Deapioplatycodin D inhibits glioblastoma cell proliferation by inducing BNIP3L-mediated incomplete mitophagy by Yu Sun, Guangze Zhu, Renshuang Zhao, Yaru Li, Hongyang Li, Yunyun Liu, Ningyi Jin, Xiao Li, Yiquan Li, Tiemei Liu

“…This study aimed to investigate the effects of DPD on glioblastoma (GBM) cells and to determine its intrinsic mechanism of action. Using a CCK8 assay, it was found that DPD significantly inhibited the growth of GBM cells. …”
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Estimates of Combining Ability and Heterosis for Yield and Its Related Traits in Pearl Millet Inbred Lines under Downy Mildew Prevalent Areas of Senegal by Ghislain Kanfany, Amadou Fofana, Pangirayi Tongoona, Agyemang Danquah, Samuel Offei, Eric Danquah, Ndiaga Cisse

“…However, the contribution of GCA to total mean squares was higher than that of SCA for all the traits, providing that additive gene action was more important in their inheritance. The top-cross hybrid IBL155-2-1 × Sosat C 88 exhibited negative and significant SCA effects for downy mildew incidence, flowering time, and plant height. …”
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Phytochemical profile, therapeutic potentials, nutritional composition, and food applications of ginger: a comprehensive review by Great Iruoghene Edo, Ufuoma Augustina Igbuku, Raghda S. Makia, Endurance Fegor Isoje, Tayser Sumer Gaaz, Emad Yousif, Agatha Ngukuran Jikah, Khalid Zainulabdeen, Patrick Othuke Akpoghelie, Rapheal Ajiri Opiti, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar

“…Although been generally recognized as safe, there is an incomplete understanding of the mechanisms of action of ginger constituents. This lack of complete knowledge necessitates that caution be taken with its use.…”
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EEG-based multivariate and univariate analyses reveal the mechanisms underlying the recognition-based production effect: evidence from mixed-list design by Bohua Zhang, Bohua Zhang, Alhassan Abdullah, Minmin Yan, Yongqing Hou, Antao Chen, Helen McLaren

“…In summary, the current results support the role of distinctiveness (enhanced memory for auditory or action information, consistent with recollection) in the PE, rather than the role of strength (enhanced memory trace, consistent with familiarity). …”
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Villes durables : leviers de nouveaux modèles économiques et de développement? by Jean-Christophe Lipovac, Antoine Boutonné

“…Pour avancer collectivement sur ces questions, le CERDD et la CCI Grand Lille ont initié en décembre 2010 un Groupe de réflexion et d'action sur le thème des « Villes Durables et Nouveaux modèles économiques » dans la perspective de mener une réflexion transversale et prospective sur la ville durable de demain et ses innovations pour des modes de vie durables. …”
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5-HT1A receptor: its role in the regulation of different kinds of behavior by V. S. Naumenko, E. G. Ponimaskin, N. K. Popova

“…Special attention is focused on the involvement of 5-HT1А receptors in the regulation of 1) fear-induced aggression towards man – the basis of domestication, 2) intermale aggression underling asocial behavior in men, 3) depression and in the mechanism of antidepressant action. The described data extend the idea on the 5-HT1А receptor as a key player in the brain 5-HT system.…”
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ELEMENTS OF CENTRALITY DYNAMICS IN BUZĂU CITY by IOAN IANOŞ, ILINCA VALENTINA STOICA

“…La centralité de la ville de Buzău a connu une évolution fluctuante déterminée par les effets territoriaux que la succession de certaines séries de facteurs d’amplification ou de blocage a eu sur ses relations avec les localités urbaines et rurales de sa grandeaire d’influence. Suite à l’action de ces facteurs se sont enregistrées des périodes de réduction ou de croissance des fonctions de lieu central de la ville de Buzau à différents niveaux territoriaux. …”
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Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA): A Targeted Antioxidant Strategy to Counter Oxidative Stress in Retinopathy by Marco Zeppieri, Caterina Gagliano, Fabiana D’Esposito, Mutali Musa, Irene Gattazzo, Maria Sole Zanella, Federico Bernardo Rossi, Alessandro Galan, Silvia Babighian

“…This comprehensive review aims to evaluate the current literature on the role of omega-3 fatty acids, exploring their mechanisms of action and anti-inflammatory, anti-angiogenic, and neuroprotective roles in the retina. …”
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Preterm nutrition and brain development by Chiara Nava, Gianluca Lista, Enrica Lupo

“…Further studies are needed to better understand the mechanisms of action of different nutrients on brain development in the preterm infant and thus the effects on long-term neurological outcomes.…”
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Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose by Rong Liu, Zukang Fu, Fengjie Zhang, Qingzhong Mao, Chunguang Luan, Xinglin Han, Jie Xue, Deliang Wang, Si Qin, Feike Hao

“…The above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action.…”
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The Consequences of Mining Damage and their Impact on the Natural Environment – a Case Study of Trzebinia by Krzysztof Cygańczuk, Jacek Roguski

