Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…Several therapeutic monoclonal antibodies (mAbs), including those targeting epidermal growth factor receptor, human epidermal growth factor receptor 2 (HER2), and CD20, mediate fragment crystallizable gamma receptor (FcγR)–dependent activities as part of their mechanism of action. These activities include induction of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), which are innate immune mechanisms of cancer cell elimination. …”
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Prevention of sufentanil-induced cough during induction of general anesthesia by low-dose esketamine by Xueyue Zhou, Chaoping Guo, Boyu Liu, Yongqing Guan, Shengxiang Wang, Jun Ji

“…Abstract Background Sufentanil is commonly used to induce general anaesthesia due to its rapid onset of action, strong analgesic effect, long-lasting effect, and stable haemodynamics; however, it often induces cough, increasing the risk of anaesthesia. …”
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Clinical integration of germline findings from a tumor testing precision medicine program by Maria Carolina Sanabria-Salas, Nina C. Anggala, Brittany Gillies, Kirsten M. Farncombe, Renee Hofstedter, Larissa Peck, Helia Purnaghshband, Laura Redondo, Emily Thain, Wei Xu, Peter Sabatini, Philippe L. Bedard, Raymond H. Kim

“…Tier I TGVs, interpreted as pathogenic/likely pathogenic (P/LP) and found in most- or standard-actionable genes with high germline conversion rates (GCRs) in any context, were more likely to be considered germline relevant (p-value < 0.05). …”
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Anti-blastocystis activity of hop extracts in vitro by S.I. Pokhil, V.V. Kazmirchuk, O.M. Tymchenko, V.Y. Yevsiukova, A.L. Melnyk

“…According to the results of in vitro sensitivity of 5 clinical isolates of Blastocystis sp. to the action of carbonic acid hop extract, alcohoicl hop extract and metronidazole, a direct positive pattern in the dose-response and contact time-response effects was established. …”
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Visit of the Soviet Union journalists' delegation to Finland and the Baltic countries in 1937: the report of the leader of the delegation, Boris Michailov, to Stalin and Molotov by Zenonas Butkus, Magnus llmjärv

“…The visit itself was not just an ordinary fact of cultural ties but an action motivated by international political considerations, which has not been addressed in historical works yet. …”
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A synthesis of academic literature on eco-spirituality by A.H.A. Adow, M.M. Safeer, M.G.H. Mohammed, M. Sayeed Alam, M.M. Sulphey

“…The study also underscores the significance of eco-spirituality as a catalyst for environmental consciousness and sustainable action. The innovation of the study is that it has revealed eco-spirituality's transformative role in promoting environmental sustainability and bridging interdisciplinary insights with practical applications. …”
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Epilepsy care pathway: The Finnish model by Reetta Kälviäinen, Zakarya Hadj‐Allal, Jarkko Kirjavainen, Reina Roivainen, Tarja Linnankivi, Jukka Peltola, Kai Eriksson, Salla Lamusuo, Tuire Lähdesmäki, Johanna Annunen, Päivi Vieira, Virpi Tarkiainen, Leena Jutila, Anni Saarela, Leena Kämppi, Liisa Metsähonkala, Eija Gaily, Niina Lähde, Jaana Antinmaa, Sini Erme, Anna‐Leena Pirttisalo, Jari Virolainen, Milla Ylijoki, Laura Kela, Jonna Komulainen‐Ebrahim, Paula Sorjonen, Finnish Severe Epilepsy Coordination Group

“…They must align with the WHO Global Action Plan on Epilepsy, ensuring best practices and cost‐effective management. …”
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Question–Answer Methodology for Vulnerable Source Code Review via Prototype-Based Model-Agnostic Meta-Learning by Pablo Corona-Fraga, Aldo Hernandez-Suarez, Gabriel Sanchez-Perez, Linda Karina Toscano-Medina, Hector Perez-Meana, Jose Portillo-Portillo, Jesus Olivares-Mercado, Luis Javier García Villalba

“…The QA framework allows developers to query vulnerabilities and receive precise, actionable insights, enhancing its applicability in dynamic environments that require frequent updates and real-time analysis. …”
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Geological history plants dominated the net accumulation of coal by Yanqiang SHI, Yakun SHI

“…During the clastic explosion period, the terrigenous clastic reservoir collapsed, some clasts rushed to the edge of the peat swamp to form rock and coal interbedding, and some were transported by peat rafts into the peat swamp to deposit intermittently, forming large sedimentary breccia scattered in the coal, while a large number of clasts were transported to the sea / lake delta by the swamp river. The plant action in the process of coal accumulation can reasonably explain some “abnormal” phenomena in coal geology and fill the blank of coal geology research.…”
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Comparison of the Insertion Conditions and Haemodynamic Changes during I-Gel Insertion using Propofol, Ketamine-Propofol (Ketofol) and Thiopentone Intravenous Induction Agents: An... by Pooja Arpapan Shah, Aashi Nilesh Surti, Anupapama Kumari, Dinesh K Chauhan, Sara Mary Thomas

