Failure Mechanism and Stability Control of Surrounding Rock of Docking Roadway under Multiple Dynamic Pressures in Extrathick Coal Seam by Xiangye Wu, Shuai Wang, Chen Tian, Changxing Ji, Jingya Wang

“…The results show that (1) through the analysis of the superimposed stress under the concentrated coal pillar and the coal seam in advance, the specific butt joint position is arranged at 860 m away from the open-off cut, which is 10 m away from the goaf of No. 12 coal seam. (2) With the working face 031604 advancing through the process, the deviatoric stress value of the withdrawal roadway gradually increases, the maximum principal stress of the two sides of the roadway deflects clockwise from the vertical direction to the horizontal direction, its angle also gradually increases, and the shape of the plastic zone gradually expands from symmetry to asymmetry. (3) It is revealed that the peak value of deviatoric stress on both sides of the docking position of docking roadway increases gradually under the influence of mining and deflects anticlockwise to the vertical direction with the principal stress angle. The joint action of both is the mechanical mechanism that causes the plastic zone to expand in an asymmetric shape. (4) The coordinated control scheme of support (anchor bolt and anchor cable)—modified (grouting)—is adopted for the withdrawal roadway, and the coordinated control scheme of support (anchor bolt and anchor cable)—changing the cross-section shape of the roadway—is adopted for the docking roadway. …”
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Two Small Peptides from <i>Buthus martensii</i> Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways by Mengshuang Zhu, Shanshan Zhang, Jiyang Tang, Hairong Hou, Lizhen Wang, Houwen Lin, Xuanming Zhang, Meng Jin

“…In silico prediction of therapeutic targets, MGC-803 cells and transgenic zebrafish models, and immunoblotting experiments were used to reveal the molecular mechanism of action of the peptides. The peptides AK and GK competitively bound to the receptor to modulate the TNF/TNFR-signaling cascade and alter the tumor microenvironment. …”
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Investigation on True Stress-Strain Curves of Flat and Corner Regions of Cold-Formed Section Using 3D Digital Image Correlation Method by Bo Xu, Junwu Xia, Renwei Ma, Jian Wang, Xiaomiao Chen, Hongfei Chang, Lihai Zhang

“…The stress status of the corner region is developed to ultimate strength at the early strain phase and exhibits a slight increase compared with the nominal values at the plastic phase. Cold-rolling action limits the ductility performance of the corner region, which highly restrains the tensile strain hardening at the plastic condition. …”
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Les syndicats, les commissaires et le politique : (re)valorisations et conflits autour de la profession policière en Tunisie (2011-2022) by Audrey Pluta

“…Finally, these upheavals of institutional norms as a result of union action can be seen in the questioning of a distribution of posts based on a historical division between "civilian" bodies (corresponding in particular to commissioners, inspectors, etc.) and "uniformed" bodies (officers, commanders, brigadiers, etc.). …”
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Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Results: Perfusate and intratracheal delivery of rIL-10 did not provide the therapeutic anti-inflammatory action that has been traditionally achieved with gene therapy. …”
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Persistence of gastrointestinal symptoms in irritable bowel syndrome and ulcerative colitis: study protocol for a three-arm randomised controlled trial (SOMA.GUT-RCT) by Ansgar W Lohse, Bernd Löwe, Kerstin Maehder, Yvonne Nestoriuc, Antonia Zapf, Eik Vettorazzi, Viola Andresen, Sina Hübener, Luisa Peters

“…The study will shed light onto the efficacy and mechanisms of action of a targeted expectation management intervention for persistent gastrointestinal symptoms in patients with UC and IBS. …”
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Synergistic Effects of FGF-18 and TGF-β3 on the Chondrogenesis of Human Adipose-Derived Mesenchymal Stem Cells in the Pellet Culture by Liangjie Huang, Lingxian Yi, Chunli Zhang, Ying He, Liangliang Zhou, Yan Liu, Long Qian, Shuxun Hou, Tujun Weng

“…TGF-β3 has shown a strong chondrogenic action on ADSCs. Recently, fibroblast growth factor 18 (FGF-18) has gained marked attention due to its anabolic effects on cartilage metabolism, but existing data regarding the role of FGF-18 on the chondrogenic potential of mesenchymal stem cells (MSCs) are conflicting. …”
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Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway by Katyakyini Muniandy, Sivapragasam Gothai, Khaleel M. H. Badran, S. Suresh Kumar, Norhaizan Mohd Esa, Palanisamy Arulselvan

“…In line with that, in this present study, we attempted to study the suppression activity of the proinflammatory cytokines and mediators as a characteristic of anti-inflammatory action, by using stem extract of A. sessilis in the lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophage cell line. …”
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Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 by Yanqing Liu, Jie Chen, Xiang Li, Yu Fan, Cheng Peng, Xiaochun Ye, Yingshuang Wang, Xin Xie

