Monoclonal anti-CD38 therapy in human myeloma: retrospects and prospects by Alberto L. Horenstein, Angelo C. Faini, Angelo C. Faini, Fabio Morandi, Erika Ortolan, Paola Storti, Nicola Giuliani, Nicola Giuliani, Paul G. Richardson, Fabio Malavasi, Fabio Malavasi

“…This review, a collaborative effort between basic scientists and clinical experts, explores some of the lesser-known mechanisms of antibody action and interactions with CD38 at key stages of treatment. …”
Get full text

A vida como projeto: a pedagogia do homo economicus e as iniciativas de fomento ao “espírito do capitalismo” via educação pública by Miqueli Michetti

“…From the symbolic authority implied in their “managerial capital”, they assume a “pedagogical role” aiming the reform of the dispositions to action of public-school students. The analysis of the pedagogy of the homo economicus, based on the notion of “project of life”, brought elements to clarify the agency of “corporate philanthropy” in the expanding model of “integral education”. …”
Get full text

LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain by J Van Der Walt, R Parker

“…This narrative review presents healthcare workers with a framework to understand the method of action of these drugs in chronic nociplastic pain pathways and a brief history into their use. …”
Get full text

Anti-cancer effect of midazolam via downregulating YWHAH in papillary thyroid cancer cells by Yang Li, Ai-Ping Tan, Yu-Shan Zhong

“…Abstract The work is aimed to investigate whether midazolam functions in thyroid cancer and reveal the potential mechanism of action. Cell viability was detected by CCK-8 method when treated by varying doses of midazolam to detect the cytotoxicity of midazolam on human thyroid follicular epithelial cell line and thyroid cancer cell lines. …”
Get full text

Harnessing parental involvement and educational equity for sustainable development in South African schools by Newlin Marongwe, Godfrey Mutesasira

“…Through exploring effective parental in¬volvement strategies, this paper provides actionable insights for enhancing academic outcomes and advancing SDG 4 (Quality Education) and SDG 10 (Reduced Inequalities) within the South African context. …”
Get full text

Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) by So-Yoon Park, Van-Long Truong, Su-Gyeong Jeon, So-Young Choe, Razanamanana H. G. Rarison, Byoung-Hoon Yoon, Ji-Won Park, Hye-Jeong Jeong, Woo-Sik Jeong

“…Among the extracts, the 95% ethanol extract exhibited the most potent inhibition of reactive oxygen species (ROS) and nitric oxide (NO) production, warranting further exploration of its mechanisms of action. Further analysis revealed that the ethanol extract modulated key inflammatory signaling pathways, including MAPK and NF-κB, contributing to its anti-inflammatory activity. …”
Get full text

Cell-Type-Specific Differentiation and Molecular Profiles in Skin Transplantation: Implication of Medical Approach for Genetic Skin Diseases by Noritaka Oyama, Fumio Kaneko

“…From a dermatological viewpoint, we review the recent update of cell-type- and molecular-specific action associated with reconstitution of the grafted skin and also focus on the novel application of BM transplantation medicine in genetic skin diseases.…”
Get full text

Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes by Maima Matin, Natalia Ksepka, Kamil Wysocki, Michel-Edwar Mickael, Alpana Pande, Jarosław Olav Horbańczuk, Artur Jóźwik, Olga Adamska, Artur Stolarczyk, Laszlo Barna Iantovics, Yordanka Ilieva, Pencho Penchev, Atanas G. Atanasov

“…These upregulated activities are in general indicative of increased carbohydrates turnover and detoxification processes, and might provide clues for a better understanding of the mechanisms of action of curcumin in vivo, as well as for novel approaches to rationally impact animal or human health and wellbeing through targeted supplementation.…”
Get full text

Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901 by Zhiying Ai, Jingjing Shao, Xinglong Shi, Mengying Yu, Yongyan Wu, Juan Du, Yong Zhang, Zekun Guo

“…Thus, to seek for the crucial miRNA and key regulatory genes that establish ESC properties in MEK/ERK pathway, we performed microarray analysis and small RNA deep-sequencing of J1 mESCs treated with or without PD0325901 (PD), a well-known inhibitor of MEK/ERK signal pathway, followed by verification of western blot analysis and quantitative real-time PCR verification; we found that PD regulated the transcript expressions related to self-renewal and differentiation and antagonized the action of retinoic acid- (RA-) induced differentiation. …”
Get full text

Anticancer potential of coumarins from the Ferulago genus by Mansour Mofasseri, Elham Eini, Saber Mofasseri, Bahram Hanifehpour, Fatemeh Zanbili, Ahmad Poursattar Marjani

“…This study was aimed to highlight the most promising coumarins from Ferulago genus, their mechanisms of action, and potential therapeutic applications in cancer treatment. …”
Get full text

