Disruption of zinc homeostasis reverses tigecycline resistance in Klebsiella pneumoniae by Jinyu Wang, Jinyu Wang, Cuiping Xia, Cuiping Xia, Zhaoxin Xia, Zhaoxin Xia, Jilu Shen, Jilu Shen

“…The changes in intracellular zinc ion levels, superoxide dismutase activity, reactive oxygen species concentration, and cell wall synthesis pathway were monitored to evaluate the mechanism of action of PBT2.ResultsOur results revealed that PBT2 successfully reversed the resistance of K. pneumoniae to tigecycline. …”
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The Impact of Lockdown on Air Quality in Pakistan during the COVID-19 Pandemic Inferred from the Multi-sensor Remote Sensed Data by Rehana Khan, Kanike Raghavendra Kumar, Tianliang Zhao

“…This is attributed to the limited transportation and control action plans of industrial activities including combustion sources taken by the Government of Pakistan for the DLP-2020 phase. …”
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Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavi... by Man Zhang, Xiao-Long Wang, Hui Shi, Lan-Qing Meng, Hong-Feng Quan, Lin Yan, Hui-Fang Yang, Xiao-Dong Peng

“…The purpose of this study was to investigate the neuroprotective effect of betaine on LPS-induced depression-like behavior in mice and its mechanism of action. ICR mice were randomly divided into four groups: the control group, the LPS model group (0.83 mg/kg), the positive drug group (MIDO, 50 mg/kg), and the betaine group (5% and 1% in drinking water). …”
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Stimulating Financial-Fiscal Instruments of Supporting Development of Renewable Energy Sources: Bibliometric Analysis by Alla Moroz, Serhiy Lyeonov

“…The aim of this research is to identify key trends, influential contributions, and emerging themes within the field, offering actionable insights for policymakers and researchers. …”
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Distinct dynamic regulation of pectoralis muscle metabolomics by insulin and the promotion of glucose-lipid metabolism with extended duration by Xiangli Zhang, Pengfei Du, Ziyang Wang, Yao Zhu, Xuemeng Si, Wen Chen, Yanqun Huang

“…This research provides insights into the potential mechanisms of insulin action in chicken muscles.…”
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Association of COVID-19-related perceptions and experiences with depression and anxiety in Ugandan caregivers of young children with malaria and iron deficiency: A cross-sectional... by Saeun Park, Paul Bangirana, Ezekiel Mupere, Reagan I Baluku, Erika S Helgeson, Sarah E Cusick

“…Urgent attention and action are needed to support the mental well-being of this vulnerable population. …”
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Effect of Mirror Therapy Combined with Task-Oriented Training on Hemiplegic Upper Limb Functions after Stroke by HE Aiqun, WANG Yang, NIE Tiancui, YING Qixing, YE Simei, SONG Qiushuang, XU Hui, HE Maoli

“…The upper limb motor functions were assessed by the Fugl-Meyer assessment-upper extremity (FMA-UE) and action research arm test (ARAT), occupational performance was assessed by the functional test of hemiplegic upper extremity-Hong Kong (FTHUE-HK).ResultsThere were no significant differences in FMA-UE scores, ARAT scores and FTHUE-HK grade between the two groups before treatment (<italic>P</italic>&gt;0.05). …”
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Human Serum Albumin and Human Serum Albumin Nanoparticles as Carriers of 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine: In Vitro Spectroscopic Studies by Aleksandra Owczarzy, Karolina Kulig, Beata Morak-Młodawska, Małgorzata Jeleń, Tammam Muhammetoglu, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk

“…Additionally, this compound is characterized by selectivity of action towards MCF-7 breast cancer and has low cytotoxicity towards normal cells. …”
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Structural equation modeling of collective decision-making's impact on group cohesion by S. Mirbagheri, A. Rafiei Atani, M. Parsanejad, R. Jafari

“…By engaging diverse perspectives, enhancing communication, and developing collective skills, they can create environments where shared understanding and cohesive action thrive. This study can encourage managers and governors to use the collective decision-making method in their choices.…”
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SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1 by Xinjie Fan, Qichu Zhu, Chengzhuo Du, Jinlai Chen, Yingming Su