“…This review focuses on the latest advancements in targeting RAS with natural products and categorizes these natural products based on their mechanisms of action. Additionally, we discuss the challenges faced by these natural products during clinical translation, including issues related to pharmacokinetics. …”
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Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants by Amina Khatun, Mahmudur Rahman, Tania Haque, Md. Mahfizur Rahman, Mahfuja Akter, Subarna Akter, Afrin Jhumur

“…The results support their ethnomedicinal uses and require advanced investigation to elucidate responsible compounds as well as their mode of action.…”
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The Great Vietnamese Famine of 1944-45 Revisited by Geoffrey Gunn

“…No doubt a court of law would seek to distinguish between deliberate policy, benign neglect, and/or the unanticipated consequences of social action. But, rather than pinning blame as with a court of law or a war crimes trial, what I seek here is closer to a truth commission-style investigation that precisely seeks to uncover a number of thinly veiled truths that could possibly stimulate further research, not only on war and memory issues related to the famine, but also in the field of famine prevention.…”
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Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins by A. Catania, G. Colombo, C. Rossi, A. Carlin, A. Sordi, C. Lonati, F. Turcatti, P. Leonardi, P. Grieco, S. Gatti

“…It is remarkable that this mechanism of action in yeast mimics the influences of α-MSH in mammalian cells in which the peptide binds to G-protein-linked melanocortin receptors, activates adenylyl cyclase, and increases cAMP. …”
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Measurement and Analysis of Gait Pattern during Stair Walk for Improvement of Robotic Locomotion Rehabilitation System by Sang-Eun Park, Ye-Ji Ho, Min Ho Chun, Jaesoon Choi, Youngjin Moon

“…To obtain applicable data for the robotic system with vertically movable footplates, stair-walk action was measured using an optical marker-based motion capture system. …”
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Towards a net-zero healthcare system in Kenya: Stakeholder perspectives on opportunities, challenges and priorities by Iris Martine Blom, Melvine Anyango Otieno, Susannah Mayhew, Neil Spicer, Andy Haines, Sarah Whitmee

“…Conclusion: While the transition to net-zero poses challenges, stakeholders expressed optimism about the potential of current strong leadership, strategic partnerships, and the growing momentum for action on climate change and health. This research provides actionable insights and recommendations to guide Kenya's transition to a sustainable, resilient healthcare system, while offering valuable lessons for other countries facing similar challenges.…”
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Comparative effectiveness of eimeriocidal products for treatment of broiler chickens in small scale production by A. B. Dagaeva, B. M. Makhieva

“…Searching for new effective products with broad-spectrum antiparasitic action is one of priorities in avian eimeriosis control. …”
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Effect of the host-specific toxin SnTOX3 from Stagonospora nodorum on ethylene signaling pathway regulation and redox-state in common wheat by S. V. Veselova, G. F. Burkhanova, T. V. Nuzhnaya, S. D. Rumyantsev, I. V. Maksimov

“…The mechanism of SnTox3 action is likely to be linked to the regulation of redox metabolism and the influence on ethylene synthesis in the wheat plants, although the molecular mechanisms are not fully unveiled. …”
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Epidemiological Study of Hepatitis B, C and HIV Cases among the Foreigners Visiting Sulaimani City from 2013 Through 2016 by Mohammed Omer Mohammed, Asan Baram Hasan, Fenk Bakir Maarouf

“…While the highest HCV prevalence was among Europeans. An immediate action plan is needed to screen all Syrian refugees in our region for HBV, HCV and HIV to determine active infection and treat accordingly and also impose preventive measures to halt the spread of the infections. …”
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Comparative profitability of agroecological practices in Ethiopian wheat farming by Stanley Karanja Ng’ang’a, Sylvester Ochieng Ogutu, Degefie Tibebe, Devinia Akinyi, Jonathan Mockshell

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Transient Neonatal Zinc Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 (SLC30A2) Gene in the Mother Highlighting the Importance of Zn2+ for Normal... by Maria Consolata Miletta, Andreas Bieri, Kristin Kernland, Martin H. Schöni, Vibor Petkovic, Christa E. Flück, Andrée Eblé, Primus E. Mullis

“…Thus the coordinated action of both is essential for the maintenance of Zn2+ homeostasis in the cytoplasm, and accumulating evidence suggests that this is also true for the secretory pathway of growth hormone.…”
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Torque visuomotor feedback training versus standard eccentric exercise for the management of patellar tendinopathy: protocol for a randomised controlled trial by David Evans, Francesco Negro, Michail Arvanitidis, Eduardo Martinez-Valdes, Ragul Selvamoorthy, Patricio Pincheira

“…To gain insights on mechanisms of action for potential improvements, motor unit discharge characteristics of the quadriceps femoris muscles will be assessed with high-density surface electromyography. …”
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