“…Conclusion: Compared to propofol and thiopentone, ketofol demonstrated a faster onset of action and ensured better insertion conditions and greater haemodynamic stability, making it a preferred choice for I-gel insertion.…”
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Secular trend and projection of overweight and obesity among Chinese children and adolescents aged 7–18 years from 1985 to 2019: Rural areas are becoming the focus of investment by Jiajia Dang, Yunfei Liu, Shan Cai, Panliang Zhong, Di Shi, Ziyue Chen, Yihang Zhang, Yanhui Dong, Jun Ma, Yi Song, Jing Ni, Xuehong Zhang

“…A complete reversal in urban–rural prevalence is expected by 2027, with a higher prevalence of overweight and obesity in rural areas. Urgent action is needed to address health inequities and increase investments, particularly policies targeting rural children and adolescents.…”
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Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…Biological function classification and enrichment analysis were used to explore the main action pathways involving differentially expressed circRNAs. …”
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Development of an eHealth Intervention Including Self-Management for Reducing Sedentary Time in the Transition to Retirement: Participatory Design Study by Lisa Hultman, Caroline Eklund, Petra von Heideken Wågert, Anne Söderlund, Maria Lindén, Magnus L Elfström

“…It uses several behavior change techniques, such as goal setting and action planning through mental contrasting and implementation intention, as well as shaping knowledge. …”
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CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice by Yuanyu Shen, Xiaolei Zhang, Siqi Liu, Lijing Xin, Wentao Xuan, Caiyu Zhuang, Yue Chen, Beibei Chen, Xinhui Zheng, Renhua Wu, Yan Lin

“…However, whether riluzole can improve Glu and GABA homeostasis in AD brain and its related mechanism of action remain unknown. This study utilized chemical exchange saturation transfer (CEST) imaging combined with proton magnetic resonance spectroscopy (1H-MRS) to monitor the dynamic changes of Glu and GABA in riluzole-treated AD mice, aiming to evaluate the efficacy and mechanism of riluzole in AD treatment. …”
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Enabling participation in community-dwelling children and young people with acquired brain injuries and their families: a theory-based, evidence-based and person-based approach to... by Jane Williams, Rachel Keetley, Emily Bennett, Joseph C Manning, Victoria Lyon, Jade Kettlewell, Kate Radford

“…Using a case coordination model, ABI-Participate aims to address the unmet needs and barriers of this population and includes needs assessment, goal setting, action planning, health coaching, practical and emotional support for families and multiagency liaison and collaboration, adopting an individualised needs-based approach.Conclusion A systematic process using a theory-based, evidence-based and person-based approach resulted in a novel, codesigned, multifaceted intervention, grounded in an in-depth understanding of CYP with ABI participation needs, barriers and facilitators. …”
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Timber and carbon sequestration potential of Chinese forests under different forest management scenarios by Hui-Ling Tian, Jian-Hua Zhu, Xiang-Dong Lei, Xin-Yun Chen, Li-Xiong Zeng, Zun-Ji Jian, Fu-Hua Li, Wen-Fa Xiao

“…Developing forestry action plans with the goal of carbon neutrality is a critical task to identify carbon sink potential and balance the pathways of China's forests. …”
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Evaluation of the Performance of an Ocular Surface Modulator Containing ST-Lysyal Versus Hyaluronic Acid Eyedrops in Patients with Dry Eye Disease: A Pilot Study by Stefano Barabino, Andrea Rosa, Sara Marini, Carlo Domenico Bianchi, Maurizio Rolando

“…Additionally, we provide a literature overview on the effects of T-Lys in ophthalmology and non-ophthalmology conditions to elucidate its mechanisms of action. Methods A double-masked, randomized pilot study was conducted in patients with DED treated with T-Lys or hyaluronic acid (HA) 0.2% combined with tamarind seeds polysaccharide (control group) for 2 months. …”
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Association of sex and aspirin use with postoperative bleeding in patients with lower extremity long bone fractures by Michael Fisher, Kristin Salottolo, David Bar-Or, Matthew Carrick, Kaysie L Banton, Robert Madayag, Chad M Corrigan

“…The primary outcome was an overt, actionable bleed (eg, blood transfusion for surgical site hemorrhage) within 24 hours postoperative.Results There were 864 patients with lower extremity long bone fractures and 24% were aspirin users. …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…A comprehensive analysis of the multi-level bioinformatic analysis, including protein-protein interactions (PPI) and functional pathways of the targets, was conducted, followed by verification through immunohistochemistry (IHC) to clarify SHSY’s pharmacological basis and action mechanisms in treating GD.ResultsAfter 8 weeks of treatment, SHSY significantly reduced serum T4 and TRAb levels in GD mice and enhanced the morphology of thyroid tissues. …”
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Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…The resulting consensus document is based on current evidence from clinical trials and clinical practice and the panel's expert opinion, focusing on new ASMs with novel mechanisms of action, such as highly purified cannabidiol and fenfluramine. …”
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