Evaluation of the antibacterial and antibiofilm effect of mycosynthesized silver and selenium nanoparticles and their synergistic effect with antibiotics on nosocomial bacteria by Nahed Fathallah Fahmy, Marwa Mahmoud Abdel-Kareem, Heba A. Ahmed, Mena Zarif Helmy, Ekram Abdel-Rahman Mahmoud

“…Both NPs exhibited higher synergistic effect with antibiotics with different modes of action. This approach could potentially enhance the efficacy of existing antibiotics, providing a new weapon against drug-resistant bacteria where the described silver and selenium nanoparticles play a pivotal role in revolutionizing healthcare practices, offering innovative solutions to combat antibiotic resistance, and contributing to the development of advanced medical technologies.…”
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Cyanoacrylate glue in breast surgery: the GLUBREAST Trial by Emanuela Esposito, Claudio Siani, Ivana Donzelli, Anna Crispo, Sergio Coluccia, Piergiacomo Di Gennaro, Assunta Luongo, Franca Avino, Alfredo Fucito, Ugo Marone, Maria Teresa Melucci, Ruggero Saponara, Raimondo di Giacomo

“…The assumed mechanism of action in breast surgery is that the glue would create a seal coating in the operative field to occlude lymphatic leaks and limit seroma formation.Materials and methodsThe trial included 180 patients scheduled for breast-conserving surgery or for radical modified mastectomy without reconstruction. …”
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Sistem Deteksi Dini Penyakit Preeklampsia Melalui Perubahan Warna Urine Berdasarkan Protein dengan Menggunakan Metode Naïve Bayes Classifier by Fakhrul Allaam, Barlian Henryranu Prasetio, Rizal Maulana

“…Therefore, a tool that can perform automatic analysis is needed to minimize errors in the process and take action on patients. This study uses a TCS 34725 sensor to perform feature extraction in the form of color. …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…The roles of Erastin and the SIRT3 inhibitor 3-TYP were also explored to elucidate FBR2’s mechanisms of action.ResultsFBR2 treatment significantly mitigated BLM-induced lung injury in mice, as evidenced by improved body weight and survival rates, and reduced levels of inflammatory cytokines, including IL-6 and TNF-α. …”
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Using data to promote inclusion through early childhood mental health consultation by Kelsey A. Clayback, Ann M. Partee, Amanda P. Williford, Jason T. Downer, Kyra Parker, Ann S. Lhospital

“…., “consultant”) with early childhood educators to build the capacity of providers to promote inclusion by supporting young children's social and emotional development.MethodsIn this paper, we describe a model of ECMHC that combines data-driven action planning and an individualized approach to build educators' capacity to implement social and emotional teaching practices with fidelity. …”
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Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae by Sheena Francis, William Irvine, Lucy Mackenzie-Impoinvil, Lucrecia Vizcaino, Rodolphe Poupardin, Audrey Lenhart, Mark J. I. Paine, Rupika Delgoda

“…RNA sequencing and in silico modelling were used to determine the mode of action of the extracts. Results Aqueous extracts of Piper amalago var. amalago inhibited CYP6P9a, CYP6M2, and CYP6P3 with IC50s of 2.61 ± 0.17, 4.3 ± 0.42, and 5.84 ± 0.42 μg/ml, respectively, while extracts of Kalanchoe pinnata, inhibited CYP6M2 with an IC50 of 3.52 ± 0.68 μg/ml. …”
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Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review by Yan Wang, Yan Wang, Wenmin Yang, Wenmin Yang, Yuan Yang, Yuan Yang, Xingning Liu, Xingning Liu, Lanfen Peng, Lanfen Peng, Qi Huang, Qi Huang, Qi Huang, Kongli Fan, Kongli Fan, Rui Hu, Rui Hu, Jinyu Yi, Jinyu Yi, Xin Zhong, Xin Zhong, Jing Li, Jialing Sun, Xiaozhou Zhou, Xiaozhou Zhou

“…At present, the mechanism of action of this drug for ALD is still unclear, and we expect more experimental studies to prove the clinical value of Silibinin capsules.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
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A Novel Model Using ML Techniques for Clinical Trial Design and Expedited Patient Onboarding Process by Iyer A, Narayanaswami S

“…Specifically, the study investigates ML models for two critical aspects: (1) streamlining clinical trial design parameters (like the site of drug action, type of Interventional/Observational model, etc) and (2) optimizing patient/volunteer enrolment for trials through efficient classification techniques.Methods: The study utilized two datasets: the first, with 55,000 samples (from ClinicalTrials.gov), was divided into five subsets (10,000– 15,000 rows each) for model evaluation, focusing on trial parameter optimization. …”
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L’expérience touristique : une expérience des cadres de l’expérience touristique ? by Hécate Vergopoulos

“…Dans le cadre d’une troisième approche, enfin, fort influencée par les sciences de gestion, elle devient une programmatique de la consommation pour l’action touristique. Cette dernière acception en particulier permet de mettre en évidence le fait qu’ainsi définie l’expérience touristique est peut-être moins l’expérience de l’autre que l’expérience de la consommation de l’autre ou, pour le dire autrement, le fait que l’expérience touristique n’est peut-être finalement qu’une expérience des cadres de la consommation touristique.…”
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Not uni-dimension! Exploring the multi-dimensional concept of positive body image in the Chinese context by Hanqin Yan

