NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…Clinical trials have demonstrated that combination of daclatasvir with other medications possessing direct antiviral action, in particular with asunaprevir, and with pegilated interferon and ribavirin significantly increases treatment response rate at different categories of patients with chronic HCV-infection; that allows to reduce treatment duration of these patientsgroups. …”
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The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential by Ling Chen, Yi Chen, Wen Bin Fu, Dong Feng Huang, Wai Leung Ambrose Lo

“…Outcome measures of the contingent negative variation (CNV) latency and amplitude, EMG reaction time, Upper Limb Fugl-Meyer Assessment (UL-FMA), Action Research Arm Test (ARAT), and National Institutes of Health Stroke Scale (NIHSS) were recorded pre- and postintervention. …”
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Study on Overburden Rock Movement and Stress Distribution Characteristics under the Influence of a Normal Fault by Quansen Wu, Peng Kong, Quanlin Wu, Xinggang Xu, Xingyu Wu, Tao Guo

“…When the accumulated energy reaches a certain threshold, under the action of normal stress or shear stress, the fault will be activated, and a large amount of energy will be released, which can easily induce a rock burst. …”
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Experimental Study on Fe3O4 Nanoparticle-Assisted Microwave Enhancing Heavy Oil by Teng Lu, Faqiang Dang, Haitao Wang, Qingmin Zhao, Zhengxiao Xu

“…Obtaining the mechanism of nanoparticle-assisted microwave to enhance oil recovery, one of which is that nanoparticles improve the wave absorption and heating capacity of heavy oil and increase the heating speed of heavy oil; the second is that the nanoparticles form local high temperature under the action of microwave, which catalyzes the hydrocracking reaction between the heavy components in the heavy oil and the hydrogen donor, upgrading and reducing the viscosity of the heavy oil, and accelerating the production of heavy oil.…”
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Lung-homing nanoliposomes for early intervention in NETosis and inflammation during acute lung injury by Jungbum Kim, Donghyuk Seo, So-Yeol Yoo, Hye-Jin Lee, Jisun Kim, Ji Eun Yeom, Jae-Young Lee, Wooram Park, Kyung Soo Hong, Wonhwa Lee

“…Through intratracheal delivery, we intend prompt and constant action within the lungs to effectively prevent excessive NETosis. …”
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Investigation of intracellular signals generated by γ-interferon and IL-4 leading to the induction of class II antigen expression by S. Vassiliadis, N. Kyrpides, D. Stravopodis, M. Grigoriou, I. Athanassakis, J. Papamatheakis

“…These findings are firmly supported by other reports and show, in addition, a unique action exerted by γ-IFN, since IL-4, another inducer of class II antigen expression, uses different pathways. …”
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Efficacy and safety of new protease inhibitor faldaprevir in treatment of hepatitis C by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…Significant progress was achieved in development of new modes of antiviral treatment of patients with the 1st HCV genotype due to introduction of the third agent possessing direct antiviral action. Faldaprevir (BI-201335) is NS3/4A protease inhibitor with long-term half-life period that allows once per day dosing. …”
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A Woman with a Long History of Smoking and a Debilitating Dry Cough by N. D. Potskhverashvili, N. I. Kokina, E. L. Bueverova, O. Yu. Zolnikova, A. S. Cherenda, V. A. Morozova, M. V. Feldsherov, A. P. Kiryukhin, P. V. Pavlov

“…A 56-year-old patient with a long history of smoking was hospitalized in the pulmonology department of the clinic with a leading complaint of a constant debilitating dry cough during the day, not amenable to the action of drugs, as well as general weakness, sweating and weight loss by 2 kg in 3 months. …”
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Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction by Etukudo Okon Jimmy, Grace Edet Bassey, Abijah Ekwere, Udoh Idorenyin Umoh, Adeyemi Fatai Odetayo, Udoh Nsikan Malachy

“…Further investigations are necessary to elucidate the underlying mechanisms of action, determine optimal dosages, and evaluate the long-term safety profiles of these herbal extracts for potential human applications.…”
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Evaluation of community behavior regarding the risk of plastic micro-pollution on the environment health by D. Utari, N.I. Hawa, G. Fizumli, H. Agustina

