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11361
Smart Cities, Smarter land Use? Unveiling the efficiency gains from China’s digital urban transformation
Published 2025-02-01“…Furthermore, the study offers actionable policy recommendations. These insights provide valuable guidance for sustainable urban development strategies in developing countries.…”
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11362
Recent developments in the therapeutics of SARS-CoV-2 infection
Published 2024-12-01“…Further research is required to validate their efficacy, safety profiles, and mechanisms of action. A holistic approach that combines conventional medicine with herbal remedies may offer new insights into the treatment of SARS and other viral respiratory illnesses.…”
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11363
Application of Mesoporous Silica Nanoparticle-Chitosan-Loaded BMP-2 in the Repair of Bone Defect in Chronic Osteomyelitis
Published 2022-01-01“…Otherwise, we found that the permeation efficiency of Chi-MSN was significantly higher than that of PLGA delivery system, so as to effectively transport BMP-2 and Dex to action target. In the BMSC test, we found that Chi-MSN could better promote their activity and osteogenesis, and the expression of osteogenesis-related genes (runt-related transcription factor 2 (RUNX-2), osteopontine (OPN), alkaline phosphatase (ALP), and osteopontine (OCN)) in the Chi-MSN group was higher. …”
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11364
Evaluation of Awareness, Knowledge, Attitude and Practices Related to Toxoplasmosis Among Females in Algeria
Published 2024-12-01“…Results showed also a high rate of appropriate practices and positive attitudes, where 90.3% of the participants said they were in favor of any action that intended to control toxoplasmosis. These results suggest the need to increase the level of awareness of Algerian women regarding this disease.…”
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11365
Monitoring Guidelines for Home and Outpatient Parenteral Antibiotic Therapy
Published 2000-01-01“…Additional knowledge must include pharmacokinetics (absorption, distribution and elimination) and the pharmacodynamics (biochemical and physiological effects and mechanisms of action) of the commonly used antibiotics. One simple guideline is the less often a drug has to be administered, the more convenient the therapy will be for the patients, facilitating a higher rate of compliance. …”
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11366
Solution of Extraordinary Differential Equations with Physical Reasoning by Obtaining Modal Reaction Series
Published 2010-01-01“…Extra Ordinary Differential equation Systems and its solution, with Physical Principle, of action-reaction and equivalent mathematical decomposition method, are obtained as an aid for Physicists and Engineers to tackle the process dynamics with ease. …”
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11367
Antibacterial Potential of Crude Extracts from <i>Cylindrospermum alatosporum</i> NR125682 and <i>Loriellopsis cavernicola</i> NR117881
Published 2025-01-01“…The minimum inhibition concentration (MIC), minimum bactericidal concentration (MBC) using the CSLI microdilution test protocol, and crude extract potential to inhibit the growth of the tested clinical bacteria strains were evaluated. The mechanism of action of the extracts including membrane damage, efflux pump, β-lactamase activity, DNA degradation, and extract–drug interaction was investigated using standard procedures. …”
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11368
In vitro and in vivo anti-hyperglycemia effects of extract of Faloak (Sterculia quadrifida R.Br.) leaves
Published 2024-11-01“…Identifying active ingredients paves the way for further research to elucidate specific bioactive compounds and their mechanisms of action …”
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11369
Impact of neighborhood safety on adolescent physical activity in Saudi Arabia: gender and socio-economic perspectives
Published 2025-01-01“…These results contribute to the growing evidence regarding the influence of built environments on youth health and wellbeing in rapidly urbanizing regions. The study offers actionable policy recommendations for urban planners and public health officials to create safer, more inclusive environments that encourage physical activity, especially among female adolescents. …”
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11370
Estimation of genetic components, heterosis and combining ability of elite Pakistani wheat varieties for yield attributing traits and stripe rust response
Published 2023-11-01“…These findings suggest exploitation of GCA for higher grain yield is important due to the presence of additive gene action and selection in the filial generations will be effective with improved rust resistance, while cross combinations ZRG-79 × PAK-13 high GCA are best suited for hybrid development.…”
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11371
Transition to Virtual Care Services during COVID-19 at Canadian Pain Clinics: Survey and Future Recommendations
Published 2023-01-01“…We used a qualitative participatory action study design that included a cross-sectional survey for data collection and descriptive analysis to summarize the findings. …”
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11372
Algorithm of management of patient with alcohol-induced liver disease
Published 2011-02-01“…Pathogenesis of ALD is based on direct toxic operation action of ethanol on one hand and on endotoxemia and increased production of proinflammatory cytokines, on another hand. …”
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11373
Excès et sacré dans la littérature victorienne et édouardienne
Published 2006-12-01“…Bataille constructs his heterology around the threshold of the sacred, the line marked by interdictions that solicit transgressive action. If heterology centers on the sacred as posited by those things which are hidden, objects of revulsion such as the body’s excreta (tears, sweat, blood…), the sacrificial banquet stands for the opposite, for ingestion and communion.…”
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11374
CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models
Published 2025-02-01“…These effects were directly linked to their inhibition of PKM2 enzymatic activity, validating the proposed mechanism of action in their rational design. ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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11375
IMCMK-CNN: A lightweight convolutional neural network with Multi-scale Kernels for Image-based Malware Classification
Published 2025-01-01“…In light of this issue, this paper proposes the Image-based Malware Classification with Multi-scale Kernels (IMCMK), a Convolutional Neural Network (CNN) architecture using multi-scale convolution kernels mixing action to improve malware variants detection capabilities. …”
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11376
Prevalence, risk factors and management of common mental health disorders in Cameroon: a systematic review
Published 2024-04-01“…Increased priority and participatory action with all stakeholders including individuals, communities/policy holders and in research where a huge gap remains to be filled, is crucial in reducing the burden of MHDs in Cameroon.PROSPERO registration number CRD42022348427.…”
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11377
Barriers to sustainable green innovation in meeting the challenges of the global economy of firms
Published 2023-11-01“…Social innovation is essential, because it addresses concrete societal problems and promotes collective action and inclusion in novel ways within companies.…”
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11378
المواقع الالکترونیة العربیة للفتوى والارشاد: دراسة تحلیلة مقارنة لمعماریتها ومحتواها المعلوماتى
Published 2020-01-01“…And warn the public and others who addressfatwas without knowledge, and alert them to the danger of this action.…”
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11379
Physics‐Based Hazard Assessment of Compound Flooding From Tropical and Extratropical Cyclones in a Warming Climate
Published 2025-01-01“…However, challenges persist in gaining actionable insights into the changing magnitude and spatial variability of these hazards. …”
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11380
Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy
Published 2025-01-01“…Additionally, we tested the cardioprotective effects of two drug candidates in the SCM mouse model and explored their mechanism-of-action in H9c2 cells. Results: Network analysis identified 129 drugs associated with SCM, which were refined to 14 drug candidates based on strong network predictions, proven anti-infective effects, suitability for ICU use, and minimal side effects. …”
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