“…With a positive psychology perspective, and based on the holistic positive body image theory, this study explored the multi-dimensional concept of positive body image in the Chinese context, integrated its three measures, examined the overall level of positive body image among Chinese college students, and tested the gender measurement invariance, as well as explored the latent categories of positive body image in the college student population.MethodsA convenience sampling method was used to survey 670 college students in China, using the Chinese version of Body Appreciation Scale-2 (BAS-2), Functionality Appreciation Scale (FAS), Body Image Acceptance and Action Questionnaire-5 (BI-AAQ-5), and the Positive Body Talk Scale (PBTS). …”
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The influence of zeranol on certain blood biochemical values of male lambs by Ahmet ACET, Muhtar TİFTİK, Bünyamin TRAŞ, Nuri BAŞPINAR

“…The concentrations of glucose, total protein, Na⁺, K⁺, glutamic oxalacetic transaminase (GOT) and Cholesterol in blood serum were determined to investigate certain biochemical aspects of the mode of action of zeranol. Experimental animals (male lambs of Konya merinos) consisted of control (Ili5 untreated), Group I (15 male lambs implanted with 112 mg Zeranol) and Group II 015 male lambs implanted with twice H2 mg Zeranol at fourty fivedays intervals). …”
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Construction of an Interpretable Model of the Risk of Post-Traumatic Brain Infarction Based on Machine Learning Algorithms: A Retrospective Study by Li S, Li H, Wu B, Pan R, Liu Y, Wang J, Wei D, Gao H

“…Interpretations using the SHAP method offer guidance for personalized treatment of different patients, filling gaps between complex clinical data and actionable insights.Keywords: traumatic brain injury, post-traumatic cerebral infarction, retrospective study, machine learning, prediction model…”
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Physical modelling of damage mechanism of slopes containing near horizontal weak layers under rainfall conditions by Zhigang TAO, Chuang XU, Songyuan LIU, Yong LI, Kexin XIU

“…The results show that: ① from the field damage characteristics and model test results, it can be seen that the slope damage mode is the slope shear-slip caused by weak layer belt damage under the action of rainfall. The rainfall infiltration is the main factor inducing the destruction of the slope. …”
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Tackling the unyielding: testing two novel approaches against NDM-producing Enterobacterales and Pseudomonas aeruginosa isolates collected in India by Yamuna Devi Bakthavatchalam, Bijayini Behera, Anand Shah, Purva Mathur, Raja Ray, Bashir Ahmed Fomda, Kamini Walia, Balaji Veeraraghavan

“…ABSTRACT The in vitro activity of two novel antibiotics with different modes of action, (i) siderophore cefiderocol and (ii) β-lactam-enhancer mechanism-based cefepime/zidebactam, was tested against New Delhi Metallo-β-lactamase (NDM)-producing Enterobacterales and Pseudomonas aeruginosa collected in India. …”
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Interventional effect of ACT on social interaction in children aged 7-10 years with Asperger syndrome by HUANG Jin, YUAN Bin, ZHAO Shan, HU Maorong

“…All children were investigated by using Aberrant Behavior Checklist （ABC）， Screen for Child Anxiety Related Emotional Disorders （SCARED）， Self-Rating Scale Depressive Disorder in Childhood （DSRSC）， Acceptance and Action Questionnaire-2nd Edition （AAQ-Ⅱ）， Cognitive Fusion Questionnaire-Fusion （CFQ-F）， General Self-Efficacy Scale （GSES） before and after corresponding interventions and on-the-spot assessment. …”
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Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Conclusion: The lower capability of LIT in changing the population of NKT cells compared to prednisolone therapy may be due to its mechanism of action, which is related to the production of blocking antibodies. …”
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Comparing the effectiveness of narrative therapy and EMDR-GTEP protocols in the treatment of post-traumatic stress in children exposed to humanitarian crises by Elisabetta Dozio, Elisabetta Dozio, Cécile Bizouerne, Valdes Wamba, Ninon Atienza

“…The aim of the study was to analyze retrospective data collected in a mental health and psychosocial support program for children in the Central African Republic, and to compare results of two trauma-focused treatment interventions: the narrative protocol Action contre la Faim (ACF)/KONO; and the EMDR-based Group Trauma Episode Protocol (G-TEP). …”
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Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…Results Modeling TTC with high doses of epinephrine (Epi) treatment in hiPSC-CMs shows suppression of depolarization velocity (Vmax), prolongation of action potential duration (APD), and induction of arrhythmic events. …”
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CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection by Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, Koudai Furuta, Kana Izumi, Eiko Shimizu, Takashi Nishizono, Makoto Fujiwara, Tomohiro Miyasaka, Shigeo Takamori, Hiroshi Takayanagi, Keizo Nishikawa, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Makoto Yamashita, Toshiya Senda, Takatsugu Hirokawa, Haruhiko Bito, Kiyotaka Nishikawa

“…ABSTRACT Ca2+/calmodulin-dependent protein kinase II (CaMKII) is one of hundreds of host-cell factors involved in the propagation of type A influenza virus (IAV), although its mechanism of action is unknown. Here, we identified CaMKII inhibitory peptide M3 by targeting its kinase domain using affinity-based screening of a tailored random peptide library. …”
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Trends and Variability of PM2.5 at Different Time Scales over Delhi: Long-term Analysis 2007–2021 by Chetna, Surendra K. Dhaka, Gagandeep Longiany, Vivek Panwar, Vinay Kumar, Shristy Malik, A. S. Rao, Narendra Singh, A. P. Dimri, Yutaka Matsumi, Tomoki Nakayama, Sachiko Hayashida

“…Government agencies need more strict action plans, especially during winter, to comply with air quality standards.…”
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