Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

“…These studies firmly establish the murine TUSC5 gene locus as a PPARγ target, but the significance of Tusc5 in obesity phenotypes or in the pharmacologic actions of PPARγ agonists in humans remains equivocal.…”
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Esters of quinoxaline-7-carboxylate-1,4-di-N-oxide as Trichomonas vaginalis triosephosphate isomerase inhibitors by Palos Isidro, Moo-Puc Rosa, Vique-Sánchez José Luis, Benítez-Cardoza Claudia G., Monge Antonio, Villalobos-Rocha Juan Carlos, Paz-Gonzalez Alma D., Rivera Gildardo

“…Additionally, an in vitro enzyme assay and molecular docking analysis against triosephosphate isomerase of Trichomonas vaginalis to confirm their mechanism of action were performed. Ethyl (compound 12) and n-propyl (compound 37) esters of quinoxaline-7-carboxy-late-1,4-di-N-oxide derivatives showed trichomonicidal activity comparable to nitazoxanide, whereas five methyl (compounds 5, 15, 19, 20 and 22), four isopropyl (compounds 28, 29, 30 and 34), three ethyl (compounds 4, 13 and 23) and one npropyl (compound 35) ester derivatives displayed activity comparable to albendazole. …”
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Marine Prosperity Areas: a framework for aligning ecological restoration and human well-being using area-based protections by Octavio Aburto-Oropeza, Valentina Platzgummer, Erica M. Ferrer, Catalina López-Sagástegui, Rocío de Guadalupe Abud Mirabent, América Ávalos Galindo, Fabio Favoretto, Alfredo Giron-Nava, Isabel Mendoza Camacho, Claudia Núñez Sañudo, Marisol Plascencia de La Cruz, Alejandro Robles

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Comprehensive Analysis of PDLIM3 Expression Profile, Prognostic Value, and Correlations with Immune Infiltrates in Gastric Cancer by Xinpeng Hu, Minfeng Chen, Qiang Ruan, Changzheng Shi, Jinghua Pan, Liangping Luo

“…GO and KEGG analyses were performed to illuminate the molecular mechanisms of action of PDLIM3. TIMER2.0 and GEPIA were applied to investigate correlations between PDLIM3 expression and gene marker subsets signifying immune infiltration, with TIMER2.0 exploring the correlations between PDLIM3 and related signaling pathways. …”
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Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle... by Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

“…These and other cytokines also play a major role in <i>Leishmania</i>-induced hyperalgesia via two possible pathways, one involving prostaglandins and the other sympathetic amines as final mediators, preceded by a cascade of cytokines, among which TNF-α seems to play a pivotal role via a still unclear mechanism of action. This study investigates the effects of anti-TNF-α antibody (Infliximab) on <i>L. major</i>-induced hyperalgesia in susceptible BALB/c mice using the hot plate and tail flicks tests, as well as the levels of many cytokines in the infected paws of mice using the ELISA technique. …”
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Attempt to save Friendship, or What the Liberator of Prague Did in Czechoslovakia in May 1968 by I. A. Permyakov, S. G. Antonenko

“…In August 2018, at the initiative of the Prague 6 City Council, metal “information plates” were installed on the pedestal of the monument to Marshal Konev, where among other things it was stated that “In 1968, he personally backed the intelligence surveillance preceding the invasion of the armed forces of the Warsaw Pact into Czechoslovakia". This action was part of measures to prepare public opinion for the removal of the monument. …”
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Integrated approach to accounting in agriculture in the context of sustainable development and circular economy by Maryna Dubinina, Natalia Potryvaieva, Olena Dovgal, Olena Usykova, Vitalii Kuzoma

“…The analysis of enterprises from different countries, such as Nibulon, The Green Shop, and the Farmers for Climate Action cooperative, revealed concrete benefits of implementing circular approaches in reducing costs, improving resource management, increasing environmental efficiency, and increasing profitability, which confirmed their significance in modern agribusiness. …”
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Recent progress on anti-cancer activity of thiadiazoles: A review by C.R. Santhosh, Sampath Chinnam, Nagaraju Kottam, S Amreen, Guddekoppa S. Ananthnag, G.M. Madhu, Samata Gadde, Viola Tressa Fernandes, Haritha Arnipalli

“…They have shown considerable anti-cancer action against various cancer cell lines. The review covers recent anti-cancer research findings from 2021 to 2024. …”
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Design and Evaluation of an Electromagnetic Bounce-Type Refreshable Braille Display by Dapeng Chen, Song Zhang, Lianshun Shen, Chenkai Li, Jianying Hua, Jia Liu, Aiguo Song

“…By passing current in different directions to the coil, the electromagnet can bounce up and down between the two permanent magnets under the action of magnetic force, thereby achieving changes in the raised state of the Braille dot. …”
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Empowerment of volunteer nursing service providers during disasters: A qualitative study by Mostafa Roshanravan, Shandiz Moslehi, Hesam Seyedin

