Suggested Topics within your search.
Suggested Topics within your search.
- Evaluation research (Social action programs) 7
- History 4
- Evaluation 3
- Research 3
- Actions and defenses 2
- Management 2
- Methodology 2
- Philosophy 2
- Social service 2
- Study and teaching 2
- Advertising 1
- Archaeological expeditions 1
- Archeology 1
- Attitudes 1
- Balanced Scorecard 1
- Biodiversity conservation 1
- Breach of contract 1
- Children 1
- Civil law 1
- Civil procedure 1
- Climate Change 1
- Collection and preservation 1
- Conservation biology 1
- Consumers 1
- Contraception 1
- Conversation analysis 1
- Criminal investigation 1
- Criminal law 1
- Cultural policy 1
- Cultural property 1
-
10241
Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway
Published 2025-01-01“…In summary, our study identified that SDG can ameliorate CTX-induced POI with its mechanism of action intricately linked to the modulation of the PI3K/Akt signaling pathway.…”
Get full text
Article -
10242
Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle...
Published 2024-12-01“…These and other cytokines also play a major role in <i>Leishmania</i>-induced hyperalgesia via two possible pathways, one involving prostaglandins and the other sympathetic amines as final mediators, preceded by a cascade of cytokines, among which TNF-α seems to play a pivotal role via a still unclear mechanism of action. This study investigates the effects of anti-TNF-α antibody (Infliximab) on <i>L. major</i>-induced hyperalgesia in susceptible BALB/c mice using the hot plate and tail flicks tests, as well as the levels of many cytokines in the infected paws of mice using the ELISA technique. …”
Get full text
Article -
10243
Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes: Synergistic Roles of L-FABP and Glucose
Published 2013-01-01“…While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor) prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not simply accounted for by inhibition of the enzymes alone. …”
Get full text
Article -
10244
Zeatin Elicits Premature Erythrocyte Senescence Through Calcium and Oxidative Stress Mediated by the NOS/PKC/CK1α Signaling Axis
Published 2025-01-01“…Herein, we investigated the biochemical and molecular mechanisms underlying ZTN action in human RBCs. Methods: Colorimetric assays were used to quantify hemolysis and related markers and flow cytometric analysis was applied to examine eryptosis through phosphatidylserine (PS) exposure by annexin-V-FITC, intracellular Ca 2+ by Fluo4/AM, reactive oxygen species (ROS) by H 2 DCFDA, and cell size from forward scatter (FSC). …”
Get full text
Article -
10245
The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat
Published 2013-01-01“…Tesaglitazar improved whole body insulin action by greater suppression of HGO and stimulation of compared to obese controls. …”
Get full text
Article -
10246
Inhibitory Effect of Human Anti-CA I Autoantibodies and Development of Monoclonal Antibody mAb 2B8 Targeting Carbonic Anhydrase I
Published 2024-01-01“…Concurrently, our newly synthesized mouse monoclonal IgG antibody, mAb 2B8, against human CA I showcased a potent inhibitory action. An in-depth exploration into mAb 2B8′s binding dynamics with its target enzyme was undertaken. …”
Get full text
Article -
10247
Application of single-cell sequencing technology to the study of embryonic developmental toxicity of emerging contaminants: Progress and perspectives
Published 2024-12-01“…In toxicological studies, scRNA-seq technology has been applied to identify the responses of different cell types to pollutants and to elucidate the mechanisms of pollutant action during embryonic development, providing novel perspectives on the toxicity mechanisms of emerging pollutants. …”
Get full text
Article -
10248
The Antimicrobial Effect of Thymol and Carvacrol in Combination with Organic Acids Against Foodborne Pathogens in Chicken and Beef Meat Fillets
Published 2025-01-01“…The outcome demonstrated that both meats kept under similar storage conditions (4 °C/9 days) exhibited lower microbial growth, particularly with <i>Enterobacteriaceae,</i> when treated with wine-based carvacrol—thymol marinades and may extend their shelf-life. This antimicrobial action was more pronounced in the beef samples. The total phenolic content (TPC) and the antioxidant activity of the applied marinades were determined using the Folin−Ciocalteau method and ABTS and DPPH radical scavenging activity methods, respectively. …”
Get full text
Article -
10249
Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro
Published 2014-01-01“…Our findings tend to provide justification for the hypoglycaemic action of these medicinal plants which has opened novel avenues for the development of new phytopharmaceuticals geared towards diabetes management.…”
Get full text
Article -
10250
Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling
Published 2018-01-01“…While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impaired neuroplasticity occurring in TRD has been proposed. …”
Get full text
Article -
10251
Instruments reliability to measure the skill development to prevent leprosy in postgraduate studies
