FS-DDPG: Optimal Control of a Fan Coil Unit System Based on Safe Reinforcement Learning by Chenyang Li, Qiming Fu, Jianping Chen, You Lu, Yunzhe Wang, Hongjie Wu

“…The key innovation lies in applying a constrained Markov decision process to model the FCU control problem, where a penalty term for process constraints is incorporated into the reward function, and constraint tightening is introduced to limit the action space. In addition, to validate the performance of the proposed method, we established a variable operating conditions FCU simulation platform based on the parameters of the actual FCU system and ten years of historical weather data. …”
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Evaluating the antagonist effect of naltrexone implant via opioid challenge tests with escalating doses of hydromorphone injection in former heroin dependent patients by Wei Qu, Xuyi Wang, Chongyang Dong, Tao Zhang, Shugui Yin, Zhijun Sun, Shiqiang Wang, Anni Guo, Wei Hao

“…A long-acting formulation in the form of naltrexone implant (NTX-IMP) with a five-month duration of action may address this issue and improve outcomes. …”
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Metal Complexes and Their Role in Treatment of the Arthritis by Ejaz Ali, Kanwal Ashiq, Manhaz Ghulam Nabi, Maria Gul, Mubashra Gul

“…To find new treatments for diseases, it is suggested that the mechanism of action and potential toxicity of metal complexes must be assessed.…”
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Use of metabolites, metabolithotropic agents and nutritional supplements in sports and sports medicine: a modern view on the problem by I. F. Bielenichev, N. A. Gorchakova, E. Yu. Doroshenko, I. B. Samura, V. P. Ryzhenko, N. V. Bukhtiiarova

“…Based on the analysis of modern literature data and the results of our own studies, a generalized medical and pharmacological characteristic of metabolite agents, metabolitotropic drugs and nutritional supplements that can influence the main and compensatory mechanisms of macroergic phosphates production under the influence of physical activity is presented. The mechanisms of action, indications for use and main side effects of drugs and food additives based on ATP, malate, succinate, citrate, pyruvate, carnitine, carnosine, etc. are presented. …”
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Probiotic Supplementation for Periodontal Diseases - An Umbrella Review by Hunny Sharma, Manisha Ruikar, Swati Verma

“…However, there is mixed evidence on the effectiveness of probiotics in reducing gingival inflammation (GI) and dental plaque, and further research is needed to understand the mechanisms of action and potential health benefits of probiotics. …”
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Social support perception in parents of children with type 1 diabetes mellitus by Natalia Macarena Maureira MIranda, Claudia Maribel Muñoz Pavez, Maria Cecilia Toffoletto Toffoletto, Ángel Roco Videla

“…Support must go beyond the family, with important action by health professionals and the entire context in which children are inserted, to contribute to adequate management of the disease.…”
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FATIGUE STRENGTH ANALYSIS AND OPTIMIZATION OF FSC RACING EXHAUST SYSTEM by QI Qi, LIU HaoTian, WU XiaoJian, LUO Cheng

“…The exhaust pipe of engine is subjected to alternating load of low and high temperatures during operation,which is prone to fatigue damage.For the FSC（Formula Student China） racing engine with the highest speed of 11 000 r/min～13 OOOr/min,the exhaust pipe fatigue problem is more serious.In this paper,the FSC racing exhaust system is taken as the research object to analyze its fatigue strength and optimize the exhaust pipe thickness.Firstly,the Fluent software is used to analyze the conjugate heat transfer of the exhaust system to determine the temperature distribution of the exhaust system.Then the temperature distribution is mapped to the finite element mesh of the exhaust system,and the thermal stress and thermal strain are analyzed by finite element technology.Subsequently,two schemes including exhaust manifold " normal operation-parking cooling" cycle and extreme working condition cycle are designed to carry out the thermal cycle simulation.It is found that the exhaust gas accumulates plastic deformation under the alternating load of each cycle,and the exhaust system will eventually crack and be destroyed.Finally,the fatigue life of the two schemes is studied by using Ansys nCode DesignLife fatigue analysis software.The results show that both schemes effectively reflect the life expectancy of low-cycle fatigue damages under the combined action of exhaust manifold temperature field,thermal stress and strain.Based on the above analysis,the exhaust thickness is optimized by the extreme working condition circulation scheme.and it is verified by experiments that the 1.2 mm thickness steel pipe meets the FSC exhaust requirements.…”
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Chemoproteomic analysis of the promising candidate molecule of the indole derivative with lab code SV-1010 and other non-steroidal anti-inflammatory drugs by Pavel A. Galenko-Yaroshevsky, Ivan Yu. Torshin, Andrey N. Gromov, Ivan A. Reyer, Olga A. Gromova, Tereza R. Glechyan, Konstantin F. Suzdalev, Andrey V. Zadorozhniy, Anait V. Zelenskaya

