Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures by Tijana Hanauske, Carolin Christina Koretz, Tassilo Jungenitz, Jochen Roeper, Alexander Drakew, Thomas Deller

“…Our findings showed that ChR2-expressing cells generated action potentials (APs) or calcium transients in response to illumination but were otherwise functionally indistinguishable from non-transduced GCs within the same neural circuit. …”
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A Novel Pyroptosis-Based Prognostic Model Correlated with the Parainflammatory Immune Microenvironment of Pancreatic Cancer by Kong-kong Wei, Zhi-xing Du, Jun-ge Deng, Jin-wei Yang, Hao Chen

“…Pyroptosis has a dual function in malignant tumor progression and management. The action of pyroptosis-related genes (PRGs) in pancreatic cancer (PC), however, remains uncertain. …”
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Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications by Wang Meng, Wang Chao, Zhao Kaiwei, Ma Sijia, Sang Jiajia, Xu Shijie

“…This review explores bioactive compounds derived from Chinese herbal plants, focusing on their mechanisms of action, underlying pathways, and potential applications in functional food development. …”
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ANALYSIS OF AIR QUALITY IN TELEORMAN BY MEANS OF BIOMONITORS-LICHENS by Cernat POPA

“…Air pollution means the presence in the atmosphere of substances foreign to its normal composition, which depending on the concentration and time of action cause disturbances in the natural balance, affecting the health and comfort of humans or the living environment of flora and fauna (Rusanescu, M et al., 2018). …”
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Life Histories of Two Endangered Sea Skaters Halobates matsumurai Esaki and Asclepios shiranui (Esaki) (Hemiptera: Gerridae: Halobatinae) by Terumi Ikawa, Yuichi Nozoe, Natsuko Yamashita, Namiko Nishimura, Satoshi Ohnoki, Kyoko Yusa, Sugihiko Hoshizaki, Masayuki Komaba, Akihiro Kawakubo

“…The eggs had very hard shells, presumably adaptive to protect them from desiccation, solar radiation, and wave action, especially during the overwintering period.…”
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Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters by Bhawana Dhakal, Jaybir Kumar Thakur, Reema Kumari Mahato, Ishwori Rawat, D. C. Rabin, Rahul Rana Chhetri, Kedar Prasad Shah, Atul Adhikari, Jitendra Pandey

“…Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity. This project was aimed to formulate and characterize orodispersible tablets of ebastine, utilizing different proportions of three disintegrants, namely crospovidone, sodium starch glycolate, and coprocessed superdisintegrant. …”
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Effect of Repeated Wetting-Drying-Freezing-Thawing Cycles on the Mechanic Properties and Pore Characteristics of Compacted Loess by Fei Wang, Guoyu Li, Wei Ma, Yanhu Mu, Zhiwei Zhou, Jun Zhang, Dun Chen, Jinshuai Zhao

“…By comparing compression and collapse characteristics of the loess specimens subjected to wetting-drying, freeze-thaw, and WDFT cycles, we found that the dry-wet action plays the dominant role in the deterioration of engineering properties of compacted loess during WDFT cycles.…”
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Synthesis and Antimycobacterial and Photosynthesis-Inhibiting Evaluation of 2-[(E)-2-Substituted-ethenyl]-1,3-benzoxazoles by Ales Imramovsky, Jan Kozic, Matus Pesko, Jirina Stolarikova, Jarmila Vinsova, Katarina Kralova, Josef Jampilek

“…The site of inhibitory action of tested compounds is situated on the donor side of photosystem II. …”
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Designing and validating an adaptation tool for endometriosis: an exploratory mixed method study protocol by Sanaz Mollazadeh, Nahid Marvi, Talat Khadivzadeh

“…Yet, none of the conducted studies have taken action toward these objectives. Therefore, the present study will be conducted with the aim of "Designing adaptation tool for endometriosis". …”
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Nutritional Habits According to Gender, Stage of Exercise Behavior and BMI by Osman İmamoğlu, Tülin Atan

