Pharmacological effects of fibroblast growth factor 21 are sex-specific in mice with the <em>lethal yellow</em> (A^y) mutation by E. N. Makarova, T. V. Yakovleva, N. Yu. Balyibina, K. O. Baranov, E. I. Denisova, A. D. Dubinina, N. A. Feofanova, N. M. Bazhan

“…Food intake (FI), body weight (BW), blood parameters, and gene expression in the liver, muscles, brown adipose tissue, subcutaneous and visceral white adipose tissues, and hypothalamus were measured. FGF21 action strongly depended on the sex of the animals. …”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…However, its mechanism of action remains largely unexplored. In this study, we investigated the intricate mechanisms through which SM polyherbal extract exerts neuroprotective and anxiolytic effects in cultured HT-22 cells and rodent models. …”
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Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation by Dídac Llop, Pere Rehues, Silvia Paredes, Montse Guardiola, Josefa Girona, Roser Rosales, Yaiza Esteban, Lluís Masana, Daiana Ibarretxe, Joan-Carles Vallvé, Josep Ribalta

“…Abstract Backgrounds and aims Preclinical studies suggest that a triglyceride (TG)-independent proinflammatory action of apolipoprotein C-III (apoCIII) exists. We aimed to investigate the relationship between circulating apoCIII levels and subclinical inflammation markers across different cohorts with distinctive inflammatory patterns: patients with metabolic disorders (MDs), patients with rheumatoid arthritis (RA), and controls. …”
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ReMAV: Reward Modeling of Autonomous Vehicles for Finding Likely Failure Events by Aizaz Sharif, Dusica Marijan

“…To this end, we introduce a three-step methodology which i) uses offline state action pairs of any autonomous vehicle under test, ii) builds an abstract behavior representation using our designed reward modeling technique to analyze states with uncertain driving decisions, and iii) uses a disturbance model for minimal perturbation attacks where the driving decisions are less confident. …”
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The New York Times on The NATO bombing of FR Yugoslavia in 1999 by Savić Aleksandra

“…Furthermore, the paper provides an overview of significant publications that represent the perception of both the foreign and domestic press regarding NATO's military action. The paper's first hypothesis is that Serbia's negative image is constructed mainly at the lexical and stylistic levels of the language. …”
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Effective interventions to prevent youth vaping behaviours: a rapid review by Ana Paula Belon, Laura Nieuwendyk, Tasha Allen, Melissa Worrell, Candace I J Nykiforuk

“…Equity-related findings suggested that younger youth may be less responsive to the interventions. Recommendations for action are provided.Conclusions We suggest that combining multiple interventions targeting different levels of intrusiveness and outcomes may be more effective in preventing youth vaping behaviours. …”
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When do science recommendations stop being effective? The case of the sprawl of diesel electricity generators in Beirut. by Mohammad Al Hallak, Abdul Aziz Kurdieh, Amira Yassine, Rachel El Hage, Najat Saliba

“…This situation, where law of enforcement is absent, need for international action to curb emissions and for funding agencies to adopt sustainable, "carbon-free" funding strategies to support urban development in low- and middle-income countries (LMICs). …”
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Synthesis and protective effect of pyrazole conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and a... by Zang Binbin, Wang Lihui

“…The current work was conducted to elucidate the pharmacological effect of pyrazole-conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in rats in sepsis and their mechanism of action. Various pyrazole-conjugated imidazo[1,2-a]-pyrazine derivatives have been synthesized in a straightforward synthetic route. …”
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ANALYSIS OF AIR QUALITY IN TELEORMAN BY MEANS OF BIOMONITORS-LICHENS by Cernat POPA

“…Air pollution means the presence in the atmosphere of substances foreign to its normal composition, which depending on the concentration and time of action cause disturbances in the natural balance, affecting the health and comfort of humans or the living environment of flora and fauna (Rusanescu, M et al., 2018). …”
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Social network analysis of key stakeholders in Brucellosis prevention in Western Iran by Meysam Behzadifar, Mohammad Yarahmadi, Ahad Bakhtiari, Sahar Kargar, Saeed Shahabi, Samad Azari, Mariano Martini, Masoud Behzadifar

“…This study aimed to map the stakeholder network involved in brucellosis prevention in Lorestan province, identify gaps in coordination, and provide actionable recommendations for improving control strategies. …”
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FEATURES OF THE MODEL OF A SPECIALIZED GEOSPATIAL DATABASE FOR VISUALIZING INDICATORS OF HUMAN SOCIO-ECONOMIC SECURITY IN WARTIME CONDITIONS by Zakharii S. Varnalii, Oleksii P. Fedchenko, Ihor V. Pampukha, Ihor V. Tolok

