Movement and distribution of particles in the tank of jet and agitation combined flotation machine by Tao WANG, Wei ZHOU, Zilei WANG, Shujie WANG, Lingling WANG, Liang LI

“…The results showed that some particles pass through the gap between the impeller blades and spiral downward under the action of flow field, the other part of the particles are thrown out by the blade and move helically around and up under the coupling effect of the blade and the flow field. …”
Get full text

Autonomous security analysis and penetration testing model based on attack graph and deep Q-learning network by Cheng FAN, Guoqing HU, Taojie DING, Zhanhua ZHANG

“…With the continuous development and widespread application of network technology, network security issues have become increasingly prominent.Penetration testing has emerged as an important method for assessing and enhancing network security.However, traditional manual penetration testing methods suffer from inefficiency,human error, and tester skills, leading to high uncertainty and poor evaluation results.To address these challenges, an autonomous security analysis and penetration testing framework called ASAPT was proposed, based on attack graphs and deep Q-learning networks (DQN).The ASAPT framework was consisted of two main components:training data construction and model training.In the training data construction phase, attack graphs were utilized to model the threats in the target network by representing vulnerabilities and possible attacker attack paths as nodes and edges.By integrating the common vulnerability scoring system (CVSS) vulnerability database, a “state-action”transition matrix was constructed, which depicted the attacker’s behavior and transition probabilities in different states.This matrix comprehensively captured the attacker’s capabilities and network security status.To reduce computational complexity, a depth-first search (DFS) algorithm was innovatively applied to simplify the transition matrix, identifying and preserving all attack paths that lead to the final goal for subsequent model training.In the model training phase, a deep reinforcement learning algorithm based on DQN was employed to determine the optimal attack path during penetration testing.The algorithm interacted continuously with the environment, updating the Q-value function to progressively optimize the selection of attack paths.Simulation results demonstrate that ASAPT achieves an accuracy of 84% in identifying the optimal path and exhibits fast convergence speed.Compared to traditional Q-learning, ASAPT demonstrates superior adaptability in dealing with large-scale network environments, which could provide guidance for practical penetration testing.…”
Get full text

Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…This, with biophysical and functional assays, elucidated the underlying mechanism of action of ISB 1442. In solution phase, ISB 1442 forms a 2:2 complex with CD38 as determined by size-exclusion chromatography with multi-angle light scattering and electron microscopy. …”
Get full text

THE EFFECT OF QUERCETIN ON MORPHOLOGICAL AND BIOCHEMICAL CHANGES IN RAT LIVER UNDER 270TH DAY CENTRAL DEPRIVATION OF LUTEINIZING HORMONE SYNTHESIS by M.V. Rud, V.I. Shepitko, Ye.V. Stetsuk, O.Ye. Akimov

“…The flavonoid quercetin has capillary-stabilizing properties due to its antioxidant and membrane-stabilizing action. The aim of our study was to determine the changes in immunocompetent liver cells, both qualitative and quantitative, caused by inhibition of central testosterone synthesis in male rats due to the introduction of triptorelin acetate on the 270th day, and the potential effect of quercetin on morphology and liver antigen-presenting cells count against the background of previous administration of triptorelin acetate solution. …”
Get full text

Provider Preference, Logistical Challenges, or Vaccine Hesitancy? Analyzing Parental Decision-Making in School Vaccination Programs: A Qualitative Study in Sydney, Australia by Leigh McIndoe, Alexandra Young, Cristyn Davies, Cassandra Vujovich-Dunn, Stephanie Kean, Michelle Dives, Vicky Sheppeard

“…This study provides valuable insights into social determinants of vaccine acceptance and offers actionable strategies for improving vaccine uptake in school-based programs.…”
Get full text

GENERAL EQUATION OF THE HYDRAULIC FRICTION LAW FOR HINDERED FALLING OF AN INDIVIDUAL BALL AND FLUID MOTION IN GRANULAR LAYERS by M. V. Krautsov, A. M. Krautsov

“…The formulae appear in dimensionless similitude parameters that reflect correlation of the essential action forces.The presented scientific results contribute to the theory development of the applied hydromechanical phenomena and the new obtained formulae enable enhancement of the calculation procedures for structures and installations that realize the studied hydraumechanical processes. …”
Get full text

Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(N,N-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance by Samuel Treviño, Alfonso Díaz, Eduardo Sánchez-Lara, Víctor Enrique Sarmiento-Ortega, José Ángel Flores-Hernández, Eduardo Brambila, Francisco J. Meléndez, Enrique González-Vergara

“…However, mechanisms of action and toxicological threshold have been tackled poorly so far. …”
Get full text

Developing transcriptomic biomarkers for TAVO412 utilizing next generation sequencing analyses of preclinical tumor models by Ying Jin, Peng Chen, Huajun Zhou, Guangmao Mu, Simin Wu, Zhengxia Zha, Bin Ma, Chao Han, Mark L. Chiu, Mark L. Chiu

“…TAVO412 has multiple mechanisms of action for tumor growth inhibition that include shutting down the EGFR, c-Met, and VEGF signaling pathways, having enhanced Fc effector functions, addressing drug resistance that can be mediated by the crosstalk amongst these three targets, as well as inhibiting angiogenesis. …”
Get full text

