Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocy... by Chien-Ju Cheng, Lian-Chen Wang, Lichieh Julie Chu, Kuang-Yao Chen, Ching-Yun Huang, Kuo-Lun Lan, Kuo-Yang Huang

“…Collectively, our data suggest that A. cantonensis L5 EVs enhance cholesterol synthesis and potentially modulate immune response by reducing NLRP2 inflammasome-related signaling in non-permissive host cells.IMPORTANCEAngiostrongylus cantonensis is a significant causative agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans. …”
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East Asian Welfare Regimes 東アジア福祉制度 by Joseph Wong, Andrew DeWit, Ito Peng

“…During the mid-2000s they were only spending about 10% of GDP on social outlays. And then there is Korea, China, and Singapore weighing in with less than 7% of GDP spent on social outlays. …”
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Identification of Health Needs in Ukrainian Refugees Seen in a Primary Care Facility in Tenerife, Spain by Willian-Jesús Martín-Dorta, Cristo-Manuel Marrero-González, Eva-Lourdes Díaz-Hernández, Pedro-Ruymán Brito-Brito, Domingo-Ángel Fernández-Gutiérrez, Oxana-Migalievna Rebryk-De Colichón, Ana-Isabel Martín-García, Estrella Pavés-Lorenzo, María-Candelaria Rodríguez-Santos, Juan-Francisco García-Cabrera, Janet Núnez-Marrero, Alfonso-Miguel García-Hernández

“…Early provision of information about available healthcare services and protocols can facilitate access, manage expectations, and aid decision-making.…”
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Histomorphological Study of Rodenticide Poisoning: An Autopsy-based Crosssectional Study from a Tertiary Care Centre, Krishnagiri, Tamil Nadu, India by P Narmadha Priya, Jayalakshmy Pechimuthu, V Palaniappan, Teleflo Boopathy, Jeevanandham Anbazhagan, Jeevitha Muniraj

“…In a retrospective study conducted by the National Poison Information Centre, it was found that death due to rodenticide poisoning accounted for about 17.06% when compared to other pesticides, indicating a rise in the global burden of rodenticide poisoning. …”
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Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…This approach encourages us to explore the unknown functions of activating transcription factor 3 (ATF3) rather than merely confirming existing hypotheses, while no assumptions were made about ATF3 prior to the experiments. We ensured the unbiased nature of our assessment by conducting morphological evaluations with two independent observers in a blinded manner. …”
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Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized c... by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…Objectives Patients who undergo successful SEMS placement for obstructive left-sided colon adenocarcinoma without metastases will be eligible for this study. …”
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The Impact of Astaxanthin Supplementation on the Lipid Profile by Filip Arczewski, Michalina Wójcikiewicz, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“…Consequently, there is a need for larger, well-standardized clinical trials to accurately assess the efficacy and safety of astaxanthin as a therapeutic agent for lipid modulation and the prevention of metabolic disorders. …”
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Solar Flares Triggered by a Filament Peeling Process Revealed by High-resolution GST Hα Observations by Mia Mancuso, Ju Jing, Haimin Wang, Wenda Cao

“…The dynamic structures of solar filaments prior to solar flares provide important physical clues about the onset of solar eruptions. Observations of those structures under subarcsecond resolution with high cadence are rare. …”
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Environmental Life Cycle Assessment of Healthcare Waste Valorisation Alternatives by Zlaugotne Beate, Zandberga Anda, Gusca Julija, Kalnins Silvija Nora

“…Of the total scenario impacts, the largest impact is caused by waste disposal, followed by transport, which has a similar impact in all scenarios due to assumptions about the distance to be transported, and iHCW treatment also has a similar impact in all scenarios, but the bigger difference is the environmental benefit from recycled waste. …”
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Pola Tekanan Darah Pada Lansia di Posyandu Lansia Kelurahan Padang Pasir Padang Januari 2014 by Saskia Konita, Syaiful Azmi, Erkadius .

“…In 2025, Indonesia's population is projected to reach 273 million people, and nearly a quarter of the total population, or about 62.4 million people belong to a group of elderly people. …”
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Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective... by Ji Won Yeom, Hyungju Kim, Seung Pil Pack, Heon-Jeong Lee, Taesu Cheong, Chul-Hyun Cho

“…There were significant differences among the insomnia groups in stress levels, dysfunctional beliefs about sleep, and symptoms of restless leg syndrome (all P≤.001), with higher severity associated with higher scores in these factors. …”
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Survey on the presence of floating microplastics, trace metals and metalloids in seawater from Southern Italy to the United States of America by Elisabetta Morici, Gaetano Cammilleri, Sergio Scirè, Francesco Paolo Bonomo, Luigi Tranchina, Francesca Terracina, Paola Galluzzo, Vincenzo Ferrantelli, Vincenzo Paolo Monteverde, Francesco Giuseppe Galluzzo, Sergio Davì, Mariano Licciardi, Salvatore Dara