“…Introduction: For effective and safe pharmacotherapy of pain, it is important to evaluate the mechanisms and spectrum of action of non-steroidal anti-inflammatory drugs (NSAIDs), including their effect on the proteom, central effect, as well as pain relieving and anti-inflammatory effects. …”
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Systematic review and meta-analysis of propranolol in the prevention and treatment of post-traumatic stress disorder by Haipeng Li, Zhengrong Zhang, Shaojie Yang, Guoqi Zhu

“…Future researches are needed to further clarify the therapeutic potential, mechanisms of action, and long-term safety of propranolol in PTSD treatment.…”
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Blood glucose management for a patient with esophageal foreign body-induced esophageal perforation combined with mediastinal infection (1例食管异物穿孔伴纵隔感染患者的血糖管理)... by LI Pengping (李鹏萍), SUN Yulian (孙玉莲)

“…Comprehensive nursing interventions including airway management, catheter management, enteral nutrition support, skin care, observation on postoperative complications were carried out. The Plan-Do-Check-Action cycle was adopted in the blood glucose management. …”
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Understanding the current backlash against LGBTIQ+ rights through the lens of heteroactivism: A case study of the International Organization for the Family’s transnational norm dif... by Strand Cecilia, Eriksson Åsa, Svensson Jakob

“…The analysis is focused on the organisation’s Twitter (now X) account and we draw on theories of network media logic, connective action, and connective emotions. Two periods of activism – the first a low-intensity period in 2021 and the second a high-intensity period in 2022 – were purposefully selected for the analysis. …”
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Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…Background: Voltage-gated sodium channels (Nav) are critical for generating action potentials in neuronal and muscle tissues. …”
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Le courant des « pédagogies actives » dans l’enseignement supérieur : une évolution postmoderne ? by Denis Lemaître

“…L’analyse de discours menée sur ces articles met en lumière les orientations idéologiques de l’ingénierie pédagogique dans les institutions d’enseignement supérieur, à travers les schèmes de l’action, de l’adaptation, de la mise en situation et de l’autonomisation des étudiants.…”
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Principles in practice? A policy review of the IOC's environmental sustainability agenda by Alison Cain, Michael Callan

“…The IOC's ES agenda is interpreted as both strategy around ES, as a plan of action to achieve desired outcomes, and policies around ES, as matters of practice and principle to be enacted. …”
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Logiciel SIG et pratique de terrain : quel positionnement de l’outil cartographique pour les acteurs du paysage ? by Sophie-Anne Olivier

“…The first type is in the form of the proceedings of an online conference of users in 2020 (organised in four sessions on lessons learned followed by a panel discussion moderated by Thierry Joliveau) on the following theme: "Global Mapper, a field tool? Preparation, action and lessons learned". The event provided an opportunity to compare the views of professionals working on a wide range of subjects in which landscape studies play a central role: avalanche risk management, golf course mapping, notarial work and flight missions. …”
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The historical roots of post-apartheid intra-working-class racism by Tlhabane Mokhine ‘Dan’ Motaung

“…In view of this history of racialised capitalism, racism in post-apartheid South Africa is largely located within the Black and white working-class socio-economic space, as the latter forfeited its racially vested interests while the former derive the benefits of corrective state action. …”
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Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report by C. T. M. I. Issa, R. D. Castro, K. L. G. D. Albuquerque

“…Further studies are needed to elucidate these results and the mechanisms of action of cannabinoids through which they exert possible neuroprotective and neuroreparative effects. …”
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Islamic Entrepreneurship: A Study of the Waqf Well Story Saidina Uthman r.a. by Khaulah Hilaluddin, Mohd Nazri Muhayiddin, Mohd Zulkifli Muhammad, Anis Amira Ab Rahman

“…The study's findings shed light on the Companions of the Prophet's practice of Islamic entrepreneurship, highlighting their character, behavior, thought, action, and strategy to seize opportunities, prioritize the well-being of Muslims, and achieve success in the afterlife. …”
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Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity: Effects of Cadmium, Mercury, and Copper by Elena A. Belyaeva, Tatyana V. Sokolova, Larisa V. Emelyanova, Irina O. Zakharova

“…To clarify the role of mitochondrial electron transport chain (mtETC) in heavy-metal-induced neurotoxicity, we studied action of Cd2+, Hg2+, and Cu2+ on cell viability, intracellular reactive oxygen species formation, respiratory function, and mitochondrial membrane potential of rat cell line PC12. …”
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Examining Emphysematous Pyelonephritis: A Case Study on Diagnosis and Outcomes by Mahnoor Mahnoor, Syeda Aina Ali, Saira Nasir, Moiz Azmat, Hafiz Muhammad Umer Farooqi

“…However, severe cases require immediate therapeutic action. In our case, the patient was treated with antibiotic therapy and recovered. …”
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