Ce que l’anthropocène fait (faire) by Yann Calbérac

“…This article formulates the hypothesis that the Anthropocene functions as a meta-narrative, i.e. that it constitutes both a program that gives coherence to the research being developed today, and an ideological and political basis for action and commitment. From this perspective, the Anthropocene produces things as much as it makes other produce things. …”
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Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation by Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor

“…It was found that this structure seems to not express the neuronal acetylcholine (ACh) receptor subunit alpha-7, required for anti-inflammatory action of ACh. The mechanism of action involves inhibition of the proinflammatory cytokine synthesis on the periphery as well as inhibition of their de novo synthesis rather in brain microvessels and not in the CP. …”
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Investigation of sensory attenuation in the somatosensory domain using EEG in a novel virtual reality paradigm by Gianluigi Giannini, Till Nierhaus, Felix Blankenburg

“…Understanding what is unique about sensory consequences can give valuable insight into the action-perception-cycle. Sensory attenuation is the phenomenon that self-produced stimulations are perceived as less intense compared to externally-generated ones. …”
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Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings by Rong Li, Songzuo Yu, Xiao Liang, Yu Li, Keng Po Lai

“…Furthermore, biological processes, cell components, molecular functions, and pharmacological pathways involved in the action of VC against cadmium-induced fracture were identified and visualized. …”
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Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…A comprehensive and efficient way to investigate the molecular mechanism of action for adjuvants is to utilize systems biology approaches such as transcriptomics in so-called “systems vaccinology” analysis. …”
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Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients by Cristina Deflorio, Emanuela Onesti, Clotilde Lauro, Giorgio Tartaglia, Aldo Giovannelli, Cristina Limatola, Maurizio Inghilleri, Francesca Grassi

“…Denervated muscles undergo fibrillations due to spontaneous activation of voltage-gated sodium (Na+) channels generating action potentials. Fibrillations also occur in patients with amyotrophic lateral sclerosis (ALS). …”
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« La baraque [les camps], on y était ! » Faire la preuve administrative de son statut d’enfant de harki by Alice Baudy

“…This article looks at the production and appropriation of an administrative category, that of the child of a harki who has passed through the camps, within the framework of a public action program aimed at repairing prejudices linked to the colonial past. …”
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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…Mutant microglia exhibited increased activation and induced apoptosis in hippocampal neurons, leading to higher action potential frequency and excitatory synaptic marker expression. …”
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Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKα/β/NF-κB Signaling Axis by Rahul Gupta, Dipanjan Roy, Arijit Ghosh, Yasmin Begum, Dipanjan Ghosh, Snehasikta Swarnakar

“…Mebendazole (MBZ), a benzimidazole anthelmintic and cytoskeleton-disrupting compound, exhibits antitumor properties; however, its action on ovarian cancer (OC) is not clearly understood. …”
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University Interaction with Regional Subjects in the Assessments of the Faculty by M. V. Boguslavsky, N. V. Ladyzhets, O. V. Sannikova, E. V. Neborsky

“…In other words, they do not translate preparedness into action, awaiting action on the part of management.…”
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Structural Characterization of Polygonum divaricatum L. Polysaccharide and Its Inhibitory Effect on Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells by CUI Yanyan, YUAN Yongxu, GUO Mingkun, HE Wenbing, LI Ming, PEI Shichun, LI Dajun

“…Objective: To explore the in vitro anti-inflammatory activity and action mechanism of a polysaccharide extracted from Polygonum divaricatum L. …”
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Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats by Mercedes Montero, Manuel Díaz-Curiel, David Guede, Jose Ramón Caeiro, Marta Martín-Fernández, Mercedes Rubert, Daisy Navarro, Concepción de la Piedra

“…Treatment with Kalsis maintained this increase. The mechanism of action of this supplement is not through a decrease in bone remodelling rate. …”
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Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis by Xu B, Wang C, Zhu X, Zhu L, Han G, Cui C

“…And 12 key pathways involving glucose metabolism, lipid metabolism, and amino acid metabolism were identified following Corilagin treatment.Conclusion: This research provides insight into the action mechanism of Corilagin’s anti-oxidative, anti-inflammatory, anti-atherosclerotic, hepatoprotective, anti-tumor, and neuroprotective properties. …”
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PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling by Maria Moreno, Assunta Lombardi, Elena Silvestri, Rosalba Senese, Federica Cioffi, Fernando Goglia, Antonia Lanni, Pieter de Lange

“…In this paper, we focus on how nutrients control the expression and action of PPARs and how cellular signaling events regulate the action of PPARs in metabolically active tissues (e.g., liver, skeletal muscle, heart, and white adipose tissue). …”
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Sesquiterpenes α-humulene and β-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells by Ambrož Martin, Šmatová Markéta, Šadibolová Michaela, Pospíšilová Eva, Hadravská Pavlína, Kašparová Michaela, Skarková Veronika Hanušová, Králová Věra, Skálová Lenka

“…In addition, the possible mechanisms of sesquiterpene action are studied. The results show significant ability of HUM and especially of CAO to enhance the anti-proliferative effects of FU and OxPt in cancer cell lines Caco-2 and SW-620. …”
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Meaningful Engagement as a Cornerstone for Implementing the Key Recommendations to Advance the Sexual and Reproductive Health and Rights of Women Living With HIV Across Policy, Pra... by Zoë Osborne MPH, Muluba Habanyama, Brittany Cameron, Alexandra de Pokomandy MD, MSc, Brenda Gagnier, Elizabeth King MD, Jill Koebel MPH, Mona Loutfy MD, MPH, Carrie Martin BA, BSW, Renée Masching MSW, Manjulaa Narasimhan PhD, Valerie Nicholson, Neora Pick MD, Stephanie Smith, Shelly Tognazzini BA, Wangari Tharao PhD, Angela Kaida PhD

“…In 2022, a community-academic collaborative team published 5 key recommendations for developing a national action plan to advance the sexual and reproductive health and rights (SRHR) of women living with HIV in Canada. …”
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Can an organizationally anchored, multilevel intervention improve perceived stress and psychosocial factors in the workplace? A pre-post study assessing effectiveness and implement... by Vita Ligaya Dalgaard, Tanja Kirkegaard, Christian Dyrlund Wåhlin-Jacobsen, Birgit Aust, Sofie Jaspers, Thomas Faurholt Jønsson, Trine Nøhr Winding

“…Methods The intervention was based on a train-the-trainer principle and participatory risk assessment workshops on all organizational levels. Action plans were subsequently developed at the team level, and identified risks, which could not be addressed at the team level, were reported to the management for further action planning or escalation to the next management level. …”
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RHOBTB2 Variant p.Arg511Gln Causes Developmental and Epileptic Encephalopathy Type 64 in an Infant: A Case Report and Hotspot Variant Analysis by Qian Liu, Feifei Li, Qin Ruan, Nana Wang, Zhengjun Fan

“…More than half of the variants are located at Arg483 and Arg511 within the BTB domain; however, the underlying mechanism of action of these hotspot variants remains unexplored. …”
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Family Self-Support in Managing Down Syndrome Children: A Qualitative Study by Farzaneh Noroozi, Zohreh Farrar, Tayebeh Gharibi, Roqayeh Gashmard

“…Also, health policymakers in Iran can take action to increase life expectancy and reduce deaths caused by DS by improving the equitable distribution of health resources and services. …”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Clinical trials consistently demonstrate significant weight loss, positive action on cardiovascular risk and better glycemic control. …”
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