A Review of the Therapeutic Potential of Ginseng and Its Bioactive Components in Nonalcoholic Fatty Liver Disease by Hao L, Li S, Li C, Zhang Z, Hu X, Yan H

“…This review summarizes the existing evidence on the mechanisms of action of ginseng and its active components in human NAFLD, assesses their potential as therapeutic options, and proposes future research directions to provide stronger scientific support for clinical application. …”
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Ginseng exhibits adaptogenic-like activity in mice exposed to hypoxic-anoxic stress through activation of antioxidant/BDNF protective mechanisms and inhibition of pro-inflammatory... by James Olukayode Oni, Divine Oluwaferanmi Oyenekan, Yetunde Olamide Olayemi, Osarugue Christabel Irabor, Precious Ogbuji, McCarthy Oritseweyinmi Tova, Paul Ademola Adeleke, Gbemisayo Adetomiwa Abbas, Solomon Umukoro

“…This study evaluates the adaptogenic-like properties of Panax ginseng commercial product (Ginsomin) and the biochemical mechanisms underlying its action in male Swiss mice exposed to hypoxic-anoxic stress. …”
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Determination of streptococcus mutans retention in acidic and neutral pH artificial saliva environment of all-ceramic materials with different surface treatment by Yeliz Hayran, Süha Kuşcu, Ali Aydın

“…Abstract Background Although surface finishing processes are effective against Streptococcus mutans biofilm, the mechanism of action of saliva with different acidity values ​​has not been studied in detail. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…The application of commensal probiotic bacteria is one of the preferable green feed additives for antibiotic substitution in aquaculture, while the application methods and detailed action mechanisms of commensal bacteria isolated from aquatic animals are not consistent with normal mammalian-derived probiotics. …”
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Study on Micro Displacement Mechanism of Hydraulic Fracturing by Oil Displacement Agent at High Pressure by Fengjiao Wang, Xu Wang, Yikun Liu, Qingjun Deng, Jianan Hu, Yingbo Lv

“…After an oil displacement agent at high pressure is injected to fracture the formation, it not only provides efficient flow channel and larger sweep volume for an oil displacement agent. Under the flushing action of high-pressure injection fluid, the original way of line or point contact between mineral particles gradually changes to free particles. …”
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Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model by Uzdrowska K, Knap N, Konieczna L, Kamm A, Kuban-Jankowska A, Gierałtowska J, Belka M, Baran M, Chlanda A, Kowiorski KM, Żołnierski A, Gulczynski J, Lipińska L, Bączek T, Izycka-Swieszewska E, Górska-Ponikowska M

“…The presence of polar hydroxyl groups enables the binding of 2-ME to GO/rGO through hydrogen bonds with epoxy and hydroxyl groups located on the surface and carbonyl and carboxyl groups located at the edges of graphene flake sheets.Methods: The patented method of producing the subject of the invention and the research results regarding its anticancer effectiveness via cytotoxicity in an in vivo model (against A375 melanoma and 143B osteosarcoma cells) are described.Results: It was shown that the inhibition of PTP1B phosphotyrosine phosphatase is one of the mechanisms of action of GO functionalised with 2-ME (GO-2-ME). This is a very important result, considering the fact that 2-ME itself has no inhibitory properties against this phosphatase.Discussion: Graphene oxide flakes embroidered with 2-methoxyestradiol molecules may be a promising solution, bringing a new and important effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME. …”
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Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

“…Background: Chronic low back pain is a costly condition and the leading cause of disability worldwide. A recent call to action identified the overuse of low-value health care as ineffective and potentially harmful in the context of back pain. …”
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Hydroxychloroquine enhances insulin sensitivity and ameliorates abnormal lipid metabolism in obese women with polycystic ovary syndrome by Ruihan Wang, Shanqin Qi, Qi Wang, Jiajia Lang, Conghui Pang, Kehua Wang

