Człowiek i przyroda w nauce chrześcijańskiego Wschodu by Janusz Aptacy

“…Creation,  just as Rs Creator, does not thrust itself upon man, who sees the universe through the prism of his fall which in such a manner obscures and covers it, that he becomes more and more obdurate to the action of God.…”
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Assessing the feasibility of using publicly available data sources to identify healthcare data discrepancies and enhance service delivery: a retrospective cross-sectional study of... by Sheila Leatherman, Matthew Neilson, Alix Boisson-Walsh, Jack Lewis

“…Missing data existed for two specific metrics in all four countries, particularly within the improving clinical care domain.Conclusion The results are a clarion call for advancing efforts to develop standardised, publicly available, routinely collected and validated data sets to measure and publicly report LHDIS countries’ state of quality to marshal global attention and action in pursuit of more significant health equity.…”
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Pharmacological Mechanism of Zuojin Pill for Gastroesophageal Reflux Disease: A Network Pharmacology Study by Mi Lv, Jinke Huang, Jiayan Hu, Wenxi Yu, Ping Liu, Kunli Zhang, Fengyun Wang

“…Although Zuojin Pill (ZJP) is widely used in China as a traditional prescription to treat gastroesophageal reflux disease (GERD), its exact mechanism of action is still unknown. Therefore, we employed network pharmacology (NP), molecular docking (MD), and molecular dynamics simulation (MDS) to investigate the pharmacological mechanisms of ZJP against GERD. …”
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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

“…Metorigin metabolite traceability analysis and the MetaboAnalyst platform were utilized to explore the action mechanism. To evaluate changes in serum TMAO levels, targeted metabolomics was performed. …”
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Understanding the Mechanism and Selectivities of the Reaction of Meta-Chloroperbenzoic Acid and Dibromocarbene with β-Himachalene: A DFT Study by Sana El Hamidi, Malika Khnifira, El Mokhtar Lemdek, Redouan Hammal, Noureddine Barka, M’hamed Sadiq, Ahmed Benharref, Ahmed Chekroun, Hssaine Zgou, Mohamed Abdennouri

“…Transition states were located by QST2, and their highlighting was validated by the existence of only one imaginary frequency in the Hessian matrix. The action of m-CPBA on β-himachalene was analyzed on the two double bonds of β-himachalene whose theoretical calculations show that the attack affects the most substituted double bond on α side containing hydrogen of ring junction. …”
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The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review by Adam Sobiński, Matylda Czerwonka, Zuzanna Kościuszko, Katarzyna Kurza, Silvia Ciraolo, Julianna Podolec, Agnieszka Kulczycka-Rowicka, Katarzyna Lesiczka-Fedoryj, Joanna Wojda, Anna Walczak

“…It examines its mechanism of action, impact on muscle mass and strength, and role in brain health. …”
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Deprescribing and Optimal Selection of Proton Pump Inhibitors (Contributions of the 26th United Russian Gastroenterology Week) by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, V. I. Simanenkov, T. L. Lapina, I. B. Khlynov, N. N. Dekhnich, O. D. Lopina, O. P. Alekseeva, N. V. Korochanskaya, M. F. Osipenko, P. V. Pavlov, S. S. Pirogov, G. N. Tarasova, Yu. P. Uspenskiy, D. N. Andreev, D. E. Rumyantseva

“…A non-enzymatic metabolism, high acid suppression, stable antisecretory effect from day 1 of therapy and cytoprotective action justify the application of rabeprazole (Pariet®) for optimising therapies for acid-related diseases and implementing the deprescribing strategy.…”
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Developing transcriptomic biomarkers for TAVO412 utilizing next generation sequencing analyses of preclinical tumor models by Ying Jin, Peng Chen, Huajun Zhou, Guangmao Mu, Simin Wu, Zhengxia Zha, Bin Ma, Chao Han, Mark L. Chiu, Mark L. Chiu

“…TAVO412 has multiple mechanisms of action for tumor growth inhibition that include shutting down the EGFR, c-Met, and VEGF signaling pathways, having enhanced Fc effector functions, addressing drug resistance that can be mediated by the crosstalk amongst these three targets, as well as inhibiting angiogenesis. …”
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City of Wars: the Representation of Wartime London in Two Novels of the 1940s: James Hanley’s No Directions and Patrick Hamilton’s The Slaves of Solitude by Jean-Christophe Murat

“…The Slaves of Solitude choisit de décentrer l’action vers la banlieue lointaine—et fictive—de Thames Lockdon, qui accueille des Londoniens évacués par les bombardements. …”
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Application of the New Classification on Patients with a Disorder of Sex Development in Indonesia by A. Zulfa Juniarto, Yvonne G. van der Zwan, Ardy Santosa, Remko Hersmus, Frank H. de Jong, Renske Olmer, Hennie T. Bruggenwirth, Axel P. N. Themmen, Katja P. Wolffenbuttel, Leendert H. J. Looijenga, Sultana M. H. Faradz, Stenvert L. S. Drop

“…In all 58 46, XY DSD patients, 29 were suspected of a disorder of androgen action (12 with an androgen receptor mutation), and in 9, gonadal dysgenesis was found and, in 20, severe hypospadias e.c.i. …”
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ClimaWATCH: A new interactive tool for community heat-health vulnerability assessments by Aparna Keshaviah, Dheeya Rizmie, Huihua Lu, Mike Rudacille, Eric Morris, Colleen Psomas, Farid Qamar, Xindi C. Hu

