Heat-related mortality in Mexico: A multi-scale spatial analysis of extreme heat effects and municipality-level vulnerability by Lara Schwarz, Chen Chen, Javier Emmanuel Castillo Quiñones, L.C. Aguilar-Dodier, Kristen Hansen, Jaime Reyes Sanchez, David J.X. González, Gordon McCord, Tarik Benmarhnia

“…Understanding the differential risks of extreme heat events at varying scales is important to prioritize at-risk populations in action plans and policies to reduce their burden.…”
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The burden and outcomes of firearm injuries at two district-level emergency centres in Cape Town, South Africa: A descriptive analysis by L Bush, C Hendrikse, C Van Koningsbruggen, K Evans

“…Data from this study aid our understanding of the prevalence and burden of firearm injuries at district level emergency centres, and multisectoral action, supported by evidence-based primary and secondary preventive strategies, is required to reduce the burden of firearm injuries, and mitigate their effects. …”
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Methodological Guidelines of the Scientific Community for Human Microbiome Research (CHMR) and the Russian Gastroenterology Association (RGA) on the Use of Probiotics, Prebiotics,... by V. T. Ivashkin, A. V. Gorelov, D. I. Abdulganieva, O. P. Alekseeva, S. A. Alekseenko, A. Yu. Baranovsky, I. N. Zakharova, O. Yu. Zolnikova, K. V. Ivashkin, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammaev, S. V. Nikolaeva, E. A. Poluektova, A. S. Trukhmanov, D. V. Usenko, I. B. Khlynov, V. V. Tsukanov, O. S. Shifrin, I. V. Berezhnaya, T. L. Lapina, R. V. Maslennikov, N. G. Sugian, A. I. Ulyanin

“…The Methodological Guidelines contain sections on the terminology, classification, mechanisms of action, requirements for sale in the Russian Federation, requirements for proving the efficacy and safety of probiotics, prebiotics, synbiotics and metabiotics, as well as functional foods enriched with them. …”
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Functional and Structural Investigation of Myenteric Neurons in the Human Colon by Kristin Elfers, Alina Sophia Sehnert, Alexander Wagner, Ulrich Zwirner, Helena Linge, Ulf Kulik, Daniel Poehnert, Markus Winny, Benjamin Gundert, Heiko Aselmann, Gemma Mazzuoli-Weber

“…Results: Stimulation with nicotine and 5-HT elicited reproducible action potential discharge in a proportion of human myenteric neurons. …”
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Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…Both CRF and ethanol decreased paired-pulse facilitation (PPF) of evoked IPSCs and significantly enhanced the frequency, but not the amplitude, of spontaneous miniature GABAergic mIPSCs in CeA neurons of WT mice, suggesting a presynaptic site of action. The PPF effect of ethanol was abolished in CeA neurons of CRF1 KO mice. …”
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Study on the Influence of Introducing Al Transition Layer on Deuterium Resistance of Al2O3 Coating by Weijing Wang, Qinghe Yu, Xiaopeng Liu, Lei Hao, Jing Mi, Shijie Li, Shuai Li, Zheng Lu, Shanshan Li, Hao Liu

“…Due to the oxidation of the Al transition layer, the connection between the coating and the substrate is tightly connected. Under the combined action of permeation temperature and pressure of 873 K and 80 kPa, the deuterium permeability of Al/Al2O3 coating is 6.35×10−14 mol·m-1·s-1·Pa-0.5, which shows that the Al/Al2O3 coating has excellent deuterium permeation resistance. …”
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Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The objectives were i) to assess the small-scale spatial and temporal heterogeneity of physiological resistance to insecticide and behavioural resistance phenotypes, ii) to better understand their drivers, and iii) to assess their spatio-temporal predictability, at scales that are consistent with operational action. The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. …”
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UPAYA MENINGKATKAN MOTIVASI BELAJAR DAN KEMAMPUAN PEMECAHAN MASALAH SISWA MELALUI MODEL PROBLEM BASED LEARNING BERBANTU ALAT PERAGA KONSEP GERAK LURUS by Budi Santoso, Desy Hanisa Putri, Rosane Medriati

“…This research was a classroom action research on the concept of straight motion carried out in three cycles. …”
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Embryonic heat conditioning induces paternal heredity of immunological cross- tolerance: coordinative role of CpG DNA methylation and miR-200a regulation by Padma Malini Ravi, Tatiana Kisliouk, Shelly Druyan, Amit Haron, Mark A. Cline, Elizabeth R. Gilbert, Noam Meiri

“…In this study, we conducted an analysis of thermal manipulation during embryogenesis to demonstrate paternal heredity and investigate its transmission through sperm DNA methylation in coordination with miR-200a action.ResultFirst-generation embryos underwent in ovo heat conditioning (EHC), creating a cohort of embryonic EHC and control chicks. …”
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Quantitative proteomics and targeted metabolomics reveal the role of Cassia siamea L. extract in the response to high-fat diet-induced obesity in Drosophila by Ananya Dechakhamphu, Nattapong Wongchum, Theeraphan Chumroenphat, Alongklod Tanomtong, Sirithon Siriamornpun

