Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy by Rangarirai Makuku, Neda Khalili, Sepideh Razi, Mahsa Keshavarz-Fathi, Nima Rezaei

“…Among immunotherapeutic agents, immune checkpoint inhibitors have been of particular interest and have gained approval by the FDA for treatment of cancers. …”
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Telomere Biology: Key to unlocking the fountain of youth…A Systematic Review. by Anirban Poddar, Anup Kumar Rana, Ranjita Santra, Phalguni Chakrabarti

“…As the role of telomere biology is well established in ageing,current research therefore aims to develop means to reduce telomere attrition,thereby reducing ageing & age related diseases.This review will focus on summarising the role of telomere biology in ageing & age related diseases while highlighting the recent advances in research aiming towards enhanced longevity & healthy ageing.This review will further emphasize on telomere targetted therapeutics such as telomerase activators & tankyrase inhibitors while also highlighting the role of antioxidative & antiinflammatory agents alongwith indirectly related approaches such as statins.…”
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NOD Dendritic Cells Stimulated with Lactobacilli Preferentially Produce IL-10 versus IL-12 and Decrease Diabetes Incidence by Jean N. Manirarora, Sarah A. Parnell, Yoon-Hyeon Hu, Michele M. Kosiewicz, Pascale Alard

“…Evaluation of the relative production of IL-10 and IL-12 by DCs may be a very useful means of identifying agents that have therapeutic potential.…”
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In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis by Georgi Momekov, Dilyan Ferdinandov, Spiro Konstantinov, Sonja Arpadjan, Daniela Tsekova, Galina Gencheva, Panayot R. Bontchev, Margarita Karaivanova

“…A comparative assessment of both agents against the human kidney cell line 293T has shown that [Au(II)Hp-2H.…”
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Retrovirus Entry by Endocytosis and Cathepsin Proteases by Yoshinao Kubo, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto

“…Retroviruses include infectious agents inducing severe diseases in humans and animals. …”
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Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics by Heng Wei, Yingying Hao, Jin Zhang, Yue Qi, Chong Feng, Chen Zhang

“…Mechanisms such as the proton sponge effect, where NPs induce osmotic swelling and rupture of the lysosomal membrane, and membrane fusion, which facilitates the release of therapeutic agents directly into the cytoplasm, are explored in detail. …”
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Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination by Farhad Ghanizadeh Gerayeli, Farnaz Hosseini, Zohreh Bagheri, Amir Savardashtaki, Zahra Shabaninejad, Ali Mohammad Amani, Sohrab Najafipour

“…Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs. In this study, we synthesized AgNP-modified β-cyclodextrin (β-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination. …”
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Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation by Guliang Yang, Haiyan Zhong, Xinxin Xia, Zhiwen Qi, Chengzhang Wang, Shiming Li

“…Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. As the agents in protein degradation dependent on ubiquitin ligase, the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker. …”
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Treatment of irritable bowel syndrome: the past, present and future by V. T. Ivashkin, Ye. A. Poluektova, O. S. Lyashenko, D. V. Reykhart

“…Spasmolytics, laxatives or antidiarrheal agents are traditionally applied for treatment of IBS patients according to leading symptom. …”
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hpvPDB: An Online Proteome Reserve for Human Papillomavirus by Satish Kumar, Lingaraja Jena, Sangeeta Daf, Kanchan Mohod, Peyush Goyal, Ashok K. Varma

“…The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host and designing novel protein vaccines and anti-viral agents, etc. Genomic, proteomic, structural, and disease-related information on HPV is available on the web; yet, with trivial annotations and more so, it is not well customized for data analysis, host-pathogen interaction, strain-disease association, drug designing, and sequence analysis, etc. …”
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Antimicrobial Evaluation of Bacterial Isolates from Urine Specimen of Patients with Complaints of Urinary Tract Infections in Awka, Nigeria by Perpetua A. Ekwealor, Malachy C. Ugwu, Ifeanyi Ezeobi, George Amalukwe, Belinda C. Ugwu, Ugochukwu Okezie, Catherine Stanley, Charles Esimone

