TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…M6223±BA displayed a linear pharmacokinetic profile. Anti-TIGIT mode-of-action-related pharmacodynamic effects were observed in peripheral blood and in tumor tissue. …”
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Implementing psychosocial interventions for teachers' mental health: Protocol for integrating scoping review with teachers lived experiences in LMICs. by Kanika Malik, Sadananda Reddy, Yasmine A Shilla, Aditi Khanna, Ranya R Kaurr, Abbey Boban

“…The synthesis of the data will employ narrative and thematic approaches to generate actionable insights for implementing psychosocial interventions in LMICs.…”
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A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon by Junfeng Liu, Mickaël Lelek, Yunfeng Yang, Audrey Salles, Christophe Zimmer, Yulong Shen, Mart Krupovic

“…We propose the “relay race” model, whereby the cytokinesis is achieved through a sequential and concerted action of different ESCRT machinery components.IMPORTANCETwo major cytokinesis mechanisms, rooted in contractile FtsZ and endosomal sorting complexes required for transport (ESCRT) rings, respectively, have emerged in the course of evolution. …”
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Entrepreneurship education for women through project-based flipped learning: The impact of innovativeness and risk-taking on course satisfaction by Seung-chul Yoo, Tu Anh Truong, Kwanghee Jung

“…In sum, our research generates transformative theoretical insights and provides actionable strategies for improving the practice of entrepreneurship education. …”
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Comparative effectiveness of eimeriocidal products for treatment of broiler chickens in small scale production by A. B. Dagaeva, B. M. Makhieva

“…Searching for new effective products with broad-spectrum antiparasitic action is one of priorities in avian eimeriosis control. …”
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Managing cardiovascular events, hyperglycemia, and obesity in type 2 diabetes through microRNA regulation linked to glucagon-like peptide-1 receptor agonists by Xiaolei Miao, Maryam Davoudi, Zahra Alitotonchi, Ensieh Sadat Ahmadi, Fatemeh Amraee, Ashraf Alemi, Reza Afrisham

“…The highly-expressed miR-375 in pancreatic islets can be considered as a biomarker for assessing the cytoprotective action of GLP-1RAs on β-cells. GLP-1RAs also enhance β-cell responsiveness by promoting GLP-1 receptor expression through the suppression of miR-204. …”
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Implementing and evaluating the comprehensive integration of physical activity into a major health system: study design and protocol by Alex Ewing, Mark Stoutenberg, Jennifer L Trilk, Christopher Wichman, Paul A Estabrooks, John M Brooks, Meenu Jindal, James Rosemeyer, Leah M Schumacher, Lia K McNulty, Stephanie Eskuri, Frankie Bennett

“…The Reach, Effectiveness, Adoption, Implementation and Maintenance framework will inform the assessment of implementation outcomes, while the integrated Promoting Action on Research Implementation in Health Services framework will be used to explore contextual factors influencing patient-level and clinic-level outcomes.Ethics and dissemination We received ethical approval to conduct this study from the Prisma Health IRB Committee A (#1963762). …”
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ELEMENTS OF CENTRALITY DYNAMICS IN BUZĂU CITY by IOAN IANOŞ, ILINCA VALENTINA STOICA

“…La centralité de la ville de Buzău a connu une évolution fluctuante déterminée par les effets territoriaux que la succession de certaines séries de facteurs d’amplification ou de blocage a eu sur ses relations avec les localités urbaines et rurales de sa grandeaire d’influence. Suite à l’action de ces facteurs se sont enregistrées des périodes de réduction ou de croissance des fonctions de lieu central de la ville de Buzau à différents niveaux territoriaux. …”
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Pharmacognostic analysis and antimalarial evaluation of quercetin in Ilex umbellulata bark using HPTLC, in vitro screening, molecular docking, and network pharmacology by James H. Zothantluanga, Dipak Chetia, Yasangam Umbon, T. C. Lalhriatpuii, Dhritiman Roy, Nidahun Lamare, Salem Lalvenhimi

“…Network pharmacology studies revealed that quercetin could potentially alleviate malaria mainly by inhibiting pro-inflammatory response through the action of IL-4, IL-10, and IL-13 and by triggering the immune system. …”
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UPGRADED SCIENTIFIC ORHODONTIC SIMULATOR WITH TEMPERATURE CONTROL AND THERMOCHAMBER by Radu Mircea Pisc, Anne Marie Rauten, Roxana Marinescu, Horia Octavian Manolea

“…Every tooth is wrapped in coper coil and continuous electric current is injected, heating the wax generating orthodontic movement under the action of orthodontic wires. This device comes with a time regulator and the amperage is limited to 2 Amps. …”
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DYNAMICS OF SIgA CONTENT IN BREAST MILK WHEN RISK FACTORS AND LACTATIONAL CHARACTERISTICS ARE CONSIDERED by Nataliya Gromnatska