“…According to the stage of exercise behavior, the nutritional scores of students who are at the stage of pre-contemplation, contemplation and preparation are significantly lower than those in the stage of action and maintenance (p lt;0.001). As a result, nutrition levels of university students do not change much according to gender, but differ according to the BMI and to the stage of exercise behavior. …”
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Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids by Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka

“…Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated their antiglioblastoma potential in vitro and mechanism of action (inhibition of DYRK1A, Hsp90, anti-oxidative activity). …”
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Atherogenic Risk Factors in Medical Students by Airam Navarro Palacios, Miguel Ángel Serra Valdés, Rafael Comas Valdespino, Girelda Cordero López, Alain Landrian Davis, Adrian Landrian Davis

“…The study and approach of its modifiable risk factors and action on these factors can positively change the health situation. …”
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Psilocybin-assisted massed cognitive processing therapy for chronic posttraumatic stress disorder: Protocol for an open-label pilot feasibility trial. by Shakila Meshkat, Richard J Zeifman, Kathleen Stewart, Reinhard Janssen-Aguilar, Wendy Lou, Rakesh Jetly, Candice M Monson, Venkat Bhat

“…Preliminary evidence supports the potential therapeutic action of psilocybin to alleviate PTSD symptoms. This open-label pilot study aims to evaluate the feasibility, tolerability, and preliminary efficacy of a single dose 25 mg psilocybin in combination with one week of massed CPT in patients with chronic PTSD.…”
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Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Intervention... by Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S. Stone

“…We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0.25 mg/kg, 5x/week for 5 weeks] versus acute treatment with intraperitoneal morphine [10 mg/kg] and pregabalin [100 mg/kg]) in a mouse model of ovariectomized or sham-operated mice 6 months following surgery. …”
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Modification of Fe3O4 magnetic nanoparticles for antibiotic detection by Min Sun, Xue Bai, Xianshu Fu, Xiaoping Yu, Zihong Ye, Mingzhou Zhang, YuLou Qiu

“…We additionally talked about the mechanism of action of magnetic nanoparticles for the extraction of separated antibiotics and how they are utilized in practical detection methods. …”
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Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue by Josep Mercader, Zsuzsa Iffiú-Soltész, Sandy Bour, Christian Carpéné

“…Consequently, the insulin-like action of the SSAO substrate benzylamine on glucose transport was abolished in adipocytes from semicarbazide-drinking mice, while their insulin sensitivity was not altered. …”
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Measuring Transducer for Air Gap Capacitive Sensor in Hydrogenerator by A. S. Levytskyi, I. O. Zaitsev, V. O. Bereznychenko, O. E. Sukhorukova

“…Commercially available meters with capacitive sensors, by their certain characteristics, are not always suitable for use on HGs.A secondary measuring transducer with improved characteristics is proposed for a capacitive gap sensor formed by coplanar parallel electrodes.The converter is developed on the basis of a balanced compensation bridge measuring circuit. The control action in the device is formed by the phase of the unbalancing signal.The structural diagram of the converter is presented and the algorithm of its operation is described. …”
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The Impact of Anti-Diabetics on Platelets Function and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: A Narrative Review by Muthanna Zaki, Mohammed Abed, Fawaz Alassaf

“…In addition, advances in understanding the action of some anti-diabetics have demonstrated probable effects of these agents on platelet function and thrombotic state in T2DM. …”
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Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis by Véronique Ferret-Sena, Alexandra Maia e Silva, Armando Sena, Inês Cavaleiro, José Vale, Bruno Derudas, Giulia Chinetti-Gbaguidi, Bart Staels

“…These results suggest that PPAR-mediated processes may contribute to the mechanisms of action of NTZ therapy.…”
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Protective Effect of Bergapten against Human Erythrocyte Hemolysis and Protein Denaturation In Vitro by Douglas Bosco Aidoo, Daniels Konja, Isaac Tabiri Henneh, Martins Ekor

“…The ability of bergapten to inhibit protein denaturation was studied as part of an investigation on its mechanism of action. The results showed a significant concentration-dependent reduction in protein denaturation. …”
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