“…They enable the analysis of situations, the prediction of event developments, and the formulation of optimal action strategies. Modern geographic information systems, particularly ArcGIS, offer a full range of tools for collecting, organizing, and analyzing geographic data that characterize socio-economic aspects of development at local and global levels. …”
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Association Between Patient-Reported Pain and Remission or Low Disease Activity in Patients with Rheumatoid Arthritis: Data from RA-BE-REAL Prospective Observational Study by Peter C. Taylor, Walid Fakhouri, Samuel Ogwu, Ewa Haladyj, Inmaculada de la Torre, Bruno Fautrel, Rieke Alten, Peter Nash, Eugen Feist

“…Methods RA-BE-REAL reports on patients with rheumatoid arthritis (RA) who were prescribed, for the first time, baricitinib (cohort A) or a tumour necrosis factor inhibitor (TNFi) (cohort B-TNFi) or any other mode of action (OMA) (cohort B-OMA). Pain was measured using the visual analogue scale (VAS) (0–100 mm) and clinically meaningful pain improvement thresholds of ≥ 30%, ≥ 50% and ≥ 70% from baseline to 3, 6, 12 and 24 M. …”
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Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus by Nimat Abuelwafaa, Hana Ahmed, Ilham Omer, Mohamed Abdullah, Ammar Ahmed, Afraa Musa

“…Regarding abnormal NCS parameters (conduction velocity vs. amplitude of the compound action potential), conduction slowing feature predominated in 61.4% and only few (6.8%) showed amplitude reduction, while 31.8% showed mixed features. …”
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Nutritional Habits According to Gender, Stage of Exercise Behavior and BMI by Osman İmamoğlu, Tülin Atan

“…According to the stage of exercise behavior, the nutritional scores of students who are at the stage of pre-contemplation, contemplation and preparation are significantly lower than those in the stage of action and maintenance (p lt;0.001). As a result, nutrition levels of university students do not change much according to gender, but differ according to the BMI and to the stage of exercise behavior. …”
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Identification and mechanistic insights of cell senescence-related genes in psoriasis by Guiyan Deng, Cheng Xu, Dunchang Mo

“…However, the involvement and mechanisms of action of senescence-related genes in psoriasis remain unclear. …”
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Jianpi Yiqi Busui prescription alleviates myasthenia gravis by regulating Th17 through the TAK1/P38 MAPK/eIF-4E signaling pathway by Zhuming Chen, Jing Lu, Tianying Chang, Dongmei Zhang, Yibin Zhang, Miao Liu, Tong Wu, Peng Xv, Jian Wang

“…However, its mechanisms of action still require further clarification. In this study, an experimental autoimmune myasthenia gravis (EAMG) rat model was established for research. …”
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Aqueous extracts of Moringa oleifera and Cinnamomum cassia as promising sources of antibiofilm compounds against mucoid and small colony variants of Pseudomonas aeruginosa and Stap... by Eduarda Silva, Pedro Ferreira-Santos, José A. Teixeira, Maria Olivia Pereira, Cristina M.R. Rocha, Ana Margarida Sousa

“…Moreover, it aimed to gain insights into the mechanisms of action and the potential phytochemicals responsible for antibiofilm activity. …”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…It considers how incorporating longer follow-up in DREAMM-3 may have better captured the clinical benefits of belantamab mafodotin, particularly given its multimodal, immune-related mechanism of action with responses deepening over time. A non-inferiority hypothesis may have been more appropriate rather than superiority in the context of a monotherapy versus an active doublet therapy. …”
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Presenting a comprehensive multi-scale evaluation framework for participatory modelling programs: A scoping review. by Grace Yeeun Lee, Ian Bernard Hickie, Jo-An Occhipinti, Yun Ju Christine Song, Adam Skinner, Salvador Camacho, Kenny Lawson, Adriane Martin Hilber, Louise Freebairn

“…The framework consists of four categories (Feasibility, Value, Change/Action, Sustainability) with 30 evaluation criteria, broken down across project-, individual-, group- and system-level impacts.…”
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Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation by Makenna Gargus, Benneth Ben-Azu, Benneth Ben-Azu, Antonia Landwehr, Jaclyn Dunn, Joseph P. Errico, Marie-Ève Tremblay, Marie-Ève Tremblay

“…Accordingly, we review the established mechanisms of VNS action, e.g., modulation of microglia and various neurotransmitter pathways, as well as emerging preclinical and clinical evidence supporting VNS’s impact on symptoms associated with neurodevelopmental disorders, such as those related to CNS inflammation induced by infections. …”
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