Entre espaces domestiques et « espaces domestiqués » : « L’autonomisation intime » des étudiantes en Turquie by Tuğba Gökduman

“…In this article, “intimate autonomy” refers to the idea that the individual is defined as the “author of their action” in their private and sexual life. Young unmarried women, often viewed as potential sexual victims or corrupters of the moral order, are subject to surveillance in the name of “protection.” …”
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A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombina... by Xingxing Li, Yue Wu, Min Zhang, Fengliang Wang, Hong Yin, Yanrong Zhang, Shuli Zhao, Jiehua Ma, Mingming Lv, Cheng Lu

“…PDBAG1 has demonstrated substantial efficacy in suppressing triple‐negative breast cancer (TNBC) both in vitro and in vivo. Its mechanism of action involves mitochondrial impairment and the inhibition of oxidative phosphorylation (OXPHOS), achieved through direct binding to C1QBP, thereby promoting its ubiquitin‐dependent degradation. …”
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Analisis Sentimen pada Data Saran Mahasiswa Terhadap Kinerja Departemen di Perguruan Tinggi Menggunakan Convolutional Neural Network by Yuliska Yuliska, Dini Hidayatul Qudsi, Juanda Hakim Lubis, Khairul Umum Syaliman, Nina Fadilah Najwa

“…Abstract Student’s reviews about department performance can be essential for a college for it can be used to evaluate the department performance and to take an immediate action to improve its performance. This research applies sentiment analysis in the student’s reviews of college department in Politeknik Caltex Riau. …”
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Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Tria... by Joseph Studer, John A Cunningham, Elodie Schmutz, Jacques Gaume, Angéline Adam, Jean-Bernard Daeppen, Nicolas Bertholet

“…ConclusionsPerceived drinking norms, but not perceived risks, partially mediated the intervention’s effect on alcohol use, confirming one of its hypothesized mechanisms of action. These findings lend support to using normative feedback interventions to discourage unhealthy alcohol use. …”
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JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells by Ling Yan, Shengnan Liu, Chen Wang, Fei Wang, Yingli Song, Nan Yan, Shuhua Xi, Ziyou Liu, Guifan Sun

“…Excessive fluoride may cause central nervous system (CNS) dysfunction, and oxidative stress is a recognized mode of action of fluoride toxicity. In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extracellular superoxide in microglia. …”
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Observed climate trends and farmers’ adaptation strategies in Dendi District, West Shewa Zone, Ethiopia by Busha Getachew, Gonfa Kewessa, Worku Hailu, Gezahegn Girma

“…Indigenous people need to perceive that the climate is changing or likely could change, and they need to pay sufficient attention to this perception to take action. Understanding farmers’ perceptions about climate change and adaptation strategies can help support their efforts and develop interventions more suited to the local context. …”
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The global, regional, and national burden of type 2 diabetes mellitus attributable to low physical activity from 1990 to 2021: a systematic analysis of the global burden of disease... by Jiehua Wei, Luying Fan, Zixuan He, Senmao Zhang, Ying Zhang, Xidi Zhu, Fan Xia, Xinli Song, Lizhang Chen, Zhiyong Zou, Tingting Wang

“…Substantial increases in national action are urgently needed to target elder populations especially in low-middle and middle SDI regions, and special efforts should be made to promote physical activity in young adults with LPA.…”
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Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae by Sheena Francis, William Irvine, Lucy Mackenzie-Impoinvil, Lucrecia Vizcaino, Rodolphe Poupardin, Audrey Lenhart, Mark J. I. Paine, Rupika Delgoda

“…RNA sequencing and in silico modelling were used to determine the mode of action of the extracts. Results Aqueous extracts of Piper amalago var. amalago inhibited CYP6P9a, CYP6M2, and CYP6P3 with IC50s of 2.61 ± 0.17, 4.3 ± 0.42, and 5.84 ± 0.42 μg/ml, respectively, while extracts of Kalanchoe pinnata, inhibited CYP6M2 with an IC50 of 3.52 ± 0.68 μg/ml. …”
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Experimental Investigation on Shear Strength between Ultra-High-Performance Concrete and Normal Concrete Substrates by Xinghong Jiang, Hengxiang Song, Ke Li, Jing Qiang, Jing Tian

“…When the number of keyways is equivalent to the roughness index, the relationship between the shear strength and the roughness is as follows: fs=1.664+3.030Rz. Under the action of keyway, the interface slip of UHPC-NC can be simplified into four stages: the interface slip stage, the keyway strengthening stage, the shear yield stage, and the specimen failure stage. …”
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Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection by Michele Barone, Maria Teresa Viggiani, Annabianca Amoruso, Serafina Schiraldi, Annapaola Zito, Fiorella Devito, Francesca Cortese, Michele Gesualdo, Natale Brunetti, Alfredo Di Leo, Pietro Scicchitano, Marco Matteo Ciccone

“…Hepatitis C virus (HCV) infection can exert proatherogenic activities due to its direct action on vessel walls and/or via the chronic inflammatory process involving the liver. …”
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Relevant Elements of Standardisation of Federation’s Advisory Programs for Voluntary Sports Clubs by Marisa Moser, Matthias Buser, Siegfried Nagel

