Treatment with Pegylated-Interferon-α Based Therapy by Bassem Refaat, Ahmed Mohamed Ashshi, Adel Galal El-Shemi, Esam Azhar

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Converting from Seepage Irrigation to Plasticulture for Vegetable Production: A Case Study by Charles E. Barrett, Lincoln Zotarelli, Lucas G. Paranhos, Mark W. Warren

“… This article is intended to provide information to producers and Extension agents that are interested in using drip irrigation for vegetable production. …”
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Research Progress of SGLT2 Inhibitors in Cancer Treatment by Miao X, Zhang J, Huang W, Wang Y, Jin A, Cao J, Zhao Z

“…This article provides a comprehensive review of the role of SGLT2 in tumorigenesis and tumor progression, and explores the underlying mechanisms and potential therapeutic applications of SGLT2 inhibitors as anticancer agents.Keywords: SGLT2 inhibitors, SGLT2, cancer, mechanism…”
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Harmful Consequences of Proton Pump Inhibitors on Male Fertility: An Evidence from Subchronic Toxicity Study of Esomeprazole and Lansoprazole in Wistar Rats by Namra Mumtaz, Muhammad Furqan Akhtar, Ammara Saleem, Amjad Riaz

“…Proton pump inhibitors (PPIs) are frequently prescribed as gastric acid-suppressing agents. Nevertheless, there is limited evidence supporting the risk of detrimental effects of PPIs on male fertility. …”
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Postoperative Residual Neuromuscular Paralysis at an Australian Tertiary Children’s Hospital by Thomas Ledowski, Brendan O’Dea, Luke Meyerkort, Mary Hegarty, Britta S. von Ungern-Sternberg

“…Data related to patient postoperative outcome was collected in the postoperative acute care unit. Results. Data of 64 patients were analyzed. …”
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Revolutionizing Education: Harnessing Graph Machine Learning for Enhanced Problem-Solving in Environmental Science and Pollution Technology by R. Krishna Kumari

“…GML emerges as a potent and indispensable tool, adeptly leveraging the intrinsic interconnectedness embedded within environmental datasets. …”
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Idiopathic Bilateral Suprachoroidal Haemorrhage: A Rare Case Presentation by Komal Saluja, Mayuresh Naik, Rajshekhar Vemparala, Anuj Mehta

“…The patient was admitted and started on injection mannitol, oral syrup glycerol, and oral acetazolamide. Locally, timolol maleate and brimonidine were also started. The next day, his IOP was 17 mm Hg bilaterally but his visual acuity deteriorated to FC 1 m in right eye and hand movement in left eye with inaccurate projection of rays in both eyes. …”
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A Remuneração dos Capitais Utilizados para Financiamento dos Ativos de Empresas Distribuidoras de Energia Elétrica Medida por Meio da DVA by Maísa de Souza Ribeiro, Ariovaldo dos Santos

“…Como conseqüência desse endividamento e do respectivo aumento das despesas financeiras, além da falta de investimentos, os resultados têm sido negativos e boa parte das distribuidoras de energia elétrica tem acumulado prejuízos significativos. …”
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An anatomical aspect on masseteric muscles in cattle rabies by real-time pcr by Atilla Yoldaş, Ramazan İlgün, Nevin Tuzcu, Akın Yığın, Erdal Özmen

“…RT-PCR method could be helpful to detect pathways of the neurotropic agents suspected cattle.…”
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Mesenchymal stem cell-derived exosome and liposome hybrids as transfection nanocarriers of Cas9-GFP plasmid to HEK293T cells. by Behnaz Gharehchelou, Mehrnoush Mehrarya, Yahya Sefidbakht, Vuk Uskoković, Fatemeh Suri, Sareh Arjmand, Farnaz Maghami, Seyed Omid Ranaei Siadat, Saeed Karima, Massoud Vosough

“…Recently, they have garnered considerable interest as nanocarriers for the controlled transfer of therapeutic agents to cells. Here, exosomes were derived from bone marrow mesenchymal stem cells using three different isolation methods. …”
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O Estado de Coisas Inconstitucional na ADPF 347 e a sedução do Direito: o impacto da medida cautelar e a resposta dos poderes políticos by Breno Baía Magalhães

“…Ao tratar da decisão do STF na ADPF 347 como uma decisão que cria caminhos políticos a serem percorridos pelos agentes envolvidos, no caso, os Poderes Executivo, Legislativo e Judiciário, busca-se avaliar a viabilidade das respostas apresentadas no sentido de alcançarem, ou não, as exigências formuladas pela decisão judicial. …”
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