General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form by Edina Horváth, Zsuzsanna Máté, Szabolcs Takács, Péter Pusztai, András Sápi, Zoltán Kónya, László Nagymajtényi, András Papp

“…The results showed the importance of the physicochemical form of Mn in determining the toxic outcome, and suggested that neurofunctional markers of Mn action may indicate the human health effect better than conventional blood Mn measurement.…”
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The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review by Wiktoria Maria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Jakub Kurasz, Wojciech Maj, Wiktoria Podlasiewicz, Katarzyna Pala, Piotr Dudziak, Anna Nowak, Maria Golińska

“… Introduction: Vitamin D holds a crucial role in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Its mechanisms of action involve immune system modulation, specifically by reducing the production of pro-inflammatory cytokines, such as IL-6 and TNF-α, while enhancing the levels of anti-inflammatory cytokines, such as IL-10. …”
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The Mechanism of Rock Mass Crack Propagation of Principal Stress Rotation in the Process of Tunnel Excavation by Guanfeng Chang, Xinzhu Hua, Jie Zhang, Peng Li

“…The principal stress magnitude dominates the initiation and propagation of the crack and increases rock damage under the action of principal stress rotation. In this study, the theoretical calculation and numerical analysis method have been combined with the crack propagation conditions to study the stress-driven mechanism of brittle rock crack propagation under principal stress rotation. …”
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The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities by Hajed Obaid A. Alharbi, Mohammad Alshebremi, Ali Yousif Babiker, Arshad Husain Rahmani

“…Limited clinical data regarding quercetin’s safety and mechanism of action are available. It is important to conduct more clinical trials to gain a deeper understanding of the disease-preventive potential, mechanisms of action, safety, and optimal therapeutic dosages. …”
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Commonality of Virulence-Promoting Function in Rhodococcus equi Virulence Associated Proteins (Vaps) by Timothy R. Ganderton, Daniel Ghete, Karen Hogg, Graeme J. Park, Christoph G. Baumann, Anthony J. Wilkinson, Paul R. Pryor

“…VapA has been extensively studied, and although vapK and vapN genes from other R. equi virulence plasmids have been shown to be essential for R. equi intracellular survival, their mode of action is less characterised. We, therefore, examined whether VapK and VapN worked mechanistically in the same way as VapA. …”
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Anticancer Potential of Fruit Extracts from Vatica diospyroides Symington Type SS and Their Effect on Program Cell Death of Cervical Cancer Cell Lines by Atchara Chothiphirat, Kesara Nittayaboon, Kanyanatt Kanokwiroon, Theera Srisawat, Raphatphorn Navakanitworakul

“…Distinctive morphological changes were observed in ACE-treated cervical cancer cells contributing to apoptosis action. Flow cytometry analysis with Annexin V-FITC and PI staining precisely indicated that ACE induced apoptosis in HeLa and SiHa cell lines in a dose-dependent manner. …”
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Xylazine as a Drug of Abuse and Its Effects on the Generation of Reactive Species and DNA Damage on Human Umbilical Vein Endothelial Cells by Luz Silva-Torres, Christian Veléz, Lyvia Álvarez, Beatriz Zayas

“…Human xylazine (XYL) abuse among addicts has received great interest due to its potential toxic effects upon addicts and the need to understand the mechanism of action associated with the potential health effects. …”
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In vitro effects of ascorbic acid on viability and metabolism of patients’ osteosarcoma stem cells by Jovičić Marijana Šimić, Pušić Maja, Antunović Maja, Ledinski Maja, Librenjak Lucija, Kolundžić Robert, Ribičić Tomislav, Trkulja Vladimir, Urlić Inga

“…Their metabolism has been recognized as a potential target of therapeutic action. Ascorbic acid (AA) is considered to act pro-oxidative against OS-CSC in vitro by oxidative effect and by inhibition of glycolysis. …”
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The Role of Microbial Aspartic Protease Enzyme in Food and Beverage Industries by Jermen Mamo, Fassil Assefa

“…Proteases are generally grouped into two main classes based on their site of action, that is, exopeptidases and endopeptidases. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…This paper offers a review of the mechanisms underlying the protective action of these phytoagents, including boosting the antioxidant capabilities, suppression of inflammation, averting the proliferative and sclerosing/fibrosing events. …”
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Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase by Silvia Biggi, Lucia Buccarello, Alessandra Sclip, Pellegrino Lippiello, Noemi Tonna, Cristiano Rumio, Daniele Di Marino, Maria Concetta Miniaci, Tiziana Borsello