“…Extracted themes include Infrastructure Initiatives, Effective management, Research development and knowledge management, Cultural Action Measures, Policymaking and legal affairs, Individual Competency Areas. …”
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Preserving the Past, Embracing the Future: Co-Design Strategies for Achieving Harmony Between Heritage Sites and Accessibility Needs by Maryem Lakoud, Ernesto Morales, Alicia Ruiz-Rodrigo, Isabelle Feillou, Samuel Mathieu, Jonathan Riendeau, François Routhier

“…For example, cobbled streets with uneven surfaces or significant level differences create obstacles for wheelchair users and others with mobility challenges. This qualitative action research aimed to develop guidelines for shared street designs and innovative solutions that balance heritage preservation with inclusive accessibility. …”
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An Integrated Approach Exploring the Synergistic Mechanism of Herbal Pairs in a Botanical Dietary Supplement: A Case Study of a Liver Protection Health Food by Liang Chen, Chun Hu, Molly Hood, Juntao Kan, Xiaona Gan, Xue Zhang, Yi Zhang, Jun Du

“…In order to address this question, UPLC-Q-TOF/MS analysis and System Pharmacology tools were applied to explore the mechanism of action, using a White Peony (Paeoniae Radix Alba) and Licorice (Glycyrrhizae Radix et Rhizoma)-based dietary supplement. …”
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Review of climate-resilient agriculture for ensuring food security: Sustainability opportunities and challenges of India by Satiprasad Sahoo, Chiranjit Singha, Ajit Govind, Armin Moghimi

“…This study highlighted how CRA aligns with key SDGs by addressing poverty, hunger, climate action, and community wellbeing. GRACE data indicated that northwestern India emerged as a critical water scarcity hotspot, displaying negative trends of around −7.413 cm per year. …”
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circRNA Expression Profile in Dental Pulp Stem Cells during Odontogenic Differentiation by Ming Chen, Yeqing Yang, Junkai Zeng, Zilong Deng, Buling Wu

“…Recent studies showed that circular RNAs (circRNAs) have many biological functions and that competing endogenous RNA (ceRNA) is their most common mechanism of action. However, the role of circRNAs in hDPSCs during odontogenesis is still unclear. …”
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Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study by Praveen Sripad, Jessica Rosenberg, Frank Boers, Christian P. Filss, Norbert Galldiks, Karl-Josef Langen, Ralf Clauss, N. Jon Shah, Jürgen Dammers

“…In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson’s disease. The mechanism of action of this effect of zolpidem is of great research interest. …”
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Fullerene-containing modifier of magnetoactive elastomer by М.A. Vasilyeva, F.Yu. Sharikov, I.A. Bogdanov

“…Two groups included solutions obtained through diffuse dissolution, one group - with an additional mechanical action. A study of rheological, optical and electrical conductivity properties was carried out to assess changes in the structure of the solutions. …”
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The Role of Motility Impairment in the Pathogenesis of Functional Disorders of the Gastrointestinal Tract and Modern Possibilities for Their Treatment (Resolution of an Expert Coun... by I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, V. I. Simanenkov, S. R. Abdulhakov, N. A. Agafonova, V. A. Akhmedov, T. A. Ilchishina, M. G. Ipatova, O. V. Krapivnaya, Yu. A. Kucheryavyi, M. F. Osipenko, O. A. Storonova, G. N. Tarasova, G. Ya. Khismatullina, S. V. Cheryomushkin

“…The use of modern medical preparations, which are characterized by a high level of safety and the targeted action towards a specific motility disorder, allows optimal therapy results to be achieved with minimal risks for the patient.…”
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Efficacy of Hymecromone in Post-Cholecystectomy Patients by A V. Okhlobystin, A. К. Ufimtseva, M. A. Tatarkina, O. Z. Okhlobystina, V. T. Ivashkin

“…Mild increase in fasting common bile duct (CBD) diameter after treatment (7.23 ± 0.99 vs 6.78 ± 1.01; p = 0.029) was attributed to choleretic action of hymecromone. Hymecromone resulted in significant improvement of CBD response to fatty meal stimulation (ΔCBD): –1.08 ± 0.46 mm vs –0.10 ± 0.33 mm pretreatment (p = 0.016). …”
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Optimal Positioning and Sizing of Distributed Energy Sources in Distribution System Using Hunter-Prey Optimizer Algorithm by P. Rajakumar, M. Senthil Kumar, K. Karunanithi, S. Vinoth John Prakash, P. Baburao, S. P. Raja

“…HPO is a bio-inspired and population-based optimization algorithm that mimics the hunting action of an animal. The HPO algorithm evades the local optimal stagnation and reaches the optimal solution rapidly. …”
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Regulation of Recombination between gtfB/gtfC Genes in Streptococcus mutans by Recombinase A by Satoko Inagaki, Kazuyo Fujita, Yukiko Takashima, Kayoko Nagayama, Arifah C. Ardin, Yuki Matsumi, Michiyo Matsumoto-Nakano

“…Streptococcus mutans produces 3 types of glucosyltransferases (GTFs), whose cooperative action is essential for cellular adhesion. The recombinase A (RecA) protein is required for homologous recombination. …”
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