Mild heat stress promotes the differentiation of odontoblast-like MDPC-23 cells via yes-associated protein by Peiqi Liu, Zhen Li, Hui Zhang, Yijie Wang, Yuxin Liao, Yi Guo, Chenxu Wang, Yuanwu Zou, Rui Zou, Lin Niu

“…This study examined the effects and mechanism of action of mild heat stress (MHS) on the differentiation of odontoblast-like MDPC-23 cells.Methods We used a heating device to accurately control the temperature and duration, mimicking the thermal microenvironment of odontoblast-like cells. …”
Get full text

AI in Marketing Management: Executive Perspectives from Companies

“…Practically, it provides actionable strategies for business leaders to address human-centric and technological barriers, fostering a more efficient and data-driven marketing process. …”
Get full text

Experimental Study on Physical Similar Model of Fault Activation Law Based on Distributed Optical Fiber Monitoring by Dingding Zhang, Yanyan Duan, Wengang Du, Jing Chai

“…The upper rock layer on the fault face is affected by the mining action of the working face before the lower one, and the working face is affected by the fault in a larger range when advances in the lower plate than that in the upper plate, and the risk of fault activation instability occurs earlier when the working face advances in the lower plate than that in the upper plate. …”
Get full text

Ionized and total magnesium levels and health outcomes in patients with type 2 diabetes mellitus by Juhaina Salim Al-Maqbali, Salwa Al Harasi, Qasim Al Mamary, Henrik Falhammar, Ibrahim Al-Zakwani, Mohammed Al Za’abi, Abdullah M. Al Alawi

“…Abstract Magnesium (Mg) is a vital trace element in cellular processes, including glucose metabolism and insulin action. This study aimed to assess the prevalence of dysmagnesemia among patients with type 2 diabetes mellitus (T2DM) and its relationship with glycaemic control and diabetic complications. …”
Get full text

Problematic Issues of the Development and Implementation of the Code of Ukraine on Administrative Offenses by O. Yu. Kyrychenko

“…The author has provided propositions for updating the sections of the current Code of Ukraine on Administrative Offenses, in particular, the inclusion into General Part of the Code of Ukraine on Administrative Offenses of the norms consolidating its tasks, determining the concept of administrative liability, detailing the understanding of legislation on administrative liability, establishing rules for the formation of the Code, as well as the scope of its action in time, in space and by the range of persons; special attention has been paid to the revision of the system of administrative penalties. …”
Get full text

Bibliometrics and Visual Analysis of rTMS in Recent Five Years Based on CiteSpace by Heping ZHENG, Bo ZHANG, Yuxi LI, Dongling ZHONG, Yanping TIAN, Juan LI, Zhong ZHENG, Rongjiang JIN

“…The research hotspots in the field of rTMS at home and abroad mainly focus on the treatment of mental illness such as depression and schizophrenia, the research on the cognitive sequelae of cerebral apoplexy, the recovery of motor dysfunction, and the exploration of the mechanism of action of each functional area of cerebral cortex. …”
Get full text

A novel approach for agricultural carbon emission reduction by integrating fermatean neutrosophic set with WINGS and AHP-EWM by Kecheng Zhang, Zhicheng Chen, Yawen Wang

“…This research advances the field by offering a novel theoretical model for complex decision-making under uncertainty, deepening the understanding of agricultural carbon reduction dynamics, and providing actionable insights for sustainable development.…”
Get full text

Tackling Microbial Resistance and Emerging Pathogens with Next-Generation Antibiotics by Kar Jing Chong, Huang Feng, Vengadesh Letchumanan, Masita Arip, Omotayo Fatokun, Lazuardi Mochamad, Chin Tat Ng, Sasikala Chinnapan, Malarvili Selvaraja

“…Consequently, multiple initiatives have been undertaken to address these phenomena, including the development of antimicrobials with novel modes of action. Without novel discoveries of newer antimicrobial agents, we may face the risk of entering a post-antibiotic era where uncomplicated infections become untreatable. …”
Get full text

Unaccountable counting: the folly of incorporating open ocean carbon sinks in Nationally Determined Contributions by Berger, Manon, Comte, Adrien, Kwiatkowski, Lester, Bopp, Laurent

“…The national climate action plans to cut greenhouse gas emissions, referred to as Nationally Determined Contributions (NDCs), currently include anthropogenic land-based carbon fluxes but typically exclude open ocean carbon sinks within Exclusive Economic Zones (EEZs). …”
Get full text

Evolutionary Explanations of the “Actuarial Senescence in the Wild” and of the “State of Senility” by Giacinto Libertini

“…For IMICAW, it should be substituted with the concept of a physiologic phenomenon genetically determined by a balance of opposite selective pressures — strictly in terms of kin selection — and, for “age changes”, with the action of the same IMICAW-causing mechanisms at ages when selection becomes ineffective.…”
Get full text

