Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction by Stéphanie Verbeke, Aurélien Bourdon, Mathilde Lafon, Vanessa Chaire, Bertolo Frederic, Amina Naït Eldjoudi, Marie-Alix Derieppe, Francis Giles, Antoine Italiano

“…The most potent inhibitor was evaluated in vivo in two animal models and the mechanisms of action were investigated by RNA sequencing, Western blotting and immunofluorescence staining. …”
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Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes by Hector Barajas-Martinez, Maya Smith, Dan Hu, Robert J. Goodrow, Colleen Puleo, Can Hasdemir, Charles Antzelevitch, Ryan Pfeiffer, Jacqueline A. Treat, Jonathan M. Cordeiro

“…None of the 3 family members screened developed cardiac events. Action potential recordings from control hiPSC-CM showed spontaneous activity and a low upstroke velocity. …”
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The role of Akkermansia muciniphila in maintaining health: a bibliometric study by Fangfang Gao, Canyu Cheng, Canyu Cheng, Runwei Li, Zongcun Chen, Zongcun Chen, Ke Tang, Guankui Du, Guankui Du, Guankui Du

“…Therefore, future research should explore its potential further by conducting clinical trials, elucidating its mechanisms of action, and investigating its efficacy and safety in diverse patient populations.…”
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Characteristics of Land Use Change and Evaluation of Ecological Sensitivity in Chongqing by XIE Xianjian, GOU Qiantao, WU Han

“…Regions with significant changes in sensitivity levels were located in the central urban area and the southeastern Wuling Mountainous area of Chongqing. (3) The temporal and spatial evolution of comprehensive ecological sensitivity in the study area was the result of the joint action of natural environmental factors and social economic factors. …”
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Innovative Model of Socio-Professional Development of a Student’s Personality by E. F. Zeer, V. S. Tretyakova, M. V. Zinnatova

“…The mechanism of the model implementation is to build an individual student professional perspective aimed at practical action in order to improve the level of qualification, ability to work, enrichment of professional and personal qualities and behavioural patterns.Scientific novelty of the present research consists in the formation of interdisciplinary scientific knowledge (at the intersection of psychology, pedagogy, philosophy, occupational studies) on the methodology of the modelling, organisation and content of professional education taking into account modern challenges and demands of the digital economy. …”
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Human Serum Albumin and Human Serum Albumin Nanoparticles as Carriers of 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine: In Vitro Spectroscopic Studies by Aleksandra Owczarzy, Karolina Kulig, Beata Morak-Młodawska, Małgorzata Jeleń, Tammam Muhammetoglu, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk

“…Additionally, this compound is characterized by selectivity of action towards MCF-7 breast cancer and has low cytotoxicity towards normal cells. …”
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer by Yuh-Shyan Tsai, Yeong-Chin Jou, Ian Seng Cheong, Hsiu-Ting Tung, Lin-Nei Hsu, Hsin-Tzu Tsai, Tzong-Shin Tzai

“…However, its role and action mechanism in prostate cancer remain unclear. …”
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Managing Water-Ecosystem-Food Nexus using participatory approaches: insights from an innovative methodological approach developed in two Mediterranean areas by Dimitrios Malamataris, Vassilios Pisinaras, Alessandro Pagano, Valentina Baratella, Silvia Vanino, Manuel Bea, Konstantinos Babakos, Anna Chatzi, Stefano Fabiani, Raffaele Giordano, Petros Kafkias, Estrella López-Moya, Christina Papadaskalopoulou, Ivan Portoghese, Dimitris Tassopoulos, Andreas Panagopoulos

“…By fostering collaboration and stakeholder ownership, the methodology provided actionable insights and promoted context-specific solutions. …”
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Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

“…They also include adverse side effects, such as blurred vision being linked with tetracaine.DiscussionThis work represents an important advance in our understanding of how drugs cause intended and adverse side effects through their action on disease causing genes and has potential applications for drug development and repositioning.…”
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Assessing the development of health technology assessment in Iran: a policy analysis using Kingdon’s Multiple streams framework: a qualitative study by Meysam Behzadifar, Saeed Shahabi, Ahad Bakhtiari, Samad Azari, Seyed Jafar Ehsanzadeh, Mohammad Yarahmadi, Masoud Behzadifar

“…Despite the technical feasibility of implementing HTA in Iran, there is a significant gap between theoretical discussions and policy action. Resistance from the private sector and the need for political backing were identified as major barriers. …”
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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…This, with biophysical and functional assays, elucidated the underlying mechanism of action of ISB 1442. In solution phase, ISB 1442 forms a 2:2 complex with CD38 as determined by size-exclusion chromatography with multi-angle light scattering and electron microscopy. …”
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Mega-events and the climate: what’s the game? by David Gogishvili, Martin Müller

