The dipeptide carnosine alleviates acute pancreatitis in an experimental model by Heresh Rezaei, Saeed Heidari, Mohammad Mehdi Ommati, Babak Taheri, Forouzan Khodaei, Mohammad Ali Dehghani, Ayeh Rowhanirad, Azadeh Veisi-Goshtasb, Zahra Honarpishefard, Negar Azarpira, Hossein Niknahad, Reza Heidari

“…These findings suggest that carnosine is a protective agent in pancreatitis, with its antioxidative and anti-inflammatory properties playing a pivotal role in its mechanisms of action. Further research is needed to confirm these protective effects in clinical studies and assess carnosine safety in AP.…”
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Abnormal Obesity Phenotype Is Associated with Reduced eGFR among Diabetes Mellitus and Hypertensive Patients in a Peri-Urban Community in Ghana by Richard K. D. Ephraim, Frederick Ahordzor, Kwame Kumi Asare, Evans Duah, Ibrahim W. Naveh-Fio, Grace Essuman, Justice Afrifa

“…Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia due to obesity and defects in insulin action. Significant complications of DM include kidney disease due to its association with hypertension and obesity. …”
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A backwater technology for enhancing pollutants discharge from aquaculture tanks in a Litopenaeus vannamei recirculating aquaculture system: Performance and control models by Jianping Xu, Yishuai Du, Jiawei Zhang, Fudi Chen, Li Zhou, Tianlong Qiu, Jianming Sun

“…This improvement is due to the IEB device's capability to enhance the removal of SSN, thereby minimizing its dissolution, decomposition, and mineralization. Under the action of IEB, the yield of shrimp increased by 4.48 %, with energy consumption accounting for only 0.74 % of the RAS operational energy consumption. …”
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Examining the integration of refugees into the national health system in Uganda: an analysis using the policy triangle framework by Henry Komakech, Shatha Elnakib, Lama Bou Karroum, Evelyn Nyachwo, Winnie Adoch, Sarah Sali, Godfrey Goddie Okeny, Christopher Garimoi Orach

“…The findings shed light on the importance of collaboration between stakeholders, mobilization of legal and political frameworks to shape the integration of refugee health services into the national health system, and the importance of ensuring that high-level commitments translate to action and development plans at local levels.…”
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Mogroside ⅡE, an in vivo metabolite of sweet agent, alleviates acute lung injury via Pla2g2a-EGFR inhibition by Weichao Lü, Guoqing Ren, Kuniyoshi Shimizu, Renshi Li, Chaofeng Zhang

“…The study elucidated the anti-inflammatory action and molecular mechanism of M2E against acute lung injury (ALI). …”
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Coordinated control and protection scheme for fault identification in hybrid three-terminal DC line based on pre-estimation of fault characteristics by Xincui Tian, Ziqian Liu, Jieshan Shan, Jinyun Yu, Jinxiong Wang, Qiang Li, Shihong Zhang, Tuoji Zhu, Jian Hu, Kaiwen Chen, Hongchun Shu

“…In the case of high resistance faults, the control system intentionally delays taking the action and waits for the control strategy to be corrected based on the results of the opposite end in the process. …”
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Exploring therapeutic mechanisms of Chuan Huang Fang-II in the treatment of acute kidney injury on chronic kidney disease patients from the perspective of lipidomics by Ling Chen, Qian Wang, Tonglu Li, Lejia Li, Chen Wang, Bing Xu, Xuezhong Gong

“…The possible metabolic pathways might be implicated in therapeutic action of CHF-II in the prevention and treatment of patients with A on C.…”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“….), and secondarily, at impaired stimulation of pancreatic secretion or impairment of conditions, necessary for the normal action of pancreatic enzymes. Basic clinical manifestations of PEI include maldigestion and malabsorption that lead to development of nutritional failure. …”
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Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update by Imadeldin Elfaki, Rashid Mir, Mohamed E. Elnageeb, Abdullah Hamadi, Zeyad M. Alharbi, Ruqaiah I. Bedaiwi, Jamsheed Javid, Tariq Alrasheed, Dalal Alatawi, Basmah M. Alrohaf, Mohammed K. Abunab, Turki Ahmed Muqri

“…Metabolic syndrome is a metabolic disorder characterized by hypertension, dyslipidemia, impaired glucose tolerance, and abdominal obesity. Impaired insulin action or insulin resistance initiates metabolic syndrome. …”
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No easy way out: towards a framework concept of long-term governance by Dirk Scheer, Sandra Venghaus, Stefania Sardo, Sascha Stark, Sophie Kuppler, Michael W. Schmidt, Carsten Hoyer-Klick

“…Such a framework may help to structure the field of long-term policy-making, guide future research on conceptual, comparative, and empirical in-depth studies, and may provide orientation and action knowledge for making our governance system sustainable. …”
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New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness by Giuseppe Spaziano, Donato Cappetta, Konrad Urbanek, Elena Piegari, Grazia Esposito, Maria Matteis, Manuela Sgambato, Gioia Tartaglione, Rosa Russo, Raffaele De Palma, Francesco Rossi, Antonella De Angelis, Bruno D’Agostino