Changes in Gastric Smooth Muscle Cell Contraction during Pregnancy: Effect of Estrogen by Othman A. Al-Shboul, Hanan J. Al-Rshoud, Ahmed N. Al-Dwairi, Mohammad A. Alqudah, Mahmoud A. Alfaqih, Ayman G. Mustafa, Mohammad Jaafar

“…Importantly, pretreatment of GSMC with either L-NNA or ODQ abolished estrogen inhibitory action on muscle contraction. In conclusion, GSMC contractile behavior undergoes drastic changes in response to estrogen during pregnancy and this might explain some of the pregnancy-associated gastric disorders.…”
Get full text

Implementasi kebijakan penurunan stunting di kabupaten Donggala by La Samudia Dalili, Daswati Daswati, Sitti Chaeriah Ahsan

“…It is hoped that the Regent of Donggala will oversee all TPPS activities to ensure that the stunting budget is appropriately allocated; it is also expected that TPPS will draft written Standard Operating Procedures (SOPs) to serve as guidelines in the implementation of tasks related to the policy implementation of Presidential Regulation No. 72 of 2021 concerning the Acceleration of Stunting Reduction to ensure the effective execution of Convergence Action activities.…”
Get full text

Functional and Structural Investigation of Myenteric Neurons in the Human Colon by Kristin Elfers, Alina Sophia Sehnert, Alexander Wagner, Ulrich Zwirner, Helena Linge, Ulf Kulik, Daniel Poehnert, Markus Winny, Benjamin Gundert, Heiko Aselmann, Gemma Mazzuoli-Weber

“…Results: Stimulation with nicotine and 5-HT elicited reproducible action potential discharge in a proportion of human myenteric neurons. …”
Get full text

Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise by Anu Joseph, S. Parvathy, Koyikkal Karthikeya Varma

“…Insulin resistance is a state of impaired responsiveness to insulin action. This condition not only results in deficient glucose uptake but increases the risk for cardiovascular diseases (CVD), stroke, and obesity. …”
Get full text

Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types by Jeanne Shen, Sergio Pereira, Chan-Young Ock, Yung-Jue Bang, Seulki Kim, Sehhoon Park, Se-Hoon Lee, George A Fisher, Young Kwang Chae, Yoon-La Choi, Jin-Haeng Chung, Tony S K Mok, Leeseul Kim, Jun-Eul Hwang, Gahee Park, Sanghoon Song, Seunghwan Shin, Yoojoo Lim, Wonkyung Jung, Heon Song, Hyojin Kim, Taebum Lee, Sukjun Kim, Chang Ho Ahn, Seokhwi Kim, Ben W Dulken, Stephanie Bogdan, Maggie Huang, Chiyoon Oum, Siraj M. Ali

“…On subgroup analysis, the IIP was generally prognostic of favorable PFS across major patient subgroups, with the exception of the microsatellite unstable/mismatch repair deficient subgroup.Conclusion The AI-based IIP may represent a practical, affordable, clinically actionable, and tumor-agnostic biomarker prognostic of ICI therapy response across diverse tumor types.…”
Get full text

A Solution Approach on Reducing Defects in Batik Tanah Liek Production Process of a Small and Medium-sized Enterprise by Agus Sutanto, Nilda Tri Putri, Tessa Alqifti, Sha'ri Mohd Yusof

“…The study employs a systematic approach combining quality management methodologies, including data collection, problem identification, brainstorming, the Failure Mode and Effects Analysis (FMEA) approach, and actionable recommendations. Data was gathered through a questionnaire to capture perspectives on defects and quality control issues in batik production. …”
Get full text

The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications by Monika Kamińska, Maria Jasiewicz, Magdalena Miernik-Skrzypczak, Aleksandra Spyra, Marta Malicka, Natalia Dąbrowska, Aleksandra Kozioł, Katarzyna Moczyróg

“…Diabetes, characterized by hyperglycemia due to impaired insulin production or action, leads to significant complications like diabetic retinopathy (DR) and diabetic foot syndrome (DFS). …”
Get full text

World After Pandemic: New Socio-Psychological Complex Rises by Easmin Akter Eva

“…It is considered that the Covid-19 pandemic as a super transition to a more inclusive society in the newly found spirit of collective action and shared responsibility. Societies are finding alternative ways to reach their goals such as education, seminars, meetings are provided online. …”
Get full text

Standing balance of single-legged hopping robot model using reinforcement learning approach in the presence of external disturbances by S. Mohamad Hoseinifard, Majid Sadedel

“…As per the proposed model, the jumping action is facilitated through a four-link mechanism augmented by a spring, while balance preservation is achieved through the independent operation of two arms connected to the upper body. …”
Get full text

ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…In summary, this study deciphers that SUR1-TRPM4 crucially mediates the persistent activation of microglial NLRP3 inflammasome under the action of ROS after whole-brain radiation, offering novel therapeutic strategies for delayed RIBI as well as other NLRP3-related neurological disorders involving excessive ROS production.…”
Get full text