Influence of thickness of transverse and longitudinal layers on deformability and stress distribution in five-layer cross-glued wood boards by M. Yu. Troshin, A. V. Turkov

“…Due to the anisotropy of wood, this design allows for high strength and stiffness in different directions of stress action, which has made this material one of the most promising to be studied in recent decades. …”
Get full text

Metaphor in Psychotherapy by Nergis Lapsekili, Zekeriya Yelboða

“…A metaphor is a figüre of speech in which a word or phrase is applied to an object or an action that it does not literally denote in order to imply a resemblence. …”
Get full text

Improving Clinical, Cognitive, and Psychosocial Dysfunctions in Patients with Schizophrenia: A Neurofeedback Randomized Control Trial by Renata Markiewicz, Agnieszka Markiewicz-Gospodarek, Beata Dobrowolska, Bartosz Łoza

“…The method requires further research regarding its clinical specificity and understanding mechanisms of action.…”
Get full text

Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…SCZ was characterized by hyperconnectivity of the auditory network, visual system, and sensorimotor areas, and hypoconnectivity of the frontal gyrus, cerebellum, thalamus, and caudate nucleus, which were significantly linked to age, sex, duration of illness, and the severity of symptoms and functionally enriched in domains involving self, sensory, action, and social. 2922 genes were significantly over-expressed in these regions, which were enriched for important molecular functions, biological processes, and cellular components of the neurons/cells in the brain as well as SCZ and other mental diseases. …”
Get full text

Simulated Experiment of Water-Sand Inrush across Overlying Strata Fissures Caused by Mining by Guibin Zhang, Hailong Wang, Shenglei Yan, Chuanyang Jia, Xiaoyuan Song

“…The excavation of physical model can reproduce the whole process of water-sand inrush across overlying strata fissures caused by mining to the life. Under the action of mining and water pressure, after the fourth excavation, the mining-induced vertical fractures of overlying strata pass through the entire bedrock and connect the unconsolidated sand bed, which serves as pathways between the unconsolidated sand bed and working face, triggering water-sand inrush. …”
Get full text

Comparison of the Effects of Articaine and Lidocaine Anesthetics on Blood Pressure after Maxillary Infiltration Technique: A Triple-Blind Randomized Clinical Trial by Amirhossein Moaddabi, Parisa Soltani, Maryam Zamanzadeh, Kamran Nosrati, Mojtaba Mollamirzaei, Mariangela Cernera, Gianrico Spagnuolo

“…Subsequent increase in blood pressure in healthy individuals commonly occurs and may be affected by several factors such as mental and physical stress, painful stimuli, and action of catecholamines present in local anesthetic solutions. …”
Get full text

Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota by Yunjiao Shen, Yunjiao Shen, Yansong Gao, Ge Yang, Zijian Zhao, Yujuan Zhao, Lei Gao, Shengyu Li

“…Fecal analysis revealed that TMG reconstructed the gut microbiota in colorectal cancer-affected mice by augmenting the abundance of the advantageous bacterium Lactobacillus and decreasing the abundance of the harmful bacterium Proteus.ConclusionTMG can exhibit potent anti-colorectal cancer effects through diverse apoptotic mechanisms, with their mode of action closely related to the regulation of gut microbiota.…”
Get full text

Strategic Stability: Dynamics and Factors of Transformation by K. V. Bogdanov

“…Its basic principles are confined to the stability of nuclear deterrence in any realistic scenarios and do not provide for practical action. Hence, one should distinguish them from applied solutions for calculating military-strategic balances and elaboration of arms control agreements. …”
Get full text

From boundary data to bound states by Gregor Kälin, Rafael A. Porto

“…These relationships allow us to compute observables for generic orbits (such as the periastron advance ∆Φ) through analytic continuation, via a radial action depending only on boundary data. A simplified (more geometrical) map can be obtained for circular orbits, enabling us to extract the orbital frequency as a function of the (conserved) binding energy, Ω(E), directly from scattering information. …”
Get full text

Rock fracture mode and acoustic emission characteristics under true triaxial single-sided unloading path by Longpei Ma, Longpei Ma, Chongyan Liu, Guangming Zhao, Guangming Zhao

“…While the proportions of tensile cracks in siltstone and fine sandstone are 41.43% and 56.41% respectively. Under the action of axial stress, they are prone to longitudinal splitting and form tensile cracks approximately parallel to the direction of the maximum principal stress. …”
Get full text

Mechanism of the blood-brain barrier modulation by cadherin peptides by Elinaz Farokhi, Ahmed L. Alaofi, Vivitri D. Prasasty, Filia Stephanie, Marlyn D. Laksitorini, Krzysztof Kuczera, Teruna J. Siahaan

“…Aim: This study was aimed at finding the binding site on the human E-cadherin for Ala-Asp-Thr Cyclic 5 (ADTC5), ADTC7, and ADTC9 peptides as blood-brain barrier modulator (BBBM) for determining their mechanism of action in modulating the blood-brain barrier (BBB). …”
Get full text

SUSTAINABLE BUSINESS MODELS RESEARCH: A BIBLIOMETRIC ANALYSIS by Xhorxhina VANGJEL, Olimpia BAN

“…The keyword phrase was searched in the databases as a first step that initiates the continuation of this analysis. This action helps to obtain valuable data for the purpose of this study. …”
Get full text