“…Objective This study aimed to elucidate the functions and specific mechanisms of action of SNX30 in lung adenocarcinomas. Methods SNX30 levels in lung adenocarcinoma cell lines (A549 and HCC827) were determined using reverse transcription quantitative real-time PCR (RT-qPCR) or western blotting. …”
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El enfoque sociocultural en el estudio del desarrollo y la educación by Miguel Angel Martínez Rodríguez

“…This theory of development emphasises on the social origin of the psychological phenomena, and uses a methodological postulate related to mediated action as a unit of analysis. Based on this approach, we intend to explain the relationship between learning and development, taking the notions of eemiotic mediation and proximal zone as the lines of theoretical reflection to elaborate our concepts and empirical approximations in the field of education. …”
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Unmasking Job Satisfaction: Insights from Tribal India’s Nurses amongst the COVID-19 Pandemic by Vikrant Kabirpanthi, Vikas Gupta, Subramani Palaniyandi

“…The level of job fulfilment experienced by healthcare workers on the frontlines is closely linked to how well strategies for preventing and managing significant emergencies are put into action and their overall impact. Aims: However, the job satisfaction status of Indian frontline healthcare staff during the fight against COVID-19 remains unexplored, so the present study was conducted to assess the job satisfaction during the pandemic of COVID-19 among the nurses. …”
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Karakter Güçlerinin Sınıflandırılması ve Ölçülmesi: VIA-IS-P ve GACS-24 Yetişkin Formlarının Türkçeye Uyarlanması by İbrahim Demirci, Şeyma Tozlu Güldal, Halil Eksi

“… Bu araştırmanın amacı VIA (Values in Action) Karakter Güçleri Envanteri (VIA-IS-P) ile Karakter Güçleri Evrensel Değerlendirme Anketi’nin (GACS-24) Türkçe formunun psikometrik özelliklerinin incelenmesidir. …”
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Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats by Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying

“…This study aims to confirm whether it has a therapeutic effect on bleomycin-induced IPF in rats and to elucidate its mechanism of action. Male SD rats were randomly divided into the following groups: control, model, CQ + QFTL (84 mg/kg chloroquine (CQ) + 3.64 g/kg QFTL), QFTL-L, M, H (3.64, 7.28, and 14.56 g/kg, respectively) and pirfenidone (PFD 420 mg/kg). …”
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Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…Abstract Antimicrobial resistance (AMR) is a global health challenge requiring cross-sector action, with research largely focused on chickens, leaving ducks underexplored. …”
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Identification of Plasma Absorbed Components of Qingxin Zishen Prescription by UPLC-Q-TOF MS by Yu HU, Juan SHANG, Xue-jiao LI, Yun-hua FENG, Kai-cheng XIE, Wei-feng YAO, Jian-dong ZOU, Yun CHEN, Su LU, Mei-juan XU

“…This study provides not only a rapid and comprehensive analysis method for the plasma absorbed components of QZP, but also a scientific fundamental for elucidating the material basis of action of QZP.…”
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PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…The synergic action of the cytostatic drug cyclophosphamide (CP) and fragmented exogenous DNA causes illness and death in mice (Dolgova et al., 2011–2013). …”
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Phytochemical investigation and assessment of the anti-inflammatory activity of four Heracleum taxa growing in Turkey by Ekin Kurtul, Esra Küpeli Akkol, Büşra Karpuz Ağören, Büşra Yaylacı, Özlem Bahadır Acıkara, Eduardo Sobarzo-Sánchez, Eduardo Sobarzo-Sánchez

“…Further investigations are necessary to identify the active compounds and elucidate the mechanisms of action of these plants, potentially leading to the discovery of novel therapeutic options for the treatment of inflammation.…”
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Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…The combination with proteasome inhibitors (PIs) has shown to enhance RV therapeutic activity, but the mechanisms of action have not been fully elucidated. Methods Electron microscopy, q-RT-PCR, single-cell mass cytometry (CyTOF), flow cytometry, plaque assays, immunohistochemistry, and Western blot analysis were used to assess RV infection of both myeloma and immune cells. …”
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Determining the effect of drug "Warfarin sodium" on toxicity indicators in an acute experiment by D.O. Hlavachek, O.Ye. Kondratenko

“…The drug "Warfarin sodium" refers to anticoagulants of indirect action. It contains only one substance - warfarin sodium, the toxicological indicator of which have been studied in many countries. …”
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