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  1. 10241

    Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway by Yiqing Zhang, Xialu Liu, Zitong Zheng, Haiqiang Huang, Yurou Wang, Shuqin Wu, Yuan Shu, Yuxin Yang, Yufei Zhong, Pengfei Liao, Yongsong Wang, Zezheng Pan

    Published 2025-01-01
    “…In summary, our study identified that SDG can ameliorate CTX-induced POI with its mechanism of action intricately linked to the modulation of the PI3K/Akt signaling pathway.…”
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  2. 10242

    Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle... by Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

    Published 2024-12-01
    “…These and other cytokines also play a major role in <i>Leishmania</i>-induced hyperalgesia via two possible pathways, one involving prostaglandins and the other sympathetic amines as final mediators, preceded by a cascade of cytokines, among which TNF-α seems to play a pivotal role via a still unclear mechanism of action. This study investigates the effects of anti-TNF-α antibody (Infliximab) on <i>L. major</i>-induced hyperalgesia in susceptible BALB/c mice using the hot plate and tail flicks tests, as well as the levels of many cytokines in the infected paws of mice using the ELISA technique. …”
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  3. 10243

    Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes: Synergistic Roles of L-FABP and Glucose by Huan Huang, Avery L. McIntosh, Gregory G. Martin, Anca D. Petrescu, Kerstin K. Landrock, Danilo Landrock, Ann B. Kier, Friedhelm Schroeder

    Published 2013-01-01
    “…While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor) prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not simply accounted for by inhibition of the enzymes alone. …”
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  4. 10244

    Zeatin Elicits Premature Erythrocyte Senescence Through Calcium and Oxidative Stress Mediated by the NOS/PKC/CK1α Signaling Axis by Iman A. Alajeyan, Jawaher Alsughayyir, Mohammad A. Alfhili

    Published 2025-01-01
    “…Herein, we investigated the biochemical and molecular mechanisms underlying ZTN action in human RBCs. Methods: Colorimetric assays were used to quantify hemolysis and related markers and flow cytometric analysis was applied to examine eryptosis through phosphatidylserine (PS) exposure by annexin-V-FITC, intracellular Ca 2+ by Fluo4/AM, reactive oxygen species (ROS) by H 2 DCFDA, and cell size from forward scatter (FSC). …”
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  5. 10245

    The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat by Kristina Wallenius, Ann Kjellstedt, Pia Thalén, Lars Löfgren, Nicholas D. Oakes

    Published 2013-01-01
    “…Tesaglitazar improved whole body insulin action by greater suppression of HGO and stimulation of compared to obese controls. …”
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  6. 10246

    Inhibitory Effect of Human Anti-CA I Autoantibodies and Development of Monoclonal Antibody mAb 2B8 Targeting Carbonic Anhydrase I by Petra Chalova, Barbora Jankovicova, Veronika Dvorakova, Eliska Zelinkova, Zuzana Bilkova, Marcela Slovakova, Lucie Korecka, Petr Muller, Maksym Danchenko, Lenka Minichova, Jan Lakota, Ludovit Skultety

    Published 2024-01-01
    “…Concurrently, our newly synthesized mouse monoclonal IgG antibody, mAb 2B8, against human CA I showcased a potent inhibitory action. An in-depth exploration into mAb 2B8′s binding dynamics with its target enzyme was undertaken. …”
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  7. 10247

    Application of single-cell sequencing technology to the study of embryonic developmental toxicity of emerging contaminants: Progress and perspectives by Weizhao CAO, Yunhui ZHANG

    Published 2024-12-01
    “…In toxicological studies, scRNA-seq technology has been applied to identify the responses of different cell types to pollutants and to elucidate the mechanisms of pollutant action during embryonic development, providing novel perspectives on the toxicity mechanisms of emerging pollutants. …”
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  8. 10248

    The Antimicrobial Effect of Thymol and Carvacrol in Combination with Organic Acids Against Foodborne Pathogens in Chicken and Beef Meat Fillets by Ioanna Mantzourani, Maria Daoutidou, Athanasios Alexopoulos

    Published 2025-01-01
    “…The outcome demonstrated that both meats kept under similar storage conditions (4 °C/9 days) exhibited lower microbial growth, particularly with <i>Enterobacteriaceae,</i> when treated with wine-based carvacrol—thymol marinades and may extend their shelf-life. This antimicrobial action was more pronounced in the beef samples. The total phenolic content (TPC) and the antioxidant activity of the applied marinades were determined using the Folin−Ciocalteau method and ABTS and DPPH radical scavenging activity methods, respectively. …”
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  9. 10249

    Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α-Glucosidase, Glucose Entrapment, and Amylolysis Kinetics In Vitro by Carene M. N. Picot, A. Hussein Subratty, M. Fawzi Mahomoodally

    Published 2014-01-01
    “…Our findings tend to provide justification for the hypoglycaemic action of these medicinal plants which has opened novel avenues for the development of new phytopharmaceuticals geared towards diabetes management.…”
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  10. 10250

    Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling by Ginetta Collo, Laura Cavalleri, Federica Bono, Cristina Mora, Stefania Fedele, Roberto William Invernizzi, Massimo Gennarelli, Giovanna Piovani, Tilo Kunath, Mark J. Millan, Emilio Merlo Pich, PierFranco Spano

    Published 2018-01-01
    “…While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impaired neuroplasticity occurring in TRD has been proposed. …”
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  11. 10251

    Instruments reliability to measure the skill development to prevent leprosy in postgraduate studies by Tania Alemán Martínez, Onesio Esteban de León Gutiérrez, Daniela María Hernández Alemán

    Published 2024-11-01
    “…<p><strong>Foundation:</strong> the specific skills of the profession are oriented to the professional mode of action through the application of the clinical and epidemiological method that allows diagnosing, treating, rehabilitating, promoting health and preventing diseases. …”
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  12. 10252

