Epitranscriptomic RNA m6A Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities by Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang

“…There are multiple mechanisms through which tumor cells develop resistance to therapeutic agents. To date, efforts to overcome resistance have only achieved limited success. …”
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Translation of Value-Semantic Narratives in Public Digital Communication: Opportunities and Limitations by Albina B. Romashkina, Daria A. Kirichuk

“…It is determined that Internet communication and digital algorithms contribute to the formation of a variety of agendas and discourses, which are influenced not only by the state, but also by new subjects of political communication - “digital elites”, bloggers and other users who form public digital communication, including from abroad. Traditional agents of socialization cannot fully shape a person’s worldview, and therefore citizens may be more susceptible to manipulative algorithmic tools of digital platforms on which destructive narratives are broadcast that contribute to the destruction of the worldview and values of society. …”
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High Prevalence of Candida Yeast in Milk Samples from Cows Suffering from Mastitis in Poland by Bozena Dworecka-Kaszak, Alicja Krutkiewicz, Daniel Szopa, Miroslaw Kleczkowski, Malgorzata Biegańska

“…Mastitis is an economically important disease in which fungi belonging to the genus Candida may participate as etiological agents. This study focused on determining the frequency of fungal isolation and differentiation of fungal species isolated from milk of mastitic cows. …”
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Effect of Preventive Hormonal Therapy on Breast Density: A Systematic Qualitative Review by Virginie Lienart, Birgit Carly, Xin Kang, Laura Guzy, Anna-Maria Sajovitz, Fabienne Liebens

“…Consequently, it is crucial to develop practical, accurate, and reproducible methods of measurement in order to be able to compare the effect of preventive hormonal agents on BD and to determine whether change in BD can be used as a predictor of response to therapy.…”
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PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors by Francesco Dituri, Antonio Mazzocca, Gianluigi Giannelli, Salvatore Antonaci

“…In addition, we discuss, from antitumor immunological point of view, the potential benefits and disadvantages arising from use of anticancer pharmacological agents targeting the PI3K pathway.…”
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Cellular rejuvenation protects neurons from inflammation-mediated cell death by Sienna S. Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, Adam M.R. Groh, Elizabeth M.-L. Hua, Matthew A. Hintermayer, Yuancheng Ryan Lu, David Gosselin, Stephanie Zandee, Alexandre Prat, Jo Anne Stratton, David A. Sinclair, Alyson E. Fournier

“…Collectively, these data reveal an aging-like phenotype in neurons under pathological neuroinflammation and support the possibility that rejuvenation therapies or senotherapeutic agents could offer a direct avenue for neuroprotection in neuroimmune disorders.…”
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Formulation and pharmaceutical development of quetiapine fumarate sustained release matrix tablets using a QbD approach by Gavan Alexandru, Porfire Alina, Marina Cristina, Tomuta Ioan

“…For the D-optimal experimental design, the level and ratio of matrix forming agents and the type of extragranular diluent were chosen as independent inputs, which represented critical formulation factors. …”
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Evaluation of Halogenated Coumarins for Antimosquito Properties by Venugopala K. Narayanaswamy, Raquel M. Gleiser, Kabange Kasumbwe, Bandar E. Aldhubiab, Mahesh V. Attimarad, Bharti Odhav

“…Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.…”
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Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

“…This review offers new insights for CPs in molecular mechanisms, cytotoxicity, target selectivity, and the possibility of designing more effective and safe therapeutic agents.…”
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Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines by Chi-Won Choi, Edmond Changkyun Park, Sung Ho Yun, Sang-Yeop Lee, Seung Il Kim, Gun-Hwa Kim

“…These results suggest that S. pneumoniae EMVs or their individual immunogenic antigens may be useful as new vaccine agents.…”
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Radiolytic Synthesis of Colloidal Silver Nanoparticles for Antibacterial Wound Dressings by Pimpon Uttayarat, Jarurattana Eamsiri, Theeranan Tangthong, Phiriyatorn Suwanmala

