Synthesis and protective effect of pyrazole conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and a... by Zang Binbin, Wang Lihui

“…The current work was conducted to elucidate the pharmacological effect of pyrazole-conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in rats in sepsis and their mechanism of action. Various pyrazole-conjugated imidazo[1,2-a]-pyrazine derivatives have been synthesized in a straightforward synthetic route. …”
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Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats by Peng-zhi Chen, Hui-hui Jiang, Bo Wen, Shuan-cheng Ren, Yang Chen, Wei-gang Ji, Bo Hu, Jun Zhang, Fenglian Xu, Zhi-ru Zhu

“…Moreover, whole-cell patch clamp results indicated that the protective function of GAS on abnormal hyperexcitability may be partially mediated by its inhibitory action on Aβ1−42-elicited inward currents in EC neurons. …”
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Chloroplast Vesiculation and Induced Chloroplast Vesiculation and Senescence‐Associated Gene 12 Expression During Tomato Flower Pedicel Abscission by Magda Tušek Žnidarič, Maja Zagorščak, Živa Ramšak, Katja Stare, Marko Chersicola, Maruša Pompe Novak, Aleš Kladnik, Marina Dermastia

“…Ethylene signaling appears to be involved in the regulation of these processes, as treatment with a competitive inhibitor of ethylene action, 1‐methylcyclopropene, delayed vesiculation, reduced the expression of SAG12, and increased expression of Curvature Thylakoid 1A (CURT1A). …”
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Skull vibration induced nystagmus, velocity storage and self-stability by Ian S. Curthoys, David S. Zee, Georges Dumas, Georges Dumas, Christopher J. Pastras, Julia Dlugaiczyk

“…The basis for this hypothesis is that vibration is a selective stimulus for vestibular neurons with irregular resting discharge. 100 Hz mastoid vibration, while capable of generating nystagmus (skull vibration induced nystagmus SVIN), is ineffective in generating afternystagmus (in the condition of an encased labyrinth) which is a marker of the action of the VSI, leading to the conclusion that irregular afferents bypass the indirect pathway and the VSI. …”
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Effects of Homeopathic Arsenicum Album, Nosode, and Gibberellic Acid Preparations on the Growth Rate of Arsenic-Impaired Duckweed (Lemna gibba L.) by Tim Jäger, Claudia Scherr, Meinhard Simon, Peter Heusser, Stephan Baumgartner

“…It yielded evidence for specific effects of homeopathic Arsenicum album preparations and it will provide a valuable tool for future experiments that aim at revealing the mode of action of homeopathic preparations. It may also be useful to investigate the influence of external factors (e.g., heat, electromagnetic radiation) on the effects of homeopathic preparations.…”
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Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest by Jojanneke Stoof, Zakaria Kalmoua, Ana Sobota, Ruud H. Brakenhoff, Marijke Stigter, Thang V. Pham, Sander R. Piersma, Alex Henneman, Tonny Lagerweij, Richard de Goeij-de Haas, R. Jeroen A. van Moorselaar, Connie R. Jimenez, Irene V. Bijnsdorp

“…Our findings demonstrate PAS’s mode of action and suggest its potential as a promising treatment for bladder cancer, warranting further clinical studies.…”
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Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella by Yajun Zhai, Peiyi Liu, Xueqin Hu, Changjian Fan, Xiaodie Cui, Qibiao He, Dandan He, Xiaoyuan Ma, Gongzheng Hu

“…However, combination of AS and colistin (COL) revealed a weak synergistic effect against a limited number of strains, and few studies have further explored its possible mechanism of synergistic action. In this article, we found that AS and EDTA could strikingly enhance the antibacterial effects of COL against mcr-1- and mcr-1+ Salmonella strains either in vitro or in vivo, when used in triple combination. …”
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Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus by Nimat Abuelwafaa, Hana Ahmed, Ilham Omer, Mohamed Abdullah, Ammar Ahmed, Afraa Musa

“…Regarding abnormal NCS parameters (conduction velocity vs. amplitude of the compound action potential), conduction slowing feature predominated in 61.4% and only few (6.8%) showed amplitude reduction, while 31.8% showed mixed features. …”
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Atom-Driven and Knowledge-Based Hydrolysis Metabolite Assessment for Environmental Organic Chemicals by Zhe Liu, Yufan Lin, Qi He, Lingjie Dai, Qinyan Tan, Binyan Jin, Philip W. Lee, Xiaoming Zhang, Li Zhang

“…The metabolism of environmental organic chemicals often relies on the catalytic action of specific enzymes at the nanoscale, which is critical for assessing their environmental impact, safety, and efficacy. …”
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Understanding sociodemographic differences in climate behavior, climate policy acceptance, and political participation by Lena Lehrer, Lennart Hellmann, Cornelia Betsch