“…Abstract Background Hydroxychloroquine (HCQ) is frequently utilized in rheumatic immune disorders and has been discovered to exert hypoglycemic effects in some obese women with polycystic ovary syndrome(PCOS), however, the precise efficacy and mechanism of action remain ambiguous. Objective To examine the impact of HCQ on glucose and lipid metabolism as well as sex hormone levels in obese women with PCOS. …”
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RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells by Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M

“…Importantly, the inhibition of autophagy appears to be a critical component of SPP86’ s mode of action, with the modulation of autophagic processes influencing the cytotoxicity against melanoma cells.Conclusion: These promising findings suggest that SPP86 is a potential drug candidate for the treatment of melanoma, warranting further research and development.Keywords: melanoma, SPP86, autophagy, DNA damage, apoptosis, PI3k/AKT…”
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The Application of Biologically Active Components Derived from Mineral, Synthetic, Phyto- and Organic Sources for Developing Local Hemostatic Agents: Historical Traditions and Cont... by S. Abramov, S. Sokolovskyi, A. Gozhenko, I. Sobko, G. Titov, V. Gladyshev, M. Khmil, Ugis Kletnieks

“…Notably, PLANTOR does not contain procoagulant minerals or nanoparticles that could remain in the human body, and therefore does not belong to means with a chemical or biochemical mechanism of action. Based on the above, it is possible to recommend the hemostatic agent-powder "PLANTOR" of the trade mark "PLANTOR tm" and "Dr. …”
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Secondary hyperoxaluria: Cause and consequence of chronic kidney disease by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…This transporter is active at both the intestinal and renal levels, and its mechanism of action is disrupted during systemic inflammation and metabolic syndrome, which could explain the rising incidence of secondary hyperoxaluria in recent decades. …”
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Neuroprotective Role of Transchalcone in Parkinson‘s Disease through AMP-activated Protein Kinase-mediated Signaling Pathway by Yao Cheng, Shaik Althaf Hussain, Turki Mayudh Alrubie, Xiaomin Zhang

“…Inhibition of AMPK activity with compound-C suppressed the neuroprotective impacts of trans-chalcone, highlighting the contribution of AMPK signaling pathway in its mechanism of action. Neuroprotective and mitoprotective impacts of trans-chalcone were mostly mediated through the activation of AMPK-SIRT1-PGC1α pathway. …”
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Bibliotherapy, reading and life quality coherence: interdisciplinary point by Daiva Janavičienė

“…Any restrictions encroach on human quality of life. The action of forbidding something (such as using a national language) is an evident dishonor to a nation's quality of life. …”
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Construction and Simulation of Online English Reading Model in Wireless Surface Acoustic Wave Sensor Environment Optimized by Particle Swarm Optimization by Bolan Zhou

“…Combining two student interviews and learning logs, it can be seen that students’ understanding and frequency of use of vocabulary knowledge have increased significantly after the action research. It is generally recognized that vocabulary has a positive effect on improving reading level and can be based on the recognition and understanding of vocabulary. …”
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The Explo’Santé mixed methods protocol: an interventional research school health promotion project in France by Matteo Olivo, Adeline Darlington-Bernard, Corélie Salque, Laurie Fraticelli, Emmanuel Ricard, Florence Carrouel, Emily Darlington

“…Abstract Background According to WHO, “noncommunicable diseases (NCDs) kill 41 million people” annually, as the primary cause of death globally. WHO’s Global Action Plan for the prevention and control of NCDs 2013–2020 (extended) tackles this issue and its implications regarding inequalities between countries and populations. …”
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Correlation between Cortical Excitability and Hand Function in Patients with Subacute Cerebral Infarction by Ling CHEN, Junling WANG, Dongfeng HUANG