“…The uniformly dispersed AgNPs with diameter 32.3 ± 4.40 nm were evaluated as antiseptic agents in films composed of chitosan, SF, and PVA that were processed by irradiation-induced crosslinking. …”
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Implication of the endogenous midgut microbiota on cell genotoxicity and biological fitness of Culex pipiens complex (Diptera: Culicidae) by Alaa Fouaad, Nagwa A. Rashdan, Refaat M. Gabre, Emtithal M. Abdel-Samie

“…Results The current study aimed to find a new mosquito biocontrol agents through using the isolated endogenous midgut microbiota, Atlantibacter hermannii, Klebsiella sp. and Enterobacter cloacae, that were isolated from Culex pipiens complex females’ gut. …”
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Antistaphylococcal Triazole-Based Molecular Hybrids: Design, Synthesis and Activity by Kostiantyn Shabelnyk, Alina Fominichenko, Oleksii Antypenko, Olexandr Gaponov, Svitlana Koptieva, Svitlana Shyshkina, Oleksii Voskoboinik, Sergiy Okovytyy, Serhii Kovalenko, Valentyn Oksenych, Oleksandr Kamyshnyi

“…Conclusions: Obtained [2-(3-R-1<i>H</i>-[1,2,4]-triazol-5-yl)phenyl]amines reveal significant antistaphylococcal activity and deserve for further detailed study as effective antibacterial agents.…”
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De la police coloniale française à la police nationale marocaine : décolonisation et héritages policiers (1953-1960) by Benjamin Badier

“…The expulsion of the last French police agents coincides with an authoritarian shift against the Moroccan left, which denounces a police regime inherited from the colonial era.…”
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Isolation, Identification, and Susceptibility Profile of E. coli, Salmonella, and S. aureus in Dairy Farm and Their Public Health Implication in Central Ethiopia by Umer Seid Geletu, Munera Ahmednur Usmael, Abdulmuen Mohammed Ibrahim

“…High proportion of multiple drug resistant in the dairy farm alerts concern for animal and public health as these drugs are used widely for treatment and prophylaxis in animals and humans.…”
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AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…Additionally, compounds known to inhibit TLR4, including TAK-242 (Resatorvid) and benzisothiazole derivative (M62812), were predicted as bioactive agents within the applicability domain with probabilities above 0.80. …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Males receiving anti-PD-(L)1 monotherapy had the worst outcomes, with a 3-year PFS and 3-year OS of 23.9% and 41.8%, respectively, while the addition of anti-CTLA-4 agents rescued such a worse outcome. We also observed that females experienced a higher frequency of any-grade immune-related adverse events. …”
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Análisis de los efectos de cinco genes (IGF2, CTSD, TBC1D1, MC4R y FABP3) sobre la conversión alimenticia, la velocidad de crecimiento y el contenido de grasa subcutánea en cerdos... by V.B. FASSA, T.R. CARDEN, S.J. MARINI, A.D. LETT, M.R. LLOVERAS, G. MARRUBE

“…Se confirmó el efecto mayor del alelo Apat del gen IGF2 en EGD y CA (1,8 mm y 0,3kg, p<0,05) y hubo diferencias entre genotipos del gen TBC1D1 para VC. …”
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Characteristics of adherent and non-adherent patients with hypertension in a Norwegian cross-sectional study by Eirik Olsen, Lene V. Halvorsen, Stine Rognstad, Arleen Aune, Karl Marius Brobak, Ola Undrum Bergland, Vibeke N. Kjær, Knut Liestøl, Marit D. Solbu, Rune Mo, Eva Gerdts, Morten Rostrup, Sverre E. Kjeldsen, Aud Høieggen, Mimi S. Opdal, Anne Cecilie K. Larstorp, Camilla L. Søraas

“…Methods: Patients with hypertension using ≥ 2 antihypertensive agents were invited to participate in this national study performed in a semi-blinded fashion. …”
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Rol de la protección radiológica en procedimientos de cardiología intervencionista by Teodoro Rivera Montalvo, Eduardo Santiago Uruchurtu Chavarín

“… El objetivo de la protección radiológica es permitir el aprovechamiento de la radiación en todas sus formas conocidas, con un riesgo aceptable tanto para el personal que trabaja con los rayos X como para la población en general y las generaciones futuras. …”
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