Evaluation of a strategy for tumor-initiating stem cell eradication in primary human glioblastoma cultures as a model by E. V. Dolgova, A. S. Proskurina, E. A. Potter, T. V. Tyrinova, O. S. Taranov, Ya. R. Efremov, K. E. Orishchenko, S. V. Mishinov, V. V. Stupak, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…The main target of the mitomycin C + DNA regimen was TAMRA+ tumor-initiating stem cells of the glioblastoma cell populations. The action of mitomycin C alone or in the combination with DNA demonstrated effective elimination of TAMRA+ tumor-initiating stem cells and the whole primary cultures of human glioblastomas.…”
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Aménagement d’ossuaires dans le baptistère paléochrétien de Brioude (Haute-Loire) :  sélection, tri des ossements et relation À l’Âge au décès by Aline Thomas, Fabrice Gauthier, Esther Gatto, Pascal Murail

“…The identification of osteological relations of the second order among these different groups demonstrates that, first, the three ossuaries resulted from a single action and, second, the distribution of skeletal elements was not random but that selection and sorting of adult bones had been carried out according to their anatomical type (long bones, cranium, small and middle-sized bones), and these had been separated into three different deposits. …”
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A literature review of recent advances in gastric cancer treatment: exploring the cross-talk between targeted therapies by Reza Panahizadeh, Padideh Panahi, Vahid Asghariazar, Shima Makaremi, Ghasem Noorkhajavi, Elham Safarzadeh

“…The selection criteria included peer-reviewed articles published primarily within the last 10 years, with a focus on studies that provided insights into targeted therapies and their mechanisms of action, clinical efficacy, and safety profiles. The findings indicate that these immunotherapy strategies can enhance treatment outcomes for GC, aligning with current treatment guidelines. …”
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Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue by Sara Nava, Valeria Sordi, Luisa Pascucci, Carlo Tremolada, Emilio Ciusani, Offer Zeira, Moris Cadei, Gianni Soldati, Augusto Pessina, Eugenio Parati, Mark Slevin, Giulio Alessandri

“…Here, we investigated the long-term survival and content of MSCs as well the anti-inflammatory activity of LP and its derived MFAT in vitro, with the aim to better understand a possible in vivo mechanism of action. MFAT and LP specimens from 17 human donors were investigated side by side. …”
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Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…PC12 cells were used to construct an oxidative injury model using CPF, and the protective effects and mechanism of action of CAA against CPF-induced oxidative damage were explored in vitro. …”
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Resistance to viruses of potato: current status and prospects by S. S. Makarova, V. V. Makarov, M. E. Taliansky, N. O. Kalinina

“…The most promising approaches are (1) site-directed mutagenesis of the genes conferring specific resistance to make their action much broader and (2) the use of non-specific (nonhost) resistance to generate plants resistant to unrelated viruses and, in some cases, to other pathogens and even abiotic stresses. …”
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Evaluating the dynamics of fee-free higher education in South Africa: a causal loop diagram approach  [version 3; peer review: 2 approved, 1 not approved] by Grace Kanakana-Katumba, Tlotlo Ramasu

“…Using a causal loop diagram approach (CLD), the study aims to identify key factors to effective implementation, how they interact to shape the outcome of the policy, and actionable strategies to address the challenges hindering the policy sustainability. …”
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Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis by Kang Zheng, Zexu Chen, Wen Sun, Bin Liu, Danping Fan, Qingqing Guo, Hui Luo, Jiawen Shen, Li Li, Xiaojuan He, Shuang Kou, Xiaoya Li, Guoming Pang, Hongchuan Zhao, Cheng Lu

“…This study aimed at exploring the mechanism of HGT on RA using the bioinformatics analysis with in vivo and in vitro experiment validation. The potential action mechanism was first investigated by bioinformatics analysis via Ingenuity Pathway Analysis (IPA) software. …”
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Chemical Composition and Antimicrobial Activity of Subcritical CO2 Extract of Lepidium latifolium L. (Brassicaceae) by Balzhan B. Azimkhanova, Gulbaram O. Ustenova, Kamalidin O. Sharipov, Kayrolla D. Rakhimov, Galiya M. Sayakova, Ardak B. Jumagaziyeva, Elena V. Flisyuk, Nadezhda G. Gemejiyeva

“….), used in folk medicine as means of antibacterial, irritant, laxative, antitumor, analgesic, and anthelmintic action. Methods. Raw materials were collected from Almaty region (Republic of Kazakhstan). …”
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RETRACTED ARTICLE: Effect of Oroxylum indicum on hepatocellular carcinoma via the P53 and VEGF pathways based on microfluidic chips by Xi Luo, Miao Zhao, Sicong Liu, Yi Zheng, Qiang Zhang, Yong-rui Bao, Shuai Wang, Tian-jiao Li, Xian-sheng Meng

“…To further explore the mechanism of its anti-liver cancer action, the relevant signaling pathways were studied by microfluidic chips, RT‒qPCR and immunofluorescence techniques. …”
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A transferable approach for quantifying benthic fish sizes and densities in annotated underwater images by Peter C. Esselman, Shadi Moradi, Joseph Geisz, Christopher Roussi

