Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

“…They also include adverse side effects, such as blurred vision being linked with tetracaine.DiscussionThis work represents an important advance in our understanding of how drugs cause intended and adverse side effects through their action on disease causing genes and has potential applications for drug development and repositioning.…”
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Methodology for Analyzing the Actual Technical Condition of Downhole Pumping Equipment by V. V. Ivashechkin, V. I. Krytskaya, V. N. Anufriev, O. A. Avrutin

“…The reducing in the pressure characteristic of the submersible pump during operation occurs as a result of the combined action of a number of reasons. Pumping equipment wears out due to waterjet destruction of flow channels. …”
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Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis by Zhichao Wu, Han Wang, Zuan Shi, Yalan Li

“…However, the mechanisms of action of dexmedetomidine during the neuroinflammatory response that underlies POCD remain largely unknown. …”
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Cannabis sativa extracts inhibit LDL oxidation and the formation of foam cells in vitro, acting as potential multi-step inhibitors of atherosclerosis development. by Bruno Musetti, Alejandra Kun, David Menchaca, Alejandra Rodríguez-Haralambides, Javier Varela, Leonor Thomson, Edward M Bahnson

“…The effect of the cannabinoid extracts on the endocytic process was independent of the canonical cannabinoid receptors, CB1 and CB2, but related to the action of non-canonical receptors (TRPV1, TRPV4 and GPR55), involved in calcium signaling. …”
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The Image of Central European Immigrant in Popular Fiction and Its Adaptations: A Case Study of the Detective Murdoch/Murdoch Mysteries Series by Biljana Oklopcic

“…Westerns, fantasies, romances, mysteries, science fiction, adventures, etc. must have a certain kind of setting, a particular cast of (stereotypical) characters, and follow a limited number of lines of action because of their close connection to a particular society, culture, and time period. …”
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STUDY ON STRUCTURAL DYNAMIC RESPONSE AND STABILITY OF OFFSHORE SUPER LARGE WIND TURBINE by ZHANG Li, YAN YangTian, LI Chun, LIU QingSong, WANG Bo, LI ZhiHao

“…The emergency shut-down can effectively reduce the peak of the tower top displacement, the tower equivalent stress and the tower strain energy response and reduce the risk of structural damage and plastic deformation. Under the action of turbulent wind and earthquake, lateral buckling failure will occur in the middle and upper part of the leeward surface of the tower. …”
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Formation of the student civic position at the present stage of society development by Tatiana A. Miroshina

“…The substantive component of the activities of teachers, students in classroom and extracurricular activities, based on the principles of citizenship, democracy, tolerance, involvement in the experience of civic action is considered. The course of organizing the activities of curators on the formation of student civic position, the development of self-government in student groups is presented. …”
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Computer-Integrated Monitoring Technology with Support-Decision of Unauthorized Disturbance of Methane Sensor Functioning for Coal Mines by Oleksandr Vovna, Hanna Kaydash, Leszek Rutkowski, Іvan Sakhno, Іvan Laktionov, Maryna Kabanets, Sergey Zozulya

“…The implementation of the developed method of detecting unauthorized interference in the regulated mode of the methane concentration sensor made it possible to detect such interference from 15 seconds, if the concentration is more than 1.45%, to 20 seconds during the action of the minimum methane concentration of 0.24%. …”
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A New Metaheuristic-Based Hierarchical Clustering Algorithm for Software Modularization by Masoud Aghdasifam, Habib Izadkhah, Ayaz Isazadeh

“…Software refactoring is a software maintenance action to improve the software internal quality without changing its external behavior. …”
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Diabetes Mellitus in Outpatients in Debre Berhan Referral Hospital, Ethiopia by Tesfa Dejenie Habtewold, Wendwesen Dibekulu Tsega, Bayu Yihun Wale

“…Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Most people with diabetes live in low- and middle-income countries and these will experience the greatest increase in cases of diabetes over the next 22 years. …”
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Developing A Territorial Approach to Wolves through Agri-food Practices. A Survey on the Relations Between Biodiversity and Food in Belledonne by Inès Creti, Edith Chezel, Coralie Mounet, Dominique Baud, Pauline Dusseux

