Periplanta americana extract regulates the Th17/Treg cell balance via Notch1 in ulcerative colitis by Yanqiu Zheng, Yanqiu Zheng, Huibiao Li, Shiyu Qi, Fan Xiao, Jinbin Song, Shiyin Liu, Xinlin Chen, Yanwu Li, Muyuan Chen

“…PAE might be a potential candidate agent for UC treatment.…”
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Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma by Lin Qiu, Qian Gao, Yiheng Liao, Xinxin Li, Cuiying Li

“…Abstract Background Tyroservatide (YSV), a bioactive tripeptide, holds potential as an anti-tumor agent. However, its specific effects on oral squamous cell carcinoma (OSCC) have not been elucidated. …”
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Experiences of Peer Mentoring Sexual and Gender Minority Emerging Adults Who Are at Risk for Suicide: Mixed Methods Study by Jennifer T Tran, Jessica Webster, James R Wolfe, Jennifer Ben Nathan, Lindiwe Mayinja, Marin Kautz, Maria A Oquendo, Gregory K Brown, David Mandell, Danielle Mowery, José A Bauermeister, Lily A Brown

“…ObjectiveLittle is known about the training needed for PMs when working with SGDY at risk for suicide. …”
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Amebicidal and Antiadhesion Activities of Knema retusa Extract Against Acanthamoeba triangularis T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Ag... by Watcharapong Mitsuwan, Imran Sama-ae, Suthinee Sangkanu, Dhrubo Ahmed Khan, Partha Biswas, Md. Nazmul Hasan, Julalak Chuprom, Tajudeen O. Jimoh, Christophe Wiart, Masyitah Binti Zulkipli, Nor Hayati Abdullah, Maria de Lourdes Pereira, Sonia M. Rodrigues Oliveira, Shanmuga Sundar Saravanabhavan, Polrat Wilairatana, Tooba Mahboob, Veeranoot Nissapatorn

“…Medicinal plants have been used as alternative agents for the treatment of infections. This study aimed to investigate bioactivities of medicinal plant extracts including Knema retusa extract (Kre) against Acanthamoeba triangularis T4 in vitro and in silico. …”
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Identification of unmet information needs among families of critically ill patients and their association with post-intensive care syndrome-family: protocol for a single-center cro... by Yoshiyasu Ito, Takuro Hamaguchi, Masatomo Suzuki, Yasushi Otaka, Mariko Asai, Yukihiro Sakaguchi, Yuki Shirai, Eisho Yoshikawa, Amane Tateno, Shoji Yokobori

“…Abstract Background Families of critically ill patients in the intensive care unit (ICU) need a variety of information about the patient. Meeting these information needs improves the quality of communication between the family and ICU staff, as well as reduces the risk of post-intensive care syndrome-family (PICS-F). …”
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Co-designing action-oriented mental health conversations between care providers and ageing Canadians in the community: a participatory mixed-methods study protocol by Carrie McAiney, Paul Holyoke, Heather McNeil, Justine L Giosa, Elizabeth Kalles, Nelly D Oelke, Katie Aubrecht, Olinda Habib Perez

“…These barriers are exacerbated when service providers focus on physical healthcare needs or lack the skills and confidence to talk about and/or address mental health during routine visits. …”
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A positive experience in applying the biolistic approach to potato varieties Aksor and Nevskiy by N. P. Malakhova, Y. A. Skiba, G. A. Iskakova, D. A. Naizabayeva, B. K. Tezekbaeva, G. A. Ismagulova, E. R. Maltseva

“…A high number of regenerants (56) as opposed to a low number of transformants (6) reflects an attempt to increase the number of regenerants by using a lower concentration of the selective agent (kanamycin). Although this approach requires more effort, it can be used to produce potato lines with integrated genes of interest for further use in crop breeding. …”
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Surgical Treatment of Primary Intracardiac Myxoma: 20-Year Experience in “Shahid Modarres Hospital”—A Tertiary University Hospital—Tehran, Iran by Zahra Ansari Aval, Hamid Ghaderi, Hassan Tatari, Mahnoosh Foroughi, Seyedeh Adeleh Mirjafari, Mohammad Forozeshfard, Kamal Fani, Isa Khaheshi

“…In 22 patients (52.3%) after tumor resection septal defects were repaired primarily while in 18 patients (42.8%) the defects were repaired with pericardial patch and In one patient, tumor resected without any septal defect. Mean tumor size was about 5.22 cm (range of 2.2 to 8.2 cm). Postoperatively, 33 patients discharged from hospital without any complication. …”
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The Effects of Employee Relations, Workplace Well-Being, and Compensation on Turnover Intentions: The Mediation Role of Work Stress by Tine Yuliantini, Abdul Rahmat, Eri Marlapa, Fadhila Dhia Malihah, Endri

“…Originality/value (State of the art): This study considers work stress a mediating variable of work relationship factors, workplace well-being, and compensation about turnover intentions. The findings contribute significantly to developing previous empirical literature on human resource management regarding the relationship between work stress and TI. …”
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Folic acid supplementation during preconception period in sub-Saharan African countries: A systematic review and meta-analysis. by Mekuriaw Nibret Aweke, Elsa Awoke Fentie, Muluken Chanie Agimas, Lemlem Daniel Baffa, Ever Siyoum Shewarega, Aysheshim Kassahun Belew, Esmael Ali Muhammad, Berhanu Mengistu