    Design and Evaluation of an Electromagnetic Bounce-Type Refreshable Braille Display by Dapeng Chen, Song Zhang, Lianshun Shen, Chenkai Li, Jianying Hua, Jia Liu, Aiguo Song

    Published 2025-01-01
    “…By passing current in different directions to the coil, the electromagnet can bounce up and down between the two permanent magnets under the action of magnetic force, thereby achieving changes in the raised state of the Braille dot. …”
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  13. 10253

    Implementasi Problem Based Learning Pada Tema Selamatkan Makhluk Hidup Untuk Meningkatkan Prestasi Belajar dan Keaktifan Siswa Kelas VI SDN Ngepeh by Mariyono Mariyono

    Published 2023-08-01
    “…This research is a classroom action research conducted at SDN Ngepeh in two cycles. …”
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  14. 10254

    Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver by Ľudmila Pašková, Viera Kuncírová, Silvester Poništ, Danica Mihálová, Radomír Nosáľ, Juraj Harmatha, Iveta Hrádková, Tomáš Čavojský, František Bilka, Katarína Šišková, Ingrid Paulíková, Lýdia Bezáková, Katarína Bauerová

    Published 2016-01-01
    “…Its positive effect was rising during the 28-day experiment, indicating a delayed onset of N-f-5HT action. Administration of either N-f-5HT or MTX caused reduction of inflammation measured as the level of CRP in plasma and the activity of LOX in the liver. mRNA transcription of TNF-α and iNOS in the liver was significantly attenuated in both MTX and N-f-5HT treated groups of arthritic rats. …”
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  15. 10255

    Preserving the Past, Embracing the Future: Co-Design Strategies for Achieving Harmony Between Heritage Sites and Accessibility Needs by Maryem Lakoud, Ernesto Morales, Alicia Ruiz-Rodrigo, Isabelle Feillou, Samuel Mathieu, Jonathan Riendeau, François Routhier

    Published 2025-01-01
    “…For example, cobbled streets with uneven surfaces or significant level differences create obstacles for wheelchair users and others with mobility challenges. This qualitative action research aimed to develop guidelines for shared street designs and innovative solutions that balance heritage preservation with inclusive accessibility. …”
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  16. 10256

    Causes and Intervention Strategies to Reduce Childhood Obesity in Ambato by Carlos David Castañeda Guillot, Diego Fernando Vaca Sánchez, María Augusta Reyes Pérez

    Published 2024-01-01
    “…<br /><strong>Objective:</strong> evaluate the implementation of an action program aimed at reducing the rate of childhood obesity in the population under study.…”
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  17. 10257

    Hubungan Pengetahuan Plebitis dengan Keterampilan Tenaga Kesehatan dalam Menerapkan Problem Solving for Better Health pada Plebitis di Rumah Sakit X by Yuhelma Yuhelma, Yulastri Arif, Leni Merdawati

    Published 2020-01-01
    “…Penerapan PSBH belum optimal, karena masih ada tenaga kesehatan yang tidak mampu menghasilkan Plan of Action (PoA) untuk mengatasi masalah phlebitis. Ada juga yang sudah menghasilkan PoA, namun belum maksimal dalam implementasinya. …”
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  18. 10258

    Ethnoecology of pollination and pollinators by Marie Roué, Vincent Battesti, Nicolas Césard, Romain Simenel

    Published 2015-06-01
    “…By focusing their analyses instead on an important biological phenomenon threatened by human action (in this case, pollination), they hope that their audience will also include biologists, policy makers and environmental managers. …”
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  19. 10259

    Risk Analysis of Sequential Dam Break of Cascade Reservoirs and Simulation of Flood Routing by YU Zibo, XIANG Yan, MENG Ying, SU Zhengyang

    Published 2021-01-01
    “…To study the risk of sequential dam break of cascade reservoirs,and to simulate and analyze the flood routing process,by constructing a Bayesian network model for the sequential dam break of double reservoirs under the action of extra standard floods and piping,and combining the dam break and flood routing simulation of Breach dam-break numerical model and two-dimensional HEC-RAS hydrodynamic model,this paper calculates the probability of dam break,evaluates the risk of sequential dam break,and simulates the flood routing process,taking Hanconggou Reservoir and Dingguoshan Reservoir as examples.The calculation results show that:Through Bayesian-based backward inference of the known dam break of Dingguoshan Reservoir,the probability of “Hancongou Reservoir dam break” increased from 3% to 87%;while through Bayesian-based backward inference of the known dam break of Hancongou Reservoir,the probability of “Hancongou Reservoir piping” increased from 16% to 87%.Under extra standard flood and piping conditions,due to the sequential dam break of the two reservoirs,the time for the flood to reach the section CS1—CS6 is 0.8~3.0 h;under the flood conditions that occurred once in 1 000 years,the Hancongou Reservoir was opened for flood discharge but the dam was not broken.Only the Dingguoshan Reservoir was over-topped with dam break,and the flood reached the section CS1—CS6 in 21.5~26.5 h.This study can provide scientific reference for reducing dam break risk,and making emergency plan and disaster prevention &amp; mitigation plan.…”
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  20. 10260

    Yoga practices effect on VCSS-based classification of patients with chronic venous insufficiency based on hybrid machine learning algorithms by Changhong Pan, Lu Qi, Lili Zhao, Yijun Wei

    Published 2025-12-01
    “…Comparative analysis revealed that DTHB (Decision Tree optimized with Honey Badger Algorithm) with maximum Accuracy and Precision of higher than 90 % was the optimal model, especially for classifying patients with Moderate and Severe levels of CVI needing emergency medical action.…”
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