Perceptions and acceptance of COVID-19 vaccine among pregnant and lactating women in Singapore: a pre-vaccine rollout cross-sectional study by Pooja Agarwal Jayagobi, Chengsi Ong, Kee Thai Yeo, Caleb Chun Wei Lim, Meei Jiun Seet, Lee Koon Kwek, Chee Wai Ku, Jerry Kok Yen Chan, Manisha Mathur, Mei Chien Chua

“…Addressing the safety concerns when more data are available and education on the mechanism of vaccine action will likely improve acceptance among these women.…”
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A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombina... by Xingxing Li, Yue Wu, Min Zhang, Fengliang Wang, Hong Yin, Yanrong Zhang, Shuli Zhao, Jiehua Ma, Mingming Lv, Cheng Lu

“…PDBAG1 has demonstrated substantial efficacy in suppressing triple‐negative breast cancer (TNBC) both in vitro and in vivo. Its mechanism of action involves mitochondrial impairment and the inhibition of oxidative phosphorylation (OXPHOS), achieved through direct binding to C1QBP, thereby promoting its ubiquitin‐dependent degradation. …”
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Interplay of fatty acids, insulin and exercise in vascular health by Kara C. Anderson, Jia Liu, Zhenqi Liu

“…Abstract Fatty acid metabolism, exercise, and insulin action play critical roles in maintaining vascular health, especially relevant in metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease. …”
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Pandemic or “Plandemic”?: The Mediating Role of Epistemic Justification Strategies in the Relationship Between COVID‐19 Conspiracy Beliefs and COVID‐19 Vaccine Conspiracy Beliefs... by Ali Gökalp, Servet Üztemur, Po‐Ching Huang, Aslı Kartol, Hsin‐Chi Tsai, Erkan Dinç, Mark D. Griffiths, Chung‐Ying Lin

“…The present results indicate the importance of authorities in taking early action to provide scientific evidence and information to the public to avoid individuals believing false information.…”
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Efficacy and safety of non-pharmacological, pharmacological and surgical treatments for hand osteoarthritis in 2024: a systematic review by Féline P B Kroon, Margreet Kloppenburg, Ida K Haugen, Ingvild Kjeken, Nina Østerås, Anne Therese Tveter, Geir Smedslund, Daniel Huseby Bordvik, Kristine Aasness Fjeldstad, Ingrid Skaalvik

“…To better understand action mechanism of different treatments, future trials should include hand OA subtyping and be powered for subgroup analyses.…”
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Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The objectives were i) to assess the small-scale spatial and temporal heterogeneity of physiological resistance to insecticide and behavioural resistance phenotypes, ii) to better understand their drivers, and iii) to assess their spatio-temporal predictability, at scales that are consistent with operational action. The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. …”
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Nurturing a New Industry Rooted in Geoscience: Stakeholder Insights on Minewater Thermal in Scotland by K. B. Deeming, J. Dickie, J. J. Roberts, Z. K. Shipton

“…Heat decarbonisation is crucial for climate action and the transition to a sustainable society. …”
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Sensitivity analysis and uncertainty quantification of climate change effects on Tanzanian banana crop yield by Sabas Patrick, Silas Mirau, Isambi Mbalawata, Judith Leo

“…The outcomes of this study carry significance for policymakers, stakeholders, and farmers, providing actionable insights to shape adaptive agricultural strategies. …”
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The meaning of the concept of “crime prevention in the customs sphere” by R. A. Cherkasskyi

“…According to the narrow understanding of crime prevention in the customs sphere, there is a set of preventive and educational measures, tools and methods used by specially authorized entities to minimize the action and complete “removal” of determinants of crime in the state, as well as building collective social awareness about the special negative nature of such determinants and intolerance to them. …”
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Instability Mechanism of Extraction Structure in Whole Life Cycle in Block Caving Mine by Zhi-Yuan Xia, Zhuo-Ying Tan, Lei Zhang

“…The whole life cycle instability mechanism of the extraction structure in Tongkuangyu mine is revealed; the research results show that the extraction structure near the advancing undercut front is prone to producing compressive stress concentration under the action of the surrounding rock stress arch in the stope; if the rock mass shear failure condition is reached, the instability of the extraction structure occurs. …”
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Auch eine Gewerkschaft? Der Deutschnationale Handlungsgehilfenverband und die Angestellten by Martin Otto

“…However, it acted like any union in terms of providing advice to its members and negotiating wage agreements, nor did it hesitate to initiate strike action. Already before the First World War, the DHV moved towards a more pragmatic position. …”
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Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2 by Antonietta Coppola, Claudia Cuccurullo, Gianmaria Senerchia, Marica Rubino, Liana Veneziano, Francesco Brancati, Luigi Baratto, Valentina Virginia Iuzzolino, Leonilda Bilo, Pasquale Striano, Raffaele Dubbioso

