Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy by Yishen Tian, Jingxuan Li, Na Yang, Yang Zhao, Jiancao Zuo, Hang Xiong, Yiwen Pan, Li Xiao, Min Su, Feng Han, Zhixu He, Rong Hu

“…In the complex immunosuppressive microenvironment, the synergistic action of these components markedly enhanced the clearance efficacy of the immune system. …”
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Exercise promotes peripheral glycolysis in skeletal muscle through miR-204 induction via the HIF-1α pathway by Sang R. Lee, Kang Joo Jeong, Moeka Mukae, Jinhee Lee, Eui-Ju Hong

“…These findings suggest a novel physiological role for miR-204 in promoting skeletal muscle glycolysis, particularly in situations where insulin action is limited.…”
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Hydraulic Abrasion-Resistant Elastic Epoxy Resin Materials by Liqun Xu, Kai Zhang, Yanhui Liu

“…The abrasion of hydraulic concrete structures caused by the washing action of flowing water is a common problem and cannot be solved by simply increasing the strength of the concrete. …”
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Cloud and IoT based smart agent-driven simulation of human gait for detecting muscles disorder by Sina Saadati, Abdolah Sepahvand, Mohammadreza Razzazi

“…An agent-driven modeling method ensures the naturalness, accuracy, and interpretability of the simulation, incorporating neuromuscular details such as Henneman's size principle, action potentials, motor units, and biomechanical principles. …”
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Reflections on Korea in 2010: Trials and prospects for recovery of common sense in 2011 by Paik Nak-chung

“…The main reason behind this 'snatching' action apparently was to push on with the Four Great Rivers Project and to pass the related pernicious legislation known as the "Water-Friendly Region Law." …”
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On Modeling Agent Behavior Change Through Multi-Typed Information Diffusion in Online Social Networks by Masaaki Miyashita, Norihiko Shinomiya, Daisuke Kasamatsu, Genya Ishigaki

“…The toilet paper shortage in Japan in 2020 caused by people’s selfish behavior owing to the diffusion of information to correct misinformation, which is considered a general phenomenon based on three sociological characteristics: a collective action problem, a self-fulfilling prophecy, and pluralistic ignorance. …”
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Spatiotemporal dynamics and driving mechanism of eco-environmental quality in piedmont-oasis-desert ecotone based on long-term harmonized remote sensing ecological index- take Korl... by Junling He, Xifeng Ju, Chuqiao Han, Liming Liu, Haidong Zhang, Saitiniyazi Adilai, Chongbo Li

“…The degraded and essential stable areas were located in the northern and the southern, accounting for about 25% of the total area, and the overall fluctuation was low. (4) The spatiotemporal distribution results from the joint action of natural and human factors, the key factors were temperature, precipitation, and socio-economic development level. …”
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Le conflit renaissant de la figure et de l’abstraction dans Labyrinthe, journal mensuel des Lettres et des Arts (octobre 1944-décembre 1946) by Blandine Delhaye

“…This article comprehends the logic of his undertaking and also aims to communicate the scope of an individual action that was part of the growing awareness of cultural heritage in the nineteenth century.…”
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Diatoms-endoparasite association in fish from the marine pacific coast of Colombia (Buenaventura). by Vanessa Potosi-Pai, Carlos E Agudelo Morales, Javier Antonio Benavides-Montaño

“…This is the first report concerning diatoms and parasites association in fish from the Pacific Coast of Colombia and highlights the relevance of Coscinodiscus spp. and Gyrosigma spp. as important diatoms and potential candidates for studying pharmaceutical action in aquaculture. Further studies about diatoms-parasites association in aquaculture are required.…”
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Tofacitinib downregulates JAK1 and JAK3 on human intestinal monocytes and macrophages without affecting dendritic cells phenotype or function by Elisa Arribas-Rodríguez, Ángel De Prado, Beatriz de Andrés, Benito Velayos, Jesús Barrio, Alejandro Romero, Francisco Javier García-Alonso, Álvaro Martín-Muñoz, José A. Garrote, Eduardo Arranz, Luis Fernández-Salazar, David Bernardo

“…Although Tofacitinib, which inhibits the JAK1 and JAK3 signalling pathway, is approved to treat patients with UC, its specific mechanism of action remain elusive. Given the central role that conventional dendritic cells (cDC) elicit in gut homeostasis, we hypothesised that Tofacitinib acts modulating cDC function in UC. …”
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Protective Effect of Shenfu Injection against Sepsis-induced Acute Lung Injury by Suppressing Inflammation and Apoptosis Through the Regulation of the Janus Kinase 2/Signal Transdu... by Li-Juan Cao, Hai-Tang Xie, Zhong-Xia Chu, Yue Ma, Ming-Ming Wang, Shi Zhuang

