Estradiol-dependent and independent effects of FGF21 in obese female mice by T. V. Jakovleva, A. Yu. Kazantseva, A. D. Dubinina, N. Yu. Balybina, K. O. Baranov, E. N. Makarova, N. M. Bazhan

“…The results suggest that the absence of FGF21 effects on body and adipose tissue weights in OVX obese females and its benef icial effect on food intake and blood glucose levels are not associated with the action of estradiol. However, estradiol affects the transcriptional effects of FGF21 in the liver, white adipose tissue, and hypothalamus, which may underlie sex differences in the FGF21 effect on the expression of metabolic genes and, possibly, in pharmacological FGF21 effects.…”
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Ethyl Acetate Extract of <i>Cichorium glandulosum</i> Activates the P21/Nrf2/HO-1 Pathway to Alleviate Oxidative Stress in a Mouse Model of Alcoholic Liver Disease by Shuwen Qi, Chunzi Zhang, Junlin Yan, Xiaoyan Ma, Yewei Zhong, Wenhui Hou, Juan Zhang, Tuxia Pang, Xiaoli Ma

“…The ethyl acetate extract of <i>Cichorium glandulosum</i> (CGE) exhibits antioxidant and hepatoprotective properties, but its detailed mechanism of action against ALD remains unclear. This study investigates the effects and mechanisms of CGE in alleviating alcohol-induced oxidative stress and liver injury. …”
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Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics... by Chaoyan Yue, Qi Zhang, Fenyong Sun, Qiuhui Pan

“…Funding: This study was supported by National Natural Science Foundation of China (No. 82293662, No 82172357 and No 81930066), Key project of Shanghai ''Science and Technology Innovation Action Plan (22JC1402304) and Research fund of Shanghai Municipal Health Bureau (No. 2019cxjq03).…”
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Land use changes, green house gas emissions, and rehabilitation model of native tree species towards sustainable management by W.C. Adinugroho, H.L. Tata, . Darwo, Y. Lisnawati, H.S. Nuroniah, R. Dewi, I. Heriansyah, . Mawazin

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Designing a model for the development of questioning skills based on the school context in primary school students by motahare Khosravi Rad, Ahmad Akbari, Mohammad karimi, Moslem Cherabin

“…The prerequisite for this issue is the existence of a model as a guide for the action of those in charge; a model in which the background conditions, intervening conditions, causal conditions, and consequences of this issue are correctly identified. …”
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Application of Fuzzy Hierarchy Analysis method to identify factors on the professional development of newly graduated teachers from Farhangian University by Nader Habibzadeh, Ebrahim Salehiomran, Saeed Ghiyasinoshan

“…The first factor is knowledge acquisition and creation (A), the second factor is knowledge organization (B), the third factor is knowledge exchange and sharing (C), the fourth factor is knowledge application (D), the fifth factor is staying up-to-date (E), and the sixth factor is experience orientation and reflective action (F), the seventh factor of change in the way of doing work (G), the eighth factor of learner and learning (H), the ninth factor of content knowledge (I), the tenth factor of educational practice (J), and the eleventh factor of professional responsibility (K). …”
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CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma by Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Philipp Wendel, Philipp Wendel, Philipp Wendel, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Hermann Kreyenberg, Michael Merker, Michael Merker, Christian Münch, Christian Münch, Christian Münch, Elise Gradhand, Meike Vogler, Meike Vogler, Meike Vogler, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Halvard Bönig, Halvard Bönig, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger

“…Here, we characterize and compare efficacy, phenotypic subpopulations and modes of action of CAR-CIK cells and conventional CAR-T cells from same-donor samples in ErbB2+ rhabdomyosarcoma (RMS).MethodsTo benchmark CAR-CIK against conventional CAR-T cells, effector cells were generated from same-donor samples and lentivirally transduced with a second generation CD28-CD3ζ CAR. …”
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The mediating role of creative self-efficacy in the relationship between organizational intelligence and organizational agility of teachers by Abbas Gholtash

“…More theoretical considerations about the relationship between self-efficacy and creativity are proposed by Ford [1996], who considers self-efficacy as a key motivational component in his model of defined individual creative action (Karofsky et al, 2016).Organizational intelligence:Organizational intelligence is a new concept in the field of management organization and 21st century literature. …”
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Intersemiotic Translation: From Medieval Poetry to Modern Movie by Leila Nik Nasab

“…Discussion of Results and Conclusion Since the narrative has manifested in the form of a movie, it naturally incorporates elements of imagination and dramatic aspects. Some events, actions, reactions, and themes are repeated in the screenplay by the filmmaker, while others have been altered in terms of the storyline and contemporary culture, and some parts have been creatively added to the script. …”
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Investigate of preoperative hope level and analysis of influencing factors in elderly patients with femoral neck fracture (老年股骨颈骨折患者术前希望水平及影响因素分析)... by ZHANG Caixia (张彩侠), LI A Min (李阿敏), PAN Rusheng (潘如胜), LI Ling (李玲), CHE Xia (车侠)