“…<h4>Introduction</h4>Neural tube defects (NTDs) are serious congenital anomalies of the central nervous system caused by disruptions in early embryonic development. The prevalence is about twice as common in low- and middle-income countries and more prevalent in sub-Saharan Africa. …”
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Bridging the gap: understanding the perspective of healthcare professional students towards precision medicine in a Nigerian tertiary institution (a cross-sectional study) by Ezinwanne Jane Ugochukwu, Jennifer Chinwe Edom, Faith Olanrewaju Omotayo, Agatha Adaeze Amaechi, Chinedu Benneth Obetta, Chibueze Anosike, AbdulMuminu Isah, Chukwuemeka Michael Ubaka

“…Nearly half (n = 206, 47.8%) reported having information about precision medicine from the internet, and the majority (n = 341, 79.1%) expressed having an interest in a career involving research in precision medicine. …”
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Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in t... by Olalekan Bukunmi Ogunro, Mojisola Esther Karigidi, Gideon Ampoma Gyebi, Areej Turkistani, Ahmad H. Almehmadi

“…Abstract Background Tangeretin, a flavone compound (O-polymethoxylated) naturally present in tangerine and other citrus peels has demonstrated effectiveness as an anti-inflammatory and neuroprotective agent in several disease model. This study evaluated the impact of tangeretin in mitigating cognitive dysfunction and oxidative stress induced by colchicine in rats, comparing its efficacy with donepezil hydrochloride. …”
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Influence of Physicochemical Properties of Oil Sludge on Syngas Production for Energy Applications by Hiago Oliveira, Isabela Pinheiro, Ana Ramos, Osvaldo Venturini, Adriano Mariano, York Santiago

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Wound Management Property of a Hydroethanolic Leaf Extract of Cnestis ferruginea DC by Jibira Yakubu, G. A. Koffuor, Talent Atsu-Nunyawu, Jeremiah Aboagye, Irene Aasam Aabeinir, Fasilatu Alhassan, Lord Christian Ocran, Philomena Entsie

“…Nature assumes imperative part in managing both acute and chronic ailments. Cnestis ferruginea is one of the sources of healing prowlers in traditional medicine practice for the treatment of wounds. …”
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Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals by Ali Zahedi Amiri, Choudhary Ahmed, Subha Dahal, Filomena Grosso, Haomin Leng, Peter Stoilov, Maria Mangos, Johanne Toutant, Lulzim Shkreta, Liliana Attisano, Benoit Chabot, Martha Brown, Mario Huesca, Alan Cochrane

“…Treatment options for viral infections are limited and viruses have proven adept at evolving resistance to many existing therapies, highlighting a significant vulnerability in our defenses. …”
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The burden of depression, anxiety and schizophrenia among the older population in ageing and aged countries: an analysis of the Global Burden of Disease Study 2019 by Wu Hong, Ying Cheng, Yu Fang, Jinxin Zheng, Shiyang Guan, Meiti Wang

“…Notably, the conditions of burden of depressive disorders, anxiety disorders and schizophrenia in the 65–70-year-old age group were the most burdensome.Conclusions The incidence and DALYs of these three mental disorders increased while exhibiting differences between ageing and aged countries. Raising awareness about formulating health policies for preventing and treating mental disorders in the older population is necessary to reduce the future burden posed by the ageing challenge.…”
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The effect of different feed on the spawning performance of mud crab Scylla serrata broodstock by Bethsy J. Pattiasina, Endang Jamal, Agapery Y. Pattinasarany

“…Due to lack of knowledge about broodstock nutrition lead to producing rate of seeds still relatively low. …”
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Scaling of fractured rock flow. Proposition of indicators for selection of DFN based flow models by Davy, Philippe, Le Goc, Romain, Darcel, Caroline, Selroos, Jan-Olof

“…We first studied what the inflow distribution tells us about the permeability structure from a series of analyses: distribution of transmissivities as a function of depth, proportion of flowing sections as a function of section scale, and scaling of the arithmetically-averaged and geometrically-averaged permeability. …”
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The Interannual Variability of Global Burned Area Is Mostly Explained by Climatic Drivers by Andrina Gincheva, Juli G. Pausas, Miguel Ángel Torres‐Vázquez, Joaquín Bedia, Sergio M. Vicente‐Serrano, John T. Abatzoglou, Josep A. Sánchez‐Espigares, Emilio Chuvieco, Sonia Jerez, Antonello Provenzale, Ricardo M. Trigo, Marco Turco

“…Additionally, we note that BA is also significantly associated with periods of antecedent wetness and coolness, with this association being especially evident in more arid ecoregions. About 60% of the interannual variations in BA can be explained by climatic variability in a large fraction (∼77%) of the world's burnable regions.…”
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Renal transplant recipient and deceased-donor risk profiles at Wits Donald Gordon Medical Centre, Johannesburg, South Africa: A 9-year review by F van der Schyff, M Barnard, B Ströbele, M de Jager, R Britz, P Gaylard, J Loveland

“…These recipient scores predict increased recipient mortality at high scores, albeit with low sensitivity, and were not significantly associated with graft survival. …”
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