Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…These cross-reactive ipilimumab variants may facilitate improved translatability and future mechanism-of-action studies for anti-CTLA-4 targeting in murine models.…”
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Clinical profile of patients assisted in a physical therapy outpatient service in oncology of Sao Paulo city by Pascale Mutti Tacani, Karina Tamy Kasawara, Rogério Eduardo Tacani, Aline Fernanda Peres Machado, Débora Montezello, João Carlos Guedes Sampaio Góes

“…However, this population has very different profiles, demands and realities, requiring the knowledge of its features to better develop action strategies and conducts in the area of physical therapy in oncology. …”
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Transition to Virtual Care Services during COVID-19 at Canadian Pain Clinics: Survey and Future Recommendations by Victoria Borg Debono, Samuel Neumark, Norman Buckley, Ramesh Zacharias, Eleni Hapidou, Jennifer Anthonypillai, Susy Faria, Carrie-Lynn Meyer, Thomas Carter, Nadia Parker, Brenda Lau, Emmanuel Abreu, Scott Duggan, Etienne Bisson, Josie Pierre, Regina Visca, Patricia Poulin

“…We used a qualitative participatory action study design that included a cross-sectional survey for data collection and descriptive analysis to summarize the findings. …”
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Health Behavior Study in Natural Disaster Vulnerability in Palu City (Case Study of Tondo Huntap, Palu City) by Arwan Arwan, Sadly Syam, Muhammad Zikra, Firmansyah Firmansyah, Muhammad Sabri Syahrir, Muhammad Aji Satria

“…Therefore, mental health interventions are needed to enhance preparedness for disasters and take action to reduce disaster losses and damage.…”
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Experiences and Perspectives of Medication Information and Use Among Arabic-Speaking Migrant Women in Sweden: A Multistage Focus Group Study by Al Musawi A, Axelsson M, Eriksson T, Rämgård M

“…The analysis generated three themes: receiving or not receiving professional medication information, medication adherence patterns, and needs and suggestions for improved medication information—a call for action. Participants reported inadequate medication information from physicians, particularly at the time of discharge from the hospital, and described instances of intentional and unintentional non-adherence. …”
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Reimagining Global Health: Accelerating Change for a Sustainable Future by Melissa Salm, Ala Alwan, Maureen Lichtveld, Patricia J. García, Peter H. Kilmarx, Nelson K. Sewankambo, Rebecca Martin, Tahmeed Ahmed, Judith N. Wasserheit

“…The viewpoint sets the stage for the development of an action roadmap to develop a unified concept of global health; identify strategies to ensure sustained funding for global health research, education and training, and practice; establish benchmarks and metrics to measure progress; and design a collaborative governance system to promote interconnectedness and engagement among local, regional, national, and global stakeholders.…”
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Evaluation of the Management of Patients with Detectable Viral Load after the Implementation of Routine Viral Load Monitoring in an Urban HIV Clinic in Uganda by Nsumba Steven Mark, Musomba Rachel, Arvind Kaimal, Mubiru Frank, Tibakabikoba Harriet, Lwanga Isaac, Mohammed Lamorde, Castelnuovo Barbara

“…For each patient, we described the action taken by the clinicians. Results. Of 6,438 patients with VL performed, 1,021 (16%) had >1,000 copies/ml. …”
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Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

“…However, its mechanisms of action remain unclear.Methods and results In this study, a rat model of renal fibrosis was constructed by 5/6 nephrectomy in vivo, and histopathological changes were analyzed using hematoxylin-eosin and Masson’s trichrome staining. …”
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Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Additionally, we tested the cardioprotective effects of two drug candidates in the SCM mouse model and explored their mechanism-of-action in H9c2 cells. Results: Network analysis identified 129 drugs associated with SCM, which were refined to 14 drug candidates based on strong network predictions, proven anti-infective effects, suitability for ICU use, and minimal side effects. …”
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Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…While in mammals active demethylation is based on targeted regulated damage to mC in DNA followed by the action of repair enzymes, demethylation in plants is performed by specialized DNA glycosylases that hydrolyze the N-glycosidic bond of mC nucleotides. …”
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A new process for extracting vanadium by direct calcification using the heat of molten vanadium slag by Qu J.-W., Zhang T.-A., Lv G.-Z., Chen Y.

