Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice by Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F

“…Regarding its mode of action, we demonstrated that the 6F7 antibody is not a depleting antibody and does not block HVEM binding to BTLA, but instead induces BTLA down modulation and exhibits in vivo agonist activity.Conclusion: Overall, our data confirm the involvement of BTLA in lupus pathogenesis and provide the first evidence that BTLA is a potential therapeutic target for the treatment of lupus.Keywords: systemic lupus erythematosus, BTLA, lupus mice, inhibitory receptors…”
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The economic situation of state farms and collective farms Altai Territory in the second half of 1980s by D. S. Orlov, A. A. Chirkov

“…Using materials on the Altai Territory, the author substantiates the thesis that the action of new mechanisms for the economic development of agricultural production and a favorable investment climate became the reasons for the improvement in the welfare of collective farms and state farms in the economic period under review, led to a significant increase in agricultural production. …”
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PRDX2 induces tumor immune evasion by modulating the HDAC3-Galectin-9 axis in lung adenocarcinoma cells by Yunjia Dong, Anqi Cheng, Jiawei Zhou, Jianqiang Guo, Yafeng Liu, Xuan Li, Maoqian Chen, Dong Hu, Jing Wu

“…This study aims to investigate the impact of PRDX2, which is highly expressed in lung adenocarcinoma, on T cells in the tumor immune microenvironment, and its immune action target to promote the immune escape of lung cancer cells, to provide a theoretical basis for lung adenocarcinoma treatment with PRDX2 as the target. …”
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Exploring social capital for family caregivers of patients with chronic organ failure: study protocol for a concept mapping study by Kai Chow Choi, Carmen Wing Han Chan, Marques Shek Nam Ng, Winnie Kwok Wei So, Wallace Chi Ho Chan, Helen Yue Lai Chan

“…In Phase III, the concept map will be used to formulate action plans. The findings will be presented to the public to produce recommendations for social policy.Ethics and dissemination This study was approved by The Chinese University of Hong Kong Survey and Behavioural Research Ethics Committee (Reference No.: SBRE-20-714). …”
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Modulatory Effect of 1,25-Dihydroxyvitamin D3 on IL1β-Induced RANKL, OPG, TNFα, and IL-6 Expression in Human Rheumatoid Synoviocyte MH7A by Xiaoke Feng, Chengyin Lv, Fang Wang, Ke Gan, Miaojia Zhang, Wenfeng Tan

“…In summary, although it has a biological function to induce RANKL expression, 1,25(OH)2D3 could upregulate OPG/RANKL ratio and mediate anti-inflammatory action in an inflammatory milieu of synoviocyte, contributing to the inhibition of inflammation-induced osteoclastogenesis in RA.…”
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A thorny pathway of macrophage activating factor (GcMAF): from bench to bedside by A. A. Ostanin, S. S. Kirikovich, E. V. Dolgova, А. S. Proskurina, E. R. Chernykh, S. S. Bogachev

“…DBP is converted to GcMAF as a result of site-specific selective deglycosylation under the action of β-galactosidase and sialidase, localized on activated B and T cells, respectively. …”
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The Proapoptotic Effect of MB-653 Is Associated with the Modulation of Metastasis and Invasiveness-Related Signalling Pathways in Human Colorectal Cancer Cells by Libor Sokoli, Peter Takáč, Mariana Budovská, Radka Michalková, Martin Kello, Natália Nosálová, Ľudmila Balážová, Šimon Salanci, Ján Mojžiš

“…Flow cytometry and Western blot analysis were employed to investigate the molecular mechanisms underlying cytotoxicity, proapoptotic action, and anti-invasion effects. The proapoptotic activity was evidenced by the activation of caspases 3 and 7, mitochondrial dysfunction, and an increased number of apoptotic cells, confirmed by annexin V/PI and AO/PI staining. …”
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Development of sustained-release extemporaneous moxifloxacin loaded commercial soft hydrogel contact lenses by Duy Toan Pham, Pratthana Chomchalao, Kunasin Bunneramit, Phurichaya Kladcharoen, Rossukon Khotcharrat, Waree Tiyaboonchai

“…Conclusively, the extemporaneous moxifloxacin loaded contact lenses, with a duration of action of at least 12 h, could be further explored to become a potential treatment for eye infections.…”
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The influence of land surface temperature on Ghana’s climate variability and implications for sustainable development by Collins Oduro, Kenny Thiam Choy Lim Kam Sian, Daniel Fiifi Tawia Hagan, Hassen Babaousmail, Brian Odhiambo Ayugi, Yanjuan Wu, Tatenda Dalu, Naicheng Wu

“…The insights are vital for developing targeted adaptation strategies, including integrated land and water management, sustainable agriculture, and effective interventions, directly supporting the United Nations Sustainable Development Goals (SDG) 13 (Climate Action) and SDG 15 (Life on Land). Moreover, the study provides evidence for promoting climate-smart agriculture to ensure food security (SDG 2). …”
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Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways by Zeynab Pirmoradi, Zahra Esmaili, Mohsen Nakhaie, Kristi A. Kohlmeier, Mohammad Shabani, Moazamehosadat Razavinasab, Mehran Ilaghi

