Activation of Adenosine A3 Receptor Alleviates TNF-α-Induced Inflammation through Inhibition of the NF-κB Signaling Pathway in Human Colonic Epithelial Cells by Tianhua Ren, Yumei Qiu, Weiyun Wu, Xiao Feng, Shicai Ye, Zhuang Wang, Ting Tian, Yanting He, Caiyuan Yu, Yu Zhou

“…To investigate the expression of adenosine A3 receptor (A3AR) in human colonic epithelial cells and the effects of A3AR activation on tumor necrosis factor alpha (TNF-α-) induced inflammation in order to determine its mechanism of action in human colonic epithelial cells, human colonic epithelial cells (HT-29 cells) were treated with different concentrations of 2-Cl-IB-MECA prior to TNF-α stimulation, followed by analysis of NF-κB signaling pathway activation and downstream IL-8 and IL-1β production. …”
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Regime Change: The Need for Scientific Critical Consciousness by Usama Javed Mirza

“…SCC is presented as the ability to perceive these oppressive ideas relating to science, and to take action to counter them. The theoretical framework is developed by adapting ideas from and critiques of Freire (2017) , Greene (2011) , Boler and Zembylas (2002) , Anyon (2009) and Biesta (1998) . …”
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Biocontrol yeast Kurtzmaniella quercitrusa BS-AY-S1 controls postharvest green mold of citrus fruit by producing metabolites with antifungal activity by Bi Liao, Ou Chen, Hongyan Zhang, Wenjun Wang, Lanhua Yi, Honghai Li, Kaifang Zeng

“…In conclusion, BS-AY-S1 demonstrated potential for controlling postharvest green mold in citrus fruit, with its mechanisms of action including the ability to colonize citrus fruit wounds and produce antifungal metabolites and VOCs.…”
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Study about the Expression of CypA Proteins and Its Blocking Effect in the Cerebellum from FMR1 Gene Knockout Mice by Electroacupuncture of DU1 Acupoint by Dong LIN, Wanping BU, Xiaoting YANG

“…The blank group was given grab action, the other groups were taken acupuncture intervention. …”
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Classification-augmented survival estimation (CASE): A novel method for individualized long-term survival prediction with application to liver transplantation. by Hamed Shourabizadeh, Dionne M Aleman, Louis-Martin Rousseau, Katina Zheng, Mamatha Bhat

“…Further, we develop novel temporal feature importance methods to understand how different features may vary in survival importance over time, potentially providing actionable insights in real-world survival problems.…”
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Identification of Cognitive Training for Individuals with Parkinson’s Disease: A Systematic Review by Marina Francesca Gattoni, Silvia Gobbo, Sarah Feroldi, Anna Salvatore, Jorge Navarro, Sandro Sorbi, Francesca Lea Saibene

“…The considered studies applied various experimental interventions for the training of cognitive functions in PwPD: computer-based platforms, exergames, paper-and-pencil programmes, dual-task or treadmill training with action observation therapy, motor imagery, and virtual reality components, interventions targeting precise cognitive domain, tele-rehabilitation, transcranial direct current stimulation, structured cognitive training, and multimodal treatments. …”
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Evaluation of Different Rates of Ampligo Insecticide against Fall Armyworm (Spodoptera frugiperda (JE Smith); Lepidoptera: Noctuidae) in the Coastal Savannah Agroecological Zone of... by Michael Y. Osae, Justice O. Frimpong, Joshua O. Sintim, Benjamin K. Offei, Dinah Marri, Selorm E. K. Ofori

“…Thus, some importers do not do due diligence in testing the chemical agronomically to ascertain its mode of action and also being not harmful to beneficial insect species in the Ghanaian environment. …”
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The role of Akkermansia muciniphila in maintaining health: a bibliometric study by Fangfang Gao, Canyu Cheng, Canyu Cheng, Runwei Li, Zongcun Chen, Zongcun Chen, Ke Tang, Guankui Du, Guankui Du, Guankui Du

“…Therefore, future research should explore its potential further by conducting clinical trials, elucidating its mechanisms of action, and investigating its efficacy and safety in diverse patient populations.…”
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Study on Overburden Rock Movement and Stress Distribution Characteristics under the Influence of a Normal Fault by Quansen Wu, Peng Kong, Quanlin Wu, Xinggang Xu, Xingyu Wu, Tao Guo

“…When the accumulated energy reaches a certain threshold, under the action of normal stress or shear stress, the fault will be activated, and a large amount of energy will be released, which can easily induce a rock burst. …”
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Effect of Cellulase Enzyme Treatment on Cyst Wall Degradation of Acanthamoeba sp. by Tisha Lazuana, Hendri Astuty, Ika Puspa Sari

“…A cysticidal test was performed to determine the effectiveness cysticidal action of disinfectant solution, cellulase, and the combination of disinfectant solution and cellulase in killing Acanthamoeba sp. cyst assessed by their viability value. …”
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RESEARCH ON THE FATIGUE LIFE CALCULATION METHOD OF HYDRO-TURBINE HEAD COVER CONNECTING BOLTS BASED ON PD-STFA by LIU Yu, JIN Jian, WANG YongFei, ZHAO JunJie, YU Bo