“…Many studies have been focused on the post-synaptic mechanism of JNK action, and less is known about JNK presynaptic localization and its physiological role at this site. …”
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Experimental Study on Tunnel Failure Mechanism and the Effect of Combined Anti-Dislocation Measures Under Fault Dislocation by Jiaxuan Du, Songhong Yan, Weiyu Sun, Mingxing Cao, Yuxiang Li

“…In-depth analyses were performed on the tunnel damage mechanism under strike-slip fault action and the mitigation effects of combined anti-dislocation measures. …”
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Stability Analysis of “Support-Surrounding Rock” System for Fully Mechanized Longwall Mining in Steeply Dipping Coal Seams by Shenghu Luo, Tong Wang, Yongping Wu, Jingyu Huangfu

“…Third, the magnitude and direction of the load, action point, and mining height affect the stability of the support to varying degrees, with the tangential load and action position of the roof load having the most significant impacts on the stability of the support. …”
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Extraction of Antioxidant Peptides and Activity Evaluation of Frog (Rana nigromaculata) Skin by Ultra-high Pressure Assisted Enzyme Hydrolysis by Xicai ZHANG, Rong LI, Yechuan HUANG

“…Taking the yield of highly active small molecule peptides as the index, the response surface method was utilized to optimize the four parameters containing enzyme addition, ultra-high pressure, the action time, and liquid-to-material ratio to determine the best extraction process for small molecule peptides. …”
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Le radicalisme au début du xixe siècle, ou le poids des héritages by Edmond Dziembowski

“…Considéré sous l’angle des moyens d’action, le radicalisme des années 1815-1832 est aussi l’héritier des méthodes mises sur pied par les pionniers du mouvement. …”
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Experimental Study on Undrained Shear Properties of Saline Soil under Freeze-Thaw Cycles by Shukai Cheng, Qing Wang, Jiaqi Wang, Yan Han

“…As both the confining pressure and number of freeze-thaw cycles increase, the pore water pressure increases, as does the pore water pressure coefficient in shear failure. Under the action of freeze-thaw cycles, on the p′−q plane of the stress space, the effective stress path gradually moves to the lower left side. …”
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Cytoprotective Effect of Lygodium venustum Sw. (Lygodiaceae) against Mercurium Chloride Toxicity by Fernando G. Figueredo, Luciene F. Lima, Maria Flaviana B. Morais-Braga, Saulo R. Tintino, Pablo A. M. Farias, Edinardo F. F. Matias, José Galberto M. Costa, Irwin R. A. Menezes, Raimundo L. S. Pereira, Henrique D. M. Coutinho

“…The antibacterial activity of the natural products was evaluated by microdilution method and by assays to elucidate the possible cytoprotective action when combining the natural products samples and mercurium chloride, utilizing the extract and fractions at a subinhibitory concentration. …”
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Micro-amplitude vibration-assisted scratching: a new method for one step and controllable fabrication of the microscale V-groove and nanoscale ripples by Haoxiang Wu, Hu Huang, Zhiyu Zhang, Jiwang Yan

“…The microscale V-groove was formed due to the scratching action, and the nanoscale ripple was formed due to the extrusion action of the indenter on the microscale V-groove’s surface. …”
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IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A by Xiuxia Wang, Yating Yang, Xianyu Zhou, Shun Yu, Xusong Luo, Lin Lu, Zhen Gao, Jun Yang

“…Here, we discover interferon (IFN)γ could induce KFs ferroptosis through inhibiting SPOC domain-containing protein 1 (SPOCD1), serving as a mode of action for CD8+T cell (CTL)-mediated keloid killing. …”
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The Impact of <i>Lactobacillus reuteri</i> on Oral and Systemic Health: A Comprehensive Review of Recent Research by Zihui Liu, Qing Cao, Wenqing Wang, Bowen Wang, Yilun Yang, Cory J. Xian, Tiejun Li, Yuankun Zhai

“…<i>Lactobacillus reuteri</i> has shown promising prospects in treating non-communicable biofilm-dependent oral diseases, but its mechanism of action and efficacy still need further research. In addition, <i>Lactobacillus reuteri</i> has also displayed some potential benefits in promoting overall health. …”
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