“…Conclusion: Chief heat officers, public health officials, philanthropic organizations, and others can use ClimaWATCH to develop data-driven, tailored heat action plans to address the needs of different vulnerable populations effectively and equitably, prioritize interventions based on their potential for impact, and improve community and health system resilience to extreme heat.…”
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Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…SCZ was characterized by hyperconnectivity of the auditory network, visual system, and sensorimotor areas, and hypoconnectivity of the frontal gyrus, cerebellum, thalamus, and caudate nucleus, which were significantly linked to age, sex, duration of illness, and the severity of symptoms and functionally enriched in domains involving self, sensory, action, and social. 2922 genes were significantly over-expressed in these regions, which were enriched for important molecular functions, biological processes, and cellular components of the neurons/cells in the brain as well as SCZ and other mental diseases. …”
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Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract by Jelena Mudrić, Ljiljana Đekić, Nemanja Krgović, Đorđe Medarević, Katarina Šavikin, Milica Radan, Nada Ćujić Nikolić, Tijana Ilić, Bojana Vidović, Jelena Đuriš

“…The formulation also aimed to promote the local action of the extract in the stomach. <b>Methods:</b> Tablets were obtained by direct compression of sodium bicarbonate (7.5%) and solid lipid microparticles (92.5%), which were obtained with lyophilizing double emulsions. …”
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Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity by Yuming Zhang, Jinghua Lv, Xiaoli Sun, Yiwen Zhang, Menghua Shao, Bingbing Shi, Yajie Zhang, Jihai Gu, Chenchen Zhao, Fengsong Liu

“…To elucidate the toxicity of Sb and its mechanism of action, this study aimed to investigate the adverse effects of Sb on a cosmopolitan insect, housefly (Musca domestica), under a whole life cycle (from embryonic to adult stage) exposure through the examination of a suite of parameters, including biological, physiological, behavioral, and molecular endpoints. …”
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Comparison of the Effects of Articaine and Lidocaine Anesthetics on Blood Pressure after Maxillary Infiltration Technique: A Triple-Blind Randomized Clinical Trial by Amirhossein Moaddabi, Parisa Soltani, Maryam Zamanzadeh, Kamran Nosrati, Mojtaba Mollamirzaei, Mariangela Cernera, Gianrico Spagnuolo

“…Subsequent increase in blood pressure in healthy individuals commonly occurs and may be affected by several factors such as mental and physical stress, painful stimuli, and action of catecholamines present in local anesthetic solutions. …”
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Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities by Terence Nguema Ongone, Latyfa El Ouasif, Mostafa El Ghoul, Redouane Achour, Hind Chakchak, Meryem El Jemli, Yahia Cherrah, Katim Alaoui, Amina Zellou

“…The acute toxicity of these salts is evaluated according to OECD 423 Guidelines at the doses of 300 and 2000 mg/kg; their peripheral analgesic effect is studied using the Koster test at the therapeutic dose of 200 mg/kg and their sedative action is evaluated using Traction, Chimney, Hole-board, and Rotarod tests at the doses of 200 and 400 mg/kg. …”
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Dynamics of a mechanical system with nonlinear elastic suspension and spectral analysis of the results by V. A. Nekhaev, V. A. Nikolaev, A. N. Smalev, K. O. Seryakov

“…The article considers the dynamics of a nonlinear mechanical system under the action of a kinematic perturbation on it. The object's vibration isolation system is described by a rigid cubic power characteristic and is based on compensation of external perturbations — the introduction of an additional elastic element with negative stiffness into the suspension. …”
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Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis by Simona Ceccarelli, Cristina Nodale, Enrica Vescarelli, Paola Pontecorvi, Valeria Manganelli, Giovanni Casella, Maria Giuseppina Onesti, Maurizio Sorice, Ferdinando Romano, Antonio Angeloni, Cinzia Marchese

“…Our study contributes to clarify the molecular bases of human adipogenesis, demonstrating a role of KGF in the early steps of this process, and points out a role of NRP1 as a previously unknown mediator of KGF action in ASCs.…”
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Network relationship between cognitive function and quality of life in community-dwelling older adults: an observational study from Beijing by Yitian Ye, Yichun Zhang, Jiaju Ren, Yanbo Zhu, Yanbo Zhu

“…ObjectiveThis observational study aims to comprehensively explore the network relationship and mechanism of action between cognitive function and quality of life among community-dwelling older adults aged 60 and above in Beijing.MethodsThe research encompassed a cohort of 323 older adults individuals residing in the community in Beijing. …”
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Stryphnodendron adstringens have a modulatory effect on inflammatory cytokines markers of in vitro activated macrophages by Ivana Beatrice Mânica da Cruz, Cibele Ferreira Teixeira, Neida Luiza Pellenz, Moisés Henrique Mastella, Verônica Farina Azzolin, Euler Esteves Ribeiro, Fernanda Barbisan

“…Conclusions: The findings suggest that the wound-healing action of S. adstringens may encompass differential modulation of inflammation associated with tissue injury.…”
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