“…This study aimed to investigate the potential mechanism of action of SFI in preventing sepsis-induced ALI. Materials and Methods: We established a mouse model of sepsis-induced ALI by cecal ligation and puncture (CLP). …”
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Incidence of HBV Reactivation in Psoriasis Patients Undergoing Cytokine Inhibitor Therapy: A Single-Center Study and Systematic Review with a Meta-Analysis by Meng Hsuan Kuo, Ping-Hung Ko, Sz-Tsan Wang, Chih-Wei Tseng

“…Despite the lower risk for HBsAg−/HBcAb+ patients, the potential severity of outcomes demands careful monitoring and timely action.…”
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An analysis of road accidents caused by the current road infrastructure in Romania by Gheorghe Neamțu, Marinela Ință

“…A high density of localities and the roads that cross them, the topography, the climate, traffic jams, the defective way of action of the authorities, sometimes the lack of horizontal and vertical signalization, the obstacles encountered at every turn, the non-conforming, undersized design or construction of traffic lanes and other elements of infrastructure, current legislation with many interpretations, heavy, heterogeneous and congested traffic, all of which make traffic participants unsafe and stressful and generate serious road events or accidents, resulting in human casualties and significant material damage. …”
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Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression by Nicole R. Silva, Shokouh Arjmand, Luana B. Domingos, Adriano M. Chaves-Filho, Melina Mottin, Caroline C. Real, Anna L. Waszkiewicz, Pedro H. Gobira, Alessio Nicola Ferraro, Anne M. Landau, Carolina H. Andrade, Heidi K. Müller, Gregers Wegener, Sâmia R.L. Joca

“…Ketamine (KET) is recognized as rapid-acting antidepressant, but its mechanisms of action remain elusive. Considering the role of endocannabinoids (eCB) in stress and depression, we investigated if S-KET antidepressant effects involve the regulation of the eCB system using an established rat model of depression based on selective breeding: the Flinders Sensitive Line (FSL) and their controls, the Flinders Resistant Line (FRL). …”
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Creating and Implementing an Effective and Deterrent National Cyber Security Strategy by Mustafa Senol, Ertugrul Karacuha

“…It can be concluded that the proposed effective and deterrent NCSS model and approaches might help to efficiently and effectively handle these issues for better management, control, and auditing for cyber security issues; provide new concepts for cyber security issues supported by cyber power and deterrence on this issue in the world; introduce integrated approach to cyber security strategies and policies on the stages of developing and implementing a NCSS; bring a number of issues to support cyber security and defence in different perspectives; and achieve a high degree of success, especially in terms of effectiveness and existing deterrence strategies and action plans of basic structure, with the proposed approach. …”
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Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…Its safety and efficacy, mechanism of action, pharmacokinetic parameters, and relative lack of rebound and withdrawal effects render suvorexant a reliable choice for the treatment of insomnia.…”
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Approbation of the mechanism of economic reliability on the example of an industrial enterprise by A. R. Terentyeva

“…The author of the article came to the following conclusions: the implemented mechanism of economic reliability in the activity of an industrial enterprise allows identifying bottlenecks, as well as developing measures to eliminate them, thereby increasing the level of economic reliability; the action of this mechanism should be continuous, since the intensification of technological dynamics is an aggressive factor influencing the efficiency, stability and sustainability of the functioning of an industrial enterprise. …”
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Comparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation-Induced Lung... by Rui Zhai, Fumin Tai, Kexin Ding, Xin Tan, Hujie Li, Zhengyue Cao, Changhui Ge, Xiaofei Zheng, Hanjiang Fu

“…This study aimed to investigate the therapeutic effects and mechanisms of action of three distinct sources of MSCs, including human umbilical cord mesenchymal stem cells (UCMSCs), bone marrow mesenchymal stem cells (BMSCs), and adipose-derived stem cells (ADSCs), in thoracically irradiated mice. …”
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Distinct cortico-striatal compartments drive competition between adaptive and automatized behavior. by William H Barnett, Alexey Kuznetsov, Christopher C Lapish

“…These striatal subregions each operate on unique cortical input: the DMS receives input from the prefrontal cortex (PFC) which represents outcomes, and the DLS receives input from the premotor cortex which determines action selection. Following an initial learning of a two-alternative forced choice task, we subjected the model to reversal learning, reward devaluation, and learning a punished outcome. …”
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Chitosan and its derivatives as promising plant protection tools by A. B. Shcherban

“…The review considers various mechanisms of action of chitosan as a biopesticide, including both a direct inhibitory effect on pathogens and the induction of plant internal defense systems as a result of chitosan binding to cell surface receptors. …”
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