“…PER treatment significantly reduced UMRS total scores (p = 0.001) and action‐myoclonus subscores (p = 0.002), irrespective of disease duration, age at onset, or testing time (p >0.05). …”
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Berberrubine protects against cisplatin-induced ototoxicity by promoting folate biosynthesis by Zhuang Miao, Danyang Chang, Xiaodong Du, Changling Sun

“…Immunofluorescence analysis of cochlear samples from mice was conducted to quantify the hair cell count, and concurrently, ABR (Auditory Brainstem Response) testing was utilized to evaluate auditory function. The mechanism of action of BB was explored using RNA-Seq and qRT-PCR analysis.ResultsBB significantly improved cell survival rates under cisplatin treatment, reduced levels of apoptotic markers (TUNEL, Cleaved Caspase-3, Annexin V-PI), decreased ROS and MitoSOX levels, and improved JC-1 signals in both HEI-OC1 cells and cochlear hair cells in cochlear explants culture. …”
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<i>In vitro</i> assay of biological activity of a national preparation of macrophage activating factor (GcMAF-RF) by E. V. Levites, S. S. Kirikovich, E. V. Dolgova, A. S. Proskurina, G. S. Ritter, А. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…The macrophage activator GcMAF-RF, according to its characteristics, corresponds to similar preparations which are made available to the market by foreign companies, and can be considered as a new biologically active preparation with a wide spectrum of action. Of greatest interest is its ability - through the activation of macrophages - to enhance the adaptive immunity. …”
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Prevalence of Diabetes and Prediabetes among Children Aged 11-14 Years Old in Vietnam by Duong H. Phan, Vuong V. Do, Long Q. Khuong, Hung T. Nguyen, Hoang V. Minh

“…However, there is a high prevalence in impaired fasting glucose, requiring attention from policymakers to take action to prevent the occurrence of the epidemic of type 2 diabetes in children in the future.…”
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Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile. by Ahmed M Nagy, Heba A Fahmy, Mohamed F Abdel-Hameed, Rehab F Taher, Alaa M Ali, Mohamed M Amin, Sherif M Afifi, Tuba Esatbeyoglu, Mohamed A Farag, Abdelsamed I Elshamy

“…<h4>Methods and findings</h4>The objective of this study was to profile E. heterophylla ethanol extract (EH-EtOH) and elucidate its protective role in oxidative stress, relieving inflammatory action of hyperglycemia-induced testicular degeneration and restoring the normal histological structure with physiological properties of testicular tissue in streptozotocin (STZ)-induced DM. …”
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Stages of Change Model for Participation in Physical Activity during Pregnancy by Lene Annette Hagen Haakstad, Nanna Voldner, Kari Bø

“…The questionnaire contained 53 questions with one particular question addressing the TTM and the five stages: (1) precontemplation stage, (2) contemplation stage, (3) preparation stage, (4) action stage, and (5) maintenance stage. Results. …”
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Successful open defecation-free intervention in low- and middle-income countries: a qualitative synthesis systematic review protocol by Vera Yulyani, Iswanto Iswanto, Daniel Daniel, Fitrina Mahardani Kusumaningrum, Fatwa Sari Tetra Dewi

“…Furthermore, this review seeks to identify gaps in the available literature and areas that require additional investigation and action.Methods and analysis Inclusion criteria were developed considering issues related to open defecation in LMICs, sanitation interventions and behavioural change. …”
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A Current Overview of Next-Generation Probiotics and Their Prospects in Health and Disease Management by Ke-Yan Loo, Joanne Yuen Heng Thong, Loh Teng-Hern Tan, Vengadesh Letchumanan, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law

“…These NGPs can elicit targeted effects in specific disease states while simultaneously restore gut dysbiosis by promoting beneficial bacteria, elevated short-chain fatty acid levels, and stimulate immunomodulatory effects to reduce inflammation. These modes of action are closely linked to one another, acting as a positive feedback loop to reduce inflammation in the host. …”
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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms by David Trombley McSwiggen, Helen Liu, Ruensern Tan, Sebastia Agramunt Puig, Lakshmi B Akella, Russell Berman, Mason Bretan, Hanzhe Chen, Xavier Darzacq, Kelsey Ford, Ruth Godbey, Eric Gonzalez, Adi Hanuka, Alec Heckert, Jaclyn J Ho, Stephanie L Johnson, Reed Kelso, Aaron Klammer, Ruchira Krishnamurthy, Jifu Li, Kevin Lin, Brian Margolin, Patrick McNamara, Laurence Meyer, Sarah E Pierce, Akshay Sule, Connor Stashko, Yangzhong Tang, Daniel J Anderson, Hilary P Beck

“…With this one experimental modality, we determined the potency, pathway selectivity, target engagement, and mechanism of action for identified hits. Kinetic htSMT experiments were capable of distinguishing between on-target and on-pathway modulators of ER signaling. …”
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