“…These data, together with the increased apoptosis of inflammatory cells in vivo, indicate that c-kit+ cells downregulate immune response in asthma by influencing local environment, possibly by cell-to-cell contact combined to paracrine action. In conclusion, intratracheally administered c-kit+ cells reduce inflammation, positively modulate airway remodeling, and improve function. …”
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Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells by Yanan Zhao, Ranran Zhang, Ziheng Chen, Ziyi Wang, Shuang Guan, Jing Lu

“…Collectively, our results unveiled that the protective action of BMAL1 during alcohol challenge depends on its ability to activate Nrf2-ARE antiferroptosis pathway and targeting hepatic BMAL1 to dampen hepatic ferroptosis signaling may have therapeutic potential for ALD.…”
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A novel technique of cryodenervation for murine vagus nerve: implications for acute lung inflammation by Di Wu, Ximing Liao, Jing Gao, Kun Wang, Wujian Xu, Feilong Wang, Zhixian Jin, Dandan Wu, Qiang Li, Wei Gao

“…Moreover, the activated cholinergic anti-inflammatory pathway (CAP) and elevated IL-10 expression might explain the protective action of VSCD following LPS challenge. Conclusion This study fills the gap in the cryoablation for mouse vagus nerve, thereby guiding the application of cryodenervation in clinical management of pulmonary diseases. …”
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Evaluation of a strategy for tumor-initiating stem cell eradication in primary human glioblastoma cultures as a model by E. V. Dolgova, A. S. Proskurina, E. A. Potter, T. V. Tyrinova, O. S. Taranov, Ya. R. Efremov, K. E. Orishchenko, S. V. Mishinov, V. V. Stupak, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…The main target of the mitomycin C + DNA regimen was TAMRA+ tumor-initiating stem cells of the glioblastoma cell populations. The action of mitomycin C alone or in the combination with DNA demonstrated effective elimination of TAMRA+ tumor-initiating stem cells and the whole primary cultures of human glioblastomas.…”
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Mutational Analysis of KCNQ1 Gene in Type 2 Diabetes Mellitus: A Case-control Study by Ankush Ganjewar, Ishwar B Bagoji, Sharan Badiger, Rudragouda B Bulagouda, Gurushnatappa Kadakol

“…Introduction: KCNQ1 (Potassium voltage-gated channel subfamily Q member 1) gene encodes for pore-forming subunit of a voltage-gated K+ channel that is essential for the depolarisation phase of the action potential in cardiac muscle. KCNQ1 is also associated with impaired insulin secretion in Type 2 Diabetes Mellitus (T2DM), suggesting that this impairment might underlie the diabetes susceptibility conferred by rs151290, which is associated with 30-min C-peptide levels during an Oral Glucose Tolerance Test (OGTT) and first-phase insulin secretion. …”
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From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment by Basingab FS, Alshahrani OA, Alansari IH, Almarghalani NA, Alshelali NH, Alsaiary AH, Alharbi N, Zaher KA

“…We further described the mechanisms of action for nanoparticles, including passive and active targeting, and reviewed significant breakthroughs and clinical trials that have validated their efficacy. …”
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Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) by So-Yoon Park, Van-Long Truong, Su-Gyeong Jeon, So-Young Choe, Razanamanana H. G. Rarison, Byoung-Hoon Yoon, Ji-Won Park, Hye-Jeong Jeong, Woo-Sik Jeong

“…Among the extracts, the 95% ethanol extract exhibited the most potent inhibition of reactive oxygen species (ROS) and nitric oxide (NO) production, warranting further exploration of its mechanisms of action. Further analysis revealed that the ethanol extract modulated key inflammatory signaling pathways, including MAPK and NF-κB, contributing to its anti-inflammatory activity. …”
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A participatory needs assessment to map the system dynamics of overweight related behaviours of 10-14-year-old adolescents living in an underserved neighbourhood in Amsterdam, the... by Helga Emke, Rabab Chrifou, Coosje Dijkstra, Wilma Waterlander, Karien Stronks, Stef Kremers, Mai Chinapaw, Teatske Altenburg

“…Methods We conducted Participatory Action Research (PAR) to map the system dynamics of EBRBs together with adolescents aged 10–14 years old living in a lower socioeconomic, ethnically diverse neighbourhood in Amsterdam East, the Netherlands. …”
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The Impact of Lockdown on Air Quality in Pakistan during the COVID-19 Pandemic Inferred from the Multi-sensor Remote Sensed Data by Rehana Khan, Kanike Raghavendra Kumar, Tianliang Zhao

“…This is attributed to the limited transportation and control action plans of industrial activities including combustion sources taken by the Government of Pakistan for the DLP-2020 phase. …”
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GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection by Ying Wang, Lanjie Li, Danni Chen, Jiaheng Shan, Meijuan Yi, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi

“…Furthermore, the Western blot, small interfering RNA (siRNA), drug affinity responsive target stability (DARTS), cellular thermal shift assay (CESTA), liquid chromatography-tandem mass spectrometry (LC/MS-MS), adenosine 5′-monophosphate-activated protein kinase (AMPK) mutants and surface plasmon resonance (SPR) analysis were utilized to clarify the mechanism of action and identify target protein of this molecule. …”
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