“…In this study, we explain the work carried out since 2019 in the context of a research-action-creation project in Belledonne – RECIBIOLDAL – which is based partly on a long-term survey attempting to understand the relations between biodiversity and food in terms of how the landscape has evolved since 1920, and partly on the creation of a narrative surrounding current farming and food practices, with a view to understanding relations between inhabitants, both human and non-human. …”
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Research on Mechanical Properties of Cement Emulsified Asphalt Mortar Under the Influence of Water-to-Cement Ratios and Water-Reducing Agent by Ce Zhao, Huacheng Jiao, Bing Zhou, Fei Liu, Feilin Zhang, Yong Luo, Jie Yuan

“…The hydration reaction of CA mortar is nearly complete at 3 days, with the increase in ages, the cement hydration slows down due to the coating action of asphalt, and the strength no longer changes greatly. …”
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Exploring the informational elements of opinion answers: the case of the Russo-Ukrainian war by Reijo Savolainen

“…It was examined how the answerers articulated four main elements of opinion answers: (i) the stance taken on an issue or event, (ii) emotional reaction to it, (iii) suggestion for future action, and (iv) grounds used to bolster an opinion. …”
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Integration of Metabolomics and Transcriptomics to Reveal the Antitumor Mechanism of <i>Dendrobium officinale</i> Polysaccharide-Based Nanocarriers in Enhancing Photodynamic Immuno... by Shengchang Tao, Huan Wang, Qiufeng Ji, Yushan Yang, Gang Wei, Ruiming Li, Benjie Zhou

“…<b>Methods</b>: The effects of TPA-3BCP-loaded cholesteryl hemisuccinate–<i>Dendrobium officinale</i> polysaccharide nanoparticles (DOP@3BCP NPs) and their potential molecular mechanism of action in a tumor-bearing mouse model of CRC were investigated using non-targeted metabolomics and transcriptomics. …”
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IMPACT OF MANAGEMENT CONTROL SYSTEM ON THE QUALITY OF TEACHING IN NIGERIAN PUBLIC UNIVERSITIES by Abdulfatai Olanrewaju Nurudeen, Abdul Garba

“…Result control has positive effect on the universities performance with P-value 0.000, and β = 0.737 on teaching performance. Action control is significantly related to universities performance with P-value 0,001 and β= 0.593 for teaching performance. …”
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A review of the structured framework for sustainability audits in manufacturing organizations by Dharmendra Hariyani, Poonam Hariyani, Sanjeev Mishra, Milind Kumar Sharma

“…Synthesizing insights from 448 Scopus-indexed studies, this study presents a comprehensive audit system or framework that encompasses pre-audit preparation, on-site evaluation, and post-audit reporting. It offers actionable strategies for enhancing sustainability practices, mitigating risks, and creating long-term stakeholder value. …”
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Case report: Diagnosis of impaired consciousness in a cancer patient using immune checkpoint inhibitors by Daniel Cathalifaud, Daniel Cathalifaud, Cristóbal Basáez, Tatiana Yáñez, Tatiana Yáñez

“…Immune checkpoint inhibitors (ICIs) are drugs that are being increasingly used in the field of oncology; due to their mechanism of action, they can present immune-related adverse effects (IRAEs), with various clinical manifestations, one of which is delirium. …”
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Delving into the therapeutic prospects of desmostachya bipinnata (L.) in the context of polycystic ovary syndrome (PCOS): A comprehensive review by Sarthak Mishra, Payal Mittal

“…Bipinnata which have shown various pharmacological action. We also focus on the phytochemical and pharmacological studies of D. …”
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Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis by Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Zheng Jiang, Jinjun Guo

“…The key genes involved in the action of activin and HGF in CRC were identified. …”
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Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 by Stephanie Ghio, Jean-Pierre Brincat, Yuksel Cetin, Frederick Lia

“…This review highlights studies that have investigated the antiviral activities of spices and Mediterranean herbs, as well as their mechanism of action against SARS-CoV-2. Potential therapeutic target mechanisms addressed in this review comprise both host-directed and virus-directed therapies. …”
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