“…The leading role associated with an anti-infective action of breast milk belongs to secretory IgA (SIgA). …”
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Study protocol of a randomised controlled trial on SISU, a software agent providing a brief self-help intervention for adults with low psychological well-being by Harald Baumeister, Ann-Marie Küchler, David Ebert, Natalie Bauereiss, Eileen Bendig, Benjamin Erb, Lena Weger, Echo Meißner

“…Secondary outcomes are emotional well-being (Flourishing Scale), psychological flexibility (Acceptance and Action Questionnaire-II), quality of life (Assessment of Quality of Life -8D), satisfaction with the intervention (Client Satisfaction Questionnaire-8) and side effects (Inventory for the assessment of negative effectsof psychotherapy). …”
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Effects of dietary selenium nanoparticles, selenomethionine and sodium selenite on growth performance, levels of thyroid hormones and antioxidant status of rainbow trout, Oncorhync... by Fardin Shaluei, Somayeh Hadadi, Shafigh Shafiei, Hossein Rahimi, Mehrdad Fattollahi

“…Introduction:Dietary Selenium (Se) is vital for the growth and immune system of fish. The most important action of Se biological functions comes from several specific selenoproteins, some of which are involved in thyroid hormone metabolism, while others play an antioxidant defence role. …”
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AN EXAMINATION OF CONJUGATIONAL SUFFIXES OF PASSIVE CONSTRUCTIONS IN FULFULDE by YAHAYA MOHAMMED AHMED

“… Passive voice is associated with the arrangement of a verb used when the subject is affected by the action of the verb involving a specific construction in different languages (see Tomori (1999), Hornby (2010) and O’Grady, Archibald and Katamba (2011). …”
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Correlation between METTL3 overexpression and 18F-FDG uptake in patients with soft tissue sarcoma by Tong Wu, Jinghui Xie, Hongbo Feng, Hua Zhang, Juan Tao, Bo Chen

“…Conclusions METTL3 was overexpressed in STS, which may be a meaningful target of action in STS patients. The 18F-FDG uptake was significantly elevated in tumors with high METTL3 expression, SUVmax could provide a meaningful imaging biomarker for its expression.…”
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Application of green silver nano-particles as anti-bacterial and photo-catalytic degradation of azo dye in wastewater by Zainab Haider Ali, Lubna Abdulazeem, Wurood Alwan Kadhim¹, Mazin H. Kzar³, Osamah J. Al-sareji

“…The synthesized silver nano-particles (AgNPs) exhibited a dose-dependent anti-bacterial effect against some clinical bacterial isolates as multi-drug resistant (MDR), including Gram− ve bacteria such as Pseudomonas aeruginosa and Escherichia coli, as well as Gram+ ve bacteria like Staphylococcus aureus and Streptococcus pneumoniae. The action can be ascribed to the unique biological and physicochemical features of AgNPs, which facilitate the disruption of bacterial cell membranes. …”
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Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ by Yong-Jik Lee, Hyun Soo Kim, Hong Seog Seo, Jin Oh Na, You-Na Jang, Yoon-Mi Han, Hyun-Min Kim

“…These results suggest that the activation of α1-adrenergic receptor stimulates energetic reprogramming via PPARδ that increases mitochondrial oxidative phosphorylation and has healthy and organ-specific biological effects in multiple organs, including skeletal muscle, beyond its vasomotion effect. In addition, the action mechanism of α1-adrenergic receptor may be mainly exerted via PPARδ.…”
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Knowledge and Attitude on Insulin Self-Administration among Type 1 Diabetic Patients at Metu Karl Referral Hospital, Ethiopia by Tewodros Yosef

“…Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It is a public health problem as the disease is epidemic in both developed and developing counties. …”
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THE BIOSYNTHESIS REGULATION OF POTATO STEROIDAL GLYCOALKALOIDS by K. A. Ivanova, S. V. Gerasimova, E. K. Khlestkina

“…The purpose of this review is to summarize the information on the known SGA biosynthesis genes in plants and the results of the investigation of these genes in potato, as well as to consider the mechanisms of the SGA protective toxic action against pathogens and pests. The SGA biosynthesis is realized via the cytosolic mevalonate pathway and consists of three stages. …”
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Роль міжнародного фінансового права у протидії відмиванню коштів by M. S. Sharenko, V. V. Chumachenko

“…У статті проаналізовано ключові міжнародні інструменти, такі як рекомендації FATF (Financial Action Task Force), що формують загальні стандарти боротьби з цим явищем, та надають методологію для виявлення та усунення фінансових злочинів. …”
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