“…The presence of microplastics (MPs), trace metals (TM) and metalloids (Ms) in surface seawater is a severe emerging issue of global concern. Information about the distribution of these pollutants is often lacking, and large-scale studies come with uncertainties because of difficult comparisons of results obtained using different methods to collect and process data. …”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

“…AAV8.P demonstrated superior transduction efficiency and safety, achieving about 90% liver transduction and maintaining transgene expression for up to a year. …”
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Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ Aggregation by Bong-Keun Jang, Soo Jung Shin, Hyun Ha Park, Vijay Kumar, Yong Ho Park, Jeom-Yong Kim, Hye-Yeon Kang, Sunyoung Park, Youngsun Kwon, Sang-Eun Shin, Minho Moon, Beom-Jin Lee

“…However, there was still concern about their structural instability in vivo and in vitro. …”
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Broad Diversity of Fungi in Hospital Water by Máira Gazzola Arroyo, Adriano Menis Ferreira, Oleci Pereira Frota, Natalia Seron Brizzotti-Mazuchi, Jacqueline Tanury Macruz Peresi, Marcelo Alessandro Rigotti, Carlos Eduardo Macedo, Alvaro Francisco Lopes de Sousa, Denise de Andrade, Margarete Teresa Gottardo de Almeida

“…Seventy species of fungi were identified in the water samples and about 56% of the water samples contained culturable fungi. …”
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Longitudinal impact of preregistration interprofessional education on the attitudes and skills of health professionals during their early careers: a non-randomised trial with 4-yea... by Ben Darlow, Jennifer Roberts, Patrick McHugh, Melanie Brown, Eileen McKinlay, Peter Gallagher, Lesley Gray, Gordon Purdie, Christine Wilson, Sue Pullon, Louise Beckingsale, Kaye Cheetham, Ruth Crawford, Sue Floyd, Janice Handley, Jackie Herkt, Lisa Kuperus, Alison Meldrum, Margot Skinner, Rose Schwass, Julie Weaver, James Windle, Lyndie Foster-Page

“…TIPE participants made substantially more free-text comments about benefits of interprofessional collaboration and perceived the TIPE programme had a meaningful influence on their readiness to work in teams and the way in which they performed their healthcare roles.Conclusions TIPE programme participation significantly improved attitudes towards healthcare teams and these changes were maintained over 4 years.…”
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“Common sense is hard work” but benefits from persistent collaboration: Lessons learnt from the development of The Collaborative Network for European Clinical Trials for Children (... by Sabah Attar, Carla Peacock, Mandy Wan, Erin Halil, Chloe Bickerstaff, Lionel Tan, Hafsah Bhatti, Ricardo M. Fernandes, Regis Hankard, Mark A. Turner

“…Practical actions that infrastructure developers and users can take include operational planning with a view to fostering collaborations across stakeholders, sharing information about different approaches to clinical operations, and raising awareness of the need for explicit work on collaboration, communication, and planning. …”
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Pengembangan Aplikasi E-Learning Edu IT : Pembuatan Aplikasi Ujian Essay Online serta Upload Download Materi Kuliah by Maria Bellaniar Ismiati, Latius Hermawan

“…This research will show a drop down menu which is Essay about essay with questions in the form of essays that need to be answered with complete and detail. …”
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Insights into simulation-based learning: student and faculty experiences in a PharmD program in Saudi Arabia by Reem Binsuwaidan, Najla A. Altwaijry, Alnada A. Ibrahim, Rawan A. Alghamdi, Razan Bin Humaid, Alaa A. AlSharif, Alaa A. AlHubaishi, Elshaymaa I. Elmongy, Lina I. Alnajjar, Ghadah H. Alshehri

“…Methods A mixed-method approach was employed, which used a cross-sectional survey and focus group discussion that solicited feedback from pharmacy students and academic faculty staff, respectively, about their experiences using simulation-based learning. …”
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Distribution of Major HLA-A, -B, -DR, and -DQ Loci Potentially Associated with Multiple Sclerosis in a Healthy Population from Southern Morocco by Abir Fguirouche, Fatimazahra Ouahmani, Ikram Brahim, Raja Hazime, Nissrine Louhab, Najib Kissani, Mohamed Chraa, Brahim Admou

“…Some of them are considered as predisposing, like DRB1*15, DRB1*13, DRB1*03, DRB1*04, DQB1*06, DQB1*02, while HLA A2, HLA B44, DRB1*11, and DRB1*12 are rather considered as protective. Data about such associations in the Moroccan population remain unknown. …”
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