“…Results from validation studies show that lengths and weights can be estimated with high accuracy and precision for round goby (Neogobius melanostomus) captured in distorted action camera images, and from large‐bodied lake trout (Salvelinus namaycush) imaged with a machine vision camera. …”
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NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…Clinical trials have demonstrated that combination of daclatasvir with other medications possessing direct antiviral action, in particular with asunaprevir, and with pegilated interferon and ribavirin significantly increases treatment response rate at different categories of patients with chronic HCV-infection; that allows to reduce treatment duration of these patientsgroups. …”
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The Equator Project Research School and Mentoring Network: Evaluated Interventions to Improve Equity in Geoscience Research by Natasha Dowey, Anya Lawrence, Munira Raji, Christopher Jackson, Rebecca Williams, Ben Fernando, Sam Giles, Jenni Barclay, Louisa Brotherson, Ethny Childs, Jacqueline Houghton, Anjana Khatwa, Keely Mills, George Jameson, Francisca Rockey, Steven Rogers, Catherine Souch

“…These interventions were co-created with and informed by the voices of students and professionals within the GEES community, following a Theory of Change-based, action research approach. The Equator Research School brought together 30 Black, Asian and minority ethnic students in GEES, and 12 academics, professionals and mentors, from across the UK for a 5-day residential workshop in April 2022. …”
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A Novel Sustainable Semiconductor/Metal-organic Framework Coated Electret Filter for Simultaneous Removal of PM2.5 and VOCs by Yu Zhang, Zan Zhu, Wei-Ning Wang, Sheng-Chieh Chen

“…The results showed that this novel PE-MOFilter not only captured but also effectively photodegraded VOC pollutants via the synergistic action of adsorption and photocatalytic oxidation (PCO). …”
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Novel methotrexate long-acting system using ambroxol coating and hydroxypropyl methylcellulose encapsulation for preferential and enhanced lung cancer efficiency. by Samaa Abdullah, Najla Altwaijry, Meaad Alnakhli, Ghezlan ALenezi, Alaa A Al-Masud, Hanan Henidi, Yahya F Jamous

“…MTX is an immunosuppressant following the above-mentioned mechanism of action due to its poor selectivity. The tricky move is to investigate the solid dispersions and coating using a co-delivery system of MTX and Ambroxol (ABL). …”
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DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3 by Wenjian Yao, Linlin Shang, Yinghao Wang, Lei Xu, Yu Bai, Mingyu Feng, Xiangbo Jia, Sen Wu

“…In this paper, we defined the precise action and mechanistic basis of RORA in ESCC development under hypoxia. …”
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Opportunities and Difficulties for Strategic Litigation to Advance Digital Rights in the Internet Audience Economy by Swee Leng Harris

“…Analysis of these strategic litigation opportunities necessarily encompasses the EU’s new regime for mass claims under the Representative Action Directive, and interaction between internet users’ digital rights and consumer protection laws. …”
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Rapid microcystin-LR detection using antibody-based electrochemical biosensors with a simplified calibration curve approach by Samuel Adjei-Nimoh, Lance-Nicolas Rances, Maha A. Tony, Hossam A. Nabwey, Woo Hyoung Lee

“…In this study, we developed an innovative on-site screening electrochemical impedance spectroscopy (EIS) biosensor with a simplified calibration curve that can rapidly detect blooms for early action in similar water bodies. The novel aspect of this research is that various chemical cleaning procedures and surface modifications were evaluated to improve the antibody-embedded electrochemical sensor performance. …”
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Spatiotemporal Variations in Phytoplankton Community Structure and Diversity: A Case Study for a Macroalgae–Oyster Reef Ecosystem by Min Xu, Qi Zhao, Yufu Xu, Shenzhi Wang, Yingbo Yu, Haipeng Zhang, Yun Wang, Jiabin Shen, Linlin Yang, Yunling Zhang, Takayoshi Otaki, Teruhisa Komatsu, Kaida Xu

“…., Ltd. constructed a 2 km² artificial oyster–macroalgae reef area by placing artificial reefs on the seabed adjacent to the Luanhe River Estuary. This action resulted in sustainable annual economic outputs through the fishing and sea cucumber put-and-take fishery. …”
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Multi-scenario modeling of regional dual-carbon target achievement and air quality improvement: A case study of Zhejiang province by Yuxin Yang

“…The results indicate that (1) the industrial, transport, and residential sectors contribute over 84.7% of energy consumption, CO2 emissions, and air pollutant emissions from 2020 to 2060, identifying them as key targets for mitigation strategies; (2) carbon peaking is not projected under the baseline scenario, but is expected by 2040 in the low-carbon scenario and 2029 in the deep low-carbon scenario, with a peak emission of 208.821 million tons, primarily driven by reductions in the industrial sector; (3) air pollutant emissions across scenarios rank as O3, NO2, PM10, PM2.5, and SO2, indicating the need for stronger O3 control; and (4) the proportion of days meeting national air quality standards remains unchanged, implying further action is necessary to improve air quality. This study provides a theoretical basis and policy support for provincial energy conservation, emissions reduction, and air quality management.…”
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