“…This variable influences 11.8 percent of the behavior in question. Attitude and action variables do not have a significant relationship partially or simultaneously with household plastic waste management behavior.CONCLUSION: Increased plastic consumption has led to microplastic pollution, environmental damage, and deteriorating health conditions. …”
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Influence of Dry Beach on the Dynamic Stability of Ash Storage Field: A Numerical Analysis by Fangtao She, Chang Liu, Xiangang Zhou, Changjun Qi, Jiulong Ding

“…As the length of the dry beach increases, the maximum horizontal displacements show a certain decrease, but they occur progressively further away from the third subdam, so that, under dynamic action, the dams become safer. The extent of liquefaction decreases at larger dry beach length and extends further away from the third subdam into the ash storage area. …”
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Phytochemistry and pharmacological advances of Ascophyllum nodosum in the management of human diseases: A comprehensive review by Brijesh Singh Chauhan, Yash Pal Singh

“…Results: We conducted a comprehensive review of the research progress on ANE, focusing on its pharmacological effects on various diseases using animal models, mechanisms of action, and composition, are as not explored in preceding reviews. …”
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Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats by Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan

“…These findings indicate that the depressor action and sympathetic inhibition of DCXD on salt-sensitive hypertension may be by ameliorating brain sodium sensitivity, modulating ENaC function, and inhibiting the expression of ENaC and NADPH oxidase in the hypothalamic paraventricular nucleus.…”
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Manganese Inhalation as a Parkinson Disease Model by José Luis Ordoñez-Librado, Verónica Anaya-Martínez, Ana Luisa Gutierrez-Valdez, Laura Colín-Barenque, Enrique Montiel-Flores, Maria Rosa Avila-Costa

“…After 5 months of Mn mixture inhalation, striatal dopamine content decreased 71%, the SNc showed important reduction in the number of TH-immunopositive neurons, mice developed akinesia, postural instability, and action tremor; these motor alterations were reverted with L-DOPA treatment. …”
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Administration of a Next-Generation Probiotic Escherichia coli Nissle 1917-GLP-1 Alleviates Diabetes in Mice With Type 1 and Type 2 Diabetes by Jie Luo, Yilin Fang, Zhanghua Qi, Fengyang Cui, Hong Hu, Shengjie Li, Tingtao Chen, Hongyan Zhang

“…Nonetheless, the efficacy of GLP-1 is limited by its brief duration of action, rapid clearance from the body, and challenges associated with subcutaneous administration. …”
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Integration of Metabolomics and Transcriptomics to Reveal the Antitumor Mechanism of <i>Dendrobium officinale</i> Polysaccharide-Based Nanocarriers in Enhancing Photodynamic Immuno... by Shengchang Tao, Huan Wang, Qiufeng Ji, Yushan Yang, Gang Wei, Ruiming Li, Benjie Zhou

“…<b>Methods</b>: The effects of TPA-3BCP-loaded cholesteryl hemisuccinate–<i>Dendrobium officinale</i> polysaccharide nanoparticles (DOP@3BCP NPs) and their potential molecular mechanism of action in a tumor-bearing mouse model of CRC were investigated using non-targeted metabolomics and transcriptomics. …”
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Indonesian mosaic: the essential need for multicultural education by Dwi Mariyono

“…Through a systematic review of academic literature, policy documents and reports, this study aims to provide insights into the challenges and opportunities associated with multicultural education and propose action-based and actionable solutions to promote tolerance, understanding and unity among diverse cultural groups. …”
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Rock fracture mode and acoustic emission characteristics under true triaxial single-sided unloading path by Longpei Ma, Longpei Ma, Chongyan Liu, Guangming Zhao, Guangming Zhao

“…While the proportions of tensile cracks in siltstone and fine sandstone are 41.43% and 56.41% respectively. Under the action of axial stress, they are prone to longitudinal splitting and form tensile cracks approximately parallel to the direction of the maximum principal stress. …”
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Prevalence and factors associated with symptoms of depression, anxiety and stress among traffic police officers in Kathmandu, Nepal: a cross-sectional survey by Pranil Man Singh Pradhan, Binita Yadav, Anil KC, Sandesh Bhusal

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Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations by Jingbo Xie, Jian Guo, Zaeema Kanwal, Mingzheng Wu, Xiangyang Lv, Nihal Abdalla Ibrahim, Ping Li, Manal Ali Buabeid, El-Shaimaa A. Arafa, Qingshan Sun

“…Aside from having a similar structure, these peptides have few overlapping biological activities and signal transduction action through related receptors. However, several other activities are also present that are peptide specific. …”
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