Published 2024-11-01“…<p><strong>Foundation:</strong> the specific skills of the profession are oriented to the professional mode of action through the application of the clinical and epidemiological method that allows diagnosing, treating, rehabilitating, promoting health and preventing diseases. …”
Get full text
Article -
10252
Design and Evaluation of an Electromagnetic Bounce-Type Refreshable Braille Display
Published 2025-01-01“…By passing current in different directions to the coil, the electromagnet can bounce up and down between the two permanent magnets under the action of magnetic force, thereby achieving changes in the raised state of the Braille dot. …”
Get full text
Article -
10253
Implementasi Problem Based Learning Pada Tema Selamatkan Makhluk Hidup Untuk Meningkatkan Prestasi Belajar dan Keaktifan Siswa Kelas VI SDN Ngepeh
Published 2023-08-01“…This research is a classroom action research conducted at SDN Ngepeh in two cycles. …”
Get full text
Article -
10254
Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver
Published 2016-01-01“…Its positive effect was rising during the 28-day experiment, indicating a delayed onset of N-f-5HT action. Administration of either N-f-5HT or MTX caused reduction of inflammation measured as the level of CRP in plasma and the activity of LOX in the liver. mRNA transcription of TNF-α and iNOS in the liver was significantly attenuated in both MTX and N-f-5HT treated groups of arthritic rats. …”
Get full text
Article -
10255
Preserving the Past, Embracing the Future: Co-Design Strategies for Achieving Harmony Between Heritage Sites and Accessibility Needs
Published 2025-01-01“…For example, cobbled streets with uneven surfaces or significant level differences create obstacles for wheelchair users and others with mobility challenges. This qualitative action research aimed to develop guidelines for shared street designs and innovative solutions that balance heritage preservation with inclusive accessibility. …”
Get full text
Article -
10256
Causes and Intervention Strategies to Reduce Childhood Obesity in Ambato
Published 2024-01-01“…<br /><strong>Objective:</strong> evaluate the implementation of an action program aimed at reducing the rate of childhood obesity in the population under study.…”
Get full text
Article -
10257
Hubungan Pengetahuan Plebitis dengan Keterampilan Tenaga Kesehatan dalam Menerapkan Problem Solving for Better Health pada Plebitis di Rumah Sakit X
Published 2020-01-01“…Penerapan PSBH belum optimal, karena masih ada tenaga kesehatan yang tidak mampu menghasilkan Plan of Action (PoA) untuk mengatasi masalah phlebitis. Ada juga yang sudah menghasilkan PoA, namun belum maksimal dalam implementasinya. …”
Get full text
Article -
10258
Ethnoecology of pollination and pollinators
Published 2015-06-01“…By focusing their analyses instead on an important biological phenomenon threatened by human action (in this case, pollination), they hope that their audience will also include biologists, policy makers and environmental managers. …”
Get full text
Article -
10259
Risk Analysis of Sequential Dam Break of Cascade Reservoirs and Simulation of Flood Routing
Published 2021-01-01“…To study the risk of sequential dam break of cascade reservoirs,and to simulate and analyze the flood routing process,by constructing a Bayesian network model for the sequential dam break of double reservoirs under the action of extra standard floods and piping,and combining the dam break and flood routing simulation of Breach dam-break numerical model and two-dimensional HEC-RAS hydrodynamic model,this paper calculates the probability of dam break,evaluates the risk of sequential dam break,and simulates the flood routing process,taking Hanconggou Reservoir and Dingguoshan Reservoir as examples.The calculation results show that:Through Bayesian-based backward inference of the known dam break of Dingguoshan Reservoir,the probability of “Hancongou Reservoir dam break” increased from 3% to 87%;while through Bayesian-based backward inference of the known dam break of Hancongou Reservoir,the probability of “Hancongou Reservoir piping” increased from 16% to 87%.Under extra standard flood and piping conditions,due to the sequential dam break of the two reservoirs,the time for the flood to reach the section CS1—CS6 is 0.8~3.0 h;under the flood conditions that occurred once in 1 000 years,the Hancongou Reservoir was opened for flood discharge but the dam was not broken.Only the Dingguoshan Reservoir was over-topped with dam break,and the flood reached the section CS1—CS6 in 21.5~26.5 h.This study can provide scientific reference for reducing dam break risk,and making emergency plan and disaster prevention & mitigation plan.…”
Get full text
Article -
10260
Yoga practices effect on VCSS-based classification of patients with chronic venous insufficiency based on hybrid machine learning algorithms
Published 2025-12-01“…Comparative analysis revealed that DTHB (Decision Tree optimized with Honey Badger Algorithm) with maximum Accuracy and Precision of higher than 90 % was the optimal model, especially for classifying patients with Moderate and Severe levels of CVI needing emergency medical action.…”
Get full text
Article