A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites by Yne de Vries, Nikki Lwiwski, Marieke Levitus, Bertus Kuyt, Sara J. Israels, Fré Arwert, Michel Zwaan, Cheryl R. Greenberg, Blanche P. Alter, Hans Joenje, Hanne Meijers-Heijboer

“…Based on their sensitivity to DNA cross-linking agents, FA cells have been assigned to 15 complementation groups, and the associated genes have been identified. …”
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Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms by Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin

“…The leading compound demonstrated pronounced antimycotic and antibacterial in vitro activity, comparable to or exceeding that of the reference antifungal (fluconazole, terbinafine) and antibacterial/antiseptic (miramistin, benzalkonium chloride) agents. In contrast to many antimicrobials, the leading compound was also active against biofilm-embedded staphylococci and Escherichia coli. …”
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Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome: A Case Report and Review of the Literature by B. Routy, T. Huynh, R. Fraser, C. Séguin

“…Despite survival improvement with new generation immunosuppressive agents, their mechanisms of action are poorly defined, and CAPS is still considered a high-risk complication in patients known with antiphospholipid antibody syndrome. …”
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Post-Harvest Deterioration of Cassava and its Control Using Extracts of Azadirachta Indica and Aframomum Melegueta by R. N. Okigbo, Ramesh Putheti, C. T. Achusi

“…Juss) leaves and Aframomum melegueta (Schumann) seeds were used as antifungal agents and the susceptibility of four of the isolated pathogenic fungi to them was observed in culture. …”
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An honest woman not just tomorrow, but forever: An analysis of Brazilian legislative process dealing with sexual crimes from the standpoint of the labelling approach by Jéssica Moraes Cesarino, Sergio Nojiri

“…Afterwards, we dealt with the legislative movements and institutional dialogues that removed the term “honest woman” and terms alluding to female virginity to increase protection and mitigate the stigmatization of people who have suffered sexual violence. …”
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Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking by In Won Lee, Jonghwan Yoon, Gunhee Lee, Minho Lee

“…Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers, because its expression is associated with resistance to DNA-damaging anticancer agents. Although several inhibitors already have been identified, the identification of novel kinds of potential inhibitors of APE1 could provide a seed for the development of improved anticancer drugs. …”
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Reinforcing Effect of Carbon Nanotubes/Surfactant Dispersions in Portland Cement Pastes by Oscar A. Mendoza Reales, Caterin Ocampo, Yhan Paul Arias Jaramillo, Juan Carlos Ochoa Botero, Jorge Hernán Quintero, Emílio C. C. M. Silva, Romildo Dias Toledo Filho

“…Powder MWCNTs were dispersed in deionized water using different types of surfactants as chemical dispersing agents and an ultrasonic tip processor. Cement pastes with carbon nanotubes additions of 0.15% by mass of cement were produced in two steps: first, the MWCNT/surfactant dispersions were combined with the mixing water, and then, cement was added and mixed until a homogeneous paste was obtained. …”
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Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals by Rebecca A. Keel, George G. Zhanel, Sheryl Zelenitsky, David P. Nicolau

“…All cefepime, doripenem, ertapenem and meropenem regimens achieved optimal exposures against Enterobacteriaceae, whereas target attainment was organism and dose dependent for the other agents. These results support that the currently recommended antimicrobial dosing regimens generally attain acceptable exposures to achieve the requisite pharmacodynamic targets against the Enterobacteriaceae species; however, they fall short of obtaining optimal bactericidal exposures against P aeruginosa.…”
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Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases by Ballazhi Lulzime, Popovski Emil, Jashari Ahmed, Imeri Faik, Ibrahimi Ibrahim, Mikhova Bozhana, Mladenovska Kristina

“…The study highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anticancer agents in metastatic breast cancer. Eight compounds, combining the coumarin core and five membered heterocycles (isoxazoles and thiazoles) in hydrazinyldiene- -chroman-2,4-diones, were characterized in terms of a potential antiproliferative effect on bone (SCP1833) and lung (SCP4175) metastatic breast cancer cell lines using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay. …”
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Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study by B. Baroukh, J. L. Saffar

“…In the gingiva the two agents significantly decreased PMNL recruitment and migration and increased the vascular lumen. …”
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Antimicrobial Activity of Pomegranate Peel and Its Applications on Food Preservation by Jing Chen, Chunling Liao, Xiaolu Ouyang, Ibrahim Kahramanoğlu, Yudi Gan, Mingxi Li

