Crime and misdeeds amongst certain members of Ragusan communities in medieval Serbia (1400-1459) by Marković Nikola A.

“…There were probably many more cases that weren't reported to court at all for the Ragusans would deal with them themselves if they considered that the best course of action. However, a certain level of trust in the judicial system was definitely present in the minds of the Ragusans of Serbia.…”
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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways by Hong Duan, Wei Wang, Shu Li, Han Li, Ghulam Jilany Khan, Yong Ma, Fawang Liu, Kefeng Zhai, Henggui Hu, Zhaojun Wei

“…The possibility for the treatment of COVID-19 with I. suzhouensis and its potential mechanism of action were explored by employing molecular docking and network pharmacology. …”
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Biodiversity reporting: Comparing listed entities in the United Kingdom and South Africa by Dino Da Mata, Timothy Lai, Dusan Ecim, Warren Maroun, Dannielle Cerbone

“…Practical implications: The disclosure schematic serves as a valuable tool for evaluating biodiversity reporting in different national contexts and provides a framework for companies developing biodiversity action plans. The findings help stakeholders assess organisations’ progress in achieving biodiversity objectives and integrating biodiversity considerations into business operations. …”
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Can Jurors Disregard Inadmissible Evidence? Using the Multiphase Optimization Strategy to Test Interventions Derived from Cognitive and Social Psychological Theories by Pamela N. Sandberg, Tess M. S. Neal, Karey L. O’Hara

“…Interpretation, limitations, and calls to action are discussed.…”
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Criminal law characteristics of mass destruction weapons as a criminal offense constructive objective feature (Articles 439, 440 of the Criminal Code of Ukraine) by О. V. Shamsutdinov

“…Doctrinal approaches to distinguishing the object, means and instrument of committing a criminal offense have been considered, on the basis of which it has been concluded that the object of the crime is a “passive” feature of the composition of the criminal offense, it is characterized by a criminal influence on it in the form of action or inaction, its properties are provided by the subject of the crime use in the more or less distant future. …”
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Identification of Flavonoid C-Glycosides as Promising Antidiabetics Targeting Protein Tyrosine Phosphatase 1B by Athika Rampadarath, Fatai Oladunni Balogun, Charlene Pillay, Saheed Sabiu

“…Flavonoid C-glycosides are one of the plant-derived metabolites gaining increased relevance as antidiabetic agents, but their possible mechanism of action remains largely unknown. This study investigates the antidiabetic potential of flavonoid C-glycosides against PTP1B in silico and in vitro. …”
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Health promoting palliative care interventions in African low-income countries: a scoping review by Anne-Marie Turcotte-Tremblay, Diane Tapp, Samiratou Ouedraogo, Ariane Plaisance, Carol-Anne Hyland-Carignan, Idriss Ali Gali-Gali

“…Interventions sought to strengthen community action by reinforcing the skills and knowledge of community health workers (usually unpaid volunteers). …”
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Heat-related mortality in Mexico: A multi-scale spatial analysis of extreme heat effects and municipality-level vulnerability by Lara Schwarz, Chen Chen, Javier Emmanuel Castillo Quiñones, L.C. Aguilar-Dodier, Kristen Hansen, Jaime Reyes Sanchez, David J.X. González, Gordon McCord, Tarik Benmarhnia

“…Understanding the differential risks of extreme heat events at varying scales is important to prioritize at-risk populations in action plans and policies to reduce their burden.…”
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Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial by Phillip Knebel, Thilo Hackert, Markus W Büchler, Ilse Rooman, Markus K Diener, Felix J Hüttner, André L Mihaljevic, Oliver Strobel, Gauthier Bouche, Johannes Hüsing

“…The clinical trial is accompanied by a translational study investigating the mechanisms of action of the combined therapy on a molecular basis.Ethics and dissemination The PROSPER-trial has been approved by the German Federal Institute for Drugs and Medical Devices (reference number 4042875) and the Ethics Committee of the Medical Faculty of the University of Heidelberg (reference number AFmo-385/2018). …”
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The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors by Renhao Li, Jing-Chu Hu, Li Rong, Yige He, Xiaolei Wang, Xuansheng Lin, Wenjun Li, Yangfan Wu, Chaiyaporn Kuwentrai, Canhui Su, Thomas Yau, Ivan Fan-Ngai Hung, Xiang Gao, Jian-Dong Huang

“…In mice previously immunized with BNT162b2, an mRNA-based COVID-19 vaccine encoding the spike protein of the SARS-CoV-2 virus, intratumoral injections of the same vaccine efficiently tagged the tumor cells with mRNA-expressed spike protein. This action rapidly mobilized the pre-existing memory immunity against SARS-CoV-2 to kill the cancer cells displaying the spike protein, while concurrently reprogramming the tumor microenvironment (TME) by attracting immune cells. …”
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Chemical composition by PTP 1B inhibitory activity guided analysis of a plant- based antidiabetic polyherbal drug used in ethnomedical systems by Pardon Mugari, Pamhidzai Dzomba, Stephen Nyoni

