Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans. by Alison M Day, Min Cao, Alessandra da Silva Dantas, Olga Ianieva, Carmen Herrero-de-Dios, Alistair J P Brown, Janet Quinn

“…Taken together these data reveal stress contingent changes in Hog1 pathway architecture and regulation and uncover a novel mode of action of the Ssk1 response regulator in SAPK regulation.…”
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Identification of key risk areas and failure modes using the FMEA method for the prevention and control of major infectious diseases in a stomatology department by Suqing Yang, Lingfei Yang, Yen-Ching Chuang, Gulidanna Asihaer, Xiaonan Lin

“…However, in the face of the potential spread of major infectious diseases in the future, the government and hospitals need to build a more comprehensive epidemiological notification system to provide the population with early action trajectories and warning reports.…”
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Field Study on the Law of Surface Subsidence in the High-Intensity Fully Mechanized Caving Mining Working Face with Shallow Thick Bedrock and Thin Epipedon in Hilly Areas by Yi Tan, Hao Cheng, Shuang Gong, Erhu Bai, Minchao Shao, Bingyuan Hao, Xiaoshuang Li, Han Xu

“…The research results reveal that the upper part of the slope slides towards the downhill direction under the action of tensile stress or push stress. As a result, the range of the horizontal movement towards the downhill direction of the slope and the range of surface movement both increase, and the movement angle and boundary angle both decrease compared with the plain. …”
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Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway by Yan Ye, Yan Ye, Xiaopeng Huang, Xiaopeng Huang, Xiaopeng Huang, Xueying Li, Xueying Li, Fei Gao, Wenzhen Zhong, Anqi Tang, Anqi Tang, Liangbin Zhao, Dengpiao Xie, Naijing Ye, Naijing Ye

“…Shenshuaikang enema (SSKE) has demonstrated notable efficacy and safety in treating CKD, although its mechanism of action remains unclear.MethodsThe CKD rat model was induced using 2.5% adenine, and the effect of SSKE was evaluated by detecting uremic toxins, inflammatory cytokines, and renal function. …”
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Deflection of screen surface and spatial deformation law of screen apertures during 1 mm elastic screening by Haishen JIANG, Ran YANG, Runyu LIU, Shijie YU, Peng GUO, Miao PAN, Long HUANG, Chenlong DUAN

“…Under the action of water and clay minerals, the process of wet material screening has some problems such as strong adhesion between fine particles, significant agglomeration effect, difficulty in particle separation and layering, and severe clogging on the screen surface, leading to difficulties in material sieving and poor screening performance, which can severely restrict the large-scale upgrading and processing of coal. …”
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Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking. by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

“…However, its specific mechanism of action in treating fractures remains unknown. This study aimed to elucidate the chemical constituents of the ethanol extract of Rhizoma Musae (EERM) and investigate its fracture-healing mechanism using network pharmacology.…”
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МОНІТОРИНГ ГОТОВНОСТІ ВЧИТЕЛІВ ДО ВИКОРИСТАННЯ ЦИФРОВИХ ЗАСОБІВ ПІД ЧАС ВІЙНИ В УКРАЇНІ by Оксана Василівна Овчарук

“…Новизна дослідження полягає у врахуванні при анкетуванні стратегічних пріоритетів, зокрема Плану дій цифрової освіти на 2021-2027 (Digital Education Action Plan 2021-2027) рр., ініціатив ЮНЕСКО, ЮНІСЕФ, розроблених світовою та європейською спільнотою, та оновленого інструменту самооцінювання цифрової компетентності вчителя, створеного у відповідності до Рамки цифрової компетентності для громадян DigComp 2.2 та 2.2 (The Digital Competence Framework for Citizens). …”
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We Walk: a person-centred, dyadic behaviour change intervention to promote physical activity through outdoor walking after stroke—an intervention development study by Stephan U Dombrowski, Brendan McCormack, Maggie Lawrence, Frederike Van Wijck, Jacqui H Morris, Linda A Irvine

“…Phase 1: we reviewed literature on barriers and facilitators to PA after stroke and mapped them to the Behaviour Change Wheel and Theoretical Domains Framework to define intervention components. The Health Action Process Approach determined intervention structure underpinned by person-centred principles. …”
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Empagliflozin-Metformin Combination Has Antioxidative and Anti-Inflammatory Properties that Correlate with Vascular Protection in Adults with Type 1 Diabetes by Miodrag Janić, Matej Cankar, Jan Šmid, Alenka France Štiglic, Aleš Jerin, Mišo Šabovič, Andrej Janež, Mojca Lunder

“…The empagliflozin-metformin combination increased levels of the antioxidants (TAS, SOD, and GPx up to 1.1-fold; P<0.01), decreased the levels of prooxidants (AOPP and isoprostanes up to 1.2-fold, P<0.01; AGE up to 1.5-fold, P<0.01), and decreased inflammatory parameters (up to 1.5-fold, CRP P<0.01; IL-6 P<0.001). Antioxidative action was associated with the improvement in arterial function (obtained in the previous study) in the empagliflozin-metformin combination group. …”
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To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Tri... by Laloo Phassang, Radhika Kapoor, Prashant Tyagi, Amit Wadhawan

