Synthesis and Microbiological Activity of Some Newly Synthesized Derivatives of 2-Oxo-2H-chromen-2-one by Majlinda Daci-Ajvazi, Sevdije Govori, Shuhreta Omeragiq

“…By the action of 2-amino-5-methylthio-1,3,4-thiadiazole, 3-amino-5-methylisoxazole, 2-amino-6-fluorobenzothiazole, 2-amino-5-chloropyridine, respectively, on 4-chloro-2-oxo-2H-chromene-3-sulfonyl chloride, the corresponding 9-methylthio-7,7-dioxo-7,7a-dihydro-5-oxo-7λ6,10-dithia-8,11-diaza-cyclopenta[b] phenantren-6-one, 9-methyl-7,7-dioxo-7H-5,8-dioxa-7λ6-thia-7a,11-diaza-cyclopenta[b] phenantren-6-one, 9-fluoro-7,7-dioxo-7H-5-oxa-7λ6,12-dithia-7a,13-diaza-indeno[1,2-b] phenantren-6-one and 9-Chloro-7,7-dioxo-7H-5-oxa-7λ6-thia-7a,12-diaza-benzo[α]anthracen -6-one were formed and they have been isolated in satisfying yields. …”
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Socio-philosophical analysis of education as the basis of the social and investment model of the strengthening of the statehood, social identity and elite of Kyrgyzstan by Amantur Aidaraliev, Mukhtarbek M. Madaliev

“…The developed social and investment model will allow the Kyrgyz Republic to adopt the status of great power and to reach the leading positions in Central Asia in the Decade of Action.…”
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Implementation of the pancasila student profile strengthening project on sustainable lifestyle themes by Tri Agus Tiyani, Zaka Hadikusuma Ramadan

“…The research results show that the implementation of the P5 sustainable lifestyle theme at SDN 04 Bungaraya was carried out in 3 stages: planning stage, implementation stage and evaluation stage. 1) The planning stage includes several activities, namely preparing the learning ecosystem, designing P5, designing modules, and preparing facilities and infrastructure; 2) The implementation stage includes project introduction, conceptual, contextual and project action; 3) The evaluation stage includes diagnostic assessment, formal assessment, summative assessment, and follow-up. …”
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Analyzing Key Features of Open Source Software Survivability with Random Forest by Sohee Park, Gihwon Kwon

“…By identifying these critical factors and quantifying their impacts, this research offers actionable insights for OSS project managers to enhance project survivability and address key maintenance challenges, ensuring sustainable long-term success.…”
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What are healthcare providers’ understandings and experiences of compassion? The healthcare compassion model: a grounded theory study of healthcare providers in Canada by Aynharan Sinnarajah, Shane Sinclair, Thomas F Hack, Shelley Raffin-Bouchal, Susan McClement, Kelli Stajduhar, Pavneet Singh, Neil A Hagen, Harvey Max Chochinov

“…Compassion was conceptualised as—a virtuous and intentional response to know a person, to discern their needs and ameliorate their suffering through relational understanding and action.Conclusions An empirical foundation of healthcare providers’ perspectives on providing compassionate care was generated. …”
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Comparison of Hepatoprotective Activity of Dhatri Lauha (DL) and Dhatri Lauha without Lauha Bhasma (DLWLB) on Carbon Tetrachloride Induced Hepatotoxicity in Wister Rats by Alka Gyanendra Yadav, Piyush Krantikumar Gandhi, Chatragun Eknathrao Lagad, Rajesh Kundlikrao Ingole, Sudhir Raghuttamrao Rajurkar

“…The addition of metals like Lauha (iron) may increase palatability and produce quick action within low doses. Hence, the current study will evaluate the hepatoprotective efficacy of Dhatri Lauha (DL) and DL without Lauha Bhasma (LB) (DLWLB) in experimental animals.Methods:Four groups (N = 8) received a single 0.2 ml intraperitoneal injection of carbon tetrachloride (1:1 in liquid paraffin, 9 mg/kg) to induce hepatotoxicity. …”
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The therapeutic potential of vitamins A, C, and D in pancreatic cancer by Alban Piotrowsky, Markus Burkard, Hendrik Schmieder, Sascha Venturelli, Olga Renner, Luigi Marongiu

“…Further studies are needed to better understand the exact mechanism of action of the individual compounds and to develop the best possible treatment regimen. …”
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Transformasi Layanan Pendidikan di MTs Swasta Batang Barat: Peran Komunikasi, Kompetensi, dan Etos Kerja Guru by Arif Slamet Saputro, Nurkholis Nurkholis, Ghufron Abdullah

“…Research Implications – These findings underscore the importance of enhancing teacher training and development programs focused on communication, competence, and work ethic, as these are fundamental to achieving high-quality educational services. The study offers actionable insights for educational administrators and policymakers in formulating strategies and policies to enhance teacher performance, ultimately fostering an improved educational environment aligned with community standards. …”
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GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…Here we reported the inhibitory effects of GEN-27, a new derivative of genistein, on the inflammation-related colon cancer cell proliferation and delineated the mechanism of its action. The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1β in THP-1 cells. …”
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Projeto Identicidade: espaço, identidade e fotografia by Glauber Bedini de Jesus