“…The antibacterial activities of the tested agents were in the order of Augmentin < Ceftazidime < Cefuroxime < Cefixime < Gentamicin < Ofloxacin < Ciprofloxacin < Nitrofurantoin. …”
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The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer by Jennifer H. Gunter, Amy A. Lubik, Ian McKenzie, Michael Pollak, Colleen C. Nelson

“…Prostate cancer patients present a promising cohort for the exploration of insulin stabilising agents as adjunct treatments for hormone deprivation or enhancers of chemosensitivity for treatment of advanced prostate cancer.…”
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Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization by Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk

“…This study highlighted the potential of imaging flow cytometry to advance the study of viral entry and the evaluation of antiviral agents.…”
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Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol by Marcilio S. S. Cunha-Filho, Carmen Alvarez-Lorenzo, Ramón Martínez-Pacheco, Mariana Landin

“…This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β-lapachone (βLAP). …”
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High-Strength Hollow Glass Microsphere/Epoxy Resin Composite Insulation Materials for Deep In-Situ Condition Preserved Coring by Jianping Yang, Ling Chen, Zhiqiang He, Cong Li, Bo Yu, Zijie Wei, Zhiyu Zhao, Zongxin Hao

“…An epoxy resin matrix with high strength and high-temperature resistance was selected from among epoxy resins cured by different curing agents. Then, a series of composite insulation materials with different HGM volume fractions were prepared. …”
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Laboratory Exploration of Several Potential Biocontrol Methods Against the Ambrosia Beetle, <i>Euwallacea interjectus</i> by Jialin Liu, Nan Jiang, Haiming Gao, Shengchang Lai, Yang Zhou, Dejun Hao, Lulu Dai

“…Both mites effectively parasitized beetle pupae and larvae, with no significant differences in efficacy between the two species. These agents demonstrate promise for the biological control of <i>E. interjectus</i>, offering insights for managing ambrosia beetle infestations.…”
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An Aggressive Form of Langerhan Cell Histiocytosis in an Adult: Therapeutic Challenges by Karan Seegobin, Satish Maharaj, Cherisse Baldeo, Amal Shukri, Fauzia N. Rana

“…A 35-year-old male with an incidental left iliac bone lesion was diagnosed with LCH. He later became symptomatic with hip pain and spread of the disease. …”
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Rheological Properties of Very High-Strength Portland Cement Pastes: Influence of Very Effective Superplasticizers by Adriano Papo, Luciano Piani, Riccardo Ricceri

“…Three commercial superplasticizing agents produced by Ruredil S.p.a. were used. They are based on a melamine resin (Fluiment 33 M), on a modified lignosulphonate (Concretan 200 L), and on a modified polyacrylate (Ergomix 1000). …”
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O cuidado ao surdo no serviço de saúde: um clamor silenciado by Luana Paula de Figueiredo Correia, Márcia de Assunção Ferreira

“…Os dados produzidos foram submetidos à análise lexical por meio do software Alceste. Os resultados indicam que as representações da assistência a pessoas surdas na saúde possuem três dimensões: simbólica, associada à interdição da comunicação; afetiva, demonstrada por meio de sofrimento, angústia e receio em atender usuários surdos; e atitudinal, em que os profissionais se utilizavam de estratégias com vistas ao estabelecimento de comunicação para realização da assistência.…”
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Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report by Yo Komatsuzaki, Yasuyuki Nakada, Izumi Yamamoto, Mayuko Kawabe, Takafumi Yamakawa, Ai Katsuma, Haruki Katsumata, Aki Mafune, Akimitsu Kobayashi, Yusuke Koike, Hiroki Yamada, Jun Miki, Yudo Tanno, Ichiro Ohkido, Nobuo Tsuboi, Keitaro Yokoyama, Hiroyasu Yamamoto, Takashi Yokoo

“…Despite the recent development of immunosuppressive agents, plasma cell-rich acute rejection (PCAR) has remained refractory to treatment. …”
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