“…Local drug delivery is a promising approach, targeting therapeutic agents to specific tissues or organs, optimizing efficacy by concentrating medications at the site of action. This method offers advantages over systemic delivery, such as reduced dosage and frequency, minimized systemic toxicity, and the avoidance of gastrointestinal issues and first-pass metabolism. …”
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Character in Young Adult fiction: The example of Lyra in Philip Pullman’s His Dark Materials (1995-2000) and The Book of Dust (2017- ) by Virginie DOUGLAS

“…Even if His Dark Materials identified puberty as a turning-point in the young protagonists’ process of growing up and construction of identity, it is significant that Pullman, who had already added a small companion book—entitled Lyra’s Oxford—to the trilogy’s literary universe, is still trying to explore the multiple dimensions of Lyra’s constantly shifting character: while book 1 of The Book of Dust, Pullman’s new trilogy, La Belle Sauvage (2017), is a prequel to His Dark Materials, which focuses on Lyra as a baby—before the action in Northern Lights takes place—, book 2, The Secret Commonwealth (2019), takes a closer look at Lyra once she has become a young woman, after her meeting with Will in His Dark Materials.…”
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Using the Theory of Planned Behavior to Explain Expecting Couples Birth Preparedness Intentions in a Rural Setting: A Cross-Sectional Study from Rukwa, Southern Tanzania by Fabiola V. Moshi, Stephen M. Kibusi, Flora Fabian

“…According to the Theory of Planned Behavior, an intention to carry out a certain behavior facilitates action. In the context of planning for birth, certain preparations and planning may better ensure maternal and neonatal survival. …”
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Formation of the Educational Trajectory: Educational Motives and Choices in the Narratives of Students from Moscow Leading Universities by A. V. Noskova, D. V. Goloukhova, E. I. Kuzmina

“…In the informants’ narratives, choosing a university is described as a complex, multimotivated action, in which the motives of prestige, self-development, as well as social and utilitarian motives are highlighted. …”
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Il y a 70 ans, c’était le Front populaire ! Le témoignage de  Maurice Kriegel-Valrimont (1914-2006) by Guylain Chevrier

“…Maurice Kriegel-Valrimont était membre du Comité d’action militaire du Conseil National de la Résistance, membre honoraire du Parlement, Grand Croix de la Légion d’honneur et de l’Ordre National du Mérite. …”
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Analysis of Shaking Table Tests of Underground Structures considering the Influence of the Structure-Soil Interface by Feng Shuang Guo, Yun Sheng Wang, Chang Bao Wang, LiJuan Wang

“…To investigate the seismic performance of underground structures under the action of the structure-soil interface, in this study, experiments were performed using plexiglass structures (two pieces) and a concrete structure (one piece) as the research objects. …”
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Design and implementation of an intelligent sports management system (ISMS) using wireless sensor networks by ZhiGuo Zhu

“…To ensure smooth data exchange, the integration layer connects the ISMS with third-party services, and the analytics and AI layer leverages machine learning to provide actionable insights on performance and outcomes. In addition, the IoT layer collects real-time data from sensors and wearable devices, which is essential for performance analysis and injury prevention. …”
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User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project by Pascal Raszke, Godwin Denk Giebel, Carina Abels, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Silke Mreyen, Nina Timmesfeld, Marianne Tokic, Frank Martin Brunkhorst, Nikola Blase

“…The survey is followed by the development of a requirement profile for AI-based CDSS and the derivation of policy recommendations for action, which are evaluated in a (5) expert roundtable discussion. …”
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Inhibition of triple-negative breast cancer growth via delphinidin-mediated suppression of the JAK2/STAT3/PD-L1 pathway by Xiaoping Yu, Xiaolong Song, Jiali Yan, Ziting Xiong, Lujie Zheng, Yan Luo, Fengcheng Deng, Yanfeng Zhu

“…Objective: This study investigates the effects of Dp on TNBC and aims to elucidate its specific mechanisms of action. Design: We utilized cell counting kit-8 (CCK-8) assays, colony formation assays, and scratch assays to evaluate the influence of Dp on the proliferation and migration of TNBC cells. …”
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Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…While in mammals active demethylation is based on targeted regulated damage to mC in DNA followed by the action of repair enzymes, demethylation in plants is performed by specialized DNA glycosylases that hydrolyze the N-glycosidic bond of mC nucleotides. …”
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Community knowledge, perceptions and practices around COVID-19 in Sierra Leone: a nationwide, cross-sectional survey by Maike Winters, Helena Nordenstedt, Mohammad B Jalloh, Paul Sengeh, Nance Webber, Ibrahim Ngobeh, Thomas Samba, Harold Thomas

“…A majority (70%) of women did not know you can survive COVID-19, compared with 61% of men. 60% of men and 54% of women had already taken action to avoid infection with the coronavirus, mostly washing hands with soap and water (87%). …”
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