Faktor-Faktor yang Berhubungan dengan Kejadian Filariasis di Kabupaten Padang Pariaman Tahun 2010-2013 by Dhia Afra, Nora Abdiana Harminarti, Abdiana .

“…The data analysis was based on univariate and bivariate analysis equipped with chi-square test.The results of chi-square statistical test shows that there is significant correlation between age and filariasis prevalence with p value = 0.013, OR= 0.167, 95% CI= 0.043 – 0.652 but there was no correlation between gender, occupation (p value= 0.071, OR=3.800, 95% CI=0.938-15.398), breeding places, knowledge (p value= 1.000, OR=1.135, 95% CI=0.336 – 3.835),attitudes and action. The age is closely related to the occupation, so it needs intervention from health care workers how to protect while working, such as using a long-sleeved shirt, long pants and mosquito repellent. …”
Get full text

Development, opportunities, and challenges of siRNA nucleic acid drugs by Bowen Xiao, Shaopeng Wang, Yu Pan, Wenjun Zhi, Chensheng Gu, Tao Guo, Jiaqi Zhai, Chenxu Li, Yong Q. Chen, Rong Wang

“…This review summarizes the history of siRNA drug development and the mechanisms of action, with a focus on the drug targets, indications, and key clinical trial results to introduce the status of both marketed drugs and those currently in clinical trials. …”
Get full text

Anti-inflammatory and antioxidant properties of Camellia sinensis L. extract as a potential therapeutic for atopic dermatitis through NF-κB pathway inhibition by Min Jung Kim, Ye Jin Yang, Ga-Yul Min, Ji Woong Heo, Jae Dong Son, Young Zoo You, Hun Hwan Kim, Gon Sup Kim, Hu-Jang Lee, Ju-Hye Yang, Kwang Il Park

“…Molecular docking simulations provided insights into the underlying mechanisms of CSE action, which supported its potential as a therapeutic agent for AD. …”
Get full text

Recent plastic technologies development of basal texture control to improve the property of wrought Mg alloys-a review by Xiaoyu Feng, Lifei Wang, Xiang Chen, Kunkun Deng, Xiao Wang, Liuwei Zheng, Hongxia Wang, Qiang Zhang, Ho Kwon, Bin Xing, Kwang Seon Shin

“…Consequently, the initial dense basal texture has been decreased, the basal slip systems are significantly activated, and plasticity is greatly improved. The continued action of non-basal slip concurrently enhances plasticity.The present paper provides a comprehensive overview of the texture regulation technology and mechanism of Mg alloy subjected to shear strain and torsional deformation, including extrusion, rolling, and bending. …”
Get full text

Co-creation and application of a framework for the de-prioritization of urban communities during insecticide-treated bed net mass campaigns for malaria prevention and control in Kw... by Ifeoma D. Ozodiegwu, Laurette Mhlanga, Eniola A. Bamgboye, Adeniyi F. Fagbamigbe, Cyril Ademu, Chukwu Okoronkwo, Joshua O. Akinyemi, Akintayo O. Ogunwale, IkeOluwapo O. Ajayi, Beatriz Galatas

“…Methods A participatory action research approach, combined with abductive inquiry, was employed to co-design a framework for guiding bed net distribution. …”
Get full text

The Explo’Santé mixed methods protocol: an interventional research school health promotion project in France by Matteo Olivo, Adeline Darlington-Bernard, Corélie Salque, Laurie Fraticelli, Emmanuel Ricard, Florence Carrouel, Emily Darlington

“…Abstract Background According to WHO, “noncommunicable diseases (NCDs) kill 41 million people” annually, as the primary cause of death globally. WHO’s Global Action Plan for the prevention and control of NCDs 2013–2020 (extended) tackles this issue and its implications regarding inequalities between countries and populations. …”
Get full text

Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages by Aparecida Donizette Malvezi, Rosiane Valeriano da Silva, Carolina Panis, Lucy Megumi Yamauchi, Maria Isabel Lovo-Martins, Nagela Ghabdan Zanluqui, Vera Lúcia Hideko Tatakihara, Luiz Vicente Rizzo, Waldiceu A. Verri, Marli Cardoso Martins-Pinge, Sueli Fumie Yamada-Ogatta, Phileno Pinge-Filho

“…The treatment of macrophages with either NOS inhibitors or prostaglandin E2 (PGE2) restored the invasive action of T. cruzi in macrophages previously treated with ASA. …”
Get full text

Foundational community factors: A local look at what and how neighborhoods matter for early childhood development in Quebec city, Canada by Alexandra Matte-Landry, Anne-Marie Rouillier, Nicolas R-Turgeon

“…These FCFs highlight leverage points and potential areas of action in the local context, as well as more broadly. …”
Get full text

Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…For high-risk families, the app could serve as a motivational tool to prompt action regarding potential DMUD and facilitates access to therapeutic facilities.Clinical trial registrationhttps://drks.de, identifier DRKS00033379.…”
Get full text

TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…M6223±BA displayed a linear pharmacokinetic profile. Anti-TIGIT mode-of-action-related pharmacodynamic effects were observed in peripheral blood and in tumor tissue. …”
Get full text

Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats by Baocang Yin, Baocang Yin, Mingzhen Yang, Mingzhen Yang, Bowen Wang, Bowen Wang, Yun Zhang, Yun Zhang, Ningli Li, Ningli Li, Qin Li, Yingying Li, Cory J. Xian, Tiejun Li, Tiejun Li, Yuankun Zhai, Yuankun Zhai

“…Modern pharmacological research has proved that E. ulmoides could prohibit the occurrence of osteoporosis and arthritis.AimTo investigate the effect and action mechanism of total flavonoids isolated from the leaves of E. ulmoides (TFEL) on bone loss in ovariectomized (OVX) rats, and to study its effect on intestinal flora.Materials and methodsThe 3-month-old female rats were randomly divided into six groups: sham operation group, OVX model group, estradiol group, TFEL low (TFEL-L) (50), mid (-M) (100) and high (-H) (200 mg/kg/d) dose groups. …”
Get full text

Efficacy of Intrathecal 0.75% Hyperbaric Ropivacaine versus 0.5% Hyperbaric Bupivacaine for Elective Inguinal and Perineal Surgery: A Randomised Double-blinded Clinical Study by Bhavini Shah, Dipanjali Mahanta

“…The shorter duration of action, coupled with profound sensory block and comparatively less side-effects, makes ropivacaine useful in tackling cases of day care surgery. …”
Get full text

Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Zhihan Zhao, Huan Lan, Ibrahim El-Battrawy, Xin Li, Fanis Buljubasic, Katherine Sattler, Gökhan Yücel, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin

“…Some of them contribute to action potential performance and are regulated by adrenergic stimulation.…”
Get full text

A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon by Junfeng Liu, Mickaël Lelek, Yunfeng Yang, Audrey Salles, Christophe Zimmer, Yulong Shen, Mart Krupovic

“…We propose the “relay race” model, whereby the cytokinesis is achieved through a sequential and concerted action of different ESCRT machinery components.IMPORTANCETwo major cytokinesis mechanisms, rooted in contractile FtsZ and endosomal sorting complexes required for transport (ESCRT) rings, respectively, have emerged in the course of evolution. …”
Get full text

Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…The study found that pyrazole 3b showed 100% antifungal activity between 1000 and 500 μg/ml, 50% at doses of 250 μg/ml, and no antifungal action at a dose of 125 μg/ml against the studied pathogenic fungal strains. …”
Get full text

Composition and thermal properties of starch in flint maize (Zea mays, L.) kernels: location and crop management effects by M. ACTIS, A.E. FARRONI, F.H. ANDRADE, O.R. VALENTINUZ, A.G. CIRILO

Get full text

Synergy of Remote Sensing and Geospatial Technologies to Advance Sustainable Development Goals for Future Coastal Urbanization and Environmental Challenges in a Riverine Megacity by Minza Mumtaz, Syed Humayoun Jahanzaib, Waqar Hussain, Sadia Khan, Youssef M. Youssef, Saleh Qaysi, Abdalla Abdelnabi, Nassir Alarifi, Mahmoud E. Abd-Elmaboud

“…This study’s innovative contribution lies in quantifying SDG achievements, showing varied progress: 26% for SDG 9 (Industry, Innovation, and Infrastructure), 18% for SDG 11 (Sustainable Cities and Communities), 13% for SDG 13 (Climate Action), and 16% for SDG 8 (Decent Work and Economic Growth). …”
Get full text

Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…A combination of transcriptomic analyses, cytometric and immunohistochemistry techniques allowed us to validate the underlying T cell response phenotypes of PDAC cells. The action of TGM2 via interaction with tubulin and the impact of microtubule dynamics and vesicle trafficking were evaluated by protein analyses and live-cell imaging. …”
Get full text

Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…However, its precise mechanisms of action and effects at elevated doses remain insufficiently explored. …”
Get full text

Determining the status of ecosystem degradation trends and their implications for ecological integrity in the southern African grassland biome by L.R. Vukeya, T.M. Mokotjomela, N. Pillay

“…We conclude that the functioning, biodiversity and services supplied by the southern African grassland biome is at risk that could be addressed by urgent context-specific management action, policy and selective habitat restoration/rehabilitation interventions. …”
Get full text