Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway by Xiaomei Zhong, Yibin Sun, Yanxiang Lin, Shan Deng, Huan Wang, Xian Zhou, Jinjian Lu, Yanfang Zheng, Ruoyin Luo, Mingqing Huang, Jianyuan Song

“…However, its hepatic protective effect against acute liver injury and related mechanistic action remain unexplored. To investigate the protective effect of Rd against thioacetamide (TAA)-induced acute liver injury and assess its underlying regulatory mechanisms related to autophagy and inflammation. …”
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Biosynthesis and activity of Zn-MnO nanocomposite in vitro with molecular docking studies against multidrug resistance bacteria and inflammatory activators by Samy Selim, Tarek M. Abdelghany, Mohammed S. Almuhayawi, Mohammed K. Nagshabandi, Muyassar K. Tarabulsi, Mohammed Yagoub Mohammed Elamir, Asmaa A. Alharbi, Soad K. Al Jaouni

“…The minimum binding energy was utilized to estimate the receptor’s binding site with NPs, providing additional understanding of the ways of action. Anti-inflammatory activity of Zn-MnO nanocomposites via cyclooxygenase-1 and cyclooxygenase-2 enzymes inhibition was documented with IC50 doses of 20.81 ± 0.68 µg/mL and 35.87 ± 1.35 µg/mL, respectively. …”
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„O pecunia totius mali regina, fraudis et doli amica...“ Peníze v kultuře středověku by Tomáš Krejčík

“…Obviously teaching about purgatory was a somewhat uncertain course of action and when theological speculations about how to weaken the ban on usury failed, people looked for other ways to circumvent the prohibition. …”
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Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention by Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo

“…Kinetic analyses further elucidated citrulline's non-competitive inhibition pattern while molecular dynamics analysis afforded assessment of the binding stability of citrulline with PDE5, both providing insights into its mechanism of action. Citrulline-PDE5 complex had a higher negative binding free energy (-45.06 ± 4.69 kcal/mol) relative to the conventional drug (sildenafil) (-13.86±10.23 kcal/mol). …”
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PENERAPAN PROJECT BASED LEARNING MODEL UNTUK MENINGKATKAN SIKAP ILMIAH MAHASISWA DALAM RANGKA MENGHADAPI ERA MERDEKA BELAJAR by Andik Purwanto, Desy Hanisa Putri, Dedy Hamdani

“…The research was conducted with classroom action research (PTK) which was carried out in several cycles. …”
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Pearl Millet Cover Crop Extract Inhibits the Development of the Weed <i>Ipomoea grandifolia</i> by Inducing Oxidative Stress in Primary Roots and Affecting Photosynthesis Efficienc... by Gislaine Cristiane Mantovanelli, Adriano Antônio Silva, Letycia Lopes Ricardo, Fernanda Lima Kagami, Jéssica Dario de Almeida, Mauro Cezar Barbosa, Márcio Shigueaki Mito, Isabela de Carvalho Contesoto, Paulo Vinicius Moreira da Costa Menezes, Gabriel Felipe Stulp, Beatriz Pereira Moreno, Francielli Alana Pereira Valeze, Rubem Silvério de Oliveira Junior, Debora Cristina Baldoqui, Emy Luiza Ishii Iwamoto

“…The allelopathic activity of pearl millet may be attributed, at least in part, to the impairment of energy metabolism and the induction of oxidative stress in weed seedlings, with pallidol possibly involved in this action. Such findings demonstrated that the application of the EAF extract from pearl millet can be a natural and renewable alternative tool for weed control.…”
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Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…Shaoyao Gancao Decoction (SGD) is a classic Chinese prescription with good neuroprotective activities. However, the action of SGD in PICI remains elusive. Herein, our work was set out to study the potential role and possible mechanism of SGD in PICI through network pharmacology, Mendelian analysis and animal experiments. …”
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KATALIKŲ BAŽNYČIOS KAITA LIETUVOJE TRANSFORMACIJŲ LAIKOTARPIU by Valdas Pruskus

“…The Church was induced to find ways of action corresponding to the needs of the society. …”
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Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway by Teerapap Panklai, Prapapan Temkitthawon, Nungruthai Suphrom, Corine Girard, Perle Totoson, Kowit Hengphasatporn, Yasuteru Shigeta, Krongkarn Chootip, Kornkanok Ingkaninan

“…The mechanism of WLE vascular action involved the endothelial nitric oxide (NO) pathway and stimulation of sGC, while showing no VSMC cytotoxicity.…”
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UPAYA MENINGKATKAN HASIL BELAJAR DAN KETERAMPILAN PROSES SAINS MELALUI MODEL PEMBELAJARAN BERBASIS MASALAH MENGGUNAKAN VIDEO PEMBELAJARAN PADA MATERI FLUIDA STATIS by Frans Meydy Hutagalung, Nyoman Rohadi, Irwan Koto

“…ABSTRACT   This research was a classroom action research on static fluid material which was carried out in four cycles which aimed to describe the improvement of learning outcomes and science process skills. …”
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Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer by Guo Z, Li G, Shen L, Pan J, Dou D, Gong Y, Shi W, Sun Y, Zhang Y, Ma K, Cui C, Li W, Liu Q, Zhu X

