Melatonin Rescued Reactive Oxygen Species-Impaired Osteogenesis of Human Bone Marrow Mesenchymal Stem Cells in the Presence of Tumor Necrosis Factor-Alpha by Xianjian Qiu, Xudong Wang, Jincheng Qiu, Yuanxin Zhu, Tongzhou Liang, Bo Gao, Zizhao Wu, Chengjie Lian, Yan Peng, Anjing Liang, Peiqiang Su, Dongsheng Huang

“…Melatonin (MLT) has been reported to act as an antioxidant during cell proliferation and differentiation, but its antioxidant effect and mechanism of action during osteogenesis of MSCs in the inflammatory microenvironment, especially in the presence of TNF-α, remain unknown and need further study. …”
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User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project by Pascal Raszke, Godwin Denk Giebel, Carina Abels, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Silke Mreyen, Nina Timmesfeld, Marianne Tokic, Frank Martin Brunkhorst, Nikola Blase

“…The survey is followed by the development of a requirement profile for AI-based CDSS and the derivation of policy recommendations for action, which are evaluated in a (5) expert roundtable discussion. …”
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Event-related theta synchronization over sensorimotor areas differs between younger and older adults and is related to bimanual motor control by Andreas Wulff-Abramsson, Ana Zvornik, Keenie Ayla Andersen, Yan Yang, Mikael Novén, Jesper Lundbye-Jensen, Leo Tomasevic, Anke Ninija Karabanov

“…When engaged in dynamic or continuous movements, action initiation involves modifying an ongoing motor program rather than initiating it from rest. …”
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Effective dietary interventions during pregnancy: a systematic review and meta-analysis of behavior change techniques to promote healthy eating by Hannah O’Connor, Nina Meloncelli, Shelley A. Wilkinson, Anna Mae Scott, Lisa Vincze, Alita Rushton, Samantha Dawson, Jenna Hollis, Bree Whiteoak, Sarah Gauci, Susan de Jersey

“…The BCT category Reward and threat was successful in improving dietary quality and vegetable intake, whilst 'Action planning’ (1.4) from the category Goals and planning significantly improved dietary quality. …”
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富硒生物活性肽的制备、生物活性及构效关系研究进展 "Progress on the preparation, bioactivity and structure-activity relationship of selenium-enriched bioactive peptides"... by 侯春艳，杨趁仙 HOU Chunyan, YANG Chenxian

“…The bioactivities of selenium-enriched bioactive peptides are the results of the joint action of selenium and peptides, which are closely related to the sequence, spatial structure and interaction force of amino acids, but their structure-activity relationships need to be further studied. …”
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THE PUBLIC SPHERE OF POLITICS: THE ANTHROPOLOGICAL DIMENSION IN CONTEMPORARY COMMUNICATIVE THEORY by O. A. Tretyak

“…According to Jürgen Habermas, a contradiction between the system and the life-world signifies a need for a concept that would describe the projective space of a relaxed and undistorted human communicative activity. Communicative action as a societal basis of the public sphere links this concept to the pragmatic principles of human existence in modern society. …”
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Universality of universal health coverage: A scoping review. by Aklilu Endalamaw, Charles F Gilks, Fentie Ambaw, Yibeltal Assefa

“…The study implies that urgent action on the identified policy, health system and cross-cutting barriers is required to achieve UHC.…”
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Susceptibility to organophosphate insecticides in Aedes aegypti (Diptera: Culicidae) from northern Colombia and associated resistance mechanisms by María Claudia Atencia-Pineda, Javier García-Leal, Diana Diaz-Ortiz, Paula Pareja-Loaiza, Lisandro Pacheco-Lugo, Richard Hoyos-López, Alfonso Calderón-Rangel, Pedro Fragozo-Castilla, Selene M. Gutiérrez-Rodríguez, Adriana E. Flores, Ronald Maestre-Serrano

“…Additionally, the Ace-1 gene was sequenced to identify mutations at the target site of action. Results The populations were susceptible to temephos and malathion but resistant to fenitrothion, and in three of them, to pirimiphos-methyl. …”
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Application of lipidomics in the study of traditional Chinese medicine by Yang Yang, Guangyi Yang, Wenpeng Zhang, Lingyi Xin, Jing Zhu, Hangtian Wang, Baodong Feng, Renyan Liu, Shuya Zhang, Yuanwu Cui, Qinhua Chen, Dean Guo

“…This analysis aids in uncovering potential mechanisms for treating diverse physiopathological conditions, assessing drug efficacy, understanding mechanisms of action and toxicity, and generating innovative ideas for disease prevention and treatment. …”
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Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments by Amit Verma, Vikas Pandey, Catherine Sherry, Taylor Humphrey, Christopher James, Kailie Matteson, Jason T. Smith, Alena Rudkouskaya, Xavier Intes, Margarida Barroso

