Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 by XingChun Wang, Huan Liu, Jiaqi Chen, Yan Li, Shen Qu

“…Bariatric surgery may improve metabolism through the action on GLP-1 levels. In recent years, there has been a great interest in developing effective methods to regulate glucagon-like peptide-1 secretion. …”
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Optimization of Time-Varying Temperature Profiles for Enhanced Beer Fermentation by Evolutive Algorithms by Pablo Ruarte, Nadia Pantano, Marianela Noriega, Cecilia Fernández, Emanuel Serrano, Gustavo Scaglia

“…This method integrates Fourier series and orthogonal polynomials for control action parameterization, in combination with evolutionary algorithms for parameter optimization. …”
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Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics by Xiaomin Xu, Donghua Yu, Yu Wang, Xin Jiang, Fang Lu, Shumin Liu

“…Through related metabolic pathway analysis, the most affected metabolic pathways were found to be Sphingolipid metabolism, Glycerophospholipid metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Pantothenate and CoA, Citrate cycle (TCA cycle), and Arachidonic acid metabolism.ConclusionResveratrol can regulate the biosynthetic pathways of arachidonic acid, phenylalanine, tyrosine, and tryptophan, pantothenic acid and CoA biosynthesis pathways, TCA cycle, and other metabolic pathways, thereby regulating the NF-κB, MAPK, and JAK/STAT3 signaling pathways, and inhibiting the acute inflammatory response during GA attacks, showing characteristics of multi-pathway and multi-target action.…”
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Oxidative Stress Markers in Patients with Metabolic Syndrome by Axana Rodríguez Núñez, Jorge Calá Fernández, Haydee Cruz Vadell, Miguel Ángel Montoya Deler

“…<strong>Background:</strong> oxidative stress is the balance alteration existing in the body between the action of oxidizing agents. Oxidative stress plays an important role in the pathogenesis of the metabolic syndrome because it affects the function of pancreatic beta cells and alters glucose transport in muscle and adipose tissue.…”
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Ischemic monomelic neuropathy following arteriovenous fistula surgery: a case report by Da Woon Kim, You Hyun Jeon, Miju Bae, Sang Heon Song

“…A nerve conduction study above the wrist revealed reduced compound muscle action potential (CMAP) of the left ulnar nerve and no CMAP of the left median nerve. …”
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Perceptions and acceptance of COVID-19 vaccine among pregnant and lactating women in Singapore: a pre-vaccine rollout cross-sectional study by Pooja Agarwal Jayagobi, Chengsi Ong, Kee Thai Yeo, Caleb Chun Wei Lim, Meei Jiun Seet, Lee Koon Kwek, Chee Wai Ku, Jerry Kok Yen Chan, Manisha Mathur, Mei Chien Chua

“…Addressing the safety concerns when more data are available and education on the mechanism of vaccine action will likely improve acceptance among these women.…”
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Instructional design of the subject General Psychology in its virtual modality by Yaritza García Ortiz, Idalmis Ramirez Oves, Yurianely Machado Machado, Delia Maria Santiesteban Pineda, Yanexy Valdés Garciga, Omar Cruz Martín

“…Methods: an educational research was carried out at Villa Clara University of Medical Sciences from September 2022 to April 2023, following the action research method and organized by the phases proposed by Chiape for the instructional design of a course: analysis of key factors, instructional design, production of learning resources and issuance. …”
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Taking stock of the social determinants of health: A scoping review. by Kelsey Lucyk, Lindsay McLaren

“…Health equity was understood in different ways with implications for action on the SDOH.<h4>Conclusions</h4>Among the vast SDOH literature, there is a need to identify and clearly articulate the essence and implications of the SDOH concept. …”
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Research on Integrated Control Strategy for Highway Merging Bottlenecks Based on Collaborative Multi-Agent Reinforcement Learning by Juan Du, Anshuang Yu, Hao Zhou, Qianli Jiang, Xueying Bai

“…By transforming the control framework into a Decentralized Partially Observable Markov Decision Process (Dec-POMDP), state and action spaces for heterogeneous agents are designed. …”
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The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (H... by Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

“…This study aims to explore the relationship between endothelial dysfunction in HFpEF and the mechanisms of action of GLP-1R agonists, highlighting their potential therapeutic benefits. …”
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Circumstances to Be Clarified under the Investigation of Interference into Law Enforcement Officer’s Activity by V. O. Gusieva