“…The peels of pomegranate fruits are the major by-products produced during food processing of pomegranate enriched in antioxidants and broad-spectrum antimicrobial agents and can prevent food deterioration even. This health potential of pomegranate is known to vary significantly upon the varieties, growing conditions, cultivation practices, stages of the development, and the extraction methods. …”
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Fatal Hepatic Decompensation in a Patient with Hepatitis B Cirrhosis Following Famciclovir Withdrawal by Robert P Myers, Rabindra Chaudhary, Kevin Fonseca, Samuel S Lee

“…Until further data are available regarding the safety of withdrawal of these agents, indefinite treatment may be required in patients with established cirrhosis.…”
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Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults by Eric J Bow, Gerald Evans, Jeff Fuller, Michel Laverdière, Coleman Rotstein, Robert Rennie, Stephen D Shafran, Don Sheppard, Sylvie Carle, Peter Phillips, Donald C Vinh

“…Over the past few years, a new and broader understanding of the epidemiology and pathogenesis of C/IC has emerged and has been coupled with the availability of new antifungal agents and defined strategies for targeting groups at risk including, but not limited to, acute leukemia patients, hematopoietic stem cell transplants and solid organ transplants, and critical care unit patients. …”
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Estilhaços da memória no pântano da história: Noite dentro da noite, de J. R. Terron by Rita Olivieri-Godet

“…Aunque situada en la dictadura de 1964, evoca, igualmente, el periodo anterior y posterior, captando la barbarie de una “era de extremos” a través del filtro de una visión apocalíptica y profética. Se aleja de la representación realista y opta por la transfiguración expresionista de los sucesivos genocidios, en cuyos escenarios evolucionan los personajes en situaciones extremas. …”
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Peripheral Giant Cell Granuloma Associated with a Dental Implant: A Case Report and Review of the Literature by Amy Louise Brown, Paulo Camargo de Moraes, Marcelo Sperandio, Andresa Borges Soares, Vera Cavalcanti Araújo, Fabrício Passador-Santos

“…Immunohistochemistry, using the antibody CD68, was performed to investigate the origin of the multinucleated giant cells, with their immunophenotype being similar to those of other giant cell lesions, including central giant cell granuloma, foreign-body reactions, and granulomatous reactions to infectious agents.…”
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Rendimiento y desempeño hortícola de semillas desnudas de calabaza en el sur de Florida by Geoffrey Meru, Yuqing Fu, Monique Scoggin, Carlos F. Balerdi, Laura Vasquez, Teresa Olczyk

“… Las semillas de calabaza (Cucurbita pepo L.) con una fina cubierta se llaman semillas desnudas y se han convertido en un ingrediente popular para la elaboración de alimentos. Son ricas en aceite, proteínas y ácidos grasos insaturados. Su consumo reporta beneficios para la salud, incluyendo la reducción del riesgo de ciertos tipos de cáncer. …”
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How informative is your XAI? Assessing the quality of explanations through information power by Marco Matarese, Francesco Rea, Katharina J. Rohlfing, Alessandra Sciutti

“…The proliferation of diverse explanation strategies in recent years promises to improve the interaction between humans and explainable agents. This poses the challenge of assessing the goodness and efficacy of the proposed explanation, which so far has primarily relied on indirect measures, such as the user's task performance. …”
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Granulomatous Osteonecrosis in Crohn’s Disease by Hugh J Freeman, David Owen, Mario Millan

“…She had a complex clinical course that required treatment with multiple pharmacological agents, including intravenous, oral and rectal corticosteroids. …”
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Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications by Tu N. Le, Van-Anh Nguyen, Giang L. Bach, Lam D. Tran, Ha H. Cao

“…In this study, a manual micro-valve system (dimension: w × h: 1000 × 50 μm with 8-integrated channel valves was designed for controlling up to 8 different flows of agents (including magnetic nanoparticle flow) injected into the mixture zone of the microfluidics. …”
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Resource Management Framework Based on the Stackelberg Game in Vehicular Edge Computing by Guang-Shun Li, Ying Zhang, Mao-Li Wang, Jun-Hua Wu, Qing-Yan Lin, Xiao-Fei Sheng

“…In this paper, we combined MEC and IoV to propose a specific vehicle edge resource management framework, which consists of fog nodes (FNs), data service agents (DSAs), and cars. A dynamic service area partitioning algorithm is designed to balance the load of DSA and improve the quality of service. …”
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