“…Long-term alternating loads on the connecting bolts of hydro-turbine head cover,which results in fatigue damage causing many serious accidents.Therefore,it is necessary to carry out in-depth study on the calculation method of fatigue life of head cover bolts in order to improve the accuracy of fatigue life calculation.In order to solve the above problems,a method for calculating the fatigue life of Turbine head cover bolts based on combination of power density and short-time Fourier analysis（PD-STFA） is put forward,with emphasis on the influence of coupling action of loading frequency and amplitude load on the fatigue life of head cover bolts.Firstly,the position and stress of dangerous section of connecting bolt are calculated by finite element method;secondly,the average stress of contact surface of bolt head is measured by strain-based hollow pressure sensor,and then the measured average stress of contact surface of bolt head is transformed into the stress of dangerous section according to generalized Hooke’s law;finally,based on linear damage accumulation theory,the fatigue life of the head cover bolts is calculated by PD-STFA method and the traditional rain flow counting method.The calculation results show that the fatigue life of the head cover bolts is 1.966× 10~5 h based on PD-STFA method and 4.113 ×10~5 h based on traditional rain flow counting method.According to the investigation of power plant users,the calculation results based on PD-STFA method are closer to the actual service life of bolts for about 30 years,and can predict the fatigue life of the turbine head cover connecting bolts more accurately,thus providing theoretical guarantee for the safe and stable operation of the hydro-turbine.…”
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Deformation approach to the calculation of compressive strength of steel-reinforced concrete elements by D. N. Lazouski, A. I. Hil, D. O. Hlukhau

“…Two stages of their operation are considered: under the action of forced shrinkage deformations during concrete hardening and subsequent loading. …”
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Investigation of intracellular signals generated by γ-interferon and IL-4 leading to the induction of class II antigen expression by S. Vassiliadis, N. Kyrpides, D. Stravopodis, M. Grigoriou, I. Athanassakis, J. Papamatheakis

“…These findings are firmly supported by other reports and show, in addition, a unique action exerted by γ-IFN, since IL-4, another inducer of class II antigen expression, uses different pathways. …”
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Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice by A. A. Natalsky, S. V. Tarasenko, A. A. Nikiforov, O. V. Zaytsev, O. D. Peskov

“…Carriers of A allele of TNF-α gene G-308A have higher risk of obstructive jaundice on a background of gallstone disease, while Т alleles of NAT2 Leu161Leu and IL4 C-589T genes have protective action for posthepatic cholestasis.…”
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Research on the influence of Siberian fir polyprenols on learning and memory of mice with an experimental model of Alzheimer's disease by Nikolay I. Suslov, Yulia S. Fedorova, Maxim L. Korobov

“…Conclusion: The presented study demonstrates the discovery of a new agent with anti-amnestic action based on the sum of polyprenols from Siberian Fir (Abies sibirica Ledeb.), family Pinaceae. …”
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A primary school-based dengue solution model for post-COVID-19 in southern Thailand: Students understanding of the dengue solution and larval indices surveillance system. by Jiraporn Jaroenpool, Sarunya Maneerattanasak, Femi Adesina, Atchara Phumee, Muhammad Haroon Stanikzai, Chumpon Ponprasert, Yingqin Zheng, Shamarina Shohaimi, Truong Thanh Nam, Temesgen Anjulo Ageru, Amin Nordin Syafinaz, Charuai Suwanbamrung

“…An applied community participatory action research (CPAR) design was used to develop a school-based model intervention. …”
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Estimation of alfalfa weevil, Hypera postica (Coleoptera: Curculionidae) economic damage based on the larval laboratory feeding rate by Mahsa Ghahramani, Seyed Ali Safavi, Shahzad Iranipour

“…If all larvae survive to pupate (whole lifetime consumption), 2.0-4.5 larvae m-2 are tolerable and need no action. However, if a total mortality of 25, 50, or 75% occurs with a constant rate, tolerable densities will increase to (2.5-5.4), (3.2-7.0), and (4.8-10.6) m-2, respectively. …”
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Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…Background Muscarinic receptor agonism and positive allosteric modulation is a promising mechanism of action for treating psychosis, not present in most D2R-blocking antipsychotics. …”
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Assessment of Land Use and Land Cover Changes in Afi River Forest Reserve Cross River State, Nigeria by C. I. Duru, U. D. Chima, C. Fredrick

“…The observed trends highlight the urgent need for immediate action to combat environmental degradation in the Afi River Forest Reserve. …”
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Subnational trends and inequalities of under-immunisation and zero-dose among children aged 12–23 months in Uganda: a national population-based cross-sectional study by Aluísio J D Barros, Peter Waiswa, Rornald Muhumuza Kananura, Jennifer Harris Requejo, Ronald Wasswa, Thiago M Santos

“…Objective Despite the Global Vaccine Action Plan’s goal of at least 90% vaccine coverage for all children, Uganda has made limited progress in vaccination over the past decade. …”
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