“…It has been established that the circumstances to be clarified during the interference in the activities of a law enforcement officer include: 1) circumstances related to the criminal offense, namely: time, place, situation and traces of a criminal offense, methods of its commission (preparation, direct commission and concealment), tools and means used during the interference, the scope of procedural costs; circumstances that are the basis for ceasing criminal proceedings; the reasons and conditions that contributed to the commission of a criminal offense; 2) circumstances related to the identity of the victim, including: socio-demographic characteristics of the victim, place of work, position held; official and functional responsibilities, the victim’s belonging to a law enforcement agency during the commission of a criminal offense against him; the type and scope of damage caused to the victim; 3) circumstances related to the identity of the offender, namely: socio-demographic data of the offender, physiological and psychological condition, gender, citizenship, financial status, place of work, the record of criminal conviction and the facts of bringing to administrative liability; the presence of dependent disabled people; the presence of guilt in the form of direct intent, the purpose of the action; circumstances that aggravate or mitigate the punishment of the offender are grounds for releasing from criminal liability or punishment that exclude criminal liability; presence of accomplices.…”
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Recycling Waste Soils for Stability Enhancement in Bored Pile Construction by Feng Li, Lei Zhang, Zhengzhen Wang, Qiqi Liu, Tiantao Su, Jinke Wang

“…Finally, the stability of the hole wall of bored pile under the action of mud slurry was calculated, and the stress on the pile hole wall was analyzed when local instability and overall instability occurred, respectively. …”
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Cross-cultural adaptation of the writer-reader relationship in non-translated and translated English health information websites on HIV and TB diagnostic testing by Amy Dara Hochberg

“…Natives and immigrants should have a culturally adapted website in their language hosted by their place of residence that imparts the facts and incites a call to action to improve health, and ultimately reduces disease in the diverse community. …”
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Research Progress of TiN Formation and Control in the Smelting Process of Ti-Microalloyed Steel by Yang　Rui, Li　Yang, Sun　Meng, Ma　Shuai, Mao　Yunqie, Jiang　Zhouhua

“…On the control of TiN， the effects of the synergistic action of Al， B and Ti on the formation of TiN， the effects of Mg treatment， Ca treatment， and rare earth （Ce， La， Y） treatment on the formation of TiN in steel are mainly summarized in this paper.The amount， size and morphology of TiN can be affected by the synergistic effect between other elements and Ti element in steel. …”
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Reactive Oxygen Species Donors Increase the Responsiveness of Dorsal Horn Neurons and Induce Mechanical Hyperalgesia in Rats by Hee Young Kim, Inhyung Lee, Sang Woo Chun, Hee Kee Kim

“…The t-BOOH increased the frequency and the amplitude of excitatory postsynaptic potentials, depolarized membrane potential in SG neurons, and increased the frequency of action potentials evoked by depolarizing current pulses. …”
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Force and Deformation Analysis of H(t)-T Loaded Pile Based on Pasternak Foundation Model by JIANG Jie, CHEN Lijun, CHAI Wencheng, AI Yonglin, OU Xiaoduo, GONG Jian

“…The force and deformation of the pile foundation under the combined action of horizontal dynamic load H(t) and torque T are rather complicated. …”
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4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets by Angel H. Romero, Francisco Delgado

“…These facts make it possible to generate safe leishmanicidal agents targeted at key aspects of parasite survival.The current review summarizes the most current examples of leishmanicidal agents based on 4-aminoquinolines focusing the analysis on two essential aspects: (i) structure–property relationship to identify the key pharmacophores and (ii) mode of action focused on key targets in parasite survival (e.g., depolarization of potential mitochondrial, accumulation into macrophage lysosome, and immunostimulation of host cells). …”
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Experimental Study on the Damage and Deterioration Behaviour of Deep Soft Rock under Water-Rock Interaction by Zenghui Zhao, Hao Liu, Xianzhou Lyu, Lei Wang, Zhongxi Tian, Jiecheng Sun

“…Due to ion-exchange adsorption and the wedging action of water molecules, the edge of contact between particles changes from staggered to smooth, which leads to the expansion of pores, the loosening of mudstone structures, and a decrease in mechanical strength. …”
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WHEAT ANTIMICROBIAL PEPTIDES by T. I. Odintsova, T. V. Korostyleva, L. L. Utkina, Ya. A. Andreev, A. A. Slavokhotova, E. A. Istomina, V. A. Pukhal’skii, T. A. Egorov

“…AMPs differ in structure and mode of action. Most of them belong to cysteine-rich peptides; their molecules contain even numbers of cysteine residues involved in the formation of disulphide bonds, which stabilize the peptide structure. …”
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Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines by Reem A. Al Alawi, Jörg D. Hoheisel, Mohamed Saiel Saeed Alhamdani, Younis Baqi

“…Future work will be focused on isolation and identification of the active compounds and explore their mechanisms of action.…”
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