“…A polyherbal drug consisting of a mixture of two herbal plants, Zanthoxylum chalybeum and Xeroderris stuhlmannii root powder mixed in equal amounts using a tea cup, was studied to investigate its chemical composition and possible mode of action. Methods Phytochemicals were isolated using Column and Thin Layer Chromatography, and antidiabetic activity was ascertained using an enzyme inhibition model. …”
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Bridging the gap: challenges and adoption of climate-resilient agriculture technologies in agricultural landscapes across agro-climatic zones of Bihar, India by Raj Kumar Jat, Vijay Singh Meena, Vijay Singh Meena, Shubham Durgude, Ravindra Kumar Sohane, Ratnesh Kumar Jha, Abhay Kumar, Ujjwal Kumar, Anjani Kumar, Raj Narain Singh, Suneel Kumar, Illathur R. Reddy, S. Pazhanisamy, Rakesh Kumar, Sunita Kumari Meena, Ved Prakash, Sanjay Kumar, Anirban Mukherjee, Brijendu Kumar, Umesh Narayan Umesh, Ranjan Kumar Singh, Ranjan Kumar Singh, Ravikant Chaubey, Vikash Kumar, Mukesh Kumar, Vinod Kumar, Kumari Sharda, Susheel Singh, Rama Kant Singh, Rama Kant Singh, Seema Kumari, Kamleshwari Prasad Singh, Govind Kumar, Ravindra Kumar Tiwari, Vineeta Kashyap, Suneeta Kushwaha, Sripriya Das, Prem Prakash Gautam, Nurnabi Meherul Alam, Shailesh Kumar, Sanjay Kumar, Sanjay Kumar, Bharati Upadhaya, Sumit Kumar Singh, Sanchita Ghosh, Shubham Bhagat, Shubham Bhagat, Amit Kumar Lenka

“…Study supports not only the sustainable agricultural development but also align with the United Nations Sustainable Development Goals (SDGs), particularly SDG 1 (No Poverty), SDG 2 (Zero Hunger), SDG 13 (Climate Action), and SDG 15 (Life on Land).…”
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Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics by Xiaomin Xu, Donghua Yu, Yu Wang, Xin Jiang, Fang Lu, Shumin Liu

“…Through related metabolic pathway analysis, the most affected metabolic pathways were found to be Sphingolipid metabolism, Glycerophospholipid metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Pantothenate and CoA, Citrate cycle (TCA cycle), and Arachidonic acid metabolism.ConclusionResveratrol can regulate the biosynthetic pathways of arachidonic acid, phenylalanine, tyrosine, and tryptophan, pantothenic acid and CoA biosynthesis pathways, TCA cycle, and other metabolic pathways, thereby regulating the NF-κB, MAPK, and JAK/STAT3 signaling pathways, and inhibiting the acute inflammatory response during GA attacks, showing characteristics of multi-pathway and multi-target action.…”
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Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study by Jing Wang, Chen Chen, Xiaoying Hu, Yi Fan, Yaping Wang, Yu Qiu, Qiujiao Yang, Mingming Xu, Yanfeng Weng, Yanni Li, Lisong Lin, Fa Chen, Baochang He, Fengqiong Liu

“…These insights provide actionable targets for mitigating financial burdens and improving patient outcomes.…”
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Injury characteristics, mechanisms, and game circumstances in junior community-level Australian football by Indianna L. Franke, Andrea B. Mosler, Brooke E. Patterson, Kay M. Crossley, Patrick Clifton, Steven McPhail, Mark J. Scholes, Matthew G. King

“…Objective: Describe the injury characteristics, game circumstances, and immediate action and management of injuries sustained by boys and girls participating in junior community Australian football. …”
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Molecular mechanisms induced by phase modifiers used in hydrometallurgy: consequences on transfer efficiency and process safety by El Maangar, Asmae, Prévost, Sylvain, Dourdain, Sandrine, Zemb, Thomas

“…However, the effect of these additives on the extraction efficiency as well as their mechanisms of action are still poorly understood. The phase modifiers used in industrial processes are mainly fatty alcohols, called “lipotropes”. …”
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Taking stock of the social determinants of health: A scoping review. by Kelsey Lucyk, Lindsay McLaren

“…Health equity was understood in different ways with implications for action on the SDOH.<h4>Conclusions</h4>Among the vast SDOH literature, there is a need to identify and clearly articulate the essence and implications of the SDOH concept. …”
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Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice by Sonia Sanchez-Bezanilla, Daniel J. Beard, Rebecca J. Hood, N. David Åberg, Patricia Crock, Frederick R. Walker, Michael Nilsson, Jörgen Isgaard, Lin Kooi Ong

“…These findings suggest region-specific mechanisms of action of GH treatment and provide further understanding for how GH treatment promotes neurorestorative effects after stroke.…”
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Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC by Helena Bote-de Cabo, MD, Marco Siringo, MD, Esther Conde, MD, PhD, Susana Hernández, PhD, Fernando López-Ríos, MD, PhD, Alicia Castelo-Loureiro, MD, Esther García-Lorenzo, MD, Javier Baena, MD-PhD, Mercedes Herrera, MD, Ana Belén Enguita, MD, Yolanda Ruano, PhD, Jon Zugazagoitia, MD, PhD, Luis Paz-Ares, MD, PhD

“…Results: Forty-three patients in cohort 1 (34%) and 49 patients in cohort 2 (33%) harbored European Society for Medical Oncology Scale for Clinical Actionability of Molecular Targets (ESCAT) I or II targetable driver alterations. …”
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Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-Resistant Staphylococcus aureus: A Vantage Point by Parya Shokrollahi, Alka Hasani, Mohammad Aghazadeh, Mohammad Yousef Memar, Akbar Hasani, Maryam Zaree, Mohammad Ahangarzadeh Rezaee, Javid Sadeghi

“…This review highlights the comprehensive view on ACME and COMER structure, their distribution, and the mechanism of action along with pathogenetic features of USA3000 encompassing their role in biofilm formation, adhesion, quorum sensing, resistance to antibiotics, chemotaxis, and nutrient uptake. …”
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