Genetic analysis and heterosis breeding of seed yield and yieldattributing traits in Indian mustard (Brassica juncea (L.) Czern & Coss.) by Sanghamitra Rout, Suvendu Kumar Roy, Rupsanatan Mandal, Saurav Singla, Mehdi Rahimi, Bijaya Sur, Naderla Umamaheswar, Moumita Chakraborty, Lakshmi Hijam, Sahanob Nath, Manoj Kanti Debnath, Tulsi Saran Ghimiray

“…The estimation of genetic components of variance underscored a predominant influence of non-additive gene action, especially in traits linked to yield. Specific combining ability (SCA) consistently surpassed general combining ability (GCA), underscoring the substantial role of non-additive genetic effects. …”
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Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model. by Zubair Khalid Labu, Samira Karim, Md Tarekur Rahman, Md Imran Hossain, Sarder Arifuzzaman, Md Shakil

“…Future research is warranted to isolate the specific bioactive compounds and elucidate their mechanisms of action to further support the development of new treatments and contributing to modern medicinal practices based on this plant leaves.…”
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Effectiveness of women-led community interventions in improving tuberculosis preventive treatment in children: results from a comparative, before–after study in Ethiopia by Jacob Creswell, Degu Jerene, Ahmed Bedru, Dawit Assefa, Kalkidan Tesfaye, Samuel Bayu, Samuel Seid, Fikirte Aberra, Amera Khan

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Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…Biological function classification and enrichment analysis were used to explore the main action pathways involving differentially expressed circRNAs. …”
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Copper Does Not Induce Tenogenic Differentiation but Promotes Migration and Increases Lysyl Oxidase Activity in Adipose-Derived Mesenchymal Stromal Cells by Marta Milewska, Anna Burdzińska, Katarzyna Zielniok, Katarzyna Siennicka, Sławomir Struzik, Piotr Zielenkiewicz, Leszek Pączek

“…Moreover, a high level of CuSO4 stimulated the action of intracellular superoxide dysmutase. The hASC secretion profile after a 5-day exposure to 50 μM cupric sulfate differed from that of untreated cells and was similar to the secretion profile of human tenocytes. …”
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Development of an eHealth Intervention Including Self-Management for Reducing Sedentary Time in the Transition to Retirement: Participatory Design Study by Lisa Hultman, Caroline Eklund, Petra von Heideken Wågert, Anne Söderlund, Maria Lindén, Magnus L Elfström

“…It uses several behavior change techniques, such as goal setting and action planning through mental contrasting and implementation intention, as well as shaping knowledge. …”
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Cloud-edge hybrid deep learning framework for scalable IoT resource optimization by Umesh Kumar Lilhore, Sarita Simaiya, Yogesh Kumar Sharma, Anjani Kumar Rai, S. M. Padmaja, Khan Vajid Nabilal, Vimal Kumar, Roobaea Alroobaea, Hamed Alsufyani

“…PPO enhances policies in continuous action spaces to guarantee reliable performance in real-time, dynamic IoT settings. …”
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Comprehensive approach to predictive analysis and anomaly detection for road crash fatalities by Chopparapu Gowthami, S. Kavitha

“…To find anomalies or outliers in the data and take preventative action to reduce the impact of accidents, anomaly detection utilizing an Isolation Forest model is utilized. …”
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Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase by Bright Obeng, Lucas J. Bennett, Bailey E. West, Dylan J. Wagner, Patrick J. Fleming, Morgan N. Tasker, Madeleine K. Lorenger, Dorothy R. Smith, Tetiana Systuk, Sydni M. Plummer, Jeongwon Eom, Marissa D. Paine, Collin T. Frangos, Michael P. Wilczek, Juyoung K. Shim, Melissa S. Maginnis, Julie A. Gosse

“…In the current study, these findings are extended to human mast cells (LAD2); this paper presents data indicating that a mechanism of action for CPC might center on its positively-charged quaternary nitrogen in its pyridinium headgroup. …”
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Pseudomonas azotoformans and Pseudomonas putida: Novel kiwifruit-native biological control agents against Pseudomonas syringae pv. actinidiae by Cristiana Correia, Antonio Cellini, Irene Donati, Panagiotis Voulgaris, Adebayo Ebenezer Obafemi, Elia Soriato, Elodie Vandelle, Conceição Santos, Francesco Spinelli