“…As a result of this process, further areas requiring action after the mines are closed will be created, especially in Upper Silesia. …”
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Fungal Biocontrol Agents in the Management of Postharvest Losses of Fresh Produce—A Comprehensive Review by Phathutshedzo Ramudingana, Ndivhuho Makhado, Casper Nyaradzai Kamutando, Mapitsi Silvester Thantsha, Tshifhiwa Paris Mamphogoro

“…This article provides an overview of (i) the methods currently used for management of postharvest diseases of fresh produce, highlighting their limitations, and (ii) the use of biocontrol agents as an alternative strategy for control of such diseases, with emphasis on fungal antagonists, their mode of action, and, more importantly, their advantages when compared to other methods commonly used. …”
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UPGRADED SCIENTIFIC ORHODONTIC SIMULATOR WITH TEMPERATURE CONTROL AND THERMOCHAMBER by Radu Mircea Pisc, Anne Marie Rauten, Roxana Marinescu, Horia Octavian Manolea

“…Every tooth is wrapped in coper coil and continuous electric current is injected, heating the wax generating orthodontic movement under the action of orthodontic wires. This device comes with a time regulator and the amperage is limited to 2 Amps. …”
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Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway by Lili Wu, Chunfeng Liang, Xuemei Huang, Xiujun Deng, Jiming Jiang, Zuojie Luo

“…In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor 2 (eIF2α), can induce apoptosis of human adrenocortical carcinoma (ACC) cell via activating the PERK/eIF2α/ATF4 signaling pathway, and the potential mechanisms of this action were explored. The ACC cell lines, including SW-13 and NCI–H295 R, were used. 3-(4,5)-Dimethylthiazol(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, cell scratch experiments, flow cytometry, and JC-1 staining assays were performed to detect the cell viability, cell migration, and cell apoptosis. …”
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An analysis of the burden of migraine and tension-type headache across the global, China, the United States, India and Japan by Rongjiang Xu, Ruonan Zhang, Liang Dong, Xiaonuo Xu, Xiaoping Fan, Jiying Zhou

“…Forecasting models reveal that without policy action, migraine prevalence will grow but TTH prevalence would stay unchanged. …”
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Lung and blood early biomarkers for host-directed tuberculosis therapies: Secondary outcome measures from a randomized controlled trial. by Robert S Wallis, Sibuse Ginindza, Trevor Beattie, Nishanee Arjun, Morongwe Likoti, Modulakgotla Sebe, Vinodh A Edward, Mohammed Rassool, Khatija Ahmed, Katherine Fielding, Bintou A Ahidjo, Mboyo D T Vangu, Gavin Churchyard

“…Instead, they each appear to show highly specific responses related to HDT mechanisms of action.…”
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Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules by Shifana C. Sadiq, Maria Pellissery Joy, Sreekumar U. Aiswarya, Abhishek Ajmani, Chenicheri K. Keerthana, Tennyson P. Rayginia, Noah Isakov, Ruby John Anto

“…The diverse array of phytochemicals discussed here encompasses polyphenols, flavonoids, alkaloids, terpenoids, and many others, each with distinct molecular targets and modes of action. This review is an attempt to elucidate and correlate the regulatory role of phytochemicals on cellular signaling pathways implicated in oncogenesis and inflammatory responses, highlighting the significance and potential of phytochemical-based therapies for cancer prevention and treatment, as well as for managing inflammatory conditions. …”
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Factors influencing compassion satisfaction and compassion fatigue among nurses: a study in a tertiary hospital by Sarah Sharmala Nadarajan, Ping Lei Chui, Wan Ling Lee, Noor Hanita Zaini

“…These findings provide valuable insights, as there may be detrimental effects on the healthcare industry and retention of nurses if no action is taken to combat compassion fatigue. Recommendations to motivate nurses and reduce demands at work should be explored by healthcare organizations to increase nurses’ performance and job satisfaction.…”
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Chinese economic presence in East Africa: the case of Kenya by K. A. Gemueva

“…The first ever Russia-Africa Summit and Economic Forum in October 2019 demonstrates not only interest of both sides in developing bilateral cooperation, but also has every chance of becoming a turning point in translating words into action. Due to advantageous geographical position, dynamic economic development and its role as a transport, logistics and financial center in East Africa, Kenya is justifiably considers as an "entry point" to the African market for foreign companies. …”
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The Effects of Different Phase on Independent Visual Fields SSVEP Responses by Dalu Zheng, Songyun Xie, Xinzhou Xie, Michael Scholz, Hao Tang

“…By stimulating only half of the visual field and “coding” the stimulus further with different phases individual contributions of pathways and eyes can be easily separated and thus the mode of action becomes clearer. In a first proof-of-principles study on 15 subjects we demonstrate that IVFS with a 180° phase difference causes left and right scalp SSVEPs to exhibit a similar phase difference, and the propagation mechanism of SSVEPs conforms to the standing wave mode. …”
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