“…Results The total HHI score of 206 elderly patients with femoral neck fractures was (31.73+-9.68) points, and scores of each dimension were: positive attitude towards reality and the future (9.14+-1.10), taking positive actions (11.69+-5.36), maintaining close relationships with others (10.89+-3.22); Among them, 63 cases (30. 6%) were high hope levels, 131 cases (65. 6%) were medium hope levels, and 12 cases (3. 8%) were low hope levels. …”
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Incidence and predictors of respiratory tract infections among birth cohorts in Ethiopia, 2023 by Fekade Demeke Bayou, Mastewal Arefaynie, Anissa Mohammed, Abiyu Abadi Tareke, Awoke Keleb, Natnael Kebede, Yawkal Tsega, Bayu Hailemariam Mersha, Abel Endawkie, Shimels Derso Kebede, Kaleab Mesfin Abera, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare

“…Methods This was a retrospective follow up study using data from Performance Monitoring for Action Ethiopia (PMA Ethiopia). A two-stage cluster sampling technique was used to select a total 2,246 eligible study participants from 206 enumeration areas. …”
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Ginseng exhibits adaptogenic-like activity in mice exposed to hypoxic-anoxic stress through activation of antioxidant/BDNF protective mechanisms and inhibition of pro-inflammatory... by James Olukayode Oni, Divine Oluwaferanmi Oyenekan, Yetunde Olamide Olayemi, Osarugue Christabel Irabor, Precious Ogbuji, McCarthy Oritseweyinmi Tova, Paul Ademola Adeleke, Gbemisayo Adetomiwa Abbas, Solomon Umukoro

“…This study evaluates the adaptogenic-like properties of Panax ginseng commercial product (Ginsomin) and the biochemical mechanisms underlying its action in male Swiss mice exposed to hypoxic-anoxic stress. …”
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Effects of Standardized Natural Citrus Extract on Growth, Gut Health, Carcass Quality, and Welfare of Broiler Chickens by Sekhou Cisse, Arkadiusz Matuszewski, Damian Bień, Patrycja Ciborowska, Anna Zalewska, Jakub Urban, Monika Michalczuk, Marta Mendel, Urszula Latek, Joanna Polak, Małgorzata Sobczak-Filipiak, Paweł Konieczka, Mohammed El Amine Benarbia

“…This study provides valuable insights into the mechanisms of action that may underlie the observed effects of SNCE on performance, as demonstrated in this study and others. …”
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Endogenous 17β-estradiol regulates sexually dimorphic anxiety responses in zebrafish via the HPI axis and 5-HT/DA pathways by Hong Tao, Hong Tao, Ying–Ying Zhang, Ying–Ying Zhang, Yan–Jun Shen, Yan–Jun Shen, Qi–Liang Chen, Qi–Liang Chen, Zhi–Hao Liu, Zhi–Hao Liu

“…These findings strongly suggest that E2 positively regulates sexually dimorphic anxiety responses possibly by modulating plasma cortisol levels and the synthesis and action of 5-HT/DA in the brain.…”
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Valine potentiates cefoperazone-sulbactam to kill methicillin-resistant Staphylococcus aureus by Shao-hua Li, Yuan Tao, Zhi-cheng Yang, Huan-zhe Fu, Hui-yin Lin, Xuan-xian Peng, Hui Li

“…Both together increased cefoperazone uptake, which outpaces efflux action and thereby intracellular drug is elevated to effectively kill MRSA. …”
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Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…ObjectiveThe main objective of this feasibility study was to assess the feasibility, usability, and acceptability of the More In Action (MIA) app, designed to promote PA among older adults. …”
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Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur by Xue Zheng, Yuhua Luo, Rui Huo, Yiwen Wang, Youbang Chen, Mianrong Chen, Qi Zhao, Kexin Li, Hanyi Zhang, Xiaotong Li, Xiang Li, Hui Zhang, Zaopeng He, Li Huang, Chun-tao Yang

“…PSCP also impaired mitochondrial function by inhibiting mitochondrial respiratory complex I, with Ndus3 likely being the target of PSCP’s action. Supplementation with ATP significantly countered PSCP-induced SNU398 cell injury. …”
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Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis by Wenbo Chen, Zhengguang Geng, Haixia Luo, Zhaoyuan Huang, Yufen Yang, Xun Luo, Bao Fu, Zhi Liu, Xiaoyun Fu

“…The aim of this study was to examine whether there was a deficiency of TH in mouse lung tissue after PQ administration, and to explore the effect of T3, and potential mechanisms of action, in alleviation of PQ-induced pulmonary fibrosis. …”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Nonetheless, myrrh’s precise rudimentary mechanisms of action in regulating genes involved in breast cancer evolution and progression remain elusive. …”
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Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ by Yong-Jik Lee, Hyun Soo Kim, Hong Seog Seo, Jin Oh Na, You-Na Jang, Yoon-Mi Han, Hyun-Min Kim

“…These results suggest that the activation of α1-adrenergic receptor stimulates energetic reprogramming via PPARδ that increases mitochondrial oxidative phosphorylation and has healthy and organ-specific biological effects in multiple organs, including skeletal muscle, beyond its vasomotion effect. In addition, the action mechanism of α1-adrenergic receptor may be mainly exerted via PPARδ.…”
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