“…Methods: Data from four waves (2022–2023) of the Planetary Health Action Survey (PACE) were analyzed (N = 3,830, nonprobabilistic representative German sample). …”
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3D printed magnesium silicate/β-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis by Lulu Wang, Mingkui Shen, Zhongxin Tang, Jun Tan, Kuankuan Li, Haijun Ma

“…In this research, we evaluated and analyzed magnesium silicate/β-Tricalcium phosphate (MS/β-TCP) scaffold on angiogenesis and bone regeneration in vitro and in vivo, and the mechanism of its action were described. Achieving magnesium and silicon ions sustained release, 3D printed MS/β-TCP scaffolds possessed appropriate mechanical properties and had excellent biocompatibility that was suitable for osteoblastic MC3T3-E1 cells and human umbilical vein endothelial cells (HUVECs) with proliferation, adhesion, and migration. …”
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The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review by Ambra Di Piazza, Federica Vernuccio, Massimo Costanzo, Laura Scopelliti, Dario Picone, Federico Midiri, Francesco Salvaggi, Francesco Cupido, Massimo Galia, Sergio Salerno, Antonio Lo Casto, Massimo Midiri, Giuseppe Lo Re, Roberto Lagalla

“…Gastrointestinal tract involvement in these patients may also due to both a direct action of antibodies against organs and pharmacological therapies. …”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…It considers how incorporating longer follow-up in DREAMM-3 may have better captured the clinical benefits of belantamab mafodotin, particularly given its multimodal, immune-related mechanism of action with responses deepening over time. A non-inferiority hypothesis may have been more appropriate rather than superiority in the context of a monotherapy versus an active doublet therapy. …”
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Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity by Vinay Mishra, Priya Ghumatkar, Maulik V. Patel, Shilpesh Devada, Ramchandra Ranvir, Prabodha Swain, Rajesh Sundar, Rajesh Bahekar, Mukul R. Jain

“…The present study was designed to evaluate the cardioprotective action of T3 in isoproterenol-(ISO-) induced cardiac toxicity. …”
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An Overview of the Impact of Statin Therapy on Cardiac Incident Risk by Urszula Świrk, Aleksandra Paprocka, Karolina Kalinowska, Paulina Fijałek, Jan Karczmarz, Marika Gutowska, Agnieszka Kosińska, Wiktoria Belcarz, Joanna Orzechowska, Michał Orzechowski

“…This review presents a comprehensive overview of the impact of statin therapy on cardiac incident risk, examining its efficacy in primary and secondary prevention, the underlying mechanisms of action, associated adverse effects, and considerations for patient adherence. …”
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Recent Advances in Biotechnological Methods for Wheat Gluten Immunotoxicity Abolishment – a Review by Vijole Bradauskiene, Lina Vaiciulyte-Funk, Bakht Ramin Shah, Darius Cernauskas, Mihaela Adriana Tita

“…Some of the enzymes hydrolyze gluten, others block the action of toxic protein fragments. The majority of studies were carried out using lactic acid bacteria cultures, as single strains or in consortia. …”
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Low-Level Laser Therapy and Calcitonin in Bone Repair: Densitometric Analysis by Tatiana Pinto Ribeiro, Simone Bustamante Nascimento, Claúdia Alessandra Cardoso, Raduan Hage, Janete Dias Almeida, Emilia Angela Loschiavo Arisawa

“…Calcitonin has antiosteoclastic action and LLLT is a treatment that uses low-level lasers or light-emitting diodes to alter cellular function. …”
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Efficacy and compatibility mechanism of bear bile powder in Shexiang Tongxin dropping pills for acute myocardial infarction treatment by Yu Luo, Fangmin Zhang, Lidan Zhu, Jianfeng Ye, Hong-ye Pan, Xiaoyan Lu, Xiaohui Fan

“…The efficacy and compatibility mechanisms of action of BBP in STDP against cardiovascular diseases remain unclear. …”
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Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (Gadus mor... by Fekadu Yadetie, Xiaokang Zhang, Anna Reboa, Gwenaëlle Samantha Chloe Noally, Mariann Eilertsen, Mitchell Stewart Fleming, Jon Vidar Helvik, Inge Jonassen, Anders Goksøyr, Odd André Karlsen

“…IntroductionThe pituitary and liver are among the main sites of action of estrogens in fish. Years of research has shown that xenoestrogens can interfere with functions of estrogens. …”
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Interaction of norsecurinine-type monomeric and dimeric alkaloids with α-tubulin: a molecular docking study by Gérard Vergoten, Christian Bailly

“…The study contributes to a better understanding of the mechanism of action of Flueggea alkaloids and should help the design of anticancer analogues targeting the pironetin site of α-tubulin.…”
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