“…The effect of the cooling method, CaO addition, and reaction time on the phases of calcified vanadium slag was studied. Under the action of oxygen and CaO, the molten vanadium slag underwent calcification reaction to form acid-soluble calcium vanadate phase and the feasibility of its main chemical reaction was calculated by Factsage8.1. …”
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GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…Here we reported the inhibitory effects of GEN-27, a new derivative of genistein, on the inflammation-related colon cancer cell proliferation and delineated the mechanism of its action. The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1β in THP-1 cells. …”
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An Evidence-Based Update on the Impact of Local Antimicrobials as Adjunct to Periodontal Therapy by Nabaz Yahya Hussein, Sadat Abdulla Aziz, Twana Mohammed M. Ways, Omed Amiri, Hisham Al-Obaidi, Dianne Ford

“…MTZ showed the lowest clinical improvement among the agents reviewed, but it remains valuable due to its targeted action against anaerobic bacteria, which are prominent in periodontal infections. …”
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Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study by Vlad M. Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur

“…In our study, significant angiogenesis is linked with a greater tissue formation, indicating that in bone engineering with the allografts we used, inflammation has more benefic effects, the catabolic action being exceeded by the tissue formation.…”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…Aim of the study: We explored the mechanism of action of TG on hypertension by 16S rDNA gene sequencing and non-targeted metabolomics, verified the correlation between hypertension and intestinal flora, searched for potential markers of intestinal flora, and screened for the correlation between different flora and different metabolites, which facilitates a more scientific and reasonable guidance for the administration of TG. …”
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Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT3AR and 5-HT3BR Expression in the Rat Brain by Fang Li, Jizhen Feng, Dongmei Gao, Jieqiong Wang, Chunhong Song, Sheng Wei, Mingqi Qiao

“…The effects of the Shuyu capsule on 5-HT3AR and 5-HT3BR expression in a rat model of premenstrual syndrome (PMS) depression and on 5-HT3AR and 5-HT3BR expression and hippocampal neuron 5-HT3 channel current were investigated, to elucidate its mechanism of action against PMS depression. PMS depression model rats were divided into depression and Shuyu- and fluoxetine-treated groups, which were compared to control rats for frontal lobe and hippocampal 5-HT3AR and 5-HT3BR expression and behavior. …”
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Knowledge translation initiatives at the Transitional Pain Service: insights from healthcare provider outreach and patient education by Anna M. Lomanowska, Rabia Tahir, Christina Choo, Sabrina Zhu, Dora Y. Wang, P. Maxwell Slepian, Joel Katz, Hance Clarke

“…Guided by the Knowledge to Action (KTA) framework, knowledge translation activities undertaken by our TPS team include clinician training, resources and outreach activities for providers, and patient education. …”
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Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio) by Gabrielli Aparecida Sanches Tesolin, Marina Menezes Marson, Claudio Martín Jonsson, António José Arsénia Nogueira, Daniel Andrade de Siqueira Franco, Sydnei Dionísio Batista de Almeida, Marcus Barifouse Matallo, Monica Accaui Marcondes de Moura

“…The mixture model that best describes the relationship between the two components is independent action and toxicity of the mixture is dose-dependent, occurring antagonism at low doses and synergism at high doses. …”
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Pharmacological effects of fibroblast growth factor 21 are sex-specific in mice with the <em>lethal yellow</em> (A^y) mutation by E. N. Makarova, T. V. Yakovleva, N. Yu. Balyibina, K. O. Baranov, E. I. Denisova, A. D. Dubinina, N. A. Feofanova, N. M. Bazhan

“…Food intake (FI), body weight (BW), blood parameters, and gene expression in the liver, muscles, brown adipose tissue, subcutaneous and visceral white adipose tissues, and hypothalamus were measured. FGF21 action strongly depended on the sex of the animals. …”
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Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Conclusion: The lower capability of LIT in changing the population of NKT cells compared to prednisolone therapy may be due to its mechanism of action, which is related to the production of blocking antibodies. …”
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