“…An imaging methodology that can non‐invasively quantify the binding of TZM‐HER2, which is required for therapeutic action, and distribution within tumors with varying tumor microenvironments is much needed. …”
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Multiple Mini Interviews vs Traditional Interviews: Investigating Racial and Socioeconomic Differences in Interview Processes by Banks PW, Hagedorn II JC, Soybel A, Coleman DM, Rivera G, Bhardwaj N

“…President & Fellows of Harvard College, which ended race-conscious admissions, or affirmative action, and upheld holistic admissions practices, encouraged medical school admissions committee to reevaluate their approach to admissions.Methods: Data from six admissions cycles (2018– 2022), totaling 5799 interviewees, were analyzed to assess potential biases and the effectiveness of the admissions process. …”
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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities by Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu

“…Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.…”
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Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer by Jerzy Hohendorff, Anna Drozdz, Sebastian Borys, Agnieszka H. Ludwig-Slomczynska, Beata Kiec-Wilk, Ewa L. Stepien, Maciej T. Malecki

“…The mechanism of NPWT’s action may be associated with its influence on circulating molecules. …”
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Blood Glucose Lowering Efficacy of Strawberry Extracts Rich in Ellagitannins with Different Degree of Polymerization in Rats by Juśkiewicz Jerzy, Jurgonski Adam, Kołodziejczyk Krzysztof, Kosmala Monika, Milala Joanna, Zduńczyk Zenon, Fotschki Bartosz, Żary-Sikorska Ewa

“…The experiment 1 comprised three oral sugar tolerance tests, GTT (with glucose; to examine monosaccharide transport across epithelium), SuTT (with sucrose; to examine the activity of mucosal disaccharidase) and StTT (with starch; to examine the action of salivary alpha-amylase, and then of pancreatic amylase in the small intestine as well as all the aforementioned mechanisms), while in the experiment 2 the healthy and pre-diabetic rats were subjected to 1-h small intestine perfusion with fluids containing glucose or sucrose. …”
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Focus on Depression in Parkinson’s Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics by Luis Agüera-Ortiz, Rocío García-Ramos, Francisco J. Grandas Pérez, Jorge López-Álvarez, José Manuel Montes Rodríguez, F. Javier Olazarán Rodríguez, Javier Olivera Pueyo, Carmelo Pelegrín Valero, Jesús Porta-Etessam

“…Efficacious and well-tolerated pharmacological options for Parkinson’s comorbid depression were selective serotonin reuptake inhibitors (especially sertraline), dual-action serotonin and norepinephrine reuptake inhibitors (venlafaxine, desvenlafaxine, and duloxetine), multimodal (vortioxetine, bupropion, mirtazapine, and tianeptine), and anti-Parkinsonian dopamine agonists (pramipexole, ropinirole, and rotigotine). …”
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On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (<i>Actaea racemosa</i> L.) by Martin J. Spiering, James F. Parsons, Edward Eisenstein

“…Botanical dietary supplements are widely used, but issues of authenticity, consistency, safety, and efficacy that complicate their poorly understood mechanism of action have prompted questions and concerns in the popular and scientific literature. …”
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Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes by Panayota Mitrou, Eleni Petsiou, Emilia Papakonstantinou, Eirini Maratou, Vaia Lambadiari, Panayiotis Dimitriadis, Filio Spanoudi, Sotirios A. Raptis, George Dimitriadis

“…Vinegar’s effect on carbohydrate metabolism may be partly accounted for by an increase in glucose uptake, demonstrating an improvement in insulin action in skeletal muscle. This trial is registered with Clinicaltrials.gov NCT02309424.…”
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Evaluating a novel team learning approach for integrating drugs in sports education in preclinical medical training by Samuel Pelobello, Grayson Potter, Daniel K. Rogstad, Andrew J. Mock, Sean M. Wilson

“…Future iterations will focus on emphasizing drug pharmacology, mechanisms of action, and physiological effects for MS1 students, while providing opportunities for more comprehensive knowledge integration through the case studies for MS2 students. …”
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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease by Giuseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph N. Martins, Paul E. Fraser, Philip Newsholme

“…Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD. …”
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PENERAPAN KONSEP PENGHAWAAN ALAMI PADA DESAIN SANATORIUM DI KABUPATEN GOWA by Suhardi M, Marwati Marwati, Nursyam Nursyam

“…The Sanatorium is a container with an implementation base of preventive action that serves as a place of isolation, maintenance, and rehabilitation of TB patients (Tuberculosis). …”
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