“… Introduction: The Olympics and the Men's Football World Cup are both significant carbon emitters, yet they hold potential for raising awareness and driving action on climate change (Chalip, 2006; Martiskainen & Sovacool, 2021). …”
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PENINGKATAN KEMAMPUAN GENERIK FISIKA DAN PEMAHAMAN KONSEP DALAM PEMBELAJARAN GUIDED DISCOVERY MELALUI EKSPERIMEN PADA ALAT-ALAT OPTIK by Partogi Nainggolan, Nyoman Rohadi, Eko Risdianto

“…This research was a classroom action research conducted in three cycles. Subjects in this study were all students of class XI MIA 2 that consists of 32 people consisting of 14 male students and 18 female students. …”
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$$\hbox {H}_2$$ -roaming dynamics in the formation of $$\hbox {H}_{3}^{+}$$ following two-photon double ionization of ethanol and aminoethanol by Aaron Ngai, Sebastian Hartweg, Jakob D. Asmussen, Björn Bastian, Matteo Bonanomi, Carlo Callegari, Miltcho Danailov, Michele di Fraia, Raimund Feifel, Sarang Dev Ganeshamandiram, Sivarama Krishnan, Aaron LaForge, Friedemann Landmesser, Ltaief Ben Ltaief, Moritz Michelbach, Nitish Pal, Oksana Plekan, Nicolas Rendler, Lorenzo Raimondi, Fabian Richter, Audrey Scognamiglio, Tobias Sixt, Richard J. Squibb, Katrin Dulitz, Frank Stienkemeier, Marcel Mudrich

“…In contrast to previous studies, we additionally analyze a broad range of dissociative ionization products, which feature distinct dynamics from that of $$\hbox {H}_{3}^{+}$$ and allow initial insight into the action of the disruptive UV-probe pulse.…”
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The Art and life of Alàgbà Fálétí – A Pic torial, Art and Artifacts Exhibition in Honor of Alàgbà Adébáyọ̀ Fálétí (1921- 2017) curated by Akinsola Adejuwon and Seyi Ogunjobi... by Akinsola Adejuwon

“…Within a lifetime of close to one century, Fálétí delivers perhaps unique classical Yorùbá messages in words matched with action, first to Africa and then the world. This review looks at the pictorial and art exhibition covering the world of Alàgbà Adébáyọ̀ Akande Fálétí. …”
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Запобігання фінансуванню тероризму в Україні: окремі питання теорії та практики by A. Nekoz, A. Vlasov

“…Стаття також розглядає роль міжнародних стандартів, таких як FATF (Financial Action Task Force), які визначають основні засади протидії відмиванню грошей і фінансуванню тероризму. …”
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Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…Our previous investigations have highlighted MI's potential antiepileptogenic effects, although its exact mechanisms of action during epileptogenesis remain unclear. A critical, unexplored area is how inositols interact with proteins. …”
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A synthesis of academic literature on eco-spirituality by A.H.A. Adow, M.M. Safeer, M.G.H. Mohammed, M. Sayeed Alam, M.M. Sulphey

“…The study also underscores the significance of eco-spirituality as a catalyst for environmental consciousness and sustainable action. The innovation of the study is that it has revealed eco-spirituality's transformative role in promoting environmental sustainability and bridging interdisciplinary insights with practical applications. …”
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Être touareg dans le Sud libyen en transition: une citoyenneté encore inachevée by Pauline Poupart

“…If the movement could structure itself and expand in the country and abroad, it is currently constrained in its capacity for action. The main hardships it faces are the blocked political situation at the national level, internal rivalries among the Tuareg community and, most of all, the multiplication of armed groups who confiscated the public space while framing the use of force as the ultimate tool to access rights. …”
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Assessment of the essential oil extracted from Citrus aurantifolia leaves using solvent-free microwave extraction technique by G.M. Masud Rana, Md. Jasim Uddin, Jaytirmoy Barmon, Bijoy Chandra Ghos, Tahmina Akter Chowdhury, Amit Kumar Dey, Bijoy Maitra, Ismat Moin Tamanna, AHM Mahbubur Rahman, Barun Kanti Saha, Mst. Sarmina Yeasmin

“…The EO also exhibited antimicrobial action against gram-positive Listeria monocytogenes (ATCC 13,932) and gram-negative Escherichia coli, Pseudomonas aeruginosa and S. choleraesuis (ATCC 10,708). …”
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