Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IF... by Lúcia Cristina Jamli Abel, Ludmila Rodrigues Pinto Ferreira, Isabela Cunha Navarro, Monique Andrade Baron, Jorge Kalil, Ricardo Tostes Gazzinelli, Luiz Vicente Rizzo, Edecio Cunha-Neto

“…However, little is known about whether T. cruzi or GPI-mucins exert a similar action in human cells. We therefore decided to further investigate the in vitro cytokine production profile from human mononuclear cells from uninfected donors exposed to T. cruzi as well as tGPI-mucins. …”
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Strengthening public health education and humanitarian response through academic volunteerism by Faiza Rab, Mekdes Assefa, Salim Sohani, Ilja Ormel, Farwa Arshad, Ahmad Firas Khalid

“…Abstract Introduction Volunteers are an integral part of the International Red Cross and Red Crescent (RCRC) Movement, with over 16 million people actively contributing to humanitarian action worldwide. Academic volunteerism within the Movement includes contributions from students, volunteers and professionals from academic institutions who offer their time and expertise. …”
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Methodology for finding parameters of cutting transitions in APQP process of preproduction of new automotive components by L. R. Safarova, S. V. Kasyanov, D. T. Safarov

“…Using the example of an internal landing hole, the finding of diagnostic components of a special characteristic that are the result of the action of preknown technological factors is considered. …”
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Connecting the uninsured to care: Engaging new primary care patients at a new York City safety net system by Caroline Cooke, Christine Zhang, Jonathan Jiménez, Remle Newton-Dame

“…In lieu of state or federal action, city-sponsored healthcare access programs may offer a pathway to care for uninsured patients, including undocumented immigrants. …”
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The Effect of Calcitonin Gene-Related Peptide (CGRP) on the Cytosolic Calcium Concentration and Force in Rat Intramural Coronary Arteries by M. Sheykhzade, N.C.B. Nyborg

“…In resting coronary arteries, only pretreatment with the combination of 1 μM glibenclamide and 100 nM charybdotoxin attenuated the CGRP-induced decrease in the [Ca2+]i and tension, suggesting a different mechanism of action for CGRP in resting coronary arteries. We conclude that CGRP relaxes precontracted rat coronary arteries via three mechanisms: (1) a decrease in [Ca2+]i by inhibiting the Ca2+ influx through membrane hyperpolarization mediated partly by activation of BKCa channels, (2) a decrease in [Ca2+]i presumably by sequestrating cytosolic Ca2+ into thapsigargin-sensitive Ca2+ storage sites, and (3) a decrease in the Ca2+ -sensitivity of the contractile apparatus.…”
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Behavioral, biochemical, immune, and histological responses of Nile tilapia (Oreochromis niloticus Linnaeus, 1758) to lead, mercury, and pendimethalin exposure: individual and comb... by Rasha M. Reda, Eman M. Zaki, Ahmed A. A. Aioub, Mohamed M. M. Metwally, Aya M. Yassin, Fatma Mahsoub

“…Abstract The aquaculture sector is facing environmental issues because of rising chemical pollution of aquatic systems, which may be caused by man-made or natural causes. The combined action of these mixtures can produce an effect that is either severalfold higher or severalfold lower than the overall toxicity of the individual components. …”
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Evaluation of fluorinated phospholipid analogs: A study on ADMET profiles, molecular docking and dynamics simulation in anticancer therapy by Saqib Ishaq, Obaid Habib, Abdul Aziz, Raheel Tahir, Hira Mushtaq, Said Hassan, Sarah Sarwar, Mohammad S. Mubarak, Ajaz Ahmad, Amin Ullah

“…These findings position Edelfosine drug as a promising candidate for targeted cancer therapy appropriated further experimental validation to elucidate its mechanisms of action and therapeutic efficacy.…”
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Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3′-Processing Suppression by Sharif Karim Sayyed, Marzuqa Quraishi, D. S. Prabakaran, Balaji Chandrasekaran, Thiyagarajan Ramesh, Satish Kumar Rajasekharan, Chaitany Jayprakash Raorane, Tareeka Sonawane, Vinothkannan Ravichandran

“…<b>Conclusions</b>: Zinc C295’s dual inhibition of HIV-1 integrase ST and 3′P establishes it as a promising candidate for next-generation ART. Its dual-action mechanism may offer potential advantages in enhancing treatment efficacy and addressing drug resistance. …”
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Hybrid Approach in the Analysis of Bovine Milk Protein Hydrolysates as a Source of Peptides Containing Di- and Tripeptide Bitterness Indicators by Anna Iwaniak, Piotr Minkiewicz, Monika Hrynkiewicz, Justyna Bucholska, Małgorzata Darewicz

“…Hydrolysis was simulated using the BIOPEP-UWM “Enzyme(s) action” tool. Potentially released peptides (called parent peptides) were analyzed for the presence of shorter peptide regions with bitter taste. …”
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Oxytocin as a physiological correlate of dyadic music therapy relationships — a randomized crossover pilot study by Paula Kristin Busse, Lutz Neugebauer, Götz Kaschubowski, Dennis Anheyer, Dennis Anheyer, Dennis Anheyer, Thomas Ostermann

“…However, the mechanism of action of music or music therapy is not well understood. …”
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Toxicity of the Herbicide Roundup Original DI^® in Tadpoles of <i>Physalaemus erikae</i> and <i>Physalaemus cicada</i> (Anura: Leptodactylidae) by Mario Barbosa da Silva Junior, Renan Nunes Costa, Iuri Ribeiro Dias, Yvonnick Le Pendu, Mirco Solé, Caio Vinícius de Mira-Mendes, Victor Goyannes Dill Orrico