INTENSITY OF NITRIC OXIDE SYNTHESIS IN THE BLOOD OF RATS UNDER THE INFLUENCE OF SODIUM FLUORIDE by I.L. Kolisnyk

“…The decrease in nitrite and nitrate anions at the end of long-term action of FN indirectly indicates a decrease in nitric oxide generation, which may be associated, in particular, with an increase in peroxynitrite concentration due to the use of nitric oxide in reaction with superoxide anion radical and antioxidant deficiency.…”
Get full text

Review of Interventional Therapies for Refractory Pediatric Migraine by Jacquelin Peck, Justin Zeien, Megha Patel, Elyse M. Cornett, Amnon A. Berger, Jamal Hasoon, Hisham Kassem, Jai Won Jung, Giovanni F. Ramírez, Paola Colon Fugueroa, Neil R. Singhal, Jaehong Song, Adam M. Kaye, Alan D. Kaye, Sarang S. Koushik, Natalie H. Strand, Latha Ganti

“…Blocking the sphenopalatine ganglion can be achieved through nasal approach, and achieves a similar action by blocking the entire ganglion. Interventional techniques may provide a key component in the alleviation of this otherwise debilitating chronic migraine pain. …”
Get full text

Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation by Marcelo Larami Santoro, Ana Teresa Azevedo Sachetto, Jaqueline Gomes Rosa, Ricardo José Soares Torquato, Débora Andrade-Silva, Dilza Trevisan-Silva, Cynthia Zaccanini de Albuquerque, Solange M. T. Serrano, Vânia Gomes de Moura Mattaraia, Aparecida Sadae Tanaka, Maria Elisa Peichoto

“…Injection of these fractions caused thrombocytopenia in control or Vwf −/− mice, showing that the axis platelet GPIb – von Willebrand factor is not involved in their biological action in vivo. New studies are necessary to understand how these proteins act in vivo.…”
Get full text

Cellular cross-talk drives mesenchymal transdifferentiation in diabetic kidney disease by Arunita Chatterjee, Jacqueline Tumarin, Sharma Prabhakar

“…Additionally, the observations of slowing of glomerular filtration rate (GFR) decline and reduction of proteinuria by recent drugs such as SGLT-2 blockers, whose primary mechanism of action is on proximal tubules, further strengthen the concept of cross-talk between the tubular and glomerular cells. …”
Get full text

Numerical Theoretical Study on Mechanical Properties of New Reinforced Tenon Precast Shear Walls by Wei Chen, Qing Wu, Dongyue Wu, Longji Dang, Feifei Jiang

“…It is found that the boundary components provide bending strength and the reinforced tenon can reduce the harmful influence of dowel-action shear stress on longitudinal connecting reinforcements. …”
Get full text

Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding by B. Glueck, Y. Han, G. A. M. Cresci

“…Butyrate has many biological mechanisms of action including anti-inflammatory and immunoprotective effects, and its depletion is associated with intestinal injury. …”
Get full text

Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress, modulation of infl ammatory cytokines, NF-κB, MAPK and gut microbiota composit... by Lingyu Li, Ning Qiu, Yaqi Meng, Chenyan Wang, Yoshinori Mine, Russell Keast, Vincent Guyonnet

“…Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects, but their mechanisms of action remain unknown. This study aimed to investigate the anti-inflammatory effects of preserved egg white (PEW) treatment on dextran sulfate sodium (DSS)-induced colitis in mice and the underlying mechanisms. …”
Get full text

Maximizing network throughput by cooperative reinforcement learning in clustered solar-powered wireless sensor networks by Yujia Ge, Yurong Nan, Xianhai Guo

“…The cooperative strategy of Q -learning and SARSA( λ ) is applied in this multi-agent environment based on the node residual energy, the predicted harvested energy for the next time slot, and cluster head energy information. The node takes action accordingly to adjust its operating duty cycle. …”
Get full text

The potential for justice through tourism by Freya Higgins-Desbiolles

“…Efforts to make tourism more responsible, ethical and just have been critiqued, both from a neoliberal perspective that tourism is not a site for moralisation and from a critical race positioning that many forms of justice tourism might not attain their goals of solidarity and emancipation.Looking forward, this analysis suggests that it is imperative that future research and action addresses the larger structural issues of justice and that the critical tourism studies movement is potentially a promising vehicle for this work. …”
Get full text

Novel Considerations in the ML/AI Modeling of Large-Scale Learning Loss by Mirna Elizondo, June Yu, Daniel Payan, LI Feng, Jelena Tesic

“…We demonstrate that data-driven unbiased data analysis at a larger scale can offer policymakers an actionable understanding of how to identify learning-loss tendencies and prevent them in public schools.…”
Get full text