“…Even though we can notice a close relation among the themes that were researched throughout the creation process, the product entitled “Projeto Identicidade” allowed for the construction of a space/time fundamentally processual, revealing the obstacles of creating an identity from visual elements, where the hermetic quality of the technologic processes are a constant presence and, in some cases, can shape an artistic action. Parallel to that, the project also highlighted the inability to visually represent the subject’s identity through a reading of the living spaces, since these spaces become part of the landscape once they are treated as photographic images and, as such, are nothing but transtemporal interpretations of life, voided of an organic content. …”
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No Modulatory Effects when Stimulating the Right Inferior Frontal Gyrus with Continuous 6 Hz tACS and tRNS on Response Inhibition: A Behavioral Study by Hannah Brauer, Navah Ester Kadish, Anya Pedersen, Michael Siniatchkin, Vera Moliadze

“…Response inhibition is the cognitive process required to cancel an intended action. During that process, a “go” reaction is intercepted particularly by the right inferior frontal gyrus (rIFG) and presupplementary motor area (pre-SMA). …”
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Two-photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure by Zaneta D. Musimbi, Arkadi Kundik, Jürgen Krücken, Anja E. Hauser, Sebastian Rausch, Peter H. Seeberger, Raluca Niesner, Ruth Leben, Susanne Hartmann

“…Overall, two-photon NAD(P)H-FLIM proved to be a powerful tool for studying specific metabolic pathways in Ascaris larvae and host macrophages, offering valuable insights into the metabolic mechanisms of drug action on both parasite and host.…”
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The Role of Industrial Designers in Achieving the Green Economy Through Recycling by Tamer Yousif, Richie Moalosi

“…The goal of the study was to inspire greater awareness, advocacy, and action toward building a more environmentally conscious and resource-efficient society. …”
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Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response by Seunga Choi, Han-Gyu Choi, Ki-Won Shin, Yong Woo Back, Hye-Soo Park, Jae Hwi Lee, Hwa-Jung Kim

“…Here, we studied the action of Rv3841 in maturation of dendritic cells (DCs) and its engagement in the development of T-cell immunity. …”
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Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study by Evi Lusiana, Ernawati Sinaga, Zen Hafy, Debby Handayati Harahap, Ramzi Amin, Irsan Saleh

“…Anthocyanins derived from I. batatas can suppress the action of Transforming Growth Factor beta Type II Receptor (TGFβRII) to prevent fibrosis progression. …”
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Theoretical aspects of heterosis by L. V. Khotyleva, A. V. Kilchevsky, M. N. Shapturenko

“…Recent advancements in genetics and molecular biology indicate the importance of various types of gene action for heterosis and confirm the necessity of systemlevel approaches to understanding this unique phenomenon.…”
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Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy by Weijian Zhu, Qiang Yi, Zheng Chen, Jiaqi Wang, Kui Zhong, Xinting Ouyang, Kuan Yang, Bowei Jiang, Jianing Zhong, Jinghua Zhong

“…This review summarizes the mechanisms of action, regulatory functions, and immunotherapeutic applications of MAGEA4 in cancer.MAGEA4 promotes tumor initiation and progression through multiple pathways, including ubiquitination and degradation of the tumor suppressor P53, regulation of cell cycle and apoptosis, modulation of DNA damage repair, and enhancement of cancer cell survival. …”
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Incorporating Stud Attachments in the Bar Design for an Implant-Supported Overdenture by Dimokritos Papalexopoulos, Christos Partalis, Panagiotis Lampropoulos, Ioli-Ioanna Artopoulou, Nikitas Sykaras

“…Bars, telescopic attachments, or stud attachments have been used to provide retention through a different mechanism of action based on specific design characteristics. The purpose of this report is to thoroughly describe the applied protocol for the fabrication of an implant overdenture supported by two bars incorporating stud attachments. …”
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The Effects of Destemming/Crushing and Pressing Conditions in Rosé Wine Production by Lorenzo Guerrini, Ferdinando Corti, Giulia Angeloni, Piernicola Masella, Agnese Spadi, Luca Calamai, Alessandro Parenti

“…This could be related to the chemical composition and consistency of the different berry zone, which interact with the mechanical action of the destemmer/crusher and press. Conclusions. …”
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Understanding the behavioral intention of rural women to engage in green poultry farming: A psychological analysis by Pouria Ataei, Hamed Ghadermarzi, Hamid Karimi, Meysam Menatizadeh, Nasim Izadi

“…The results indicated that perceived benefits, perceived susceptibility, cues to action, and conformity significantly influenced rural women's intention to produce green poultry, collectively explaining 51 % of the variance. …”
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