“…Our results extend the knowledge regarding the action of pesticides mainly for species of the genus <i>Physalaemus</i>, which is the best-known genus for glyphosate based-herbicide toxicity.…”
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Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model by Uzdrowska K, Knap N, Konieczna L, Kamm A, Kuban-Jankowska A, Gierałtowska J, Belka M, Baran M, Chlanda A, Kowiorski KM, Żołnierski A, Gulczynski J, Lipińska L, Bączek T, Izycka-Swieszewska E, Górska-Ponikowska M

“…The presence of polar hydroxyl groups enables the binding of 2-ME to GO/rGO through hydrogen bonds with epoxy and hydroxyl groups located on the surface and carbonyl and carboxyl groups located at the edges of graphene flake sheets.Methods: The patented method of producing the subject of the invention and the research results regarding its anticancer effectiveness via cytotoxicity in an in vivo model (against A375 melanoma and 143B osteosarcoma cells) are described.Results: It was shown that the inhibition of PTP1B phosphotyrosine phosphatase is one of the mechanisms of action of GO functionalised with 2-ME (GO-2-ME). This is a very important result, considering the fact that 2-ME itself has no inhibitory properties against this phosphatase.Discussion: Graphene oxide flakes embroidered with 2-methoxyestradiol molecules may be a promising solution, bringing a new and important effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME. …”
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Study on Seismic Dynamic Response of Deep-Buried Tunnel Based on Tectonic Stress by Junjie He, Song Hu, Yonggang Guo

“…The dynamic responses of the tunnel-engineering area under seismic action were calculated, followed by an analysis of the dynamic response characteristics. …”
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Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics by David Chamoso-Sanchez, Martina Panini, Clarissa Caroli, Matilde Marani, Lorenzo Corsi, Francisco J Rupérez, Antonia Garcia, Federica Pellati

“…., which has shown an antiproliferative action in these type of cancer cells. CBD treatment reduced cell viability and initiated apoptotic and necrotic processes in both cancer cell lines in a time and dose-dependent manner, showing acute myeloid leukaemia (HL-60) cells greater sensitivity than chronic myeloid leukaemia ones (K-562), without differences in the activation of caspases 3/7. …”
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Research on Hydraulic Fracturing Pressure Relief Technology in the Deep High-Stress Roadway for Surrounding Rock Control by Wen Zhai, Yachao Guo, Xiaochuan Ma, Nailv Li, Peng Zhang, Kun Ma, Yuanxin Jing, Hong Yu, Xiaotong Li

“…The numerical simulation shows that under the action of hydraulic fracturing, the cutting slot is formed, the deformation and failure mode of the roof are changed, the stress of surrounding rock is reduced, and the development of the plastic zone of surrounding rock is limited. …”
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Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids by Arun Sridhar, Ingunn Bakke, Shreya Gopalakrishnan, Nimo Mukhtar Mohamud Osoble, Emilie Prytz Hammarqvist, Henrik P. Sahlin Pettersen, Arne Kristian Sandvik, Ann Elisabet Østvik, Marianne Doré Hansen, Torunn Bruland

“…It is likely that these drugs will have distinct mechanisms of action (MOA) in intestinal epithelium relevant for homeostasis that will vary among patients. …”
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Technicolor Middle Ages: (Ex)changes and Transformations from Medieval to Present Day Perception of Colour by Agnès Blandeau

“…Dans chacun d’eux, l’action se situe au moyen-âge. Il s’agit de The Adventures of Robin Hood (1938), Ivanhoe (1952) et The Knights of the Round Table (1953). …”
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Green guardians: The biocontrol potential of Pseudomonas-derived metabolites for sustainable agriculture by Ruihuan Yang, Xiangning Du, Moein Khojasteh, Syed Mashab Ali Shah, Yongzheng Peng, Zhangfei Zhu, Zhengyin Xu, Gongyou Chen

“…It discusses the chemical diversity of these metabolites, their broad-spectrum bioactivities against pathogenic bacteria and fungi, oomycetes, nematodes, and their modes of action. The genetic and enzymatic processes involved in AMs production, and the regulatory mechanisms that control these pathways in response to environmental signals. …”
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Energy-innovation knowledge common connection point management in preventing outbreak of the Covid-19 pandemic in a University by V. Shcherbak, I. Gryshchenko, L. Ganushchak-Yefimenko, O. Nifatova, V. Bobrovnyk, M. Verhun

“…In the optimistic scenario (end of Covid-19 pandemic), by means of the suggested energy efficiency monitoring system, the probability of using category A offices makes 100%, B offices- 50% and C offices - 13%.CONCLUSION: Implementation of the developed energy efficiency action plan will offer the opportunity for the University to use reasonably the common connection point of knowledge management of energy complexes with non-conventional renewable energy sources in the context of preventing a new outbreak of the Covid-19 pandemic. …”
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A cycle of invisibilisation: a qualitative study of Brazilian health system factors shaping access to long COVID care by Emma-Louise Aveling, Margareth Crisóstomo Portela, Letícia Soares, Bárbara Caldas, Brenda Sabaine, Flora Cornish

“…Professionals’ under-recognition perpetuates administrators’ de-prioritisiation of resources, policies and training necessary to ensure access to appropriate care, creating a cycle of invisibilisation.Conclusion Urgent action to disrupt a cycle of invisibilisation is essential to mitigate patients’ suffering and intensification of inequalities. …”
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