“…Objective:To observe the cortical activation characteristics of cerebral motor prediction in patients with subacute cerebral infarction in the palm grasping task, and to explore the correlation between cortical excitability and hand function in patients with cerebral infarction.Methods:A total of twenty-five patients with subacute cerebral infarction who were hospitalized in the first affiliated hospital of Sun Yat-sen University from January 2017 to March 2018 were selected as the experimental group, and twenty-five healthy individuals matched with the gender and age of the experimental group were selected as the control group.Event related potentials were used to collect the electroencephalogram signals of the two groups in the palm grasping task, and then analyzed the latencies and amplitudes of the contingent negative variation(CNV)in the cerebral cortex before motor activation.Action Research Arm Test(ARAT)was used to assess the function of hand, and the correlation between CNV amplitude and ARAT score was analyzed.Results:Compared with the control group, the CNV latencies in the midline region of the experimental group were significantly shorter during the left hand grasp and right hand grasp, and the CNV amplitude were statistically significantly increased in the midline, bilateral frontal lobe and primary motor area(M1)(<italic>P</italic>&lt;0.05).There was no significant difference in CNV latency between left hand grasp and right hand grasp in the experimental group(<italic>P</italic>&gt;0.05), with the CNV amplitude of Cz electrode in midline statistically significantly greater than that of C4 electrode in contralateral M1(<italic>P</italic>&lt;0.05).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during right hand grasp in the experimental group(F4: <italic>r</italic>=0.510; C4: <italic>r</italic>=0.442; Fz: <italic>r</italic>=0.428).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during left hand grasp in the experimental group(F4: <italic>r</italic>=0.422; C4: <italic>r</italic>=0.496; Fz: <italic>r</italic>=0.446).Conclusion:The neural mechanism of motor anticipation in patients with subacute cerebral infarction is abnormal, the time of brain motor preparation is prolonged, and the non-lesioned frontal lobe and M1 are hyperactivity compensatory during motor anticipation.There was moderate correlation between the cortical excitability and hand dysfunction.Therefore, CNV may be a neural indicator of the severity of hand dysfunction in patients with cerebral infarction.…”
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Is longer really better? Results of a retrospective real-life cohort study evaluating the benefit of adding a weekly educational session to a traditional 8-week home-based pulmonar... by Cécile Chenivesse, Olivier Le Rouzic, Jean-Marie Grosbois, Sarah Gephine, Sophie Peres

“…Primary hypothesis was that 8 home-based supervised sessions will be equivalent to 16 home-based supervised sessions at both short- and long-term after PR.Design Retrospective cohort study conducted on prospectively collected real-life data, from January 2010 to December 2021.Setting FormAction Santé, Pérenchies France.Participants Eligible individuals were aged &gt;18 years with a diagnosis of COPD and referred to the home-based PR programme by their respiratory physician. …”
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Exploring the Functional Brain Activity of Motor Control of Abdominal Muscle Associated with Voluntary Voiding Based on Functional Near-Infrared Spectroscopy by SHI Yinshuang, WANG Menghuan, PAN Yingying, LIN Feng

“…ObjectiveThe contractions of abdominal muscle during voluntary urination is a motor control task, Which aims to explore the central activity characteristics of this action with functional near-infrared spectroscopy (fNIRS).MethodsA total of 19 healthy subjects aged 18 years or older were recruited to undergo fNIRS testing twice, performing repetitive abdominal muscle contractions in the no-urine and strong-urine states. …”
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Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies by Xiangjun Wang, Xiaowen Xia, Xianliang Song, Yi Zhou, Mingyu Ma, Yashuang Ren, Xitai Chen, Zenghui Xia, Yinghui Guo, Chunhong Song

“…The study of the efficacy and mechanism of action of rutin in PMDD-depressed subtype model rats plays an important role in the discovery of new drugs for the treatment of PMDD.MethodsBinding of rutin to gamma-aminobutyric acid type A receptors (GABAA receptors) was probed using molecular docking, microscale thermophoresis, radioactive receptor ligand binding assay and cell membrane clamp experiment. …”
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Abnormal Obesity Phenotype Is Associated with Reduced eGFR among Diabetes Mellitus and Hypertensive Patients in a Peri-Urban Community in Ghana by Richard K. D. Ephraim, Frederick Ahordzor, Kwame Kumi Asare, Evans Duah, Ibrahim W. Naveh-Fio, Grace Essuman, Justice Afrifa

“…Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia due to obesity and defects in insulin action. Significant complications of DM include kidney disease due to its association with hypertension and obesity. …”
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