“…Thus, federations offer tools and training courses and have started implementing advisory programs supporting voluntary sports clubs' (VSCs') strategic alignment and action (cf. Klenk et al., 2017). However, the effectiveness of external guidance can be limited due to the level of autonomy and independence that VSCs typically show (Nagel & Schlesinger, 2012; Schlesinger et al., 2021). …”
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Implementasi Algoritma Naïve Bayes untuk Mendeteksi Resiko Tinggi Diabetes Melitus Pada Ibu Hamil (Studi Kasus : Puskesmas Kabupaten Malang) by Fatmawati Fatmawati, Satrio Agung Wicaksono, Satrio Hadi Wijoyo

“…In addition, recommendations from the system can support a midwife's decision making in taking action to pregnant women. The highest accuracy value is found in the 4th test of 82,4324% and the lowest accuracy value in the 2nd test is 75%. …”
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Disorders of the central nervous system cognitive and mnestic functions in genetic arterial hypertension and with the use of beta-blockers of different generations by A. O. Svitlytskyi, A. A. Yehorov, O. V. Melnikova, T. A. Hrekova

“…Drug correction of arterial hypertension with hypertril (a β-blocker of the latest generation with NO-mimetic action) has a highly effective effect on the development of conditioned-reflex skills and the ability to learn that indicates a reduction in cognitive deficits in SHR with essential arterial hypertension.…”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…However, its mechanism of action remains largely unexplored. In this study, we investigated the intricate mechanisms through which SM polyherbal extract exerts neuroprotective and anxiolytic effects in cultured HT-22 cells and rodent models. …”
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Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance by Atsunori Ueyama, Nobuhiro Ban, Masanori Fukazawa, Tohru Hirayama, Minako Takeda, Tatsuo Yata, Hiroyasu Muramatsu, Masaki Hoshino, Marii Yamamoto, Masao Matsuo, Yuka Kawashima, Tatsuhiko Iwase, Takehisa Kitazawa, Youichi Kushima, Yuichiro Yamada, Yoshiki Kawabe

“…Although mitogen-activated protein kinase kinase (MEK) is a key signaling molecule and a negative regulator of insulin action, it is still uncertain whether MEK can be a therapeutic target for amelioration of insulin resistance (IR) in type 2 diabetes (T2D) in vivo. …”
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Failure Mechanism and Kinematics of the Deadly September 28th 2016 Sucun Landslide, Suichang, Zhejiang, China by Hai Tian, Jianjun Gan, Hui Jiang, Chun Tang, Changtai Luo, Chenghui Wan, Bin Xu, Faliang Gui, Chengyi Liu, Nian Liu

“…In addition, there are rock avalanches on the rear edge of the slope subjected to the combined action of rainfall and gravity. Moreover, there are some resistance anomaly areas of the aquifer and soil between 2 and 50 m where the resistivity is less than 120 ohm-m, and they were deduced to be full of water, confirming a “bathtub” type structure. …”
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Cortisol regulates neonatal lung development via Smoothened by Shanshan Lu, Yifei Chen, Jiawen Song, Liangliang Ren, Jun Du, Donglai Shen, Jiayin Peng, Yao Yin, Xia Li, Yuqing Wang, Yan Gao, Siman Han, Yichang Jia, Yun Zhao, Yizheng Wang

“…To explore the effect of cortisol action on the SHH pathway on neonatal lung development, we generated a genetic mouse, in which leucine 116 (L112 in human) of SMO was mutated to alanine 116 (L116A, Smo a/a ) by the CRISPR-Cas9, based on sequence differences between human and mice. …”
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Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition by Da Som Kim, Hong-Ki Min, Eun Kyung Kim, Seung Cheon Yang, Hyun Sik Na, Seon-Yeong Lee, Jeong-Won Choi, Kyung-Ah Jung, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

“…This study was performed to examine whether SAHA has therapeutic potential in an animal model of RA and to investigate its mechanism of action. Collagen-induced arthritis (CIA) mice were orally administered SAHA daily for 8 weeks and examined for their arthritis score and incidence of arthritis. …”
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Insidensi Tuberkulosis Paru pada Pasien Diabetes Melitus Tipe 2 di Ruang Rawat Inap Penyakit Dalam RSUP Dr. M. Djamil Padang by Dina Fitri Fauzia, Masrul Basyar, Asman Manaf3 Manaf

“…</strong></p><p><strong>Kata kunci: </strong>insidensi, tuberkulosis paru, diabetes melitus tipe 2</p><p> </p><p><strong><em>Abstract</em></strong></p><p>Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. Type 2 DM makes up about 80% of all cases of DM. …”
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Small extracellular vesicles derived from miRNA-486 overexpressed dental pulp stem cells mitigate high altitude pulmonary edema through PTEN/PI3K/AKT/eNOS pathway by Changyao Wang, Zhuang Mao, Drolma Gomchok, Xue Li, Huifang Liu, Jingyuan Shao, Hu Cao, Guanzhen Xue, Lin Lv, Junzhao Duan, Tana Wuren, Hua Wang

“…To supplement in vivo findings, pulmonary microvascular endothelial cells (PMVEC) were stressed with cobalt chloride to emulate hypoxic damage, and then treated with sEVNull and sEVmiR−486 to unravel the mechanism of action. The sEVNull mitigated pathological changes in the lungs, reduced pulmonary artery pressure and lung water content, and alleviated oxidative stress and inflammatory responses in cases of HAPE. …”
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