“…Moreover, this study investigated the effects of the extract combined with a high-fat diet on amino acid metabolism and proteomic profiles to clarify its mechanism of action. Results: Syringic acid was the most abundant phenolic compound in CSE, followed by gallic acid, sinapic acid, protocatechuic acid, cinnamic acid, chlorogenic acid, and ferulic acid. …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…The roles of Erastin and the SIRT3 inhibitor 3-TYP were also explored to elucidate FBR2’s mechanisms of action.ResultsFBR2 treatment significantly mitigated BLM-induced lung injury in mice, as evidenced by improved body weight and survival rates, and reduced levels of inflammatory cytokines, including IL-6 and TNF-α. …”
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UPAYA MENINGKATKAN MOTIVASI DAN HASIL BELAJAR SISWA DENGAN MODEL DISCOVERY LEARNING BERBANTUAN VIRTUAL LABORATORY by Faiz Brikinzky Adyan, Andik Purwanto, Nirwana Nirwana

“…This research was a classroom action research. The subject of research was the whole student of XI MIPA A SMAN 2 city of Bengkulu that amounted 32 student. …”
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Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings by Shyam Kumar Mishra, Tanzina Akter, Umme Laila Urmi, George Enninful, Manjulatha Sara, Jiawei Shen, Dittu Suresh, Liangjun Zheng, Elias Shiferaw Mekonen, Binod Rayamajhee, Francesco M. Labricciosa, Massimo Sartelli, Mark Willcox

“…We explore the mechanism of action of AMPs against bacteria, viruses, fungi and parasites. …”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…These effects were directly linked to their inhibition of PKM2 enzymatic activity, validating the proposed mechanism of action in their rational design. ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Prevalence, risk factors and management of common mental health disorders in Cameroon: a systematic review by Emmanuel Kah, Che Henry Ngwa, John Njuma Libwea, Marion Keinamma, Frankline Sevidzem Wirsiy, Limkile Mpofu, Tchokokam Patricia, Rejoice Uche Obiora, Danga Aloleko Ines, Ngo Valery Ngo, Egbe Henrieta Oneke, Crayton E Bessong, Ngozi Margaret Oguguah, Eman Sobh

“…Increased priority and participatory action with all stakeholders including individuals, communities/policy holders and in research where a huge gap remains to be filled, is crucial in reducing the burden of MHDs in Cameroon.PROSPERO registration number CRD42022348427.…”
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Weak coupling of observed surface PM2.5 in Delhi-NCR with rice crop residue burning in Punjab and Haryana by Poonam Mangaraj, Yutaka Matsumi, Tomoki Nakayama, Akash Biswal, Kazuyo Yamaji, Hikaru Araki, Natsuko Yasutomi, Masayuki Takigawa, Prabir K. Patra, Sachiko Hayashida, Akanksha Sharma, A. P. Dimri, Surendra K. Dhaka, Manpreet S. Bhatti, Mizuo Kajino, Sahil Mor, Ravindra Khaiwal, Sanjeev Bhardwaj, Vimal J. Vazhathara, Ravi K. Kunchala, Tuhin K. Mandal, Prakhar Misra, Tanbir Singh, Kamal Vatta, Suman Mor

“…This indicates that there exists only a very weak coupling between PM2.5 mass over Delhi-NCR and the CRB over Punjab, highlighting the effectiveness of the Graded Response Action Plan (GRAP) in controlling air pollution in the region.…”
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The Battle of Žalgiris / Grunwald: Unanswered Questions by Alfredas Bumblauskas

“…This means that the themes of the tactics of three corps ("drei Treffen"), the gonfanons, and wedge formations, which enable us to look anew both at the level, composition, formation of the army of the Grand Duchy of Lithuania and its action in the battlefield. The sources unambiguously speak about three corps of the army of the Grand Duchy of Lithuania whose gonfanons could contain two major heraldic signs - Vytis (the State emblem of Lithuania - the White Knight astride a leaping stallion) and the Pillars of Gediminaičiai (one of the major symbols of statehood), as well as forming of corps in wedges. …”
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Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse by Sara Carmela Credendino, Nicole Lewin, Miriane de Oliveira, Swaraj Basu, Barbara D’Andrea, Elena Amendola, Luigi Di Guida, Antonio Nardone, Remo Sanges, Mario De Felice, Gabriella De Vita

“…The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. …”
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Farmer perception of impacts of fall armyworm (Spodoptera frugiperda J.E. Smith) and transferability of its management practices in Uganda by Andrew Kalyebi, Michael H. Otim, Tom Walsh, Wee Tek Tay

“…A small number of farmers (ca. 4%) in both districts reportedly took no intentional action against FAW. Conclusions The farmers believe they can manage FAW if they have the appropriate and efficacious chemical insecticides as they are able to correctly apply them and follow recommended procedures. …”
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Trends and Variability of PM2.5 at Different Time Scales over Delhi: Long-term Analysis 2007–2021 by Chetna, Surendra K. Dhaka, Gagandeep Longiany, Vivek Panwar, Vinay Kumar, Shristy Malik, A. S. Rao, Narendra Singh, A. P. Dimri, Yutaka Matsumi, Tomoki Nakayama, Sachiko Hayashida

“…Government agencies need more strict action plans, especially during winter, to comply with air quality standards.…”
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