“…Overall, these results open new perspectives to develop commercial products for Psa management based on kiwifruit-native bacteria, well-adapted to common orchard management practices, with a high efficiency of host plant colonization, at Psa-conducive temperatures, and point out possible mechanisms of action for these two BCA candidates, supporting further steps to assess their effectiveness in orchard conditions.…”
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Red Currant (<i>Ribes rubrum</i> L.) Fruit Waste Extract and Juice as Potential Spasmolytic Agents by Maja Cvetković, Bojana Miladinović, Suzana Branković, Milica Randjelović, Slavoljub Živanović, Nemanja Kitić, Milica Milutinović, Miloš Jovanović, Dušica Stojanović, Haris Nikšić, Katarina Šavikin, Dušanka Kitić

“…The antispasmodic effects were assessed in in vitro conditions, and the potential impact of the samples and possible action mechanisms were revealed. The results showed the prevalence of cyanidin-3-<i>O</i>-glucoside as the dominant anthocyanin with higher content in the juice sample. …”
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Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…The resulting consensus document is based on current evidence from clinical trials and clinical practice and the panel's expert opinion, focusing on new ASMs with novel mechanisms of action, such as highly purified cannabidiol and fenfluramine. …”
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Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2 by Antonietta Coppola, Claudia Cuccurullo, Gianmaria Senerchia, Marica Rubino, Liana Veneziano, Francesco Brancati, Luigi Baratto, Valentina Virginia Iuzzolino, Leonilda Bilo, Pasquale Striano, Raffaele Dubbioso

“…PER treatment significantly reduced UMRS total scores (p = 0.001) and action‐myoclonus subscores (p = 0.002), irrespective of disease duration, age at onset, or testing time (p >0.05). …”
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Visually Impaired People Learning Virtual Textures Through Multimodal Feedback Combining Vibrotactile and Voice by Dapeng Chen, Yi Ding, Hao Wu, Qi Jia, Hong Zeng, Lina Wei, Chengcheng Hua, Jia Liu, Aiguo Song

“…We first propose an Informer based haptic texture rendering model that can fuse texture images with real-time action information to generate vibration acceleration (VA) signals. …”
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Transcriptional profiles analysis of effects of Toxoplasma gondii rhoptry protein 16 on THP-1 macrophages by Ningai Yang, Ningai Yang, Ningai Yang, Mingyang Li, Hong Yang, Jiaming Li, Tiantian Dang, Guangqi Li, Zhijun Zhao, Zhijun Zhao, Zhijun Zhao

“…However, the precise mechanisms underlying the involvement of type II ROP16 proteins in infection, inflammation, and other processes remain unknown.MethodsTo investigate the mechanism of action of gonococcal ROP16 proteins in human macrophages, we constructed a lentivirus overexpressing ROP16 and established stably transfected cell lines. …”
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Exploring the Pathophysiology, Diagnosis, and Treatment Options of Multiple Sclerosis by Simone Lorenzut, Ilaria Del Negro, Giada Pauletto, Lorenzo Verriello, Leopoldo Spadea, Carlo Salati, Mutali Musa, Caterina Gagliano, Marco Zeppieri

“…DMTs that are now on the market include interferons, glatiramer acetate, monoclonal antibodies, and oral immunomodulators; each has a unique mode of action and safety profile. Symptomatic treatments improve patients' general well-being by addressing specific symptoms, including pain, sphincter disorders, fatigue, and spasticity. …”
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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing by Xiaofei Wang, Xiaowen Cheng, Huiling Liu, Xiaohuan Mu, Hao Zheng

“…Dietary food often selectively presents its mechanism of action on different cell types, and participates in the modulation of targeted cells and their microenvironments within organs. …”
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Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors by Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer

“…However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated. …”
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Analysis of the structure and function of the tomato <i>Solanum lycopersicum</i> L. MADS-box gene <i>SlMADS5</i> by A. V. Nezhdanova, M. A. Slugina, E. A. Dyachenko, A. M. Kamionskaya, E. Z. Kochieva, A. V. Shchennikova

“…At all stages of flowering, a decisive role is played by the family of MADS-domain transcription factors, the combinatorial action of which is described by the ABCDE-model of flower development. …”
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Analysis of chronic kidney disease epidemiology in Kazakhstan using nationwide data for 2014–2020 and forecasting future trends of prevalence and mortality for 2030 by Gulnur Zhakhina, Kamilla Mussina, Sauran Yerdessov, Arnur Gusmanov, Yesbolat Sakko, Valdemir Kim, Dmitriy Syssoyev, Meruyert Madikenova, Ainur Assan, Zhanat Kuanshaliyeva, Duman Turebekov, Kuanysh Yergaliyev, Bolat Bekishev, Abduzhappar Gaipov

“…By 2030, the prevalence and mortality of CKD will significantly increase, according to the predicted model. A thorough action plan with effective risk factor management, enhanced screening among risk populations, and prompt treatment are required to lessen the burden of disease in Kazakhstan.…”
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