“…The ability of agmatine to normalize Lingo‐1 and IL‐6 expression suggests regulation of these pathways could underlie its neuroprotective action. These results suggest promise for agmatine as a prospective therapeutic agent in ET.…”
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Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons by Yuanlong Song, Zifen Xu, Liangpin Zhang, Linlin Gao

“…Our results revealed several key findings: (1) The expression of Sig-1R was found to be upregulated during the progression of inflammatory pain, with a notable translocation from the cytoplasm to the membrane; (2) Inhibition of peripheral Sig-1R using S1RA resulted in a reduction of CFA-induced allodynia; (3) Activation of Sig-1R through PRE-084 led to a decrease in the fast sodium current in isolated DRG neurons from CFA-treated rats, which was associated with a diminished action potential (AP) peak and maximum depolarizing rate (MDR), as well as an increased rheobase; (4) Furthermore, PRE-084 was observed to enhance the slow component of the sodium current, resulting in hyperpolarization of the threshold potential and an increase in AP firing frequency, alongside an elevation in the mRNA expression of the slow sodium channel Nav1.9 in CFA-treated rats. …”
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MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models by Jianwei Lv, Yiran Huang, Shiguo Zhu, Ganggang Yang, Yujian Zhang, Jing Leng, Juanjie Bo, Dongming Liu

“…This study was undertaken to explore the mechanism of action of MCP-1 in the development of IC/BPS. Methods. …”
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Research on Corrosion Damage and Bearing Characteristics of Bridge Pile Foundation Concrete under a Dry-Wet-Freeze-Thaw Cycle by Zhongju Feng, Jianwei Huo, Haibo Hu, Ruixin Zhao, Fuchun Wang, Guan Jiang, Xianhua Yao, Tie Li, Zhenyu Song

“…After one year of outdoor dry-wet-freeze-thaw cycle test, due to the interaction of compound salts, the quality of specimens is reduced under the denudation of chloride ions, while the mass of specimens is increased by the corrosion products formed under the joint action of carbonate and sulfate, resulting in less obvious change of specimen quality, the antierosion coefficient of the specimens decreased, the maximum loss rate of compressive strength was 38.2%, and the pile foundation began to deteriorate. …”
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Factors related to milk donation based on the theory of planned behavior in pregnant women by Leili Alizamani, Rasoul Raesi, Vahid Ghavami, Hadi Tehrani, Javad Moghri, Sara Khazaei Nasir Abadi, Seyed Saeed Tabatabaee

“…Abstract The willingness to donate milk is influenced by maternal behavior, and the Theory of Planned Behavior is recognized as a significant predictor of this action. This study aims to identify the factors associated with milk donation among pregnant women based on the Theory of Planned Behavior. …”
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Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diab... by Shimaa Ramadan, Amany Mohamed Hegab, Yahya S. Al-Awthan, Mohammed Ali Al-Duais, Ahmed A. Tayel, Mahmoud A. Al-Saman

“…Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels that occurs either due to insufficient insulin production or mounting resistance to its action. The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica, and Punica granatum leaves had any effect on blood sugar levels in normal and streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract. …”
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Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori by Tieshan Feng, Ping Lin, Jiao Gong, Dong Cheng, Xi Yang, Quan Zhang, Tingcai Cheng

“…These results suggest that α-toxin can induce various immune responses in silkworm, and further studies are warranted to understand the mechanism of α-toxin action in silkworm. Further, lncRNAs and differentially expressed genes were correlated using coexpression network analysis. …”
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An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice. by Paromita Bag, Durbadal Ojha, Hemanta Mukherjee, Umesh Chandra Halder, Supriya Mondal, Nidhi S Chandra, Suman Nandi, Ashoke Sharon, Mamta Chawla Sarkar, Sekhar Chakrabarti, Debprasad Chattopadhyay

“…The cytotoxicity (CC50), effective concentrations (EC50) and the mode of action of HM was determined by MTT, plaque reduction, time-of-addition, immunofluorescence (IFA), Western blot, qRT-PCR, EMSA, supershift and co-immunoprecipitation assays; while the in vivo toxicity and efficacy was evaluated in BALB/c mice. …”
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Pathogenetic Substantiation of the Therapeutic Impact on Microbiota in Irritable Bowel Syndrome by Yu. O. Shulpekova, G. H. Babaeva, V. Yu. Rusyaev

“…The majority of studies on IBS have demonstrated the predominance of intestinal bacteria with pro-inflammatory potential (Enterobacteriaceae) and the lack of bacteria with a pronounced anti-inflammatory, antimicrobial and enzymatic action (Lactobacillus and Bifidobacterium), as well as increased mucus degradation. …”
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Inhibitory effects of rambutan (Nephelium lappaceum l.) leaves ethanolic extract on Methicillin-Resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes by Leonny Dwi Rizkita, Rizka Ariani, Muhammad Farid, Ardestya Rastrani, Widya Aryana Ramadhania, Ratna Aprillia Eka Putri

“…These findings underscore the potential of rambutan leaf extract as a natural antimicrobial agent against resistant Gram-positive bacteria, warranting further investigation into its bioactive compounds and mechanisms of action.…”
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The Role of Non-Governmental Organisations (NGOs) on the Socio¬economic Transformation of Rural Areas in Nyarusiza Sub-County Kisoro District. by Izabayo, Joan

“…The data collection methods are put into action in Chapter 3. The research used both qualitative and quantitative methods of data collection and analysis. …”
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