“…The photothermal performance, cellular uptake and distribution, cytotoxicity, anti-tumor effects, and mechanism of action of GDNPs@ICG were investigated both in vitro and in vivo.Results: GDNPs@ICG were taken up by tumor cells via a lipid-dependent pathway. …”
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Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease by Femke C. C. van Rhijn-Brouwer, Bas W. M. van Balkom, Diana A. Papazova, Diënty H. M. Hazenbrink, Anke J. Meijer, Isaac Brete, Vidalmar Briceno, Arjan D. van Zuilen, Raechel J. Toorop, Joost O. Fledderus, Hendrik Gremmels, Marianne C. Verhaar

“…Bone marrow- (BM-) derived mesenchymal stromal cells (MSCs) enhance tissue repair and induce neoangiogenesis through paracrine action of secreted proteins and extracellular vesicles (EVs). …”
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Chemical Composition of Mexicali Propolis and Its Effect on Gastric Repair in an Indomethacin-Induced Gastric Injury Murine Model by Pilar Dominguez-Verano, Nadia Jacobo-Herrera, Andrés Castell-Rodríguez, Octavio Canales-Alvarez, Maria Margarita Canales-Martinez, Marco Aurelio Rodriguez-Monroy

“…It is important to highlight that this study provides a preliminary exploration of the reparative effect of Mexican propolis, describing the potential mechanisms of action of the compounds present in Mexicali propolis.…”
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Immune Modulation Effect of Administration of Rice Bran Extract with Increased Solubility Fermented by <i>Lentinus edodes</i> UBC-V88 in Cyclophosphamide-Treated Mice Model by Gi-Jung Kim, Yelim Jang, Ji-Yoon Hong, Kyoung-Tae Kwon, Dae-Weon Kim, Dae-Jung Kang, Sung-Joo Hwang, Jung-Yun Lee, Emmanouil Apostolidis, Young-In Kwon

“…In this study, the immunomodulatory effect and mechanism of action of rice bran extract fermented by <i>Lentinus edodes</i> was investigated. …”
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Statistically Coherent Calibration of X-Ray Fluorescence Spectrometry for Major Elements in Rocks and Minerals by Surendra P. Verma, Sanjeet K. Verma, M. Abdelaly Rivera-Gómez, Darío Torres-Sánchez, Lorena Díaz-González, Alejandra Amezcua-Valdez, Beatriz Adriana Rivera-Escoto, Mauricio Rosales-Rivera, John S. Armstrong-Altrin, Héctor López-Loera, Fernando Velasco-Tapia, Kailasa Pandarinath

“…If the analytical instruments were routinely calibrated from the UWLR model, this action would make the science of geochemistry more quantitative than at present.…”
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Dealing With the Complexity of Effective Population Size in Conservation Practice by Ancuta Fedorca, Joachim Mergeay, Adejoke O. Akinyele, Tamer Albayrak, Iris Biebach, Alice Brambilla, Pamela A. Burger, Elena Buzan, Ino Curik, Roberta Gargiulo, José A. Godoy, Santiago C. González‐Martínez, Christine Grossen, Myriam Heuertz, Sean Hoban, Jo Howard‐McCombe, Maria Kachamakova, Peter Klinga, Viktoria Köppä, Elenora Neugebauer, Ivan Paz‐Vinas, Peter B. Pearman, Laia Pérez‐Sorribes, Baruch Rinkevich, Isa‐Rita M. Russo, Adélaïde Theraroz, Nia E. Thomas, Marjana Westergren, Sven Winter, Linda Laikre, Alexander Kopatz

“…To address the challenges associated with estimating Ne for conservation purposes, the COST Action 18134, Genomic Biodiversity Knowledge for Resilient Ecosystems (G‐BiKE), organized an international workshop that met in August 2022 in Brașov, Romania. …”
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Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…Abstract Antimicrobial resistance (AMR) is a global health challenge requiring cross-sector action, with research largely focused on chickens, leaving ducks underexplored. …”
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Identification of Plasma Absorbed Components of Qingxin Zishen Prescription by UPLC-Q-TOF MS by Yu HU, Juan SHANG, Xue-jiao LI, Yun-hua FENG, Kai-cheng XIE, Wei-feng YAO, Jian-dong ZOU, Yun CHEN, Su LU, Mei-juan XU

“…This study provides not only a rapid and comprehensive analysis method for the plasma absorbed components of QZP, but also a scientific fundamental for elucidating the material basis of action of QZP.…”
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Secular trend and projection of overweight and obesity among Chinese children and adolescents aged 7–18 years from 1985 to 2019: Rural areas are becoming the focus of investment by Jiajia Dang, Yunfei Liu, Shan Cai, Panliang Zhong, Di Shi, Ziyue Chen, Yihang Zhang, Yanhui Dong, Jun Ma, Yi Song, Jing Ni, Xuehong Zhang

“…A complete reversal in urban–rural prevalence is expected by 2027, with a higher prevalence of overweight and obesity in rural areas. Urgent action is needed to address health inequities and increase investments, particularly policies targeting rural children and adolescents.…”
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SEED (Stoke Disease Early Detection Application) - Rancang Bangun Aplikasi Mobile Berbasis Android untuk Mendiagnosis Gejala Dini Penyakit Stroke Menggunakan K-Nearest Neighbor (K-... by Dedin Anike Putra, Muhammad Dimas Setiawan Sanapiah, Azifatul Istna Hanifah, Tri Afirianto

“…Data from Syaiful Anwar Hospital (RSSA) Malang City shows that 30% of stroke patient's age is among 18-30 years old. Preventif action needs to be done for reducing the risk level of stroke. …”
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